LOCUS       NM_001399287            1013 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus caseinolytic mitochondrial matrix peptidase
            proteolytic subunit (Clpp), mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001399287 XM_217313
VERSION     NM_001399287.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1013)
  AUTHORS   Greene,A.W., Grenier,K., Aguileta,M.A., Muise,S., Farazifard,R.,
            Haque,M.E., McBride,H.M., Park,D.S. and Fon,E.A.
  TITLE     Mitochondrial processing peptidase regulates PINK1 processing,
            import and Parkin recruitment
  JOURNAL   EMBO Rep 13 (4), 378-385 (2012)
   PUBMED   22354088
REFERENCE   2  (bases 1 to 1013)
  AUTHORS   Kang,S.G., Dimitrova,M.N., Ortega,J., Ginsburg,A. and Maurizi,M.R.
  TITLE     Human mitochondrial ClpP is a stable heptamer that assembles into a
            tetradecamer in the presence of ClpX
  JOURNAL   J Biol Chem 280 (42), 35424-35432 (2005)
   PUBMED   16115876
REFERENCE   3  (bases 1 to 1013)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   4  (bases 1 to 1013)
  AUTHORS   Kang,S.G., Ortega,J., Singh,S.K., Wang,N., Huang,N.N., Steven,A.C.
            and Maurizi,M.R.
  TITLE     Functional proteolytic complexes of the human mitochondrial
            ATP-dependent protease, hClpXP
  JOURNAL   J Biol Chem 277 (23), 21095-21102 (2002)
   PUBMED   11923310
REFERENCE   5  (bases 1 to 1013)
  AUTHORS   Andresen,B.S., Corydon,T.J., Wilsbech,M., Bross,P., Schroeder,L.D.,
            Hindkjaer,T.F., Bolund,L. and Gregersen,N.
  TITLE     Characterization of mouse Clpp protease cDNA, gene, and protein
  JOURNAL   Mamm Genome 11 (4), 275-280 (2000)
   PUBMED   10754102
REFERENCE   6  (bases 1 to 1013)
  AUTHORS   de Sagarra,M.R., Mayo,I., Marco,S., Rodriguez-Vilarino,S.,
            Oliva,J., Carrascosa,J.L. and Casta n,J.G.
  TITLE     Mitochondrial localization and oligomeric structure of HClpP, the
            human homologue of E. coli ClpP
  JOURNAL   J Mol Biol 292 (4), 819-825 (1999)
   PUBMED   10525407
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Jan 5, 2022 this sequence version replaced XM_217313.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231323.1, SRR26643288.36491.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: downstream AUG is associated
                                                  with N-terminal localization
                                                  signal
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               JAXUCZ010000009.1  1919039-1919249
            212-283             JAXUCZ010000009.1  1919342-1919413
            284-380             JAXUCZ010000009.1  1919966-1920062
            381-568             JAXUCZ010000009.1  1921579-1921766
            569-674             JAXUCZ010000009.1  1922403-1922508
            675-1013            JAXUCZ010000009.1  1924368-1924706
FEATURES             Location/Qualifiers
     source          1..1013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1013
                     /gene="Clpp"
                     /note="caseinolytic mitochondrial matrix peptidase
                     proteolytic subunit"
                     /db_xref="GeneID:301117"
                     /db_xref="RGD:1588583"
     exon            1..211
                     /gene="Clpp"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..844
                     /gene="Clpp"
                     /EC_number="3.4.21.92"
                     /note="caseinolytic peptidase, ATP-dependent, proteolytic
                     subunit homolog; putative ATP-dependent Clp protease
                     proteolytic subunit, mitochondrial; ClpP caseinolytic
                     peptidase, ATP-dependent, proteolytic subunit homolog"
                     /codon_start=1
                     /product="ATP-dependent Clp protease proteolytic subunit,
                     mitochondrial precursor"
                     /protein_id="NP_001386216.1"
                     /db_xref="GeneID:301117"
                     /db_xref="RGD:1588583"
                     /translation="MWPRVLLRDGRAAAGGCRALLSRFAVRFSPPWSTGSDSPLRSNL
                     HGTATRAFPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFL
                     QSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSP
                     GMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKRQLYNIYAKHTKQSLQVIES
                     AMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPELVQKETTTAPADPPAPAGT"
     exon            212..283
                     /gene="Clpp"
                     /inference="alignment:Splign:2.1.0"
     exon            284..380
                     /gene="Clpp"
                     /inference="alignment:Splign:2.1.0"
     exon            381..568
                     /gene="Clpp"
                     /inference="alignment:Splign:2.1.0"
     exon            569..674
                     /gene="Clpp"
                     /inference="alignment:Splign:2.1.0"
     exon            675..1013
                     /gene="Clpp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaccaagcc tggatgcacg gaggcatgtg gcccagagtg ttgctgaggg acgggcgggc
       61 agctgcgggc gggtgccggg ctctcttgtc tcgcttcgcc gtgcgtttct ccccgccatg
      121 gagtactggg agcgattcac ccctgcgaag caacctgcat ggaactgcga cgcgagcttt
      181 cccactcatc cctatagtgg tggagcagac gggtcgaggc gagcgcgctt acgacatata
      241 ctcgaggctg ttgcgggaac gcatcgtgtg cgtcatgggc ccgattgatg acagcgtggc
      301 cagcctggtc atcgcccagc tgttgttctt acagtcagaa agcaacaaga aacccattca
      361 tatgtacatc aatagcccag gtggtgtggt gactgcaggc ctggccatct acgacacaat
      421 gcaatatatt ctgaacccca tctgcacatg gtgcgttgga caggctgcca gcatgggctc
      481 cctgctcctt gctgctggca gcccagggat gcgccattcg ctgcccaatt ccagaatcat
      541 gatccaccag ccctctggag gagccagggg ccaagccaca gacatcgcta tccaggcaga
      601 ggagatcatg aagctgaaaa ggcagctgta caacatctat gccaagcaca ccaagcagag
      661 cctgcaggtg atcgagtcag ccatggagag ggaccgctac atgagcccca tggaggccca
      721 agagtttggc atcttggaca aggtcttggt ccacccgcct caggatgggg aggatgagcc
      781 agaactggta cagaaggaga ccaccacagc accagcggac cctcctgccc cagcaggcac
      841 ctaaggactt gacctcctct ccaggagtgt ggagaccaga ctgaggactg ctacacttcc
      901 tctgctgggc tagaaaaccc ctggaggaga tgtggtttga ggttgccctc acagcagggc
      961 agcctgcctg agacattgtg attttaaatt aaatctttgt ggtctttgtc cca
//
