LOCUS       NM_022218               2530 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus chemerin chemokine-like receptor 1 (Cmklr1),
            mRNA.
ACCESSION   NM_022218
VERSION     NM_022218.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Zhang,Y., Zhang,J., Zhao,Y., Zhang,Y., Liu,L., Xu,X., Wang,X. and
            Fu,J.
  TITLE     ChemR23 activation attenuates cognitive impairment in chronic
            cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced
            neuronal pyroptosis
  JOURNAL   Cell Death Dis 14 (11), 721 (2023)
   PUBMED   37932279
  REMARK    GeneRIF: ChemR23 activation attenuates cognitive impairment in
            chronic cerebral hypoperfusion by inhibiting NLRP3
            inflammasome-induced neuronal pyroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Quan,X.Z., Ye,J.H., Yang,X.Z. and Xie,Y.
  TITLE     HOXA9-induced chemerin signals through CMKLR1/AMPK/TXNIP/NLRP3
            pathway to induce pyroptosis of trophoblasts and aggravate
            preeclampsia
  JOURNAL   Exp Cell Res 408 (2), 112802 (2021)
   PUBMED   34461109
  REMARK    GeneRIF: HOXA9-induced chemerin signals through
            CMKLR1/AMPK/TXNIP/NLRP3 pathway to induce pyroptosis of
            trophoblasts and aggravate preeclampsia.
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Yamamoto,A., Otani,K., Okada,M. and Yamawaki,H.
  TITLE     Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive
            Rats Mediates Systemic Hypertension
  JOURNAL   Int J Mol Sci 22 (21), 11812 (2021)
   PUBMED   34769243
  REMARK    GeneRIF: Chemokine-like Receptor 1 in Brain of Spontaneously
            Hypertensive Rats Mediates Systemic Hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Yamamoto,A., Matsumoto,K., Hori,K., Kameshima,S., Yamaguchi,N.,
            Okada,S., Okada,M. and Yamawaki,H.
  TITLE     Acute intracerebroventricular injection of chemerin-9 increases
            systemic blood pressure through activating sympathetic nerves via
            CMKLR1 in brain
  JOURNAL   Pflugers Arch 472 (6), 673-681 (2020)
   PUBMED   32462328
  REMARK    GeneRIF: Acute intracerebroventricular injection of chemerin-9
            increases systemic blood pressure through activating sympathetic
            nerves via CMKLR1 in brain.
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Omori,A., Goshima,M., Kakuda,C., Kodama,T., Otani,K., Okada,M. and
            Yamawaki,H.
  TITLE     Chemerin-9-induced contraction was enhanced through the
            upregulation of smooth muscle chemokine-like receptor 1 in isolated
            pulmonary artery of pulmonary arterial hypertensive rats
  JOURNAL   Pflugers Arch 472 (3), 335-342 (2020)
   PUBMED   31965243
  REMARK    GeneRIF: Chemerin-9-induced contraction was enhanced through the
            upregulation of smooth muscle chemokine-like receptor 1 in isolated
            pulmonary artery of pulmonary arterial hypertensive rats.
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Goralski,K.B., McCarthy,T.C., Hanniman,E.A., Zabel,B.A.,
            Butcher,E.C., Parlee,S.D., Muruganandan,S. and Sinal,C.J.
  TITLE     Chemerin, a novel adipokine that regulates adipogenesis and
            adipocyte metabolism
  JOURNAL   J Biol Chem 282 (38), 28175-28188 (2007)
   PUBMED   17635925
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Rodriguez Parkitna,J., Korostynski,M., Kaminska-Chowaniec,D.,
            Obara,I., Mika,J., Przewlocka,B. and Przewlocki,R.
  TITLE     Comparison of gene expression profiles in neuropathic and
            inflammatory pain
  JOURNAL   J Physiol Pharmacol 57 (3), 401-414 (2006)
   PUBMED   17033093
  REMARK    GeneRIF: Data suggest the importance of immune response- and
            microglia activation-related genes in chronic neuropathic pain.
