LOCUS       NM_031974               1124 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus clathrin, light chain A (Clta), mRNA.
ACCESSION   NM_031974
VERSION     NM_031974.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Catsburg,L.A., Westra,M., van Schaik,A.M. and MacGillavry,H.D.
  TITLE     Dynamics and nanoscale organization of the postsynaptic endocytic
            zone at excitatory synapses
  JOURNAL   Elife 11, e74387 (2022)
   PUBMED   35072626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   Li,H., Alavian,K.N., Lazrove,E., Mehta,N., Jones,A., Zhang,P.,
            Licznerski,P., Graham,M., Uo,T., Guo,J., Rahner,C., Duman,R.S.,
            Morrison,R.S. and Jonas,E.A.
  TITLE     A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics
            during endocytosis
  JOURNAL   Nat Cell Biol 15 (7), 773-785 (2013)
   PUBMED   23792689
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Saheki,Y. and De Camilli,P.
  TITLE     Synaptic vesicle endocytosis
  JOURNAL   Cold Spring Harb Perspect Biol 4 (9), a005645 (2012)
   PUBMED   22763746
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Bu,W., Lim,K.B., Yu,Y.H., Chou,A.M., Sudhaharan,T. and Ahmed,S.
  TITLE     Cdc42 interaction with N-WASP and Toca-1 regulates membrane
            tubulation, vesicle formation and vesicle motility: implications
            for endocytosis
  JOURNAL   PLoS One 5 (8), e12153 (2010)
   PUBMED   20730103
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1124)
  AUTHORS   Mettlen,M., Loerke,D., Yarar,D., Danuser,G. and Schmid,S.L.
  TITLE     Cargo- and adaptor-specific mechanisms regulate clathrin-mediated
            endocytosis
  JOURNAL   J Cell Biol 188 (6), 919-933 (2010)
   PUBMED   20231386
  REMARK    GeneRIF: The results underscore the highly dynamic and
            cargo-responsive nature of CCP assembly and suggest that the
            observed heterogeneity is, in part, related to compositional
            differences (e.g., cargo and adaptors) between CCPs.
REFERENCE   6  (bases 1 to 1124)
  AUTHORS   Drake,M.T., Downs,M.A. and Traub,L.M.
  TITLE     Epsin binds to clathrin by associating directly with the
            clathrin-terminal domain. Evidence for cooperative binding through
            two discrete sites
  JOURNAL   J Biol Chem 275 (9), 6479-6489 (2000)
   PUBMED   10692452
REFERENCE   7  (bases 1 to 1124)
  AUTHORS   Saito,Y., Tsubuki,S., Ito,H., Ohmi-Imajo,S. and Kawashima,S.
  TITLE     Possible involvement of clathrin in neuritogenesis induced by a
            protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12
            cells
  JOURNAL   J Biochem 112 (4), 448-455 (1992)
   PUBMED   1490999
REFERENCE   8  (bases 1 to 1124)
  AUTHORS   Maycox,P.R., Link,E., Reetz,A., Morris,S.A. and Jahn,R.
  TITLE     Clathrin-coated vesicles in nervous tissue are involved primarily
            in synaptic vesicle recycling
  JOURNAL   J Cell Biol 118 (6), 1379-1388 (1992)
   PUBMED   1325974
REFERENCE   9  (bases 1 to 1124)
  AUTHORS   Kirchhausen,T., Scarmato,P., Harrison,S.C., Monroe,J.J., Chow,E.P.,
            Mattaliano,R.J., Ramachandran,K.L., Smart,J.E., Ahn,A.H. and
            Brosius,J.
  TITLE     Clathrin light chains LCA and LCB are similar, polymorphic, and
            share repeated heptad motifs
  JOURNAL   Science 236 (4799), 320-324 (1987)
   PUBMED   3563513
REFERENCE   10 (bases 1 to 1124)
  AUTHORS   Brodsky,F.M.
  TITLE     Clathrin structure characterized with monoclonal antibodies. II.
            Identification of in vivo forms of clathrin
  JOURNAL   J Cell Biol 101 (6), 2055-2062 (1985)
   PUBMED   4066749
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M15882.1.
            
            [WARNING] On Mar 18, 2025 this sequence was replaced by
            NM_031974.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M15882.1, FQ213034.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132285, SAMD00132291
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1124
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="clathrin, light chain A"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
     exon            1..332
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..862
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /note="clathrin, light polypeptide (Lca); clathrin, light
                     chain (Lca); lca"
                     /codon_start=1
                     /product="clathrin light chain A"
                     /protein_id="NP_114180.1"
                     /db_xref="GeneID:83800"
                     /db_xref="RGD:70919"
                     /translation="MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIA
                     GIENDEAFAILDGGAPGPQAHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDR
                     LQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAVKELEEWYARQDEQLQKTKAS
                     NRVADEAFYKQPFADVIGYVTNINHPCYSLEQAAEEAFVNDIDESSPGTEWERVARLC
                     DFNPKSSKQAKDVSRMRSVLISLKQAPLVH"
     exon            333..370
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            371..488
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..600
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..654
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..690
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1124
                     /gene="Clta"
                     /gene_synonym="LCA1; LCA2; LCA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctccgctcg tcctccggta gcagccgcca gcacagtgtc cgctgctggg cggggtgtcg
       61 gcggatcggt cggttggttt cggcttcggt gtcgctgcgt ttgagttggg ccgtcatggc
      121 tgagttggat ccatttggcg ctcccgccgg tgcgcccggt ggccccgcgc tcgggaacgg
      181 ggtggcgggc gccggcgagg aagacccggc cgcggccttc ttggcgcagc aggagagtga
      241 gattgcgggc atagagaacg acgaggcctt cgccatccta gacggcggcg cccccgggcc
      301 gcaggcacac ggcgagccgc cggggggtcc tgatgcggtt gatggagtga tgaatggcga
      361 atactaccag gagagcaatg gtccaacaga cagttacgca gccatttcag aagtggatcg
      421 gttgcagtca gagcctgaaa gtatccgtaa gtggagagaa gagcagacag agcgcctgga
      481 agccctcgat gccaattctc ggaagcagga agcagagtgg aaagaaaagg cagtgaagga
      541 gctggaagag tggtacgcaa ggcaggatga gcagctacag aagacaaaag ccagcaacag
      601 ggtggcagat gaagctttct acaaacaacc cttcgctgac gtgattggtt atgtcacaaa
      661 cataaaccat ccttgctaca gcctagaaca ggcagcagaa gaagcctttg taaacgacat
      721 tgacgagtca tccccaggca ctgagtggga gcgggtggcc cgcctgtgtg actttaaccc
      781 caagtccagc aaacaggcca aagatgtctc tcgcatgcgc tcagtcctca tctccctgaa
      841 gcaggcgccc ctggtgcatt gaagagccac cctgtggaaa cactacgtct ccgatcttaa
      901 tcctactcag tgaagctgtt cacgcaattg gattaattat gccgagttct tttggaccaa
      961 accttttgtc tttagagttg atcattgttt gtgattgcat gtttccttca actgtgttct
     1021 ccctggcatt cagagaagag agaggaagag gaagggaggg gagctcccaa cagtagcctc
     1081 aacctgtgct tttgtgcatt attctgagaa taaatttctg tttc
//
