LOCUS       NM_020976               1183 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus collectrin, amino acid transport regulator
            (Cltrn), mRNA.
ACCESSION   NM_020976
VERSION     NM_020976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Esterhazy,D., Akpinar,P. and Stoffel,M.
  TITLE     Tmem27 dimerization, deglycosylation, plasma membrane depletion,
            and the extracellular Phe-Phe motif are negative regulators of
            cleavage by Bace2
  JOURNAL   Biol Chem 393 (6), 473-484 (2012)
   PUBMED   22628310
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Gu,X., Neric,N.J., Crabb,J.S., Crabb,J.W., Bhattacharya,S.K.,
            Rayborn,M.E., Hollyfield,J.G. and Bonilha,V.L.
  TITLE     Age-related changes in the retinal pigment epithelium (RPE)
  JOURNAL   PLoS One 7 (6), e38673 (2012)
   PUBMED   22701690
  REMARK    GeneRIF: Collectrin expression in the retinal pigment epithelium
            was significantly modulated during aging.
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Esterhazy,D., Stutzer,I., Wang,H., Rechsteiner,M.P., Beauchamp,J.,
            Dobeli,H., Hilpert,H., Matile,H., Prummer,M., Schmidt,A.,
            Lieske,N., Boehm,B., Marselli,L., Bosco,D., Kerr-Conte,J.,
            Aebersold,R., Spinas,G.A., Moch,H., Migliorini,C. and Stoffel,M.
  TITLE     Bace2 is a beta cell-enriched protease that regulates pancreatic
            beta cell function and mass
  JOURNAL   Cell Metab 14 (3), 365-377 (2011)
   PUBMED   21907142
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1183)
  AUTHORS   Yasuhara,A., Wada,J., Malakauskas,S.M., Zhang,Y., Eguchi,J.,
            Nakatsuka,A., Murakami,K., Kanzaki,M., Teshigawara,S., Yamagata,K.,
            Le,T.H. and Makino,H.
  TITLE     Collectrin is involved in the development of salt-sensitive
            hypertension by facilitating the membrane trafficking of apical
            membrane proteins via interaction with soluble
            N-ethylmaleiamide-sensitive factor attachment protein receptor
            complex
  JOURNAL   Circulation 118 (21), 2146-2155 (2008)
   PUBMED   18981302
  REMARK    GeneRIF: Upregulation of collectrin by high NaCl independent of
            aldosterone functionally links to the trafficking of apical
            membrane proteins via the SNARE complex, and collectrin may be
            responsible for the sodium retention in salt-sensitive
            hypertension.
            Erratum:[Circulation. 2014 Feb 4;129(5):e325]
REFERENCE   6  (bases 1 to 1183)
  AUTHORS   Danilczyk,U., Sarao,R., Remy,C., Benabbas,C., Stange,G.,
            Richter,A., Arya,S., Pospisilik,J.A., Singer,D., Camargo,S.M.,
            Makrides,V., Ramadan,T., Verrey,F., Wagner,C.A. and Penninger,J.M.
  TITLE     Essential role for collectrin in renal amino acid transport
  JOURNAL   Nature 444 (7122), 1088-1091 (2006)
   PUBMED   17167413
REFERENCE   7  (bases 1 to 1183)
  AUTHORS   Akpinar,P., Kuwajima,S., Krutzfeldt,J. and Stoffel,M.
  TITLE     Tmem27: a cleaved and shed plasma membrane protein that stimulates
            pancreatic beta cell proliferation
  JOURNAL   Cell Metab 2 (6), 385-397 (2005)
   PUBMED   16330324
REFERENCE   8  (bases 1 to 1183)
  AUTHORS   Fukui,K., Yang,Q., Cao,Y., Takahashi,N., Hatakeyama,H., Wang,H.,
            Wada,J., Zhang,Y., Marselli,L., Nammo,T., Yoneda,K., Onishi,M.,
            Higashiyama,S., Matsuzawa,Y., Gonzalez,F.J., Weir,G.C., Kasai,H.,
            Shimomura,I., Miyagawa,J., Wollheim,C.B. and Yamagata,K.
  TITLE     The HNF-1 target collectrin controls insulin exocytosis by SNARE
            complex formation
  JOURNAL   Cell Metab 2 (6), 373-384 (2005)
   PUBMED   16330323
REFERENCE   9  (bases 1 to 1183)
  AUTHORS   Zhang,H., Wada,J., Hida,K., Tsuchiyama,Y., Hiragushi,K.,
            Shikata,K., Wang,H., Lin,S., Kanwar,Y.S. and Makino,H.
