LOCUS       NM_001007092            4408 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus calsyntenin 1 (Clstn1), mRNA.
ACCESSION   NM_001007092 XM_001075647 XM_243040
VERSION     NM_001007092.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4408)
  AUTHORS   Zhou,F., Hu,R., Wang,Y., Wu,X., Chen,X., Xi,Z. and Zeng,K.
  TITLE     Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models
  JOURNAL   Synapse 78 (5), e22307 (2024)
   PUBMED   39171546
  REMARK    GeneRIF: Calsyntenin-1 expression and function in brain tissue of
            lithium-pilocarpine rat seizure models.
REFERENCE   2  (bases 1 to 4408)
  AUTHORS   Ster,J., Steuble,M., Orlando,C., Diep,T.M., Akhmedov,A.,
            Raineteau,O., Pernet,V., Sonderegger,P. and Gerber,U.
  TITLE     Calsyntenin-1 regulates targeting of dendritic NMDA receptors and
            dendritic spine maturation in CA1 hippocampal pyramidal cells
            during postnatal development
  JOURNAL   J Neurosci 34 (26), 8716-8727 (2014)
   PUBMED   24966372
REFERENCE   3  (bases 1 to 4408)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   4  (bases 1 to 4408)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4408)
  AUTHORS   Vagnoni,A., Perkinton,M.S., Gray,E.H., Francis,P.T., Noble,W. and
            Miller,C.C.
  TITLE     Calsyntenin-1 mediates axonal transport of the amyloid precursor
            protein and regulates Abeta production
  JOURNAL   Hum Mol Genet 21 (13), 2845-2854 (2012)
   PUBMED   22434822
  REMARK    GeneRIF: findings show that amyloid precursor protein (APP) and
            calsyntenin-1 are co-transported through axons, that loss of
            calsyntenin-1 disrupts axonal transport of APP and that
            calsyntenin-1 loss also leads to altered APP processing and
            increased production of Abeta
REFERENCE   6  (bases 1 to 4408)
  AUTHORS   Araki,Y., Kawano,T., Taru,H., Saito,Y., Wada,S., Miyamoto,K.,
            Kobayashi,H., Ishikawa,H.O., Ohsugi,Y., Yamamoto,T., Matsuno,K.,
            Kinjo,M. and Suzuki,T.
  TITLE     The novel cargo Alcadein induces vesicle association of kinesin-1
            motor components and activates axonal transport
  JOURNAL   EMBO J 26 (6), 1475-1486 (2007)
   PUBMED   17332754
REFERENCE   7  (bases 1 to 4408)
  AUTHORS   Konecna,A., Frischknecht,R., Kinter,J., Ludwig,A., Steuble,M.,
            Meskenaite,V., Indermuhle,M., Engel,M., Cen,C., Mateos,J.M.,
            Streit,P. and Sonderegger,P.
  TITLE     Calsyntenin-1 docks vesicular cargo to kinesin-1
  JOURNAL   Mol Biol Cell 17 (8), 3651-3663 (2006)
   PUBMED   16760430
  REMARK    GeneRIF: Calsyntenin-1 links a certain type of vesicular and
            tubulovesicular organelles to the Kinesin-1 motor.
REFERENCE   8  (bases 1 to 4408)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   9  (bases 1 to 4408)
  AUTHORS   Araki,Y., Tomita,S., Yamaguchi,H., Miyagi,N., Sumioka,A., Kirino,Y.
            and Suzuki,T.
  TITLE     Novel cadherin-related membrane proteins, Alcadeins, enhance the
            X11-like protein-mediated stabilization of amyloid beta-protein
            precursor metabolism
  JOURNAL   J Biol Chem 278 (49), 49448-49458 (2003)
   PUBMED   12972431
REFERENCE   10 (bases 1 to 4408)
  AUTHORS   Vogt,L., Schrimpf,S.P., Meskenaite,V., Frischknecht,R., Kinter,J.,
            Leone,D.P., Ziegler,U. and Sonderegger,P.
