LOCUS       NM_001108240            2312 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CLPTM1-like (Clptm1l), mRNA.
ACCESSION   NM_001108240 XM_001056887 XM_229475
VERSION     NM_001108240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2312)
  AUTHORS   Ji Z, Li Y, Xiang C, Luo X, Yuan P, Long J, Shen N, Shen Y, Deng L,
            Li J and Cheng L.
  TITLE     TERT-rs33963617 and CLPTM1L-rs77518573 reduce the risk of non-small
            cell lung cancer in Chinese population
  JOURNAL   Gene 731, 144357 (2020)
   PUBMED   31935503
REFERENCE   2  (bases 1 to 2312)
  AUTHORS   Liu Z, Goldstein AM, Hsu WL, Yu KJ, Chien YC, Ko JY, Jian JJ, Tsou
            YA, Leu YS, Liao LJ, Chang YL, Wang CP, Wu JS, Hua CH, Lee JC, Yang
            TL, Hsiao CK, Wu MS, Tsai MH, Huang KK, Yu K, Jones K, Zhu B,
            Yeager M, Yu G, Lou PJ, Chen CJ and Hildesheim A.
  CONSRTM   GEV-NPC group
  TITLE     Evaluation of Rare and Common Variants from Suspected Familial or
            Sporadic Nasopharyngeal Carcinoma (NPC) Susceptibility Genes in
            Sporadic NPC
  JOURNAL   Cancer Epidemiol Biomarkers Prev 28 (10), 1682-1686 (2019)
   PUBMED   31270100
REFERENCE   3  (bases 1 to 2312)
  AUTHORS   Yu J, Li X, Zhou B and Yan A.
  TITLE     Polymorphisms of the TERT-CLPTM1L Gene Are Associated with
            Pharynx-Larynx Cancer
  JOURNAL   DNA Cell Biol 38 (9), 915-921 (2019)
   PUBMED   31429604
REFERENCE   4  (bases 1 to 2312)
  AUTHORS   Yadav S, Chandra A, Kumar A and Mittal B.
  TITLE     Association of TERT-CLPTM1L and 8q24 Common Genetic Variants with
            Gallbladder Cancer Susceptibility and Prognosis in North Indian
            Population
  JOURNAL   Biochem Genet 56 (4), 267-282 (2018)
   PUBMED   29450669
REFERENCE   5  (bases 1 to 2312)
  AUTHORS   Lee HW, Park WJ, Heo YR, Park TI, Park SY and Lee JH.
  TITLE     TERT-CLPTM1 locus polymorphism (rs401681) is associated with the
            prognosis of hepatocellular carcinoma
  JOURNAL   Onco Targets Ther 10, 4853-4858 (2017)
   PUBMED   29042796
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2312)
  AUTHORS   Li C, Yin Z, Wu W, Li X, Ren Y and Zhou B.
  TITLE     Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in
            Chinese women nonsmokers
  JOURNAL   PLoS One 8 (5), e64988 (2013)
   PUBMED   23738012
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2312)
  AUTHORS   Pande M, Spitz MR, Wu X, Gorlov IP, Chen WV and Amos CI.
  TITLE     Novel genetic variants in the chromosome 5p15.33 region associate
            with lung cancer risk
  JOURNAL   Carcinogenesis 32 (10), 1493-1499 (2011)
   PUBMED   21771723
REFERENCE   8  (bases 1 to 2312)
  AUTHORS   Wauters E, Smeets D, Coolen J, Verschakelen J, De Leyn P, Decramer
            M, Vansteenkiste J, Janssens W and Lambrechts D.
  TITLE     The TERT-CLPTM1L locus for lung cancer predisposes to bronchial
            obstruction and emphysema
  JOURNAL   Eur Respir J 38 (4), 924-931 (2011)
   PUBMED   21622582
REFERENCE   9  (bases 1 to 2312)
  AUTHORS   Wang Y, Broderick P, Matakidou A, Eisen T and Houlston RS.