            Expression of the Calca (aka CGRP) gene in the dorsal horn of the
            spinal cord could be involved in persistence of its symptoms.
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Arita,M., Bianchini,F., Aliberti,J., Sher,A., Chiang,N., Hong,S.,
            Yang,R., Petasis,N.A. and Serhan,C.N.
  TITLE     Stereochemical assignment, antiinflammatory properties, and
            receptor for the omega-3 lipid mediator resolvin E1
  JOURNAL   J Exp Med 201 (5), 713-722 (2005)
   PUBMED   15753205
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Wittamer,V., Franssen,J.D., Vulcano,M., Mirjolet,J.F., Le Poul,E.,
            Migeotte,I., Brezillon,S., Tyldesley,R., Blanpain,C., Detheux,M.,
            Mantovani,A., Sozzani,S., Vassart,G., Parmentier,M. and Communi,D.
  TITLE     Specific recruitment of antigen-presenting cells by chemerin, a
            novel processed ligand from human inflammatory fluids
  JOURNAL   J Exp Med 198 (7), 977-985 (2003)
   PUBMED   14530373
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Owman,C., Lolait,S.J., Santen,S. and Olde,B.
  TITLE     Molecular cloning and tissue distribution of cDNA encoding a novel
            chemoattractant-like receptor
  JOURNAL   Biochem Biophys Res Commun 241 (2), 390-394 (1997)
   PUBMED   9425281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB707803.1 and JAXUCZ010000012.1.
            
            On Dec 3, 2005 this sequence version replaced NM_022218.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.41700.1,
                                           SRR26643285.57756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               CB707803.1         257-397
            142-2530            JAXUCZ010000012.1  48682416-48684804
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..2530
                     /gene="Cmklr1"
                     /note="chemerin chemokine-like receptor 1"
                     /db_xref="GeneID:60669"
                     /db_xref="RGD:69359"
     exon            1..88
                     /gene="Cmklr1"
                     /inference="alignment:Splign:2.1.0"
     exon            89..2530
                     /gene="Cmklr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1209
                     /gene="Cmklr1"
                     /note="chemokine receptor-like 1; G-protein coupled
                     receptor DEZ; chemokine-like receptor 1; G-protein coupled
                     chemoattractant-like receptor"
                     /codon_start=1
                     /product="chemerin-like receptor 1"
                     /protein_id="NP_071554.2"
                     /db_xref="GeneID:60669"
                     /db_xref="RGD:69359"
                     /translation="MEYEGYNDSSIYGEEYSDGSDYIVDLEEAGPLEAKVAEVFLVVI
                     YSLVCFLGILGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPIHITYAAMDYH
                     WVFGKAMCKISSFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSVRLAYMTCVV
                     VWVLAFFLSSPSLVFRDTVSTSHGKITCFNNFSLAAPEPFSHSTHPRTDPVGYSRHVA
                     VTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKTKKPFKIIITIIITFFLCWCPYH
                     TLYLLELHHTAVPASVFSLGLPLATAVAIANSCMNPILYVFMGHDFKKFKVALFSRLV
