LOCUS       NM_019299               6069 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus clathrin heavy chain (Cltc), mRNA.
ACCESSION   NM_019299
VERSION     NM_019299.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6069)
  AUTHORS   Moulakakis,C., Steinhauser,C., Biedziak,D., Freundt,K., Reiling,N.
            and Stamme,C.
  TITLE     Surfactant Protein A Enhances Constitutive Immune Functions of
            Clathrin Heavy Chain and Clathrin Adaptor Protein 2
  JOURNAL   Am J Respir Cell Mol Biol 55 (1), 92-104 (2016)
   PUBMED   26771574
  REMARK    GeneRIF: SP-A transiently enhances the basal protein expression of
            CHC and alpha-adaptin.
REFERENCE   2  (bases 1 to 6069)
  AUTHORS   Pouly,D., Chenaux,S., Martin,V., Babis,M., Koch,R., Nagoshi,E.,
            Katanaev,V.L., Gachon,F. and Staub,O.
  TITLE     USP2-45 Is a Circadian Clock Output Effector Regulating Calcium
            Absorption at the Post-Translational Level
  JOURNAL   PLoS One 11 (1), e0145155 (2016)
   PUBMED   26756164
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6069)
  AUTHORS   Feutlinske,F., Browarski,M., Ku,M.C., Trnka,P., Waiczies,S.,
            Niendorf,T., Stallcup,W.B., Glass,R., Krause,E. and Maritzen,T.
  TITLE     Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates
            focal adhesion dynamics and cell motility
  JOURNAL   Nat Commun 6, 8535 (2015)
   PUBMED   26437238
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6069)
  AUTHORS   Zhao,Z., Sagare,A.P., Ma,Q., Halliday,M.R., Kong,P., Kisler,K.,
            Winkler,E.A., Ramanathan,A., Kanekiyo,T., Bu,G., Owens,N.C.,
            Rege,S.V., Si,G., Ahuja,A., Zhu,D., Miller,C.A., Schneider,J.A.,
            Maeda,M., Maeda,T., Sugawara,T., Ichida,J.K. and Zlokovic,B.V.
  TITLE     Central role for PICALM in amyloid-beta blood-brain barrier
            transcytosis and clearance
  JOURNAL   Nat Neurosci 18 (7), 978-987 (2015)
   PUBMED   26005850
  REMARK    Erratum:[Nat Neurosci. 2024 Jan;27(1):208. doi:
            10.1038/s41593-023-01509-y.. PMID: 37985802]
REFERENCE   5  (bases 1 to 6069)
  AUTHORS   Glebov,O.O., Tigaret,C.M., Mellor,J.R. and Henley,J.M.
  TITLE     Clathrin-independent trafficking of AMPA receptors
  JOURNAL   J Neurosci 35 (12), 4830-4836 (2015)
   PUBMED   25810514
  REMARK    GeneRIF: findings reveal a novel role for neuronal
            clathrin-independent endocytosis controlled by actin dynamics.
REFERENCE   6  (bases 1 to 6069)
  AUTHORS   Saito,Y., Tsubuki,S., Ito,H., Ohmi-Imajo,S. and Kawashima,S.
  TITLE     Possible involvement of clathrin in neuritogenesis induced by a
            protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12
            cells
  JOURNAL   J Biochem 112 (4), 448-455 (1992)
   PUBMED   1490999
REFERENCE   7  (bases 1 to 6069)
  AUTHORS   Maycox,P.R., Link,E., Reetz,A., Morris,S.A. and Jahn,R.
  TITLE     Clathrin-coated vesicles in nervous tissue are involved primarily
            in synaptic vesicle recycling
  JOURNAL   J Cell Biol 118 (6), 1379-1388 (1992)
   PUBMED   1325974
REFERENCE   8  (bases 1 to 6069)
  AUTHORS   Corvera,S., Folander,K., Clairmont,K.B. and Czech,M.P.
