LOCUS       NM_001108017            3054 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cytidine/uridine monophosphate kinase 2 (Cmpk2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001108017 XM_001075137 XM_234017
VERSION     NM_001108017.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Chen,Y., Wu,L., Shi,M., Zeng,D., Hu,R., Wu,X., Han,S., He,K.,
            Xu,H., Shao,X. and Ma,R.
  TITLE     Electroacupuncture Inhibits NLRP3 Activation by Regulating CMPK2
            After Spinal Cord Injury
  JOURNAL   Front Immunol 13, 788556 (2022)
   PUBMED   35401582
  REMARK    GeneRIF: Electroacupuncture Inhibits NLRP3 Activation by Regulating
            CMPK2 After Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   Amiri,M., Conserva,F., Panayiotou,C., Karlsson,A. and Solaroli,N.
  TITLE     The human adenylate kinase 9 is a nucleoside mono- and diphosphate
            kinase
  JOURNAL   Int J Biochem Cell Biol 45 (5), 925-931 (2013)
   PUBMED   23416111
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Goertsches,R.H., Hecker,M., Koczan,D., Serrano-Fernandez,P.,
            Moeller,S., Thiesen,H.J. and Zettl,U.K.
  TITLE     Long-term genome-wide blood RNA expression profiles yield novel
            molecular response candidates for IFN-beta-1b treatment in
            relapsing remitting MS
  JOURNAL   Pharmacogenomics 11 (2), 147-161 (2010)
   PUBMED   20136355
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Xu,Y., Johansson,M. and Karlsson,A.
  TITLE     Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase
            localized in mitochondria
  JOURNAL   J Biol Chem 283 (3), 1563-1571 (2008)
   PUBMED   17999954
REFERENCE   5  (bases 1 to 3054)
  AUTHORS   Lee,C.G. and O'Brien,W.E.
  TITLE     A unique member of the thymidylate kinase family that is induced
            during macrophage activation
  JOURNAL   J Immunol 154 (11), 6094-6102 (1995)
   PUBMED   7751651
REFERENCE   6  (bases 1 to 3054)
  AUTHORS   Arima,T., Akiyoshi,H. and Fujii,S.
  TITLE     Characterization of pyrimidine nucleoside monophosphokinase in
            normal and malignant tissues
  JOURNAL   Cancer Res 37 (6), 1593-1597 (1977)
   PUBMED   192455
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001075137.1, XM_234017.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3054
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /note="cytidine/uridine monophosphate kinase 2"
                     /db_xref="GeneID:314004"
                     /db_xref="RGD:1305881"
     exon            1..668
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1337
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /EC_number="2.7.4.14"
                     /note="thymidylate kinase family LPS-inducible member;
                     cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial"
                     /codon_start=1
                     /product="UMP-CMP kinase 2, mitochondrial"
                     /protein_id="NP_001101487.1"
                     /db_xref="GeneID:314004"
                     /db_xref="RGD:1305881"
                     /translation="MARPRRFTVELPDCSLTHFVLGDAAGHRDARLTELLGPPGRSYA
                     LCVPLVPGEGCGPRVQAARVYQRLQLQLRQGPLQRCELSKLLGYGPGDQASEAQHGFL
                     LRDPSDHPDTRQDLLQLLGSCQEATRLHLAEFQADSQGLLWQRLWELQGDRQVQVDCA
                     CVLPAPEPHLHPLLPDLLNSAVFQDRDAARAVLEECTSFIPEAREVLDLVDQCPREIQ
                     KGKFQVIAIEGLDATGKTTLTQSVSESLQAVLLQSPPPCISQWRKLFDDEPTIIRRAF
                     YSLGNYLVASEIAKQSAKFPVIVDRYWHSTATYAIATEVSGGLQYLPPAHHPVYQWPR
                     DLLKPDLVLLLTVNSEERVRRLQGRGQEKTKEEAELEVNSVFRQKVEATYQRMENPSC
                     RLVDASPSRETVLQTVLQLIQRAGH"
     exon            669..783
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /inference="alignment:Splign:2.1.0"
     exon            784..985
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1219
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..3054
                     /gene="Cmpk2"