  TITLE     Calsyntenin-1, a proteolytically processed postsynaptic membrane
            protein with a cytoplasmic calcium-binding domain
  JOURNAL   Mol Cell Neurosci 17 (1), 151-166 (2001)
   PUBMED   11161476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY569014.1.
            
            On or before Sep 18, 2011 this sequence version replaced
            XM_243040.5, XM_001075647.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY569014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4408
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4408
                     /gene="Clstn1"
                     /note="calsyntenin 1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
     exon            1..276
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3044
                     /gene="Clstn1"
                     /note="alc-alpha; alcadein-alpha"
                     /codon_start=1
                     /product="calsyntenin-1 precursor"
                     /protein_id="NP_001007093.1"
                     /db_xref="GeneID:313717"
                     /db_xref="RGD:1306458"
                     /translation="MLRRPAPALARAVRLLLAGLLYGGGVWAARVNKHKPWLEPTYHG
                     IVTENDNTVLLDPPLIALDKDSPLRFAGEICGFKIHGQNVPFDAVVVDKSTGEGIIRS
                     KEKLDCELQKDYTFTIQAYDCGKGPDGTGVKKSHKATVHIQVNDVNEYAPVFKEKSYK
                     AAVVEGKQHGSILRVEAVDADCSPQFSQICSYEILTPDVPFTVDKDGYIKNTEKLNYG
                     KEHQYKLTVTAYDCGKKRATEDVLVKISVKPTCSPGWQGWSSRIEYEPGTGALAVFPS
                     IHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTSELLPSPSSS
                     FNWTVGLPTDNGHDSDQVFEFNGTQAVRIPDGVVTLDPKEPFTISVWMRHGPFGRKKE
                     TILCSSDKTDMNRHHYSLYVHGCRLIFLLRQDPSEEKKYRPAEFHWKLNQVCDEDWHH
                     FVLNVEVPSVTLYVDGVSHEPFSVTEDYPLHPTKIETQLVVGACWQGGDLHMTQFFRG
                     NLAGLTVRSGKLADKKVIDCLYTCKEGLDLQVPEDGNRGVQIQTSSSQAVLTLEGENV
                     GELDKAMQHISYLNSRQFPTPGIRRLKITSTVKCFNEAACIEVPPVEGYVMVLQPEEP
                     KISLSGVHHFARAASEFESPEGVSLFPELKIISTITREVEPEADGAEDPTVQESLVSE
                     EIVHDLDTCEVTVEGEELNAEQESLEVDVARLQQKGIEVNHSDLGVVFTGVETMASYE
                     EVLHLLRYRNWHTRSLLDRKFKLICSELNGRYLSNEFKVEVNVIHTANPVEHANHMAA
                     QPQFVHPEHRSFVDLSGHNLASPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAA
                     HQRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEE
                     DITSAESESSEEEEGGPGDGQNTTRQQQLEWDYSTLSY"
     exon            277..399
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..595
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..804
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..954
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1140
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1389
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1511
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1674
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1832
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1981
