LOCUS       NM_001007802            3246 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CKLF-like MARVEL transmembrane domain containing
            6 (Cmtm6), mRNA.
ACCESSION   NM_001007802 XM_006243969 XM_236668
VERSION     NM_001007802.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3246)
  AUTHORS   Burr,M.L., Sparbier,C.E., Chan,Y.C., Williamson,J.C., Woods,K.,
            Beavis,P.A., Lam,E.Y.N., Henderson,M.A., Bell,C.C., Stolzenburg,S.,
            Gilan,O., Bloor,S., Noori,T., Morgens,D.W., Bassik,M.C.,
            Neeson,P.J., Behren,A., Darcy,P.K., Dawson,S.J., Voskoboinik,I.,
            Trapani,J.A., Cebon,J., Lehner,P.J. and Dawson,M.A.
  TITLE     CMTM6 maintains the expression of PD-L1 and regulates anti-tumour
            immunity
  JOURNAL   Nature 549 (7670), 101-105 (2017)
   PUBMED   28813417
REFERENCE   2  (bases 1 to 3246)
  AUTHORS   Mezzadra,R., Sun,C., Jae,L.T., Gomez-Eerland,R., de Vries,E.,
            Wu,W., Logtenberg,M.E.W., Slagter,M., Rozeman,E.A., Hofland,I.,
            Broeks,A., Horlings,H.M., Wessels,L.F.A., Blank,C.U., Xiao,Y.,
            Heck,A.J.R., Borst,J., Brummelkamp,T.R. and Schumacher,T.N.M.
  TITLE     Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
  JOURNAL   Nature 549 (7670), 106-110 (2017)
   PUBMED   28813410
REFERENCE   3  (bases 1 to 3246)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Mar 18, 2021 this sequence version replaced
            XM_006243969.4, NM_001007802.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107930.1, SRR26643288.35953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000008.1  123301131-123301314
            185-361             JAXUCZ010000008.1  123306115-123306291
            362-460             JAXUCZ010000008.1  123308822-123308920
            461-3246            JAXUCZ010000008.1  123316445-123319230
FEATURES             Location/Qualifiers
     source          1..3246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3246
                     /gene="Cmtm6"
                     /gene_synonym="Cklfsf6; Da2-17; LRRGT00102"
                     /note="CKLF-like MARVEL transmembrane domain containing 6"
                     /db_xref="GeneID:316035"
                     /db_xref="RGD:1307765"
     exon            1..184
                     /gene="Cmtm6"
                     /gene_synonym="Cklfsf6; Da2-17; LRRGT00102"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..598
                     /gene="Cmtm6"
                     /gene_synonym="Cklfsf6; Da2-17; LRRGT00102"
                     /note="chemokine-like factor super family 6;
                     chemokine-like factor superfamily 6"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 6"
                     /protein_id="NP_001007803.1"
                     /db_xref="GeneID:316035"
                     /db_xref="RGD:1307765"
                     /translation="MENGAVYSPTTEAAPGAGRGARSGLAAYFFLGRLPWYRRILKGL
                     QLLLSLLAFICEEVVSECGLCGGLYFFEFVSCSAFLLSLLLLIVYCTAVYDRVDTGKV
                     KSSDFYITLGTGCVFLLASIIFVSTHSGTSAEIAAIVFGFLGSSMFLLDFVVMLCEKL
                     RESPLRKPENNARAEALTEPLNA"
     exon            185..361
                     /gene="Cmtm6"
                     /gene_synonym="Cklfsf6; Da2-17; LRRGT00102"
                     /inference="alignment:Splign:2.1.0"
     exon            362..460
                     /gene="Cmtm6"
                     /gene_synonym="Cklfsf6; Da2-17; LRRGT00102"
                     /inference="alignment:Splign:2.1.0"
     exon            461..3246
                     /gene="Cmtm6"
                     /gene_synonym="Cklfsf6; Da2-17; LRRGT00102"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatcccggc ggagactttt gctgggcgag cgagtatttg cgggcgatgg agaacggagc
       61 ggtgtacagt cccaccacgg aggcggcccc gggcgctggc aggggcgctc gcagcggcct
      121 ggccgcctac ttcttcctgg gccggctccc atggtatcgg cgcatcctca agggcttgca
