LOCUS       NM_001106232            2453 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CLPTM1 regulator of GABA type A receptor forward
            trafficking (Clptm1), mRNA.
ACCESSION   NM_001106232 XM_001067335 XM_214859
VERSION     NM_001106232.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Zhang XL, Zhou JY, Zhang P, Lin L, Mei R, Zhang FL, Chen YM and Li
            R.
  TITLE     Clptm1, a new target in suppressing epileptic seizure by regulating
            GABAA R-mediated inhibitory synaptic transmission in a PTZ-induced
            epilepsy model
  JOURNAL   Kaohsiung J Med Sci 39 (1), 61-69 (2023)
   PUBMED   36519412
  REMARK    GeneRIF: Clptm1, a new target in suppressing epileptic seizure by
            regulating GABAA R-mediated inhibitory synaptic transmission in a
            PTZ-induced epilepsy model.
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ and
            Craig AM.
  TITLE     Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale
            Inhibitory Synaptic Strength
  JOURNAL   Neuron 97 (3), 596-610 (2018)
   PUBMED   29395912
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Takeuchi T, Kuro-o M, Miyazawa H, Ohtsuki Y and Yamamoto H.
  TITLE     Transgenic expression of a novel thymic epithelial cell antigen
            stimulates abberant development of thymocytes
  JOURNAL   J Immunol 159 (2), 726-733 (1997)
   PUBMED   9218588
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   Takeuchi T, Tamamoto T, Tamura H and Yamamoto H.
  TITLE     Characterization of a 50 kDa surface membrane protein on thymic
            stromal cells as an important factor for early T cell development
  JOURNAL   Int Immunol 7 (4), 583-590 (1995)
   PUBMED   7547685
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067335.1, XM_214859.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166760.1, SRR8487231.190885.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2453
                     /gene="Clptm1"
                     /note="CLPTM1 regulator of GABA type A receptor forward
                     trafficking"
                     /db_xref="GeneID:292696"
                     /db_xref="RGD:1310959"
     exon            1..84
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2007
                     /gene="Clptm1"
                     /note="cleft lip and palate transmembrane protein 1; cleft
                     lip and palate associated transmembrane protein 1; CLPTM1,
                     transmembrane protein"
                     /codon_start=1
                     /product="putative lipid scramblase CLPTM1"
                     /protein_id="NP_001099702.1"
                     /db_xref="GeneID:292696"
                     /db_xref="RGD:1310959"
                     /translation="MAAAQEADGAGSAVVAAGGGSSGQVTSNGSIGRDTPAETQPQNP
                     PPQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPSPQDQSGPGGAPRVASRNLFPKDTL
                     MNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQ
                     NGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEA
                     DPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYY
                     PIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDEL
                     YEQSDEEQDSVKVALLETSPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLS
                     VRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAG
                     IFPCPTFRDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVL
                     SMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVM
                     YRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDVSAAASGAQASTAAGALTPS
                     PSTAVTGEDASTVPTATPGACTASQPQEDPPKPAEDKKKD"
     exon            85..197
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..321