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2208
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2379
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2525
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2661
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2846
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..4393
                     /gene="Clstn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgcagcg ctgccgacga ggggagggcg cgcgcggccc agcagcacgg cggctgccgc
       61 tcacatcccg gtgctcgccg cgccgcccag ccgctggccc ccggctgccc gcacccctct
      121 cggcgtcccg cgcgactccc tgctgcttcc gcgtcgggcc ggccgcggcg ctccgagccc
      181 gagcgatgct gcgccgccct gcgcccgcgc tggcccgggc tgtccggctg ctgctggcgg
      241 ggctgctgta cggcggcggg gtctgggccg cgcgagttaa caagcacaag ccatggctgg
      301 agcccaccta ccacgggatc gtcaccgaga acgataacac ggtgctgctc gacccccccc
      361 tcatcgccct ggacaaagac tcaccgctgc gctttgcagg tgagatttgt ggctttaaaa
      421 tccacgggca gaatgtcccc ttcgatgccg tggtagtgga taagtccacg ggtgagggaa
      481 taatccgatc aaaagagaaa ctggactgtg agttgcagaa agactataca ttcaccatcc
      541 aggcctacga ctgcgggaag ggacccgatg gcaccggtgt gaaaaaatct cacaaagcaa
      601 ccgtgcacat ccaggtgaac gacgtgaatg agtacgcccc cgtgttcaag gagaagtcgt
      661 acaaggcggc cgtggtggag ggcaagcagc acggcagcat cctcagggtg gaggccgtgg
      721 atgcagactg ctcgccccag ttcagccaga tctgcagcta tgagattctc accccagatg
      781 tgccgttcac tgtggacaaa gacggttaca tcaaaaacac agagaagctt aactacggca
      841 aagagcatca gtataagctc actgtcaccg cctatgactg tgggaagaaa agagccacgg
      901 aggacgtcct ggtgaagatc agcgttaagc ccacctgcag ccccgggtgg caaggctgga
      961 gcagcagaat tgaatatgag cccggcacag gcgctttggc cgtcttcccg agcatccact
     1021 tggagacctg cgacgagcct gtcgcctctg tgcaggccac agtggagctg gagaccagcc
     1081 acatagggaa aggctgcgac cgagacacct actccgagaa gtccctccac cggctctgtg
     1141 gggctgctgc tggtacctca gagctgctcc cgtcgcccag tagctccttc aattggaccg
     1201 tcggcctccc cactgacaac ggccatgaca gtgaccaggt ctttgagttc aatggcacac
     1261 aggcggtgcg gatcccagac ggtgttgtga cccttgaccc caaagagcct tttacaattt
     1321 ccgtgtggat gcggcatggg ccttttggcc ggaagaagga gacaattctc tgcagttcgg
     1381 ataaaacaga tatgaaccga caccattatt cgctctatgt ccacgggtgc agactcattt
     1441 tcctcctccg tcaggacccg tctgaggaga agaagtacag gcctgcggag ttccactgga
     1501 agctgaacca agtctgtgat gaggattggc accactttgt cctcaatgtg gaagtcccaa
     1561 gtgtgaccct ctatgtggac ggcgtctctc atgagccctt ctccgtgacc gaggactacc
     1621 cacttcatcc aaccaaaata gaaactcagc ttgtggtcgg agcttgctgg caaggtggtg
     1681 acctgcacat gacgcagttt ttccgaggta acctggctgg cctcacagtc cgttctggga
     1741 aactggcaga taagaaagtg atcgactgtc tgtacacctg caaagagggg ctggacctgc
     1801 aggtccctga ggatggcaac agaggggtgc agatccaaac aagctccagt caggcggtat
     1861 tgaccttgga gggggagaat gtcggagagt tggataaggc catgcagcac atttcttacc
     1921 tcaactcaag gcagttcccc acaccaggca tccgcaggct gaaaatcacc agcaccgtca
     1981 agtgctttaa tgaggcggct tgcatcgagg tgcctccggt ggagggctac gtgatggttt
