LOCUS       NM_031719               1406 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus chloride nucleotide-sensitive channel 1A
            (Clns1a), mRNA.
ACCESSION   NM_031719
VERSION     NM_031719.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1406)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 1406)
  AUTHORS   Guderian,G., Peter,C., Wiesner,J., Sickmann,A., Schulze-Osthoff,K.,
            Fischer,U. and Grimmler,M.
  TITLE     RioK1, a new interactor of protein arginine methyltransferase 5
            (PRMT5), competes with pICln for binding and modulates PRMT5
            complex composition and substrate specificity
  JOURNAL   J Biol Chem 286 (3), 1976-1986 (2011)
   PUBMED   21081503
REFERENCE   3  (bases 1 to 1406)
  AUTHORS   Chari,A., Golas,M.M., Klingenhager,M., Neuenkirchen,N., Sander,B.,
            Englbrecht,C., Sickmann,A., Stark,H. and Fischer,U.
  TITLE     An assembly chaperone collaborates with the SMN complex to generate
            spliceosomal SnRNPs
  JOURNAL   Cell 135 (3), 497-509 (2008)
   PUBMED   18984161
REFERENCE   4  (bases 1 to 1406)
  AUTHORS   Fronz,K., Otto,S., Kolbel,K., Kuhn,U., Friedrich,H., Schierhorn,A.,
            Beck-Sickinger,A.G., Ostareck-Lederer,A. and Wahle,E.
  TITLE     Promiscuous modification of the nuclear poly(A)-binding protein by
            multiple protein-arginine methyltransferases does not affect the
            aggregation behavior
  JOURNAL   J Biol Chem 283 (29), 20408-20420 (2008)
   PUBMED   18495660
REFERENCE   5  (bases 1 to 1406)
  AUTHORS   Furst,J., Schedlbauer,A., Gandini,R., Garavaglia,M.L., Saino,S.,
            Gschwentner,M., Sarg,B., Lindner,H., Jakab,M., Ritter,M.,
            Bazzini,C., Botta,G., Meyer,G., Kontaxis,G., Tilly,B.C., Konrat,R.
            and Paulmichl,M.
  TITLE     ICln159 folds into a pleckstrin homology domain-like structure.
            Interaction with kinases and the splicing factor LSm4
  JOURNAL   J Biol Chem 280 (35), 31276-31282 (2005)
   PUBMED   15905169
REFERENCE   6  (bases 1 to 1406)
  AUTHORS   Ritter,M., Ravasio,A., Jakab,M., Chwatal,S., Furst,J., Laich,A.,
            Gschwentner,M., Signorelli,S., Burtscher,C., Eichmuller,S. and
            Paulmichl,M.
  TITLE     Cell swelling stimulates cytosol to membrane transposition of ICln
  JOURNAL   J Biol Chem 278 (50), 50163-50174 (2003)
   PUBMED   12970357
  REMARK    GeneRIF: ICln associates with the cell membrane after cell swelling
REFERENCE   7  (bases 1 to 1406)
  AUTHORS   Krapivinsky,G.B., Ackerman,M.J., Gordon,E.A., Krapivinsky,L.D. and
            Clapham,D.E.
  TITLE     Molecular characterization of a swelling-induced chloride
            conductance regulatory protein, pICln
  JOURNAL   Cell 76 (3), 439-448 (1994)
   PUBMED   8313467
REFERENCE   8  (bases 1 to 1406)
  AUTHORS   Abe,T., Takeuchi,K., Ishii,K. and Abe,K.
  TITLE     Molecular cloning and expression of a rat cDNA encoding MDCK-type
            chloride channel
  JOURNAL   Biochim Biophys Acta 1173 (3), 353-356 (1993)
   PUBMED   8391324
REFERENCE   9  (bases 1 to 1406)
  AUTHORS   Ishibashi,K., Sasaki,S., Uchida,S., Imai,T. and Marumo,F.
