LOCUS       NM_001014031            3748 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cap methyltransferase 1 (Cmtr1), mRNA.
ACCESSION   NM_001014031 XM_241622
VERSION     NM_001014031.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Werner,M., Purta,E., Kaminska,K.H., Cymerman,I.A., Campbell,D.A.,
            Mittra,B., Zamudio,J.R., Sturm,N.R., Jaworski,J. and Bujnicki,J.M.
  TITLE     2'-O-ribose methylation of cap2 in human: function and evolution in
            a horizontally mobile family
  JOURNAL   Nucleic Acids Res 39 (11), 4756-4768 (2011)
   PUBMED   21310715
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Belanger,F., Stepinski,J., Darzynkiewicz,E. and Pelletier,J.
  TITLE     Characterization of hMTr1, a human Cap1 2'-O-ribose
            methyltransferase
  JOURNAL   J Biol Chem 285 (43), 33037-33044 (2010)
   PUBMED   20713356
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085799.1.
            
            On Apr 20, 2005 this sequence version replaced XM_241622.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085799.1, SRR8487231.160548.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3748
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /note="cap methyltransferase 1"
                     /db_xref="GeneID:309656"
                     /db_xref="RGD:1307801"
     exon            1..90
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            91..225
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2609
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /EC_number="2.1.1.57"
                     /note="S-adenosyl-L-methionine-dependent methyltransferase
                     FTSJD2; ftsJ methyltransferase domain-containing protein
                     2; cap1 2'O-ribose methyltransferase 1; FtsJ
                     methyltransferase domain containing 2"
                     /codon_start=1
                     /product="cap-specific mRNA
                     (nucleoside-2'-O-)-methyltransferase 1"
                     /protein_id="NP_001014053.1"
                     /db_xref="GeneID:309656"
                     /db_xref="RGD:1307801"
                     /translation="MKRRTDPECTAPLKKQKRIGELARHLSSTSDDEPLSSVSHAAKA
                     STTSLSGSDSETEGKQPCSDGFKDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREG
                     EGLGKYSQGRKDIVETSNQKGRRGLGLTLQGFDQELNVDWRDEPEPNACEQVSWFPEC
                     TTEIPDSREMSDWMVVGKRKMVIEDETEFCGEELLHSMLKCKSVFDILDGEEMRRART
                     RANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPLDSSGKPLLKESDIDLLYFADVC
                     AGPGGFSEYVLWRRKWHAKGFGMTLKGPNDFKLEDFYSASSELFEPYYGEGGVDGDGD
                     ITRPENINAFRNFVLDNTDRKGVHFVMADGGFSVEGQENLQEILSKQLLLCQFLMALS
                     VVRTGGHFVCKTFDLFTPFSVGLIYLLYCCFERVCLFKPVTSRPANSERYVVCKGLKV
                     GIDDVREYLFSVNIQLNQLRNTDSDVNLVVPLSVIKGDHEFNDYMIRSNESYCSLQIK
                     ALAKIHAFVQDTTLSEPRQAEIRKECLQLWEIPDRARVAPSPSDPKFKFFELIKDTDI
                     NIFSYKPTLLTAKTLEKIRPVLEYRCMVSGSEQKFLLGLGKSQIYTWDGRQSDRWVKL
                     DLKTELPRDTLLCVEIVHELKGEGKAQRKISAIHILDVLVLNGSDVREQHFNQRIQLA
                     EKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKLIKGSGGTPKLSYTGRDDR
                     HFVPTGVYIVRTVTEPWTMAFSKGWKKKFFYNKKTGESFFTLPPESIAPFHTCYYTRL
                     FWEWGDGFHMRDSQKPQDPDKLSKEDVLSFIQSHNPLGP"
     exon            226..377
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            378..536
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            537..629
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            630..701
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            702..796
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            797..869
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1068
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1187
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1284
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1417
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1597
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1654
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1712
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1781
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1913
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2036
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2128
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2197
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2245
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2358
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2467
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..3718
                     /gene="Cmtr1"
