LOCUS       NM_001025655            1871 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus cytidine/uridine monophosphate kinase 1 (Cmpk1),
            mRNA.
ACCESSION   NM_001025655 XM_216506
VERSION     NM_001025655.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Amiri,M., Conserva,F., Panayiotou,C., Karlsson,A. and Solaroli,N.
  TITLE     The human adenylate kinase 9 is a nucleoside mono- and diphosphate
            kinase
  JOURNAL   Int J Biochem Cell Biol 45 (5), 925-931 (2013)
   PUBMED   23416111
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Ryu,J.S., Shin,E.S., Nam,H.S., Yi,H.G., Cho,J.H., Kim,C.S.,
            Kim,H.J. and Lee,J.E.
  TITLE     Differential effect of polymorphisms of CMPK1 and RRM1 on survival
            in advanced non-small cell lung cancer patients treated with
            gemcitabine or taxane/cisplatinum
  JOURNAL   J Thorac Oncol 6 (8), 1320-1329 (2011)
   PUBMED   21642870
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Hirosawa,N., Yano,K., Suzuki,Y. and Sakamoto,Y.
  TITLE     Endocrine disrupting effect of di-(2-ethylhexyl)phthalate on female
            rats and proteome analyses of their pituitaries
  JOURNAL   Proteomics 6 (3), 958-971 (2006)
   PUBMED   16400681
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Huang,M. and Graves,L.M.
  TITLE     De novo synthesis of pyrimidine nucleotides; emerging interfaces
            with signal transduction pathways
  JOURNAL   Cell Mol Life Sci 60 (2), 321-336 (2003)
   PUBMED   12678497
  REMARK    Review article
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Liou,J.Y., Dutschman,G.E., Lam,W., Jiang,Z. and Cheng,Y.C.
  TITLE     Characterization of human UMP/CMP kinase and its phosphorylation of
            D- and L-form deoxycytidine analogue monophosphates
  JOURNAL   Cancer Res 62 (6), 1624-1631 (2002)
   PUBMED   11912132
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Yuh,I., Yaoi,T., Watanabe,S., Okajima,S., Hirasawa,Y. and
            Fushiki,S.
  TITLE     Up-regulated uridine kinase gene identified by RLCS in the ventral
            horn after crush injury to rat sciatic nerves
  JOURNAL   Biochem Biophys Res Commun 266 (1), 104-109 (1999)
   PUBMED   10581173
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Seagrave,J. and Reyes,P.
  TITLE     Pyrimidine nucleoside monophosphate kinase from rat bone marrow
            cells: chromatographic, electrophoretic, and sedimentation behavior
            of active and inactive enzyme forms
  JOURNAL   Arch Biochem Biophys 247 (1), 76-83 (1986)
   PUBMED   3010881
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Scott,E.M. and Wright,R.C.
  TITLE     Kinetics and equilibria of pyrimidine nucleoside monophosphate
            kinase from human erythrocytes
  JOURNAL   Biochim Biophys Acta 571 (1), 45-54 (1979)
   PUBMED   40615
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Arima,T., Akiyoshi,H. and Fujii,S.
  TITLE     Characterization of pyrimidine nucleoside monophosphokinase in
            normal and malignant tissues
  JOURNAL   Cancer Res 37 (6), 1593-1597 (1977)
   PUBMED   192455
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098727.1.