  TITLE     A highly phosphorylated subpopulation of insulin-like growth factor
            II/mannose 6-phosphate receptors is concentrated in a
            clathrin-enriched plasma membrane fraction
  JOURNAL   Proc Natl Acad Sci U S A 85 (20), 7567-7571 (1988)
   PUBMED   2971973
REFERENCE   9  (bases 1 to 6069)
  AUTHORS   Kirchhausen,T., Harrison,S.C., Chow,E.P., Mattaliano,R.J.,
            Ramachandran,K.L., Smart,J. and Brosius,J.
  TITLE     Clathrin heavy chain: molecular cloning and complete primary
            structure
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 8805-8809 (1987)
   PUBMED   3480512
REFERENCE   10 (bases 1 to 6069)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019299.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03583.1, SRR26643296.28069.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000010.1  72070552-72070691   c
            141-348             JAXUCZ010000010.1  72055024-72055231   c
            349-617             JAXUCZ010000010.1  72051631-72051899   c
            618-779             JAXUCZ010000010.1  72051132-72051293   c
            780-893             JAXUCZ010000010.1  72049551-72049664   c
            894-1067            JAXUCZ010000010.1  72049049-72049222   c
            1068-1265           JAXUCZ010000010.1  72046215-72046412   c
            1266-1466           JAXUCZ010000010.1  72045011-72045211   c
            1467-1619           JAXUCZ010000010.1  72042234-72042386   c
            1620-1742           JAXUCZ010000010.1  72041666-72041788   c
            1743-1880           JAXUCZ010000010.1  72040247-72040384   c
            1881-2045           JAXUCZ010000010.1  72039499-72039663   c
            2046-2226           JAXUCZ010000010.1  72039229-72039409   c
            2227-2390           JAXUCZ010000010.1  72037820-72037983   c
            2391-2516           JAXUCZ010000010.1  72033072-72033197   c
            2517-2659           JAXUCZ010000010.1  72032322-72032464   c
            2660-2894           JAXUCZ010000010.1  72031823-72032057   c
            2895-3017           JAXUCZ010000010.1  72029601-72029723   c
            3018-3163           JAXUCZ010000010.1  72028217-72028362   c
            3164-3347           JAXUCZ010000010.1  72027576-72027759   c
            3348-3540           JAXUCZ010000010.1  72027199-72027391   c
            3541-3698           JAXUCZ010000010.1  72026308-72026465   c
            3699-3863           JAXUCZ010000010.1  72025453-72025617   c
            3864-3971           JAXUCZ010000010.1  72025221-72025328   c
            3972-4139           JAXUCZ010000010.1  72024976-72025143   c
            4140-4421           JAXUCZ010000010.1  72024582-72024863   c
            4422-4532           JAXUCZ010000010.1  72024376-72024486   c
            4533-4703           JAXUCZ010000010.1  72023023-72023193   c
            4704-4925           JAXUCZ010000010.1  72022617-72022838   c
            4926-5001           JAXUCZ010000010.1  72017586-72017661   c
            5002-6069           JAXUCZ010000010.1  72014986-72016053   c
FEATURES             Location/Qualifiers
     source          1..6069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..6069
                     /gene="Cltc"
                     /note="clathrin heavy chain"
                     /db_xref="GeneID:54241"
                     /db_xref="RGD:2364"
     exon            1..140
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..5126
                     /gene="Cltc"
                     /note="clathrin, heavy chain (Hc); clathrin, heavy
                     polypeptide (Hc)"
                     /codon_start=1
                     /product="clathrin heavy chain 1"
                     /protein_id="NP_062172.2"
                     /db_xref="GeneID:54241"
                     /db_xref="RGD:2364"
                     /translation="MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKV
