LOCUS       NM_001009599            1835 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cleavage factor polyribonucleotide kinase subunit
            1 (Clp1), mRNA.
ACCESSION   NM_001009599 XM_230276
VERSION     NM_001009599.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1835)
  AUTHORS   Yoshihisa,T.
  TITLE     Handling tRNA introns, archaeal way and eukaryotic way
  JOURNAL   Front Genet 5, 213 (2014)
   PUBMED   25071838
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1835)
  AUTHORS   Schaffer,A.E., Eggens,V.R., Caglayan,A.O., Reuter,M.S., Scott,E.,
            Coufal,N.G., Silhavy,J.L., Xue,Y., Kayserili,H., Yasuno,K.,
            Rosti,R.O., Abdellateef,M., Caglar,C., Kasher,P.R., Cazemier,J.L.,
            Weterman,M.A., Cantagrel,V., Cai,N., Zweier,C., Altunoglu,U.,
            Satkin,N.B., Aktar,F., Tuysuz,B., Yalcinkaya,C., Caksen,H.,
            Bilguvar,K., Fu,X.D., Trotta,C.R., Gabriel,S., Reis,A., Gunel,M.,
            Baas,F. and Gleeson,J.G.
  TITLE     CLP1 founder mutation links tRNA splicing and maturation to
            cerebellar development and neurodegeneration
  JOURNAL   Cell 157 (3), 651-663 (2014)
   PUBMED   24766810
REFERENCE   3  (bases 1 to 1835)
  AUTHORS   Karaca,E., Weitzer,S., Pehlivan,D., Shiraishi,H., Gogakos,T.,
            Hanada,T., Jhangiani,S.N., Wiszniewski,W., Withers,M.,
            Campbell,I.M., Erdin,S., Isikay,S., Franco,L.M.,
            Gonzaga-Jauregui,C., Gambin,T., Gelowani,V., Hunter,J.V., Yesil,G.,
            Koparir,E., Yilmaz,S., Brown,M., Briskin,D., Hafner,M., Morozov,P.,
            Farazi,T.A., Bernreuther,C., Glatzel,M., Trattnig,S., Friske,J.,
            Kronnerwetter,C., Bainbridge,M.N., Gezdirici,A., Seven,M.,
            Muzny,D.M., Boerwinkle,E., Ozen,M., Clausen,T., Tuschl,T.,
            Yuksel,A., Hess,A., Gibbs,R.A., Martinez,J., Penninger,J.M. and
            Lupski,J.R.
  CONSRTM   Baylor Hopkins Center for Mendelian Genomics
  TITLE     Human CLP1 mutations alter tRNA biogenesis, affecting both
            peripheral and central nervous system function
  JOURNAL   Cell 157 (3), 636-650 (2014)
   PUBMED   24766809
REFERENCE   4  (bases 1 to 1835)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   5  (bases 1 to 1835)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   6  (bases 1 to 1835)
  AUTHORS   Weitzer,S. and Martinez,J.
  TITLE     The human RNA kinase hClp1 is active on 3' transfer RNA exons and
            short interfering RNAs
  JOURNAL   Nature 447 (7141), 222-226 (2007)
   PUBMED   17495927
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087130.1.
