LOCUS       NM_134376               3019 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus calsyntenin 3 (Clstn3), mRNA.
ACCESSION   NM_134376 XM_346720
VERSION     NM_134376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3019)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   2  (bases 1 to 3019)
  AUTHORS   Pettem,K.L., Yokomaku,D., Luo,L., Linhoff,M.W., Prasad,T.,
            Connor,S.A., Siddiqui,T.J., Kawabe,H., Chen,F., Zhang,L.,
            Rudenko,G., Wang,Y.T., Brose,N. and Craig,A.M.
  TITLE     The specific alpha-neurexin interactor calsyntenin-3 promotes
            excitatory and inhibitory synapse development
  JOURNAL   Neuron 80 (1), 113-128 (2013)
   PUBMED   24094106
  REMARK    GeneRIF: The transmembrane form of calsyntenin-3 can trigger
            excitatory and inhibitory presynapse differentiation in contacting
            axons.
REFERENCE   3  (bases 1 to 3019)
  AUTHORS   Rindler,M.J., Xu,C.F., Gumper,I., Cen,C., Sonderegger,P. and
            Neubert,T.A.
  TITLE     Calsyntenins are secretory granule proteins in anterior pituitary
            gland and pancreatic islet alpha cells
  JOURNAL   J Histochem Cytochem 56 (4), 381-388 (2008)
   PUBMED   18158283
  REMARK    GeneRIF: Results indicate that calsyntenins function outside the
            nervous system and potentially are modulators of endocrine
            function.
REFERENCE   4  (bases 1 to 3019)
  AUTHORS   Hintsch,G., Zurlinden,A., Meskenaite,V., Steuble,M.,
            Fink-Widmer,K., Kinter,J. and Sonderegger,P.
  TITLE     The calsyntenins--a family of postsynaptic membrane proteins with
            distinct neuronal expression patterns
  JOURNAL   Mol Cell Neurosci 21 (3), 393-409 (2002)
   PUBMED   12498782
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ431642.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346720.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ431642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3019
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="OFA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..3019
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /note="calsyntenin 3"
                     /db_xref="GeneID:171393"
                     /db_xref="RGD:621153"
     exon            1..205
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..3015
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /note="alc-beta; alcadein-beta"
                     /codon_start=1
                     /product="calsyntenin-3 precursor"
                     /protein_id="NP_599203.1"
                     /db_xref="GeneID:171393"
                     /db_xref="RGD:621153"
                     /translation="MTLLLVSLLLASLLQISSGNKANKHKPWIEAEYQGIVMENDNTV
                     LLNPPLFALDKDAPLRYAGEICGFRLHGSGVPFKAVILDKATGEGLIRAKEPVDCEAQ
                     KEHTFTTQAYDCVDGPDGANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLY
                     DRILRVEAIDGDCSPQYSQICYYEILTPNTPFLIDNDGNIENTEKLQYSGEKLYKFTV
                     TAYDCGKKRAADDAEVEIQVKPTCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEP
                     LWNIQATIELQTSHVAKGCDRDNYSERALRKLCGAATGEVDLLPMPGPNANWTAGLSV
                     HYSQDSSLIYWFNGTQAVQVPLGGPAGLGSGPQDGLSDHFTLSFWMKHSVTPSKGKKE
                     EETIVCNTIQNEDGYSHYSLTVHGCRIAFLYWPLLESARPVKFLWKLEQVCDDEWHHY
                     ALNLEFPTVTLYTDGISFDPALIHDNGLIHPPRREPALMIGACWSEEKNKEKEKGGEN
                     STDTTSGDPLPIHHYFHGYLAGFSVRSGRLESREVIECLYACREGLDYRDFESLGKGM
                     KVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLRFATPGVRPLRLTTAVKCFSEESC
                     VSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEGPEGVPLFPDLQITCSISHQVE
                     AKADESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPERESLLLDMASLQQRGLELT
                     NRSAYLTIAGVETITVYEEILRQARYQLRHGAALYARKFRLSCSEMNGRYSSNEFIVE
                     VNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHRNSMVPSAATLIIVVC
                     VGFLVLMVILGLVRIHSLHRRVSGTGGPSGASADPKDPDLFWDDSALTIIVNPMESYQ
                     NQQTGVAGVAGGQQEEEDSSDSEAADSPSSDERRIIESPPHRY"
     exon            206..328
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..524
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            525..733
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            734..883
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1069
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1351
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1464