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            322..480
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..598
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..684
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..805
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1050
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1144
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1335
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1431
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1567
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1735
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..2453
                     /gene="Clptm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcagga agatggcggc ggcgcaggag gcggacgggg ccggcagcgc cgtggtggcg
       61 gccgggggag gcagctctgg tcaggtgacc agcaatggca gcattgggag ggacacacca
      121 gccgagaccc agcctcagaa ccctccaccc cagccagccc ccaacgcctg gcaggtcatc
      181 aaaggcgttc tgttcaggat cttcatcatc tgggccatca gcagctggtt ccgccgaggg
      241 ccatcccctc aggaccagtc aggccctgga ggagccccac gtgtcgccag ccgaaactta
      301 ttccccaaag acactctaat gaacctgcac gtgtacatct cagagcacga gcacttcaca
      361 gacttcaatg ccacctcggc gctcttctgg gagcaacatg acctggtcta tggtgactgg
      421 accagtggag agaactccga tggctgctac gagcactttg cagagcttga catcccacag
      481 agtgtacagc agaatggctc catctatatc catgtctatt tcaccaagag tggcttccac
      541 ccagaccccc ggcagaaggc cctgtaccgc cggcttgcca ccgtccacat gtcccggatg
      601 atcaacaaat acaagcgtag acgatttcag aaaaccaaga acctactgac aggagagaca
      661 gaagctgacc cggaaatgat caagagggct gaggactatg gccctgtaga agtgatctca
      721 cactggcacc ccaacatcac catcaatatc gtggatgacc acacaccatg ggtgaagggc
      781 agcgtgccac ccccactgga ccaatatgtg aagtttgatg ccgtgagtgg tgactactac
      841 cccatcatct atttcaatga ctactggaac ctgcagaagg attactaccc cattaatgag
      901 agcctagcca gtctaccact gcgcgtctct ttctgccctc tgtcactgtg gcgctggcaa
      961 ctttatgctg cacagagtac caagtcaccc tggaacttct taggtgatga gctgtatgag
     1021 caatcggacg aggaacagga ttcagtgaag gttgccctgc tggagaccag cccctatctt
     1081 ctggcactta ccatcatcgt ctccattgtc cacagtgtct tcgagttcct ggctttcaaa
     1141 aatgacattc agttctggaa cagtcgtcag tctctggagg ggctgtctgt gcggtctgtc
     1201 ttctttggcg ttttccagtc ctttgtggtt ctcctttaca tcctggacaa tgagaccaac
     1261 ttcgtggtac aggtcagcgt cttcattggg gtcctcattg acctctggaa gattaccaag
     1321 gtcatggatg tccggctgga ccgggagcac agagtggcag ggatcttccc ttgtccgaca
     1381 ttcagagaca agtccaccta cattgagtct tcaaccaaag tatatgatga catggcgttc
     1441 cggtacctgt catggatcct ctttcccctg ctaggctgct atgccgtcta cagccttctg
     1501 tacctggagc acaagggctg gtactcctgg gtgctcagca tgctctacgg cttcctgctg
     1561 acctttggct tcatcaccat gacaccccaa ctgttcatca actataagct caagtctgtg
     1621 gcccacttgc catggcgaat gctcacctac aaggccctca acactttcat tgatgacttg
     1681 tttgcctttg tcatcaagat gcctgtcatg taccggattg gctgcctgcg ggacgatgtg
     1741 gttttcttca tctacctcta ccaacggtgg atctaccgcg tcgaccccac ccgtgtgaac
     1801 gagttcggta tgagtggaga ggatgtctca gcagcggcat ccggggccca ggcatccact
     1861 gcagcagggg ctctcacacc ttcacccagc acagctgtca ccggagagga tgcctccaca
     1921 gtcccaacgg ctactcctgg ggcctgcacg gccagccaac cccaggaaga ccctccaaaa
     1981 ccagcagagg acaagaaaaa ggattagcca ctgcagttct ccttatctgc tcctggtgac
     2041 tgaccgccaa ccaccttccg ggcccctacc ctaccctccc tgtcgccctt ttcctggaca
     2101 gatcaggccg gggcggcagg aggcccccag ggccagggcc cagtgtgtga gatggggccg
     2161 ggcaggctgg ggctggctgt gtgtatgtgg aggcaaccgt ccgtcgtctt gtctgtctgt
     2221 tcctgtgtgt ttgcagacat ctcgccctgc cagcccagca ccatcgggaa tcatggtgaa
     2281 gccaatatgg cgccgagggt gggccaggcg gggaaggggc cagggctcct ctgtgggatg
     2341 cctatggtcc tccatcatct tgtccctcat cccctgacca ccctgctccc agaccaccac
     2401 cctttaacac agtctggatt taataaattc atatgggtgt ttaacttaag ctc
//