      181 gctgctgctg tctctcctgg ccttcatctg tgaagaggtt gtgtccgagt gtgggctgtg
      241 tggaggcctg tacttctttg agtttgtgag ctgcagtgcc tttctcctga gccttctcct
      301 gctgatcgtg tactgcacag cagtgtacga cagagtggat actggaaaag tcaagtcatc
      361 ggatttttac atcaccctgg gcacagggtg tgtgtttctg ctggcttcta tcatcttcgt
      421 ctctacccat tccgggacct cggctgagat tgctgcaatt gtgtttggct tcctaggaag
      481 ctcaatgttt ctactggact tcgtcgtcat gctgtgtgag aagctgcggg agagccctct
      541 tagaaagccc gagaacaacg ctagagctga agccctcact gaaccactga atgcttaaag
      601 acaaggagtg ggggctgtgg acccaaacag aggctccctc cttgtgacct gtgtcatgtg
      661 tgcacctttt ggagagaagg gaaaggacag aagaacagct tcacagagct gggctggatg
      721 acagcccagc agtaagctca gagggttttt aataactgtt ggaacctgtc tcaaacggag
      781 gaggtggtgt ttgtttgttt gtttgttttg ttcttagaga tgaagactgc tgtctctttg
      841 aattgcatgt ctgtcatttt gctacaggac gcctgcccct catcagggtt agcttccaga
      901 ccgtgccttg tccgtccttt caggaactgg ttaatttctg ttgtgtcgtt agagatttaa
      961 tttgtgttta agtgactggt gtaggcttct ctccttaatg ttagatcctt tactggatcc
     1021 cactcagtct tacacttatg tgctaacctt tcaaagcaat tattcttaat tccttctgag
     1081 ccatgcattg cctaacagaa aatgtgtagc ctgctggtgt ttatttgtat gaaagcaaca
     1141 gtagcatcag ccttgtggtg gcttttacat tgcactttgg ttgttgagat taagtttgtt
     1201 atgggccaca gggaagtgag ggaactgatt agtctagcta aagaccaaag agaagagact
     1261 gtcccgcaca gcaggtgtaa tcacacagag aggccttgat cactcggcag agatgtgaag
     1321 ggttggtgct gtgttcacac acgcagacag ttgatgacgt cagactggag actgggtctc
     1381 cctctgggca gatgatcatt tctgctcaag cgaacacagc tctgccggct tctcttcaga
     1441 ggcctagctg ggagctctcg cccaccagag atgcctcctt tctgaccagc tctagaatgg
     1501 tcccgtgctg tgtaccgtct gtgaaagtga gcgcgcactc tcactctccg ttctcttccc
     1561 actgtcagcc atctccaggc catccagagt cgtgtccctt ctcgtcacca agcgtctgag
     1621 gcaggagtgt caggctcgtc ccatgggcct ctgcttgggt ttctctccag ggaggtgtct
     1681 tgagaaagcg aatcctagaa gccctgctag tgaatactgc tggtggtgta aggaggccag
     1741 acttcttggg actttggaag aattgcttgt tgctggaagg ctgtcttaga gccactgggc
     1801 accctggtga ccaaagggga cccttcttac cttcctacag tttaactgag actcaggttt
     1861 cccaggctgg ggtttctctc tgaagcgatg cgatcatgcg atcatatttc cagggagtca
     1921 ctgtaaagtc cccctccgtt ccagtgtctt gtctgccatt gtgtgtggaa gacggtttca
     1981 gtttcatgag tgagcctgct acagttcttg gaagtggctg aatctgggca cacagcttct
     2041 gctctgtgcc tgcctcactg tctgactgat ctgctggcct cagggtttac attgctggtg
     2101 atgtcaccat agctgctttg gagatcatga aactaatcat ggatgttgcc ttactgggtg
     2161 tgccttctca gagaggtgac agtaggctct tgaagctaag aatagaaaaa ttcaaaagta
     2221 gccagtttat tgcagacaat tttagagttt catatcaagc tgtgctgtag ttactgtaaa
     2281 tatcatttag acctgttgag aattaacagc aaattggggc tactttagtg ttgccaatta
     2341 ttagtcagct gacttaccat agcaaaatac ctgagacaat caacttaaaa agaggaaggg
     2401 ctggagaaag ggttaatctt ggtttgcagt ttggaggctt caacccttgg tcagacctgt
     2461 tgttttagaa ggcagcacat cacttgggga gttcatggta gagctgcaag caaggaaaga
     2521 agggtggtga cttgaggtcc tgaggtctct taagggtcac ctccctgtcc ccgctgacct
     2581 aagacttcac actggtcccc acctctaaag gtgtctgcct gcaatagtgc catcctgaga
     2641 cctagcttct aactcgcagg tgcttaggga cattgtactc tgtggtaggc gcctctctgc
     2701 ccgtgtgtgg cttgttcgtg attgacagtc actctggcct gctgtgttag tgtcccacag
     2761 cgggggactc tgccgggcca cttcaggctt tccttttagg aagataattt ggtcacttgt
     2821 gtctgtggcc actcttagaa ctttctcttt tgggggaacc tgtggctggt tgacttctgg
     2881 attcgatgga gagagatgat attaaagact gtggcaacaa acaccctgca gaagcactgg
     2941 aaccagagac tgtcagcaca gtagggacaa tgtcttttct agtagctgtg gcagatttga
     3001 gttcctgtaa tttatacaaa ttgtttagaa tggtttttaa gacttagaag ggaaatatac
     3061 ttacagcaca agacttttat aattatactt taaattatgc tttatgtggg acaggaaaaa
     3121 tgtattttta cattgcttat atcagatcac ttttgtattt gttgatttaa agcctgtggg
     3181 tcttttttta tcactcttaa tatcaacttt tataatcttt taaaataaat cctcttaatt
     3241 ccagtg
//