                     /gene_synonym="Ftsjd2; LRRG00129; MTr1; RGD1307801"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggaggtt acaaggccag cggcgacact ggacagtggc ggcctgatcc ctcgtttccg
       61 ctcgccggca gttcgcccca tgccctcagt taacaatgaa gaggagaact gacccagagt
      121 gcactgcccc cctcaagaaa cagaagcgaa ttggggagct tgcccggcac ctcagctcca
      181 catctgatga tgaacctctc tcctctgtca gtcatgcggc aaaagcatct actacaagcc
      241 tcagcggatc tgacagtgag acagagggga agcagccctg ctctgatggt ttcaaagatg
      301 ccttcaaagc agactccctt gtggagggaa catcttctcg ctattccatg tataacagtg
      361 tttcccagaa gcttatggcc aaaatgggct tcagggaagg cgaggggttg ggtaagtaca
      421 gccagggtcg gaaggacatc gtggagacct ccaatcagaa aggtcgacgt ggtttgggcc
      481 tgacactgca gggcttcgat caggagctga atgtggactg gcgagatgag ccagagccca
      541 atgcctgtga gcaggtatcg tggtttccag aatgcaccac tgaaattcct gactctcggg
      601 aaatgagtga ctggatggtc gtgggaaaga gaaaaatggt tattgaagat gaaacggagt
      661 tctgtgggga ggagctgctt cacagcatgc tcaagtgtaa gagcgtgttt gacatcctgg
      721 atggggagga gatgcggcga gcgcgcacca gagccaatcc ctatgagatg atccgaggtg
      781 tcttcttcct taacagggca gcaatgaaga tggctaacat ggattttgtg tttgatcgta
      841 tgttcacaaa tcctctggac tcttctggga agccgctgct gaaggagtcg gacattgacc
      901 ttctgtactt tgctgatgtg tgtgcaggcc caggtggctt ctctgagtat gtgctgtgga
      961 ggaggaagtg gcacgcaaaa ggctttggga tgacgctgaa gggccccaat gacttcaagc
     1021 tggaggactt ctactccgcc tccagtgagc tcttcgagcc ctactatggt gagggtgggg
     1081 tcgatggaga tggcgacatc acccgtccag agaacatcaa cgcgtttcgg aattttgtcc
     1141 tggacaacac agatcgcaag ggcgtccact ttgtgatggc agatgggggc ttttctgtgg
     1201 aggggcagga gaacctgcag gagatcctca gcaagcagct cctgttgtgc cagttcctca
     1261 tggccctgtc tgtagtccgc acagggggcc acttcgtctg caaaaccttt gacctcttca
     1321 caccgttcag tgtgggcctc atttatctgc tctactgctg ctttgaacga gtgtgtctct
     1381 tcaaacctgt caccagcagg cctgccaact cggagcggta tgtggtgtgc aaaggtctga
     1441 aggtgggcat agatgatgtc cgggagtacc tcttctccgt gaacattcaa ctcaaccagc
     1501 ttcgcaacac cgactccgat gtcaacctgg tcgttccctt gtcagtgatc aaaggcgacc
     1561 atgaatttaa tgactacatg atacggtcta atgagagcta ctgcagccta cagatcaaag
     1621 cgctggccaa gatccatgcg tttgtacagg acacgaccct gagcgagccc aggcaggcag
     1681 agatccggaa agagtgcctc cagctgtggg agatcccaga ccgggctcga gttgctcctt
     1741 ccccttcaga cccaaaattc aagttttttg aactaatcaa ggacactgac atcaacatct
     1801 tcagctacaa gcccacgctg ctcactgcta aaaccctgga gaagatccgg cctgtgttgg
     1861 agtatcgttg catggtgtct ggcagcgagc agaaattcct cctgggcttg gggaagtccc
     1921 aaatctacac ttgggatggc cgccaatcag accgttgggt gaagctggac ctgaagacag
     1981 agctgccccg ggacacacta ctctgtgtgg aaattgtgca tgagctaaaa ggagagggga
     2041 aggcccagcg gaagatcagc gcgatccaca tcctcgatgt cctggtgctg aatggcagcg
     2101 acgtccgaga gcagcacttc aaccagcgaa ttcagcttgc tgagaaattt gtgaaagcag
     2161 tttctaagcc cagccgaccg gacatgaatc ctatcagggt gaaggaggtg taccggctag
     2221 aagagatgga gaagattttt gtcagattag aaatgaagct catcaaaggc tctggcggca
     2281 ctccaaagct cagctacacg ggacgggacg accggcactt tgtgcccaca ggtgtctaca
     2341 ttgtcaggac tgtgactgag ccgtggacca tggcattcag caagggctgg aagaagaagt
     2401 tcttctacaa caagaaaacc ggcgagtcct tctttacact ccccccagag tccattgccc
     2461 cattccatac ctgctactac acccggctct tctgggagtg gggagatggc ttccatatgc
     2521 gcgattccca gaagccccag gatccagaca agctgtccaa ggaggacgtc ctttccttca
     2581 tccagagtca caatcctcta ggcccttaga tttccacctg atgaatgtcc tgtcattctt
     2641 aaggcagggc ccagtgactg ggttccttct gcctcttaga aaggcactgg gactgttctc
     2701 cctggtcaca gggagatggg ctcctctcca ttcccaagga gctcaattgg gaccttagag
     2761 gacgtatcct tgtggaactc tgctgcctga gagctgacac cagcagcagg cagcctcaca
     2821 agcagctgct cggggcaggt cagtgcttag cacttgccag agtggcaggc tttgggccca
     2881 gccattccta ttgtaatatg tggactcggc agtgttctga gttccatttc ctgtccccaa
     2941 gagcagtcag ctccttgttc tgcccaactt ctactaggct agccaaatgt ggagcccctc
     3001 catcacgggc tggccaggag cacctgtcgt accaatcaaa gttgtttctt gtggtctttt
     3061 ccccacccca atcctggagt ttgtcctggc aggtcaggaa ggagtgtggg cccagtgccc
     3121 ttcaaacatc agagctttgg gtactggatg taactgctcc ttgagttctc acctcttgtg
     3181 ttctaaacac tgggcagctc tggggaagga gcagcctaaa aacttgccct tttctcttcc
     3241 tctcagcagt aacagaaggt aggggtaaca ccagccctcc ctctagcagt ccaggccacc
     3301 tgaagctctt ggcagagttc tgagcgtggt ggctccagct tccctcccct tcactaggag
     3361 gtacttactg ctctgtgatt tgtttctatt ccgtcactcc atttcctgtc tctgtaagag
     3421 ggaggaatgg cgacagcttt gggttgggaa gggtacctat ggttgtttcc aatgggaaat
     3481 ctatctcaag agatgttcat gcaggctcct tagggcccca tgccagtgcc agactggttt
     3541 ccatggagat agggcactga ggcacctgtg aggttggaat tgaccaccat gggaggtccc
     3601 ttccgccagc cctcaaccct taagccagca gcaaatgcta ggatgccgta ttcacccaat
     3661 tctgggtcta tcagtgtgtc tttcagaatc ttggatcatt aaacagattt ttactgctaa
     3721 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