  TITLE     Collectrin, a collecting duct-specific transmembrane glycoprotein,
            is a novel homolog of ACE2 and is developmentally regulated in
            embryonic kidneys
  JOURNAL   J Biol Chem 276 (20), 17132-17139 (2001)
   PUBMED   11278314
REFERENCE   10 (bases 1 to 1183)
  AUTHORS   Zhang,H., Wada,J., Kanwar,Y.S., Tsuchiyama,Y., Hiragushi,K.,
            Hida,K., Shikata,K. and Makino,H.
  TITLE     Screening for genes up-regulated in 5/6 nephrectomized mouse kidney
  JOURNAL   Kidney Int 56 (2), 549-558 (1999)
   PUBMED   10432394
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_020976.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178086.1, BC078838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN13663597
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000021.1  34027062-34027124   c
            64-122              JAXUCZ010000021.1  34026679-34026737   c
            123-208             JAXUCZ010000021.1  34022338-34022423   c
            209-322             JAXUCZ010000021.1  34012726-34012839   c
            323-517             JAXUCZ010000021.1  34010644-34010838   c
            518-1183            JAXUCZ010000021.1  33993825-33994490   c
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..1183
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /note="collectrin, amino acid transport regulator"
                     /db_xref="GeneID:57395"
                     /db_xref="RGD:708489"
     exon            1..63
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..674
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /note="kidney-specific membrane protein; transmembrane
                     protein 27"
                     /codon_start=1
                     /product="collectrin precursor"
                     /protein_id="NP_066125.2"
                     /db_xref="GeneID:57395"
                     /db_xref="RGD:708489"
                     /translation="MLWALFFLVTTIHAELCRPDAENAFKVRLSIKAALGDKAYVWDT
                     DEEYLFRAMVAFSMRKVPNREGTEISHVLLCNVTQRVSFWFVVTDPLKNHTLPAAEVQ
                     SAIRMNRNRINSAFFLDDHTLEFLKIPSTLAPPMDPSVPVWIIVFGVIFCIVTVAIAL
                     LVLSGIRQRRRNKKGPPGVEDAEDKCENIITIENGIPCDPLDMKGGHINDGFLTEDER
                     LTPL"
     exon            64..122
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            123..208
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            209..322
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            323..517
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
     exon            518..1183
                     /gene="Cltrn"
                     /gene_synonym="collectrin; NX-17; Nx17; Tmem27"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagaatgct gtgggcactc tttttcctgg tgactactat tcacgctgaa ctctgccgtc
       61 cagatgcaga aaatgccttt aaagtaagac ttagcatcaa agcagctctt ggagataaag
      121 cgtatgtctg ggacacagat gaagaatatc tcttcagagc aatggtggca ttctccatga
      181 gaaaagttcc caacagagaa ggaacagaaa tttcccacgt cctgctttgc aatgtaaccc
      241 agagagtgtc attctggttt gtggtcacag accctttgaa aaaccatact cttcctgcag
      301 ctgaagtaca gtcagccata agaatgaaca ggaaccggat caacagtgca ttctttttgg
      361 atgatcatac tctggaattt ttaaaaattc cttccactct tgctcccccg atggatccat
      421 ctgtgcccgt ctggattatt gtatttggtg tgatattttg cattgttaca gttgcaattg
      481 cactactggt tttatccgga atccggcaac gaagaaggaa caagaaagga ccacctggag
      541 tggaggatgc agaagacaag tgtgaaaaca tcatcacaat tgaaaatggc atcccttgtg
      601 atcccttgga catgaaggga gggcacatta atgatggctt cttgacagag gatgagcgtc
      661 tcacccctct ctgagagtta cagtcttgta agaaaatttc aagatgcttg aatgtgatag
      721 acaacaatag accactgaaa tcataaggag ttagttggct tctcaaaata ttcgagaatt
      781 ttctttttga taaccaaata tgtaaatgta gttacacatg tttgtagtta ctgatttgag
      841 catctttaga aattaagtca gggctataac tatatttcat attttgaaga cctaaggaaa
      901 aattcttacc actggagaat gactatagca tggcacagaa ataattaaaa atggatcttt
      961 ttgaatactg tttatattag tctgtacatg atgaagcaag gaaaagtaaa catgagatgg
     1021 atgaaaatgg taatggaatt ttattctgtt ctcacacaaa cagctgcttg tatattttat
     1081 acatattagc ctttagtagg gcaagaggat ctttttgttg tttgctattt gcaatttgta
     1141 caagtcctat ctacgctgat ataataaaag tagtgatcat ctc
//