                     GEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAH
                     TMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDA
                     KQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCF
                     AVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLI
                     TKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENI
                     IPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGIL
                     RTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
                     WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKV
                     GYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFL
                     LDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQ
                     RALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQIC
                     VQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQ
                     IKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNSLQK
                     YIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLK
                     LLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDP
                     HLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLID
                     QVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLIL
                     TAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEH
                     IGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANT
                     SGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDR
                     CYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVD
                     GKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTEL
                     AILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITM
                     MNHPTDAWKEGQFKDIITKVANVELYYKAIQFYLEFKPLLLNDLLMVLSPRLDHTRAV
                     NYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNIS
                     LAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEE
                     LLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKV
                     DKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQ
                     PGFGYSM"
     exon            141..348
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            349..617
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            618..779
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            780..893
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1067
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1265
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1466
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1619
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1742
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1880
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2045
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2226
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2390
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2516
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2659
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2894
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3017
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3163
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3347
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3540
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3698
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3863
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3864..3971
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4139
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4421
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4532
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            4533..4703
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            4704..4925
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            4926..5001
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..6069
                     /gene="Cltc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcccttc cccttctcct cctctccctt ggagagcccg ggcaggcact gccctgcagc
       61 cccagtgaca ggaggagacc atactccccg acagcgccat ggcccagatt ctgccaattc
      121 gctttcagga gcatctccag ctccagaacc tgggtatcaa cccagcaaac attggcttca
      181 gtaccctgac tatggagtca gacaaattca tctgcattag agaaaaagtg ggagagcagg
      241 ctcaggtggt gatcattgac atgaatgatc caagtaatcc gattcgaaga ccaatctcag
      301 cagacagtgc catcatgaat cctgccagca aagtgattgc actgaaagct ggaaaaactc
      361 tacagatatt taacattgaa atgaaaagta aaatgaaggc ccacaccatg accgatgatg
      421 tcaccttctg gaaatggatc tctctgaata cggttgctct tgttacggat aatgcagttt
      481 atcactggag catggagggg gagtctcagc cagtgaagat gtttgatcgt cattccagcc
      541 tcgcagggtg ccagatcatc aattaccgta cagatgctaa gcagaagtgg ttgctcctga
      601 ctggcatatc tgcacagcaa aatcgcgtgg ttggagctat gcagctgtat tctgtagaca
      661 ggaaagtctc tcagcccatt gaagggcatg cggcgagttt tgcacaattt aagatggaag
      721 gaaacgcaga agaatcgacg ttattttgtt ttgctgtgcg gggtcaggca ggggggaagt
      781 tacatatcat tgaagttggt acaccaccca caggaaacca accctttcca aagaaggcag
      841 tggatgtctt ctttcctcca gaagcacaaa atgattttcc tgttgcaatg cagatcagtg
      901 aaaagcatga cgtggtgttc ctgattacca agtatggtta tattcacctc tatgaccttg
      961 agactggcac gtgcatctac atgaacagaa tcagtggaga aaccatcttt gttactgctc
     1021 ctcatgaagc cacagctgga ataataggag tcaacagaaa gggacaagtc ctatcagttt
     1081 gtgtggaaga agagaacata attccttaca tcaccaatgt cctacaaaat cctgatttgg
     1141 ctctgagaat ggctgtgcgg aacaacctag ctggtgcaga agagctcttc gcccggaaat
     1201 ttaatgctct cttcgcccag ggaaactact cagaggctgc aaaggtggct gctaatgcac
     1261 cgaagggaat ccttcgtact ccagatacca tccgtcgatt ccagagtgtc ccagctcagc
     1321 caggtcaaac ttcacctctg cttcagtatt ttggaatcct tttggaccaa ggccagctga
     1381 acaaatacga gtccttagag ttatgtagac ctgtccttca gcaagggcgg aaacaacttt
     1441 tggagaaatg gctgaaagaa gataagctgg aatgttctga agaactgggt gatctcgtaa
     1501 aatctgtgga cccaacgtta gcactgagtg tatacctcag agccaatgtc cctaataaag
     1561 tcatccagtg ctttgcagag acaggtcaag tccagaagat tgttttatat gctaaaaaag
     1621 ttggctatac tccagactgg atctttctcc tgagaaatgt catgcggatc agtccagatc
     1681 aaggacagca gtttgcccaa atgttagttc aggacgaaga acctcttgct gatatcacac
     1741 agattgtgga tgtctttatg gaatacaatc taatccaaca atgtactgcc ttcttacttg
     1801 atgctttgaa gaataatcgc ccttctgaag gtcctttgca gacgcgattg cttgagatga
     1861 accttatgca cgcacctcaa gttgcagatg ccattctagg gaatcagatg ttcacccact
     1921 atgaccgggc tcacatcgcc cagctgtgtg agaaggcggg cctactgcag cgtgcattag
     1981 aacatttcac cgacttatat gatataaaac gagcagtcgt tcatacccat cttctcaacc
     2041 ccgagtggtt agtgaattac tttgggtcct tatcagttga agattcccta gaatgtctca
     2101 gagccatgct gtctgctaat attcgtcaaa atctacagat ctgtgttcag gtcgcttcta
     2161 aatatcatga acagctgtca actcagtccc tgattgaact cttcgagtca ttcaagagtt
     2221 ttgaaggcct cttttatttt ctggggtcca ttgttaactt cagtcaagac ccagatgtgc
     2281 actttaaata tattcaggcg gcttgcaaga ctggacaaat caaagaggtg gaaagaatct
     2341 gcagagagag caactgctat gatccagagc gcgtcaagaa tttcctcaag gaggcgaaac
     2401 tcacagatca gttgccactc atcatcgtct gtgaccgctt tgacttcgtc catgacctgg
     2461 tgctgtattt atacagaaac agtcttcaga agtacataga gatatatgtc cagaaagtaa
     2521 atccaagtcg acttcctgtg gttattggag gattgctgga tgttgactgc tctgaagatg
     2581 tcattaaaaa tttgattctt gttgtgagag gtcaattctc tactgatgag cttgttgctg
     2641 aagttgagaa aagaaacaga ttgaagctgc ttcttccttg gcttgaggct agaattcatg
     2701 agggctgtga ggagcctgct acacacaatg cgttagccaa aatatacatc gacagcaata
     2761 acaacccaga gagattcctt cgtgaaaacc cctactatga cagtcgtgtc gtgggaaagt
     2821 actgtgagaa gagagaccca catctggcct gtgttgctta tgaacgtggc cagtgtgatc
     2881 tggaactaat caacgtttgc aatgagaatt ccctcttcaa aagtctttct cgctacctgg
