LOCUS       NM_013092                981 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus chymase 1 (Cma1), mRNA.
ACCESSION   NM_013092
VERSION     NM_013092.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 981)
  AUTHORS   Chu,Y., Wang,J. and Zhou,X.
  TITLE     Mast cell chymase in synovial fluid of collagen-induced-arthritis
            rats regulates gelatinase release and promotes synovial fibroblasts
            proliferation via FAK/p21 signaling pathway
  JOURNAL   Biochem Biophys Res Commun 514 (1), 336-343 (2019)
   PUBMED   31036322
  REMARK    GeneRIF: Chymase activity in synovial fluids of
            collagen-induced-arthritis rats regulates gelatinase release and
            promotes synovial fibroblasts proliferation via FAK/p21 signaling
            pathway.
REFERENCE   2  (bases 1 to 981)
  AUTHORS   Valero-Jimenez,A., Zuniga,J., Cisneros,J., Becerril,C., Salgado,A.,
            Checa,M., Buendia-Roldan,I., Mendoza-Milla,C., Gaxiola,M., Pardo,A.
            and Selman,M.
  TITLE     Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF
            lungs and increases the fibrotic response in bleomycin-induced lung
            injury
  JOURNAL   PLoS One 13 (3), e0192963 (2018)
   PUBMED   29529050
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 981)
  AUTHORS   da Silva,J.S., Gabriel-Costa,D., Wang,H., Ahmad,S., Sun,X.,
            Varagic,J., Sudo,R.T., Ferrario,C.M., Dell Italia,L.J., Sudo,G.Z.
            and Groban,L.
  TITLE     Blunting of cardioprotective actions of estrogen in female rodent
            heart linked to altered expression of cardiac tissue chymase and
            ACE2
  JOURNAL   J Renin Angiotensin Aldosterone Syst 18 (3), 1470320317722270
            (2017)
   PUBMED   28748720
  REMARK    GeneRIF: The pathobiologic response in WKY rats was directly linked
            to increases in cardiac gene expression and enzymatic activity of
            chymase and modest reductions in ACE2 activity.
REFERENCE   4  (bases 1 to 981)
  AUTHORS   Ahmad,S., Varagic,J., VonCannon,J.L., Groban,L., Collawn,J.F.,
            Dell'Italia,L.J. and Ferrario,C.M.
  TITLE     Primacy of cardiac chymase over angiotensin converting enzyme as an
            angiotensin-(1-12) metabolizing enzyme
  JOURNAL   Biochem Biophys Res Commun 478 (2), 559-564 (2016)
   PUBMED   27465904
  REMARK    GeneRIF: Compared to chymase, ACE-mediated angiotensin-(1-12)
            metabolism in the heart was several fold lower. Overall our
            findings suggest that angiotensin-(1-12), not Ang I, is the better
            substrate for Ang II formation by chymase in adult rats.
REFERENCE   5  (bases 1 to 981)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   6  (bases 1 to 981)
  AUTHORS   Lutzelschwab,C., Pejler,G., Aveskogh,M. and Hellman,L.
  TITLE     Secretory granule proteases in rat mast cells. Cloning of 10
            different serine proteases and a carboxypeptidase A from various
            rat mast cell populations
  JOURNAL   J Exp Med 185 (1), 13-29 (1997)
   PUBMED   8996238
REFERENCE   7  (bases 1 to 981)
  AUTHORS   Pfeufer,A., Osterziel,K.J., Urata,H., Borck,G., Schuster,H.,
            Wienker,T., Dietz,R. and Luft,F.C.
  TITLE     Angiotensin-converting enzyme and heart chymase gene polymorphisms
            in hypertrophic cardiomyopathy
  JOURNAL   Am J Cardiol 78 (3), 362-364 (1996)
   PUBMED   8759823
REFERENCE   8  (bases 1 to 981)
  AUTHORS   Ide,H., Itoh,H., Tomita,M., Murakumo,Y., Kobayashi,T., Maruyama,H.,
            Osada,Y. and Nawa,Y.
  TITLE     Cloning of the cDNA encoding a novel rat mast-cell proteinase,
            rMCP-3, and its expression in comparison with other rat mast-cell
            proteinases
  JOURNAL   Biochem J 311 (Pt 2) (Pt 2), 675-680 (1995)
   PUBMED   7487912
REFERENCE   9  (bases 1 to 981)
  AUTHORS   Mizutani,H., Schechter,N., Lazarus,G., Black,R.A. and Kupper,T.S.