            
            On Jan 13, 2005 this sequence version replaced XM_230276.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1835
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1835
                     /gene="Clp1"
                     /gene_synonym="Heab; RGD1307679"
                     /note="cleavage factor polyribonucleotide kinase subunit
                     1"
                     /db_xref="GeneID:311166"
                     /db_xref="RGD:1307679"
     exon            1..83
                     /gene="Clp1"
                     /gene_synonym="Heab; RGD1307679"
                     /inference="alignment:Splign:2.1.0"
     exon            84..711
                     /gene="Clp1"
                     /gene_synonym="Heab; RGD1307679"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1383
                     /gene="Clp1"
                     /gene_synonym="Heab; RGD1307679"
                     /EC_number="2.7.1.78"
                     /note="ATP/GTP-binding protein; CLP1, cleavage and
                     polyadenylation factor I subunit, homolog; polynucleotide
                     kinase Clp1; polyadenylation factor Clp1; pre-mRNA
                     cleavage complex II protein Clp1; cleavage and
                     polyadenylation factor I subunit 1"
                     /codon_start=1
                     /product="polyribonucleotide 5'-hydroxyl-kinase Clp1"
                     /protein_id="NP_001009599.1"
                     /db_xref="GeneID:311166"
                     /db_xref="RGD:1307679"
                     /translation="MSEESNDDKKPTTKFELERETELRFEVEASQSVQLELLAGMAEI
                     FGTELTRNKKFTFDAGAKVAVFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQ
                     MRRQAEKEEERGPRVMVVGPTDVGKSTVCRLLLNYAVRLGRRPTYVELDVGQGSVSIP
                     GTMGALYIERPADVEEGFSIQAPLVYHFGSTTPGTNIKLYNKITSRLADVFNQRCEVN
                     RRASVSGCVINTCGWVKGYGYQALVHAASAFEVDVVVVLDQERLYNELKRDLPHFVRT
                     VLLPKSGGVVERSKDFRRECRDERIREYFYGFRGCFYPHAFNVKFSDVKIYKVGAPTI
                     PDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIVVTSV
                     DVEHQVFTVLSPAPRPLPKNFLLIMDIRFMDLK"
     exon            712..1809
                     /gene="Clp1"
                     /gene_synonym="Heab; RGD1307679"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgtcccaa aatgcatcac gcgaccgcgt ctcctactac cgcgcaagag cggaaccgcc
       61 tttgctttcc ggctagtatt taggcacagc agctcaacag aaaagatgag tgaggaatcc
      121 aatgatgaca agaagccaac gaccaagttt gaactagagc gagaaacaga gcttcgattt
      181 gaggtggagg catctcagtc agttcagttg gagttgctgg ctggcatggc agagatcttt
      241 ggcacagaac tgaccagaaa caagaaattc acctttgatg ctggtgccaa ggtggctgtt
      301 ttcacttggc atggctgttc tctgcagttg agtggccgga ccgaggtggc ttatgtctct
      361 aaggacaccc ctatgttgct ttaccttaac actcatacag ccttggagca gatgcggagg
      421 caggcagaaa aggaagaaga gagaggcccc cgagtgatgg ttgtgggtcc tactgatgtg
      481 ggcaagtcca cggtgtgccg gctgctactc aactacgcag tgcgtttggg ccgacgtcct
      541 acttacgtgg agttggatgt agggcagggc tctgtgtcca ttcctggtac catgggggcc
      601 ctgtacattg agcgacccgc agatgtggaa gaaggtttct ccatccaggc acctcttgtg
      661 tatcattttg gctccaccac tcctggcacc aacatcaagc tttacaacaa gattacatct
      721 cgtttagcag atgtgttcaa ccaaaggtgt gaagtgaata gaagagcttc tgtgagtggc
      781 tgtgtcatca acacctgtgg ctgggtcaag ggttatggtt accaggccct ggtgcacgca
      841 gcttcagcct ttgaggtgga tgtggttgtg gttctggatc aagaacgact gtacaacgag
      901 ttgaaaaggg acctgcctca ttttgttcga actgtgctgc tcccaaaatc agggggtgtg
      961 gtagaacgct ccaaggactt ccggcgggaa tgtagggatg aacgtatccg tgaatatttc
     1021 tatggattcc gaggctgttt ctatccccat gccttcaatg tcaaattttc tgatgtgaaa
     1081 atctacaaag ttggggcacc caccatccca gactcgtgtt tacctctggg catgtctcag
     1141 gaagacaatc agctcaagtt agtacctgtc acccctggta gagatatggt gcaccatctc
     1201 ctgagtgtca gcactgctga gggcacagaa gagaaccttt ctgagacaag tgtggctgga
     1261 ttcattgttg tgaccagtgt ggacgtggaa caccaggtgt ttactgtctt gtctccagcc
     1321 ccccgcccac tgcctaagaa ctttcttctc atcatggata tccggttcat ggatctcaag
     1381 tagtgattag caaggagcct cactttctgc gccctagagt tctgaccatc accaaagcag
     1441 atggaatgag ctctggcagt cttactaagt caactgacaa ggcccaacta gcagagagca
     1501 catcctctac ctcttgaaac agtggcagta gccagagtcc tggctattat ttggttcatt
     1561 tacctggaac caaaaggaga gcgctcaaaa agaaaatctg aatatttttt taagatcgcc
     1621 taaggtacca ttttaaagat tccaagaccc tagagaactc catgtcttcc tatgctacca
     1681 tgtaggtttt cttgttatca ttttctactg tctcggtata gtatttgtta tattatttaa
     1741 ccaggacgga cgtgagaaag agttcaaact ttaaaacaat taattttaat aaatattatt
     1801 gtcatagaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