     2941 tccgtcgaaa ggatccagag ttgtggggta gtgtgctact ggaaagcaat ccatacagaa
     3001 gaccattaat tgaccaggtc gtacagacag ccttgtctga aactcaggac ccagaagaag
     3061 tgtcagtaac tgtcaaggct tttatgacag cagatcttcc taatgaactc attgagctgc
     3121 tggagaaaat tgtccttgat aactctgtat tcagtgaaca caggaatctg caaaacctcc
     3181 tcatcctcac tgcaattaag gctgaccgaa cccgagttat ggagtatatt aaccgcctgg
     3241 acaattatga tgcgccagat attgccaaca ttgccatcag caatgagctc ttcgaagaag
     3301 catttgctat tttccggaag tttgatgtca atacttcagc agtgcaggtg ttaattgaac
     3361 atattggaaa cctggatcgt gcatatgagt ttgctgaacg ctgcaatgag cctgctgttt
     3421 ggagtcaact cgcaaaagct cagttgcaga aagggatggt gaaggaagcc attgattctt
     3481 acatcaaagc agatgatcct tcgtcttaca tggaagttgt tcaggccgcc aatactagtg
     3541 gaaactggga agaattggtg aagtatttgc agatggcacg caagaaggcc cgagagtcct
     3601 acgtggagac agaattgata tttgcactgg ctaaaacaaa ccgtcttgca gaattagaag
     3661 agttcatcaa tgggccaaat aatgctcata ttcagcaagt tggtgaccgt tgttatgatg
     3721 agaaaatgta tgatgctgct aagttgttgt acaataatgt ttctaacttt ggacgtttgg
     3781 cgtctaccct ggttcacctt ggcgagtatc aggcagcagt tgatggtgct agaaaagcta
     3841 atagtactcg aacatggaaa gaggtctgct ttgcctgtgt agatgggaaa gagtttcgcc
     3901 ttgctcagat gtgtggactc catattgttg tgcatgcaga tgaattagag gagcttatca
     3961 actactatca ggatcgtgga tattttgaag aactcatcac catgttggag gcagccttgg
     4021 gactagagcg agctcacatg ggaatgttca cagagctagc aattttgtat tctaaattca
     4081 agccacagaa aatgagggaa cacctagagt tgttttggtc aagagtgaat attcctaagg
     4141 tgctgagagc cgcagagcaa gcccatcttt gggcagagct ggtgtttctg tatgacaagt
     4201 atgaagagta tgataatgcc atcatcacta tgatgaatca ccccaccgac gcatggaagg
     4261 aagggcagtt caaagacatc atcaccaagg tggctaatgt ggaactgtac tacaaagcaa
     4321 tccagttcta cttagaattc aagcccttgt tgttaaatga cttgctcatg gtgctgtctc
     4381 cacggttgga tcatactcgt gcagtcaatt atttcagcaa ggttaaacag ctaccactgg
     4441 tgaaaccata tttacgctca gttcagaacc acaacaacaa gtccgtgaac gaatccctga
     4501 acaacctctt tatcacagag gaggattacc aggctctgcg aacatcaata gatgcttatg
     4561 acaactttga caacatctca cttgctcaac gtttggaaaa acatgaactc attgaattca
     4621 gaagaattgc tgcttatctc ttcaaaggaa acaatcgctg gaaacagagt gtggagctgt
     4681 gcaagaaaga cagcctttac aaggatgcaa tgcagtatgc ctctgaatcg aaagacacag
     4741 aattggctga agaactcctg cagtggtttc tgcaggaaga gaagagagaa tgctttggag
     4801 cttgtctctt cacctgctac gatcttttaa ggccagatgt tgtcctggaa actgcatgga
     4861 gacataatat catggatttt gccatgccct atttcatcca ggtcatgaag gagtatttga
     4921 ccaaggtgga taaattagat gcttcggagt cactgagaaa agaagaagaa caagctacag
     4981 agacacagcc cattgtttat ggtcagcccc agctgatgct aacagccgga cccagtgtgg
     5041 cagtccctcc ccaggcacct tttggttatg gttatactgc accaccatat gggcagccac
     5101 agcctggctt tgggtacagc atgtgagacg gaagctgatc ccgtagtctc ctattttcat
     5161 actgaagcat cgtccaccca cttctcagtt tataaacggg aaacaggcaa cgtgttcttg
     5221 taacctttac ttcatgaagg actacttttt tgttctaact atagactcgg atcgcctatg
     5281 ttaaaacttt attttcacat tccgcatcat tagaccttct tttcaaaggg gaatagtact
     5341 cacgtgggct ttttctcccc ctcattcttt gaagaactgc ttactattca atctattgtg
     5401 aagaacctga tttgcactct gtagtgttta aagaaacaaa gaaactctaa tattgaatct
     5461 cttaaattta gtgtatgtaa acagctttca ctatgtattg tctaaatgca tttaattctc
     5521 ttttattcaa agaaaagcta acgtgaaaat actgctatgt gaccatgcaa gactgtcaga
     5581 gccaacaaag acaacactaa tcagcatatc ttacattgga tcacagcgct ctccaaatta
     5641 tttgaaaatg catacagaca acttgcctga tttttttttt ttttaaaacg agtatcacag
     5701 gccctgtaac ctatgcaggt ttccccatta tgcatataga aaatgctagt gtgttgctca
     5761 cttcatgtgt aacaggtgcc ctcatgttgt gctgtatcct gtgctttttc tgtgggacca
     5821 ttccattcag gaacaaagag caccatgact gcacacgtgt gtatttacta acccttccct
     5881 gaggtgtgtg tatgttggat attgtggtgt tttagatcac tgagtgtaca gaagagagaa
     5941 ttcaaacaag atattgctgt tcttcagttt tgtttgtgga atttgaaatt actccaattt
     6001 aaaataaatt actggactgt ggaaataaca tgtagaattg cagttttaat taaatacatc
     6061 tcaaaccag
//