  TITLE     Tissue expression of mRNA of chloride channel from MDCK cells and
            its regulation by protein kinases
  JOURNAL   Biochem Biophys Res Commun 192 (2), 561-567 (1993)
   PUBMED   7683461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031719.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26450.1, BC060555.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000001.1  161430669-161430833
            166-302             JAXUCZ010000001.1  161438415-161438551
            303-401             JAXUCZ010000001.1  161443152-161443250
            402-509             JAXUCZ010000001.1  161444032-161444139
            510-683             JAXUCZ010000001.1  161445427-161445600
            684-772             JAXUCZ010000001.1  161447399-161447487
            773-1406            JAXUCZ010000001.1  161450270-161450903
FEATURES             Location/Qualifiers
     source          1..1406
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1406
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /note="chloride nucleotide-sensitive channel 1A"
                     /db_xref="GeneID:65160"
                     /db_xref="RGD:61884"
     exon            1..165
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..751
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /note="i(Cln); chloride conductance regulatory protein
                     ICln; chloride channel current inducer; Clns 1a; chloride
                     channel, nucleotide-sensitive, 1A"
                     /codon_start=1
                     /product="methylosome subunit pICln"
                     /protein_id="NP_113907.1"
                     /db_xref="GeneID:65160"
                     /db_xref="RGD:61884"
                     /translation="MLSPAMSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYI
                     AESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNARFGEESKEPFSDE
                     DEDDNDDVEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEA
                     HEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRTY
                     EDGMEVETTPTVAGQFEDADVDH"
     exon            166..302
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
     exon            303..401
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
     exon            402..509
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
     exon            510..683
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
     exon            684..772
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1406
                     /gene="Clns1a"
                     /gene_synonym="Clci; Clcni; Icln; pICln"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctttctt ggttcctgtg gagcaatgct ttcgcccgca atgagcttcc tcaaaagctt
       61 cccgccccct gggtccgcag atggactccg gctgcagcag ccagacaccg aagctgtgct
      121 gaacgggaag gggctcggca ccggcacgct ttacattgcg gagagccgcc tgtcttggct
      181 agatggttct ggattaggat tctcactgga gtaccccacc attagtttac atgcggtatc
      241 cagggaccca aatgcttatc ctcaagaaca tctgtatgtc atggtgaatg ccagatttgg
      301 agaagaatca aaagaacctt tctctgatga agatgaggac gacaatgatg atgttgaacc
      361 catttctgag tttagatttg tgcccagtga taagtcagca ttggaggcga tgttcacagc
      421 aatgtgtgag tgccaggccc tgcatccaga ccctgaggat gaagactcgg atgactatga
      481 tggagaagag tatgatgtgg aagcacatga gcaaggacag ggggacatcc ctacatttta
      541 cacctatgaa gaaggactat cccatttaac agcagaaggg caagccacgc tggagagatt
      601 agaaggaatg ctttctcagt ctgtgagcag ccagtataat atggcaggcg tccgaacaga
      661 agattcagta agaacttacg aagatggcat ggaggtagag accacaccaa ctgttgccgg
      721 acagttcgag gatgcagacg ttgaccactg aggatgactc gtgtgactta caattctgct
      781 cataactata ggcaagaact tgatgcctct tcactccaga atggagctgg tgaaaggctt
      841 ttttcttctc caaaactcat ttctcaagac aaactataat gagacagcaa gctgtcacca
      901 gcagaaaaga ctctgacctc tattaacaaa ggtgaattaa ctgaacgggt ttttgtagtt
      961 tctcatttac ccctaagctt cctgtgtcta gttatcttct gagagggcct ctaattcctg
     1021 cctttgctgt gtgcaatctg tcagctacga ggcctgtgtg tcgtgtgcac agtgctcacg
     1081 ctgggcaaaa gtgaggtggg gagcttagat gtctctggga cttaggagga ctctctgatc
     1141 cctgagataa aaagcaaagg cctctgaggg cacagccttt agcattctcc acggacgcat
     1201 gggccctcta ctggggctca accacatctc gtcatgacaa atgcttgtgt gctacttctg
     1261 ttcctccgca tttaccatca gctctgttac attctcctag cttaggtcct tgactgtcac
     1321 agagtaaatc atctgaaatg aagtctgcaa agtactctca atgatatttt gtctttgtaa
     1381 tagttaaata aatctgggtt ttctat
//