  TITLE     Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3)
            variation and lung cancer risk in never-smokers
  JOURNAL   Carcinogenesis 31 (2), 234-238 (2010)
   PUBMED   19955392
REFERENCE   10 (bases 1 to 2312)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474002.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001056887.1, XM_229475.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2312
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /note="CLPTM1-like"
                     /db_xref="GeneID:316916"
                     /db_xref="RGD:1307896"
     exon            1..357
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1815
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /note="cleft lip and palate transmembrane protein 1-like
                     protein"
                     /codon_start=1
                     /product="lipid scramblase CLPTM1L"
                     /protein_id="NP_001101710.1"
                     /db_xref="GeneID:316916"
                     /db_xref="RGD:1307896"
                     /translation="MWSGRSSFTSLVVGVFVVYVVHTCWVMYGIVYTRPCSGDANCIQ
                     PYLARRPKLQLSVYTTTRSSLGAENNVDLVLNVEDFDVESKFERTVNVSVPKKTRNNG
                     TLYAYIFLHHAGILPWHDGKQVHLVSPLTTYMIPKPEEINLLTGESATQQQIEAERKP
                     SNALDEPVSHWRPRLTLNVMVDDFVFDGSSLPADVHRYMKMIQLGKTVHYLPILFIDQ
                     LSNRVKDLMVINRSTTELPLTVSYDKISLGRLRFWIHMQDAVYSLQQFGFSEKDADEV
                     KGIFVDTNLYLLALTFFVAAFHLLFDFLAFKNDISFWKKKKSMIGMSTKAVLWRCFST
                     VVIFLFLLDEQTSLLVLIPAGVGAAIELWKVKKALKMTVTWRGVRPVFQFGTHSESER
                     KTEKYDAQAMKYLSYLLYPLCVGGAVYSLLNIKYKSWYSWLINSFVNGVYAFGFLFML
                     PQLFVNYKMKSVAHLPWKAFTYKAFNTFIDDVFAFIITMPTSHRLACFRDDVVFLVYL
                     YQRWLYPVDKSRVNEFGESYEEQPKRKPHPD"
     exon            358..458
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            459..648
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            649..797
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            798..876
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            877..994
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1089
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1174
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1278
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1344
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1395
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1478
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1513
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1569
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1614
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1730
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..2312
                     /gene="Clptm1l"
                     /gene_synonym="RGD1307896"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggctcg gttcccggaa gcggcggccg gcaaatccgg cgaatcccgc ggcgccgggt
       61 gtaggtatcg ggagcatgcg gggcggccgg cggcccgcgc gaggcgcgtt ggtttccccg
      121 cggcggcggc ggcggcgcgc ggcggctctc ccgtgagcgg cgggcggcgg cgctgggccc
      181 gcaggttgcg gcgccatgtg gagcggccgc agctccttta ccagcttggt ggtgggcgtg
      241 ttcgtggtgt acgtggtgca tacctgctgg gttatgtatg gtatcgtcta tacccgtccg
      301 tgctcgggtg acgccaactg catccagccc tatctggccc ggcggcccaa gctgcagctg
      361 agtgtttaca ccaccacacg gtccagcctt ggtgcagaga acaatgtgga cctggtcttg
      421 aacgtggaag actttgatgt ggagtccaaa tttgaaagga cagttaatgt ttctgtacca
      481 aagaaaacaa gaaacaatgg gacgctgtac gcatatattt tcctacatca tgctgggatt
      541 ctgccctggc acgatgggaa acaggtacac ctggtcagtc ctctgactac ttacatgatc
      601 cccaaaccag aagaaattaa cttgctcact ggggagtctg ccacacagca gcagatagaa
      661 gcagagagga agccatcgaa tgccctagat gagcccgtct ctcactggcg accacggctg
      721 accctgaatg tgatggtgga tgacttcgtc tttgatggtt cctccctccc tgcagatgtg
      781 catcgataca tgaagatgat tcagcttggg aagacagttc actacctccc catcctgttc
      841 attgaccagc tgagcaaccg ggtgaaagac ctgatggtga taaatcggtc caccactgag
      901 ctgccactca ctgtgtccta tgacaagatc tcactggggc ggctgcgctt ctggatccac
      961 atgcaggatg ccgtgtactc cctgcagcag ttcgggtttt cagaaaaaga tgcagatgaa
     1021 gtgaagggaa ttttcgtaga caccaacttg tatctcttag cattgacctt ctttgttgca
     1081 gcttttcacc ttctttttga tttcctggca tttaaaaatg acatcagttt ctggaagaaa
     1141 aagaagagca tgattggaat gtctaccaaa gcagtgctct ggcgttgctt cagcactgtg
     1201 gtcatcttcc tcttcctgct ggatgaacag acaagcctgc tggtgctgat ccctgcaggt
     1261 gttggggctg ccattgagct ttggaaagtg aagaaggcat tgaaaatgac agtgacctgg
     1321 aggggcgtga gacctgtgtt tcagtttggc acccatagtg agtctgagag gaagactgag
     1381 aaatacgatg ctcaggccat gaagtacttg tcttatctgc tctaccctct ctgtgtcggg
     1441 ggcgctgtct actcactcct gaatatcaag tataagagtt ggtactcctg gctcatcaac
     1501 agctttgtga atggtgtcta tgcctttggc ttcctcttca tgttgcccca gctttttgtc
     1561 aactataaga tgaagtcagt ggcccacctg ccttggaagg ccttcaccta caaggcgttt
     1621 aacaccttca ttgatgatgt ctttgccttc atcatcacca tgcccacatc ccaccggctg
     1681 gcctgtttca gagatgacgt ggtcttcctg gtctaccttt accagcggtg gctttaccct
     1741 gtggataaga gcagggtcaa tgaatttggg gagtcttatg aggagcagcc caagcggaag
     1801 ccccacccag actgagcatc tcagcccagg ctcccaggcg gcactgcaca gcacagttgg
     1861 gccatgagta ttcctggggc ctttgggaga attcctagat accacatctt ctgcgttgcc
     1921 aaatccctct gagcatttct cagtatccct gagcaccctc tcttctcgtg ttcagaagga
     1981 accgtagcac ttgaccatat accccacatg aacttgggtc ttgggaatgg tgccagtggg
     2041 cagtcagtca agggtagctc ttagtgtatg agtgtctgat ggcagccagt ggacacctga
     2101 gcacgcatga tggatttcca tgtcagcttg tccacgtgct ccttacgtgg atttcacaca
     2161 cacaaaagtc attctgtacc aactctggga tcaaatggct ctttttccct tttgtttaaa
     2221 atttgattgt ttaaagctta atgtatgttt gtttctattt taaaataaat ttctttggct
     2281 gtgacatttt tcttaaccta taataatata ga
//