            
            On Jul 22, 2005 this sequence version replaced XM_216506.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098727.1, EV770582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1871
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /note="cytidine/uridine monophosphate kinase 1"
                     /db_xref="GeneID:298410"
                     /db_xref="RGD:1310116"
     exon            1..264
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..780
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.4.14"
                     /note="uridine monophosphate kinase; UMP/CMPK; dCMP
                     kinase; deoxycytidylate kinase; nucleoside-diphosphate
                     kinase; cytidine monophosphate kinase; UMP-CMP kinase 1;
                     cytidine monophosphate (UMP-CMP) kinase 1, cytosolic;
                     cytidylate kinase; uridine monophosphate/cytidine
                     monophosphate kinase"
                     /codon_start=1
                     /product="UMP-CMP kinase"
                     /protein_id="NP_001020826.1"
                     /db_xref="GeneID:298410"
                     /db_xref="RGD:1310116"
                     /translation="MLSSCRRWLLHVLVPSFPPLTRGLRFFPLQLMKPLVVFVLGGPG
                     AGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEGKIVPVEITISL
                     LKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFFDCNNEICID
                     RCLERGKSSGRSDDNRESLEKRIQTYLESTKPIIDLYEEMGKVKKIDASKSVDEVFGD
                     VMKIFDKEG"
     exon            265..411
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /inference="alignment:Splign:2.1.0"
     exon            412..564
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /inference="alignment:Splign:2.1.0"
     exon            565..641
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /inference="alignment:Splign:2.1.0"
     exon            642..738
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1848
                     /gene="Cmpk1"
                     /gene_synonym="CK; Cmpk; RGD1310116"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcagctgg cggcggggcc cggcgcccgc tcagcccgcc ccctccctgc cgccccgccc
       61 gcgccaccgc gccggccgct gtcagaggcg cgttgtatgc tgagcagctg tcgtcgctgg
      121 ctgctgcacg tcctggtccc gagcttcccg ccgctaaccc gcggactgcg gttcttccct
      181 ctccaactca tgaagccgtt ggtcgtgttc gttttgggcg ggcccggtgc gggcaagggg
      241 acccagtgcg cgcgcattgt tgagaaatat ggctacacac acctttctgc aggagagctt
      301 cttcgtgatg aaaggaagaa tccagattca cagtatggtg aacttattga aaagtacatt
      361 aaagaaggaa agattgtacc agttgagata accatcagtt tattaaagag ggaaatggac
      421 caaacaatgg ctgccaatgc tcagaagaat aaattcttga ttgatggctt tccaagaaat
      481 caagacaacc ttcagggttg gaacaagacc atggatggga aagcagatgt atcttttgtt
      541 ctgttttttg actgtaataa tgagatctgt attgaccgat gtcttgaaag gggaaaaagt
      601 agtggtagga gtgatgacaa cagagagagc ttggaaaaga gaattcagac ttatcttgaa
      661 tcaacaaaac caattattga cctatatgaa gaaatgggca aagtcaagaa aatagacgct
      721 tctaagtctg ttgatgaagt ttttggtgac gttatgaaga tttttgacaa agaaggctaa
      781 ctaaccctgg gacatctttg aaatcatgct tgaatattgc tttgatagct gctatcacag
      841 ccccctttta aggcagtttt aagattacat ctcaattaat gtctagaaat atatagtaag
      901 acaaattatg tgttttttaa tttgtggtca cagtgcacag tgaattcagg tttaaatcat
      961 tttaggtatt atggtgctca caaaatgaag aagggtatca gctaattctt gtctgtgtta
     1021 aaagactatc cccttaatcc cttttatgtc tgtgccttct gggagacaat ttctttttag
     1081 tatgcatgtg tatccctttt gtaattgcag tgtgttggga tttgggattt ccacttcctc
     1141 ttactgcaca tttaaaattt ccaacctgct aagtgaattt gtggaccaaa tttaaaggaa
     1201 ctttatgtgt agctggttct tgctcaaggt gtttagtaaa caaactcaga aaatggattc
     1261 ctagcaatgt tctatttatc agatgactga ccatttcctg tcgaaagtta aaacgtagag
     1321 attgatttac tacagcttgt gcaaagtctt tgttccaagg tttgagtcgg gacaggagct
     1381 tcagagcctg gcaggattgt cagctgtctt ctgacatcat ctgtggggca agggtcacaa
     1441 ggagtgactt gtgttcctgt gctctgggac acagagctag tcatcattca gccaatgtta
     1501 gcatagttcc tagaagtaga ctcttgacac gcattcacta gtttatgcta atttgttctt
     1561 gttttaataa taatttgttc aagttttttt ttgtttgttt tgtttcttag actaaataca
     1621 gagttggaat aaattagata aagcaatcta gtggttaaaa tcccatttgt attttatttt
     1681 ctggaatatg tttttcatgg ttacttgttt taaaagattt taaaaaatca ttgcactttg
     1741 gtcagaaaga taataaatat atcttataaa tgtttgattc ccttcctgct tgctttttca
     1801 ataaagtttg aaagtccaag tgattttctt tctctaaaaa attaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa a
//