     2041 tacagccaga agaacccaag atcagcctga gtggggtcca ccactttgcc cgcgcagctt
     2101 ccgagtttga gagcccggag ggtgtttccc ttttccctga gctgaaaatc ataagcacca
     2161 tcaccagaga ggtggagccc gaggcggacg gggctgagga ccccacagtg caagagtccc
     2221 tggtgtcgga ggagattgtg cacgacctgg acacctgtga ggtcacggtg gaaggggagg
     2281 agctgaacgc agagcaggag agcctagagg tggacgtggc ccgcctccag cagaagggca
     2341 tcgaagtgaa ccactctgac ctgggcgtgg tcttcacagg tgtggaaacc atggcaagct
     2401 acgaggaggt tctgcacctc ctgcgctatc ggaattggca caccaggtcc ctgctggacc
     2461 ggaagttcaa gctcatttgc tcggaactaa atggtcgtta cctcagcaac gagttcaagg
     2521 tggaggtgaa tgtgatccac acagccaacc ccgtggaaca cgctaatcac atggccgccc
     2581 agccacagtt tgtccaccct gaacaccgat ccttcgtgga cctgtctggt cacaacttgg
     2641 ccagtcctca cccatttgca gttgtcccca gcacggcgac tgtcgtgatt gtggtatgtg
     2701 tcagcttcct ggttttcatg atcatcctgg gggtgtttcg gatccgagct gcacatcagc
     2761 gaacgatgcg ggaccaggac accgggaagg agaacgagat ggactgggat gactctgcct
     2821 tgaccatcac tgtcaacccc atggagacgt acgaggacca gcacagcagt gaggaggagg
     2881 aagaagagga agaggaggag gagagtgaag acggggagga ggaggaggac atcaccagtg
     2941 ccgagtcaga gagcagtgag gaggaggaag gcggccccgg ggacggccag aacaccaccc
     3001 ggcagcagca gctagaatgg gactactcca cactcagcta ctaaacacgc gctcgcccag
     3061 cacctgctct ccagactctc ccagccatct tccagcccca cgggtccacg atgtacaaat
     3121 cattttgacc agcaggtctg cagacccctc ccccattgct gaaagtcctc ccgtgcttgg
     3181 tgtgtgggac cacaggctcc gccctccctg cccatcacgc ttgcagtttt gcttaggagc
     3241 tggcccttcc tcccagtgca ggggccccac agcacctcag accccaagtg tgtctggagt
     3301 cccctgtcag ccagggagag gacaccagca cctgggacct ccagagaagc cgcagtgagc
     3361 ggacttgtcg acagagggta aaaaattact cccacgcagt catcattttt cttcattttt
     3421 aaaagttttt atttttattt tccaatatag tgcatgtata aagtgggaga gcggggaggg
     3481 ggggttaata tgtagatgac caactgactt tttaatattt tgtaaataaa ttgggattct
     3541 ttgtgtcctt tgtgctagtg tagtccagga caggaatgtg aagtcagaac atggggccag
     3601 gaagagctct tcctcccttt tccctcccaa gaaaccaggt tggaaaggtc caagtcacag
     3661 tggcccatgc tggggtttct gtacagccat gtggccaggg ccataggttt tgagtgctgc
     3721 ctgggggagc cagacccacg cgctcccacc acattagagg ctgggaacag ccaggatggt
     3781 gccaaagccc ctggccttcc ttgtacacgc ctgtgaccag cctcgtggct tctgctaatt
     3841 agcgtgtctc cctgttggtg aaaacctgta gctgggaact gatggcaaag atggacaaca
     3901 gttctgagca gtctgcacta cagcacccaa gaggagaacc tgaggcccga aaacaaactg
     3961 ctacaatgtt tcaaaacgag ctgcgctctc ctccccagag accccacggg atgcccccgg
     4021 gatgccccct tgctgtcggg ttttggctaa gacctaagac ccagcagagg agagccagcc
     4081 ggcttggggg gtgggggtgg gggaggagac agcagctaaa acccacacag cacggcttgt
     4141 cattcacagt cacagtttag actcctccag ctggggaatc cggtcctcgc tgctagtcct
     4201 aaggatgttg acgctgtgct gcctgtggcc accctcccgt gtcctgttcc ctgtagtcgc
     4261 tttatagatg gaaacaggct atgaagaggg acactgtcgt gtgttggtag ccgcaggctc
     4321 cccttaagat gtgtatattg accccaggtc aggaagtgta tgcgttataa taaagttctg
     4381 gttctaactc caaaaaaaaa aaaaaaaa
//
