LOCUS       NP_001009419             432 aa            linear   ROD 29-JUL-2024
DEFINITION  N-acylneuraminate cytidylyltransferase [Rattus norvegicus].
ACCESSION   NP_001009419 XP_232513
VERSION     NP_001009419.1
DBSOURCE    REFSEQ: accession NM_001009419.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 432)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (residues 1 to 432)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087599.1.
            
            On Jan 7, 2005 this sequence version replaced XP_232513.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     Protein         1..432
                     /product="N-acylneuraminate cytidylyltransferase"
                     /EC_number="2.7.7.43"
                     /note="CMP-NeuNAc synthetase; CMP-N-acetylneuraminic acid
                     synthetase; CMP-NeuNAc synthase; CMP-N-acetylneuraminic
                     acid synthase; cytidine monophospho-N-acetylneuraminic
                     acid synthetase; cytidine 5'-monophosphate
                     N-acetylneuraminic acid synthetase"
                     /calculated_mol_wt=48009
     Region          1..38
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P69060.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q8NFW8; propagated from
                     UniProtKB/Swiss-Prot (P69060.1)"
     Region          15..31
                     /region_name="BC1 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P69060.1)"
     Site            35
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q99KK2; propagated from
                     UniProtKB/Swiss-Prot (P69060.1)"
     Region          42..257
                     /region_name="CMP-NeuAc_Synthase"
                     /note="CMP-NeuAc_Synthase activates N-acetylneuraminic
                     acid by adding CMP moiety; cd02513"
                     /db_xref="CDD:133006"
     Site            order(48..50,54,60,109,113,120,141,143,211,216,247)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:133006"
     Site            50
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q99KK2; propagated from
                     UniProtKB/Swiss-Prot (P69060.1)"
     Site            order(63,65..66,168,172..173,208..211,216,233,235,247,
                     250..251,254,257)
                     /site_type="active"
                     /note="tetramer interface [active]"
                     /db_xref="CDD:133006"
     Region          198..204
                     /region_name="BC2 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P69060.1)"
     Region          267..274
                     /region_name="BC3 motif"
                     /note="propagated from UniProtKB/Swiss-Prot (P69060.1)"
     Region          273..417
                     /region_name="HAD_KDO-like"
                     /note="haloacid dehalogenase-like (HAD) hydrolase, similar
                     to Escherichia coli 3-deoxy-D-manno-octulosonate
                     8-phosphate (KDO 8-P) phosphatase KdsC, and rainbow trout
                     N-acylneuraminate cytidylyltransferase; cd01630"
                     /db_xref="CDD:319769"
     Site            order(279..283,323..324,348,370..371,374..375)
                     /site_type="active"
                     /db_xref="CDD:319769"
     Site            order(281,286..293,295,297..304,307,311,325,329..330,
                     333..334,337,346,371..374,376..377,390,394,409,413,417)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:319769"
     CDS             1..432
                     /gene="Cmas"
                     /coded_by="NM_001009419.1:6..1304"
                     /db_xref="GeneID:312826"
                     /db_xref="RGD:1310911"
ORIGIN      
        1 mdalekgaat sgpaprgrps rgrppklqrs rgagrglekp phlaalvlar ggskgiplkn
       61 ikrlagvpli gwvlraalda gvfqsvwvst dhdeienvak qfgaqvhrrs setskdssts
      121 ldaiveflny hnevdivgni qatspclhpt dlqkvaemir eegydsvfsv vrrhqfrwse
      181 iqkgvrevte plnlnpakrp rrqdwdgely engsfyfakr hliemgylqg gkmayyemra
      241 ehsvdidvdi dwpiaeqrvl rfgyfgkekl keikllvcni dgcltnghiy vsgdqkeiis
      301 ydvkdaigis llkksgievr liseracskq tlsalkldck tevsvsdkla ivdewrkemg
      361 lcwkevaylg nevsdeeclk raglsavpad acsraqkavg yickcnggrg airefaehif
      421 lllekvnnsc qk
//