                     NALSEDTGPSSYPSHRSFTKMSSLIEKASVNEKETSTL"
ORIGIN      
        1 gtatttctag ccgtgcacag tgactgatca gccgaggacc taccctcgag ttctattctg
       61 caacagtgaa cagtgaaggt ctccaaagag atggagtacg agggttacaa cgactccagc
      121 atctacggtg aggagtattc tgacggctcg gactacatcg tggacttgga ggaggcgggt
      181 ccactggagg ccaaggtggc cgaggtcttc ctggtggtaa tctacagctt ggtgtgcttc
      241 ctcgggatcc taggcaatgg cctggtgatt gtcatcgcca ccttcaagat gaagaagacg
      301 gtgaacaccg tgtggtttgt caacctggcc gtggctgact tcctgttcaa catcttcttg
      361 cccatccaca tcacctatgc cgctatggac taccactggg tgttcgggaa agccatgtgc
      421 aagattagta gctttctgct aagccacaac atgtacacca gcgtcttcct gctcactgtc
      481 atcagcttcg accgctgcat ctccgtgctc ctccccgtct ggtcccagaa ccaccgcagc
      541 gtgcgtctgg cctacatgac ctgcgtggtt gtctgggtcc tggctttctt cctgagttcc
      601 ccgtccctcg tcttccggga cacggtcagc accagccacg ggaagataac ctgcttcaac
      661 aacttcagcc tggccgcgcc cgagcctttc tctcattcca cccacccgcg aacagacccg
      721 gtagggtaca gcagacatgt ggcggtcacc gtcacccgct tcctctgtgg cttcctgatc
      781 cccgtcttca tcatcacggc ctgttacctc accatcgtct tcaagttgca gcgcaaccgc
      841 ctggccaaga ccaagaagcc cttcaagatc atcatcacca tcatcatcac cttcttcctc
      901 tgctggtgcc cctaccacac actctacctg ctggagctcc accacacggc tgtgccagcc
      961 tctgtcttca gcctgggact gcccctggcc acagccgttg ccatcgccaa cagctgtatg
     1021 aaccccatcc tgtacgtctt catgggccac gacttcaaaa aattcaaggt ggcccttttc
     1081 tcccgcctgg tgaatgccct gagcgaggac acaggaccct cctcctaccc cagtcacagg
     1141 agcttcacca agatgtcctc attgattgag aaggcttcag tgaatgagaa agagaccagc
     1201 accctctgag ccttccctgg gactgtcccc aatgggctcc acagcccagg gacttgtctc
     1261 ctgaggtagg agacacgcct ggagcctttg ggtatgcccc agcgcccgct acgtcttgcg
     1321 caaggcggcc cattgttttg ggtggagttc ccaagtgtgg acactcttcc agcaaaatgg
     1381 cagacaagca acctgagccc ctgcagcagg agtataggac caacttccac cggctcagaa
     1441 aagggagggt ctctgaaacc aaggtctgag ctgtgaccca catacaggca cacaatttca
     1501 ctgtggatgc cccaaacatg ctgcacagtc tccagtgtgg gtgaggacgt cactgcagac
     1561 ctgttatggc gacatgacag tcaaaccagc aaatacccca ccaccactgt catcctccaa
     1621 gatcttgact ttggatttca gaaaaatggg gaggaccagg acctgagggg cttcatagaa
     1681 cttgcttgca agggcagccc aggtgtgtgt gtgtgtatgt gcttgtgtgt gtgtgtgtgt
     1741 gtatgtgcat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgaaga ggtggagaca
     1801 gagagcagag aaccccaaag gatgtgggta caggatatct cacaccatca tgccacaggg
     1861 agacagagct acaacgatgg gtgcttgggg gttcagatgg tggcagctct ttgcttcagt
     1921 gtgtataccc ccctagcact gtacccccag gctggagggg ggctcttcac agaagcttcc
     1981 aacccattcc agcactggct ggaagggctt gggatgtccc tggagactgg tctgggacta
     2041 tcttcaaagc gtcttccaaa ggctgctgct gaccagctca cctgactcct ccttgaacac
     2101 actccccacg tggggcatca cagccccgat ggcagcccag gatcaggcct ccctcccttg
     2161 acagggaaat gactcaccca accccatgca ctgtcagtaa caaagaccca ggcccagctc
     2221 cacctggctg atgtcattcc ctccctgggg atggggtcgc ttgcatttat ttaacatgtc
     2281 ccacaccatg ttaagcactt cacacgttat cttctcattt attcttcacg gaaacctggg
     2341 gtaggtcctc gtgcatgtga ggaagcagag gctcagagag gttaagcaac tggcccaagg
     2401 gggcccagct aggtgttggc agagaccgga ttagaacccc agttctcctg gctgaaagga
     2461 agatggagag tcagcggtgg gggaagctaa tgggtttggg gttttagcca caaatacagg
     2521 tttttcagtg
//
