LOCUS       NM_001013142             982 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus CKLF-like MARVEL transmembrane domain containing
            2A (Cmtm2a), mRNA.
ACCESSION   NM_001013142 XM_226209
VERSION     NM_001013142.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 982)
  AUTHORS   Stojkov-Mimic NJ, Bjelic MM, Radovic SM, Mihajlovic AI, Sokanovic
            SJ, Baburski AZ, Janjic MM, Kostic TS and Andric SA.
  TITLE     Intratesticular alpha1-adrenergic receptors mediate
            stress-disturbed transcription of steroidogenic stimulator NUR77 as
            well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of
            adult rats
  JOURNAL   Mol Cell Endocrinol 412, 309-319 (2015)
   PUBMED   26003139
  REMARK    GeneRIF: In vivo blockade of testicular alpha1-adrenergic receptors
            changed the stress-induced decrease of Nur77 and increase of Arr19
            and Dax1 in Leydig cells.
REFERENCE   2  (bases 1 to 982)
  AUTHORS   Sadasivam M, Ramatchandirin B, Ayyanar A and Prahalathan C.
  TITLE     Bacterial lipopolysaccharide differently modulates steroidogenic
            enzymes gene expressions in the brain and testis in rats
  JOURNAL   Neurosci Res 83, 81-88 (2014)
   PUBMED   24594480
  REMARK    GeneRIF: These findings show ARR19 might play a crucial role in
            regulation of neuronal and testicular steroidogenesis in
            inflammatory diseases
REFERENCE   3  (bases 1 to 982)
  AUTHORS   Li G, Li GY, Ji HJ, Zhao WJ, Chu SF and Chen NH.
  TITLE     [Effect of testosterone on the expression of CMTM family of the
            male spermatogenesis suppression rats]
  JOURNAL   Yao Xue Xue Bao 45 (8), 995-1000 (2010)
   PUBMED   21351585
  REMARK    GeneRIF: Testosterone was associated with the expression of CMTM
            family during spermatogenesis, and CMTM2 and CMTM4 may take part in
            the spermatogenesis process.
REFERENCE   4  (bases 1 to 982)
  AUTHORS   Qamar I, Park E, Gong EY, Lee HJ and Lee K.
  TITLE     ARR19 (androgen receptor corepressor of 19 kDa), an
            antisteroidogenic factor, is regulated by GATA-1 in testicular
            Leydig cells
  JOURNAL   J Biol Chem 284 (27), 18021-18032 (2009)
   PUBMED   19398553
REFERENCE   5  (bases 1 to 982)
  AUTHORS   Jeong BC, Hong CY, Chattopadhyay S, Park JH, Gong EY, Kim HJ, Chun
            SY and Lee K.
  TITLE     Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich
            protein that represses the transcriptional activity of androgen
            receptor through recruitment of histone deacetylase
  JOURNAL   Mol Endocrinol 18 (1), 13-25 (2004)
   PUBMED   14576337
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078975.1.
            
            On Apr 20, 2005 this sequence version replaced XM_226209.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078975.1, CK652927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..982
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p14"
     gene            1..982
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /note="CKLF-like MARVEL transmembrane domain containing
                     2A"
                     /db_xref="GeneID:307616"
                     /db_xref="RGD:1307501"
     exon            1..264
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..609
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /note="chemokine-like factor super family 1"
                     /codon_start=1
                     /product="CKLF-like MARVEL transmembrane domain-containing
                     protein 2A"
                     /protein_id="NP_001013160.1"
                     /db_xref="GeneID:307616"
                     /db_xref="RGD:1307501"
                     /translation="MASGIRYAFRPKGAQRKEDTTPKKGIRRYLFELKEGNKQFWLSG
                     HAVTKLITLGCIITALDYFESMLPHPVLVLVLSMEVAIYIFFIFLNTFAINRYITFIF
                     WPMTDLLNSLFSCVFLAGSVFFAFKARRTLPKPYLTAMIFMGVAAISCFLDIFLQLPH
                     FRGLQMR"
     exon            265..423
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..525
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..605
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..953
                     /gene="Cmtm2a"
                     /gene_synonym="Cklfsf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttgaaca ggtctggagg cacccggctc tctcttgagc tgggcctgtt cggggactgc
       61 acgcaagggt gggcggtagg gagttaagaa ctgcttttaa caaccatggc atcaggaata
      121 aggtatgcat ttcggcccaa aggagctcag cgcaaggagg acacgacccc caaaaaaggg
      181 attcgacgct atctgtttga actgaaagag ggcaataaac agttctggct gtcgggacac
      241 gccgttacaa agcttataac tttgggctgc ataatcactg cactagacta ctttgaatca
      301 atgctcccac atcctgttct ggtcctggtc ctcagtatgg aagtggcaat ctacatattc
      361 ttcatcttcc ttaatacctt tgccatcaac cggtacatta ccttcatctt ctggcctatg
      421 acagatctat tgaacagcct gttctcctgt gtgttcctcg caggctctgt attctttgct
      481 ttcaaggcta gacgaacatt gccaaagccc tacttaactg ctatgatctt catgggagtt
      541 gctgcaatct cttgtttcct cgatattttt cttcaactcc cacacttcag aggccttcag
      601 atgaggtaat aactgtggcc tctatgacct ttttcatcat ggcacaagcc catgaaccat
      661 atatcgttat cactggactt gaagtcacca tcattctctt tctcatagcc ttatatatgt
      721 gcagacttga caagatggtg agatagctct ttggcctttg cttgtaattg agaaacttca
      781 acgttaagcc ttaactacct ttcctgtcat aagacacctt agtcaactac gtggtactcc
      841 taaatctttt aaggtgatct ctgctcactg ctaaacagtc catgatgtac ttggggaagg
      901 ctctcaggga ttcaggatac ccacagaaca taaattatct ttactgtatc tacaaaaaaa
      961 aaaaaaaaaa aaaaaaaaaa aa
//
