LOCUS       NM_022947               2142 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus ClpB family mitochondrial disaggregase (Clpb),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022947 XM_346556
VERSION     NM_022947.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Perier,F., Radeke,C.M., Raab-Graham,K.F. and Vandenberg,C.A.
  TITLE     Expression of a putative ATPase suppresses the growth defect of a
            yeast potassium transport mutant: identification of a mammalian
            member of the Clp/HSP104 family
  JOURNAL   Gene 152 (2), 157-163 (1995)
   PUBMED   7835694
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Liu,A.Y., Lin,Z., Choi,H.S., Sorhage,F. and Li,B.
  TITLE     Attenuated induction of heat shock gene expression in aging diploid
            fibroblasts
  JOURNAL   J Biol Chem 264 (20), 12037-12045 (1989)
   PUBMED   2745427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022947.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB027570.1, BC070917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-448               JAXUCZ010000001.1  165440968-165441415
            449-500             JAXUCZ010000001.1  165444415-165444466
            501-587             JAXUCZ010000001.1  165463954-165464040
            588-691             JAXUCZ010000001.1  165482603-165482706
            692-820             JAXUCZ010000001.1  165498321-165498449
            821-918             JAXUCZ010000001.1  165527486-165527583
            919-1033            JAXUCZ010000001.1  165539511-165539625
            1034-1111           JAXUCZ010000001.1  165548597-165548674
            1112-1167           JAXUCZ010000001.1  165549762-165549817
            1168-1212           JAXUCZ010000001.1  165554480-165554524
            1213-1374           JAXUCZ010000001.1  165554832-165554993
            1375-1531           JAXUCZ010000001.1  165561157-165561313
            1532-1605           JAXUCZ010000001.1  165561869-165561942
            1606-1725           JAXUCZ010000001.1  165562084-165562203
            1726-1830           JAXUCZ010000001.1  165562386-165562490
            1831-2142           JAXUCZ010000001.1  165563201-165563512
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2142
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /note="ClpB family mitochondrial disaggregase"
                     /db_xref="GeneID:65041"
                     /db_xref="RGD:621328"
     exon            1..448
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..2079
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /EC_number="3.6.1.3"
                     /note="caseinolytic peptidase B protein homolog;
                     caseinolytic mitochondrial matrix peptidase chaperone
                     subunit B; suppressor of potassium transport defect 3;
                     suppressor of K+ transport defect 3; ClpB caseinolytic
                     peptidase B homolog; ClpB homolog, mitochondrial AAA
                     ATPase chaperonin"
                     /codon_start=1
                     /product="mitochondrial disaggregase"
                     /protein_id="NP_075236.2"
                     /db_xref="GeneID:65041"
                     /db_xref="RGD:621328"
                     /translation="MMLSAVLRRTAPAPRLFLGLIKSPSLQSRGGAYNRSVITGDRGE
                     PQRLRTAAWVRPGASSVLFPGRGAATGGRRGERTEIPYLTAASSGRGPSPEETLPGQD
                     SWNGVPNKAGLGMWALAMALVVQCYNKNPSNKDAALMEAARANNVQEVRRLLSEGADV
                     NARHKLGWTALMVAAISHNESVVQVLLAAGADPNLGDDFSSVYKTANEQGVHSLEVLV
                     TREDDFNNRLNHRASFKGCTALHYAVLADDYSIVKELLGGGANPLQRNEMGHTPLDYA
                     REGEVMKLLKTSETKYMEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRK
                     ENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAK
                     FIGSPPGYIGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGK
                     GKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISK
                     NFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHN
                     ITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVE
                     DSDKQLLKSPELPSPQAEKRPPTLRLEIIDKDSKTHKLDIQAPLHPEKVCYTI"
     exon            449..500
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..587
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..691
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..820
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            821..918
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1033
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1111
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1167
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1212
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1374
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1531
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1605
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1725
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1830
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2142
                     /gene="Clpb"
                     /gene_synonym="Skd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctagcacg ggggccggca ccagcaggtt ttagaagcag gtgtcatgat gttgtccgcg
       61 gtgttgagga gaaccgcgcc agcgcctcgg ctcttcctag ggttaatcaa atctccatct
      121 cttcaaagcc ggggaggtgc ttacaaccgt agcgtaatca ccggagaccg cggggagccg
      181 cagcggctga gaactgccgc ctgggtgcgc cctggagcat cttctgtctt gttccccgga
      241 cggggggcag ccaccggggg gcgccgtgga gaacgcaccg agatcccata cctgactgcc
      301 gcctcgtctg gacgcggtcc tagcccggaa gaaacactcc caggacaaga cagctggaat
      361 ggggtcccca acaaggcggg attgggcatg tgggccttgg ccatggcgct ggtggttcag
      421 tgctacaaca agaatccatc taacaaggat gcagctctga tggaagctgc ccgagccaat
      481 aatgtgcagg aagtcagaag gctgttatca gaaggtgcag atgtcaacgc aaggcacaaa
      541 cttggctgga cagcattgat ggtggcagcc atcagccaca atgagagtgt ggtacaggtt
      601 ctccttgctg ctggagctga cccaaacctt ggggacgact tcagcagtgt ctacaagact
      661 gccaatgaac agggagtcca ttctttggaa gtcctagtca ctcgagagga tgacttcaac
      721 aaccgactaa accaccgtgc aagtttcaaa ggctgcacag ccctgcacta tgctgtcctg
      781 gccgacgact acagcatcgt caaggaacta ctgggtggag gagccaaccc ccttcagagg
      841 aatgagatgg gacacacacc cctggattat gcccgggaag gggaggttat gaagcttctg
      901 aaaacttctg aaaccaagta catggagaag cagaggaagc gtgaggcaga agaacggcgc
      961 cgcttcccac tggagcagcg actgaaggag cacatcattg gccaggagag tgccattgct
     1021 accgttggtg ctgcgatccg gaggaaggag aatggctggt atgatgagga gcaccctcta
     1081 gtcttcctct tcttgggatc atctggaata gggaaaactg agctggccaa gcagacagcc
     1141 aagtatatgc acaaagatgc caaaaagggc ttcatccggc tcgacatgtc tgagttccag
     1201 gagcgacatg aggtagccaa gtttatcggt tctccgccag gctacatcgg ccatgaagaa
     1261 ggtggccaac tgaccaagaa actgaaacag tgcccaaatg cagtagttct ctttgacgag
     1321 gtggacaagg cccatccaga tgtgctcacc atcatgctgc agctgtttga tgagggccgc
     1381 ctgacagatg gcaaggggaa gaccattgac tgcaaggatg ccatcttcat catgacttcc
     1441 aatgtagcca gtgatgagat cgcccagcat gcattgcaac tgagacagga agctttggag
     1501 atgagccgaa atcgaatagc tgaaaacctt ggggatgtcc agattagtga caagatcacc
     1561 atctcaaaga acttcaaaga gaatgtgatc cgacccatcc tgaaagctca cttccggaga
     1621 gacgagtttc tgggaaggat caatgagatt gtctacttcc tccctttctg ccactcggag
     1681 ctcatccagc tggtcaacaa ggaactgaac ttctgggcca agagagccaa gcagagacac
     1741 aacatcacac tactgtggga ccgcgaggtg gcagacgtgt tggttgatgg ctacaacgtc
     1801 cactatggtg cccgctccat taagcatgag gtagagcgcc gtgtggtaaa ccagctggcg
     1861 gcagcctatg agcaggacct gctaccaggg ggctgcaccc tgcgtatcac tgtggaggac
     1921 tcagacaagc agctcctcaa gagccctgag ctgccctcgc cccaggctga aaagcgtccg
     1981 cctacactgc gactggagat cattgataag gacagcaaga cccacaaact ggacatccag
     2041 gcaccactcc accccgagaa ggtgtgctac accatctagc atccacctgc ctgtctgtgc
     2101 cctgaacatc taataaaggc cccttgctgt ggcatggcaa cc
//