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1627
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1684
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1842
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1991
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2218
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2389
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2535
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2671
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2874
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..3019
                     /gene="Clstn3"
                     /gene_synonym="Cs3; Cstn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accagcgggg tcagcaggct tctttctgat cttgtccccg gccctcccct cgtagagtct
       61 ctgcatctct cccccggggt ggcattagca ggcttgaggc tcccagggga gaggaacgcc
      121 tggcctggcg tccttaacac catgaccctc ctgctggtgt ccctcttgct ggcctctctg
      181 cttcagatca gctctggcaa caaagcgaac aagcataagc catggatcga ggccgagtac
      241 cagggcatcg tcatggagaa tgacaacacg gtcctgttga atccgccact ctttgccttg
      301 gacaaagatg ctccgctgcg ctatgcaggt gagatctgtg gcttccggct ccatgggtct
      361 ggggtaccct ttaaggctgt gatcctggac aaggcaacag gtgaagggct gatccgggcc
      421 aaggagcctg tggactgcga ggcccagaag gagcacacct ttaccaccca ggcttatgac
      481 tgtgtagatg ggcccgatgg tgccaatacc aagaagtctc acaaggcgac cgtgcatgtt
      541 cgggtcaacg atgtgaatga gtttgcccca gtctttgtgg agcgtctcta ccgtgctgca
      601 gtgactgagg ggaagctgta tgatcgcatc ttacgtgtgg aagccattga tggtgactgc
      661 tcccctcagt acagccagat ctgctactat gagatcctta cacccaacac ccctttcctc
      721 attgacaatg atggcaacat tgagaacaca gagaagttac agtacagtgg tgagaagctc
      781 tataagttca cagtgacagc atatgactgt gggaagaagc gagcagcaga tgatgctgag
      841 gtggaaatcc aggtgaagcc cacctgcaaa cccagctggc aaggctggaa caaaaggatt
      901 gaatatgccc caggagcggg gagcttggct ttgttccctg gcatccgcct ggagacctgt
      961 gatgagccac tgtggaacat tcaggccacc atagagctgc agaccagcca tgtggccaag
     1021 ggctgtgacc gagacaacta ctcagagagg gctctgcgga agctctgtgg tgctgctact
     1081 ggggaggtgg acctgttgcc catgcctggc cccaatgcca actggacagc ggggctctcg
     1141 gtacactaca gccaggacag cagcctcatc tactggttca atggcacaca agctgtgcaa
     1201 gttcccctgg gtggtccagc agggctgggc tctgggccgc aggatggcct cagtgaccac
     1261 tttaccctgt ctttctggat gaagcatagt gtgactccta gcaaggggaa gaaggaggag
     1321 gagaccattg tatgtaacac cattcagaac gaggacggct actctcacta ctcattgact
     1381 gtccacggct gcagaatcgc ctttctctac tggccgttgc ttgagagtgc acgcccggtc
     1441 aagttcctct ggaagctgga gcaggtatgt gacgatgagt ggcatcacta cgccctgaac
     1501 ctcgagttcc ccacagtcac gctctatact gatggcatct ccttcgaccc agctctcatc
     1561 cacgacaatg gtctcatcca cccacccagg agggaacctg cgctcatgat cggggcctgc
     1621 tggtctgaag agaagaacaa agagaaggag aaggggggag agaacagtac agacacgacc
     1681 tcaggagacc ccttgccgat ccaccattac ttccatggct acctagctgg tttcagcgtg
     1741 cgctcaggtc gcctggagag ccgtgaggtc atcgagtgcc tctatgcatg tcgggagggg
     1801 ctggactata gggatttcga gagcctgggc aaaggcatga aggtgcacgt gaacccctcg
     1861 cagtccctgc tcaccttgga gggggatgat gtggagacct tcaaccatgc cctgcagcac
     1921 gtggcttaca tgaacactct gcgctttgcc acgcccggcg tcaggcccct tcgcctcacc
     1981 accgctgtca agtgctttag tgaagagtcc tgtgtctcca tccctgaagt ggagggctat
     2041 gtggtggttc ttcagcccga tgccccccag atccttctga gtggcacagc tcattttgcc
     2101 cgcccagctg tggactttga gggacccgag ggagtcccct tgttccctga tcttcagatc
     2161 acctgctcca tttctcacca ggtggaggcc aaagcagatg agagttggca gggcacagtg
     2221 acagacacac gcatgtcaga tgagattgta cacaacttgg acggctgtga gatttctctg
     2281 gtgggggatg acctagaccc tgaacgagag agcctgctct tggacatggc ttccctgcag
     2341 cagcgaggcc tggaactcac caacagatct gcctacctca ccattgctgg ggtggagacc
     2401 atcactgtgt atgaagagat cctgaggcag gctcgttatc agcttcggca tggagctgcc
     2461 ctttatgcca ggaaattccg gctttcttgc tcggagatga acggccgata ctccagcaac
     2521 gaattcattg tggaggtcaa cgtcctgcac agcatgaacc gggtggccca tcccagccac
     2581 gtgctcagtt cacagcagtt cctgcaccgg ggtcaccagc ctcctcctga gatggctgga
     2641 cacagcctgg ccagctccca ccggaactcc atggtcccca gtgctgcgac tctcatcatt
     2701 gtggtatgcg tgggctttct ggtgcttatg gtcatcctcg gcctcgtgcg gatccactcc
     2761 cttcatcgcc gtgtctcagg aactggtgga ccctcagggg cttccgctga cccgaaagac
     2821 cctgacctct tctgggatga ctctgctctc accattatcg tgaatcccat ggagtcctac
     2881 cagaaccagc agactggtgt ggcaggggtt gctggtggcc agcaagagga agaggacagc
     2941 agtgattccg aagcagctga ctcccccagc agcgatgaaa gacgcatcat tgagagcccc
     3001 ccacaccgct attgaggct
//