                     /gene_synonym="Tyki"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taataagctg ccctcgagcc ccactgtggc ttgggcgact gtcgcggagg ctgtgcgcgc
       61 gacaccgggc ctgcacgggg accatggctc ggccgcggcg cttcactgta gagctgcccg
      121 attgctccct gactcacttc gtcctggggg acgcggcggg ccaccgggat gctcgcctta
      181 cggagctgct cgggccccca gggcgcagct acgcgctgtg tgtgccattg gttccaggcg
      241 aaggctgtgg gccccgggta caggcggccc gggtgtacca gcgcctgcag ctgcagctgc
      301 gccagggtcc tttgcagagg tgcgagctga gcaaactgct gggatatggt ccaggcgatc
      361 aggccagcga agcccagcat ggcttcctgc tgcgcgaccc cagcgaccac ccggacaccc
      421 ggcaagactt gctgcagctt ctgggctcat gccaggaggc gacacggctg cacttggcgg
      481 agttccaggc cgattcccag ggattgctgt ggcagcgtct gtgggagttg cagggagaca
      541 gacaggtgca ggtggactgc gcatgcgtcc tgccggcacc ggagccccat ctgcacccac
      601 tgctgcctga tctgctcaac tctgcggtgt ttcaagaccg ggacgctgca cgggctgtct
      661 tggaggagtg cacatctttt attccagaag cccgggaagt gcttgaccta gttgaccagt
      721 gcccaaggga gatccagaaa gggaagttcc aggtcattgc cattgaagga ctggatgcca
      781 ctggtaagac cacactgacg cagtccgtgt cagagtctct ccaagctgtc ctcttacagt
      841 ctccaccccc ctgcatcagc cagtggagga agctctttga tgatgagcct actatcattc
      901 ggagagcatt ttactctttg ggcaattatc tcgtggcttc tgaaatagct aaacagtcag
      961 ccaagtttcc tgttatcgta gacaggtact ggcatagcac agccacctat gccatagcca
     1021 ctgaggtgag tggaggccta cagtacctac cccctgccca ccaccctgtg taccagtggc
     1081 caagagacct gctgaagcct gacctggtcc tgctgcttac tgtgaattct gaggagagag
     1141 tgcggagact gcagggtcgg ggccaggaga agactaaaga agaggctgaa ctcgaggtca
     1201 acagcgtgtt tcgtcagaag gtggaagcca cgtaccagcg tatggagaac ccaagctgcc
     1261 gtctggtcga tgccagcccg tccagagaga cagtgctgca gacagtttta cagctgatcc
     1321 agagggctgg tcattaattg cagttgctat ggctgggttc ctcattatac cggaagagaa
     1381 gctgtgtgat gcaccaaaac ccagcacttg tcattcaggt ttcttagatt taggtcgtat
     1441 gagcaaacct agtagaaaaa aaacctggag actgtgcagt ttgcttttct tctgactgac
     1501 cgagccagcc aaagctgctg attcatttct gtctggccgt gtaccatctt cttgggatat
     1561 attttaacac cttgactttc tgatccaggg gtgagcctgc tggaggtctt actgaagctg
     1621 gaagctaagg atgtcagctt tagcccacac tgatgagctt gcctcattgg tttttacccc
     1681 aaaccctgta actaaaaaat gtcacagagc ctggctgtct aaggacattc ccttggagct
     1741 attcatgggt ggagacactt gcaaagaagc cattgatctt acttcagagg atcagggaac
     1801 cccttggaca gcctggatga gcacctcaga attgaataga tgtgtgcccc tgaactgcaa
     1861 gagctccaag cccctcttgt tctcgtctgc ttgtctgtat tcctcttctc gactctgaaa
     1921 tctcattcag agtgtaatga gcagtctgca ctgatctgga tgcgttgcac ttacccaaca
     1981 caccaatttg tttatattga tgtttacatc atgtgtttcc tcagtgtagg agctgtgtgt
     2041 gagtcacaca cacaaactga ggccaaggag ctaaatgaag catttgctca gtgttttcat
     2101 tacacaaatt taatttatct taataagcac cgtggattct ggaatgagac ttcatagtaa
     2161 attatcatgc actttgaatg tcttctgatt gcgtgtgaag tcagcttcga gggctcttta
     2221 gatagagaat agagctgtgg aagagaagcc tggtggctct gtagccttgg cttagtcatt
     2281 taacattggt aacatcaaca gtttgagctg aaagggtgca gtaatgtgct cccagaaata
     2341 tttacttggg aggctgagaa aggaaaaatt gaaagtgcta ggtgtaagtt cagaattagc
     2401 ctgggtagtg tagtgagacc ttgtcccaag ataaaaactg taaagaggat tgggggtgca
     2461 actccatagt agataaagtc tcactatact ttgtctctga aaagaggcag ttgatggccc
     2521 tgggttcatg ctctggtgtc cattcccagt accataagaa taaaaatgca aacaaaaaca
     2581 aacaataaaa gaaattaagt cattttttgg tcataagtag gtggctggac cagattatta
     2641 tttaacattc cagttccagt gtggatgtct ccctacatca ttctgatgct aagtcccatt
     2701 tcttaagaat ccatccccaa ataattatat gaaattccat gaaagcctta taaggtttac
     2761 cctaatctta aactataata agatttaaaa tttaatatta actcctcaat atttttctct
     2821 tttatgacta tgtataactt ataaaaatgt gtctatgtat ttaaatttct tgttggcttc
     2881 tgtagaacgt atttttaaag ctgattaaca ctagggctct gtgcgacatg gtagctactt
     2941 ccacagaggg ttttattcaa gcctctctga gatgattgca ccagaagctg agaaggaagt
     3001 cttagcgctc tcttcatgaa acctgcccgt gaataaactt gctctgactt tcct
//