  TITLE     Rapid and specific conversion of precursor interleukin 1 beta (IL-1
            beta) to an active IL-1 species by human mast cell chymase
  JOURNAL   J Exp Med 174 (4), 821-825 (1991)
   PUBMED   1919436
REFERENCE   10 (bases 1 to 981)
  AUTHORS   Urata,H., Kinoshita,A., Misono,K.S., Bumpus,F.M. and Husain,A.
  TITLE     Identification of a highly specific chymase as the major
            angiotensin II-forming enzyme in the human heart
  JOURNAL   J Biol Chem 265 (36), 22348-22357 (1990)
   PUBMED   2266130
  REMARK    Erratum:[J Biol Chem 1991 Jun 25;266(18):12114]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013092.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D38495.1, U67908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000015.1  33390042-33390133   c
            93-243              JAXUCZ010000015.1  33389300-33389450   c
            244-379             JAXUCZ010000015.1  33388460-33388595   c
            380-634             JAXUCZ010000015.1  33388007-33388261   c
            635-981             JAXUCZ010000015.1  33387351-33387697   c
FEATURES             Location/Qualifiers
     source          1..981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..981
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /note="chymase 1"
                     /db_xref="GeneID:25627"
                     /db_xref="RGD:2365"
     exon            1..92
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..778
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /EC_number="3.4.21.39"
                     /note="rMCP-3; rMCP-5; rMCP-III; alpha-chymase; chymase 1,
                     mast cell; mast cell protease 3; mast cell protease III;
                     mast cell protease 5"
                     /codon_start=1
                     /product="chymase precursor"
                     /protein_id="NP_037224.1"
                     /db_xref="GeneID:25627"
                     /db_xref="RGD:2365"
                     /translation="MNLHALCLLLLLLGSSTKAGEIIGGTECIPHSRPYMAYLEIVTS
                     DNYLSACSGFLIRRNFVLTAAHCAGRSITVLLGAHNKTYKEDTWQKLEVEKQFIHPNY
                     DKRLVLHDIMLLKLKEKAKLTLGVGTLPLSANFNFIPPGRMCRAVGWGRTNVNEPASD
                     TLQEVKMRLQEPQSCKHFTSFQHKSQLCVGNPKKMQNVYKGDSGGPLLCAGIAQGIAS
                     YVHPNAKPPAVFTRISHYRPWINKILREN"
     exon            93..243
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /inference="alignment:Splign:2.1.0"
     exon            244..379
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /inference="alignment:Splign:2.1.0"
     exon            380..634
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /inference="alignment:Splign:2.1.0"
     exon            635..981
                     /gene="Cma1"
                     /gene_synonym="MCP3P; Mcpt5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctgcaca gccctgagta gcccctcaga gaggatgaat ctccatgctc tgtgtctgct
       61 gctccttctc ctgggttcca gcaccaaagc tggggagatc atcgggggca cggagtgcat
      121 accacactcc cgcccctaca tggcctatct agaaattgtc acttctgaca attacctgtc
      181 agcctgcagt ggcttcctga tcagacgaaa ctttgtgctg actgcagctc actgtgcagg
      241 acggtctata accgtcctcc taggagctca taacaaaaca tataaagaag acacatggca
      301 gaagctcgag gttgaaaagc aattcattca tccaaactat gataagcgtt tggttctcca
      361 tgacatcatg ttactgaagt tgaaggagaa agccaagcta accctaggcg tgggaaccct
      421 cccactctcg gccaacttca acttcattcc acccgggaga atgtgcaggg cagttggctg
      481 gggcagaaca aacgtgaatg aaccagcctc tgacacactg caggaagtaa agatgagact
      541 ccaggagccc caatcctgca aacacttcac cagttttcaa cacaagtccc agttgtgtgt
      601 gggcaacccc aagaagatgc aaaatgtata caagggagac tctggaggac ctctcctgtg
      661 tgctgggata gcccaaggca ttgcatccta cgtacatccg aatgcaaagc cccctgctgt
      721 cttcaccaga atctcccatt acagaccctg gatcaataag atcttgaggg agaattaact
      781 ctggatctcg ggccagtgtg tgaggaaatc tggagctgga atcgtgcagg ttttctgtga
      841 catgtgggat ctggcctgtc tgtagttcct gctgaagccc ttcctgatcc ctgagcttcc
      901 agaaggttct tacaagtcac agaaagttcc taaaagtcac catcttcata aacctcaata
      961 aagagccaga tcctagactg c
//
