LOCUS       NM_001007686            2248 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus CLN8, transmembrane ER and ERGIC protein (Cln8),
            mRNA.
ACCESSION   NM_001007686 XM_225033
VERSION     NM_001007686.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Lyly,A., von Schantz,C., Heine,C., Schmiedt,M.L., Sipila,T.,
            Jalanko,A. and Kyttala,A.
  TITLE     Novel interactions of CLN5 support molecular networking between
            Neuronal Ceroid Lipofuscinosis proteins
  JOURNAL   BMC Cell Biol 10, 83 (2009)
   PUBMED   19941651
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Rusyn,E., Mousallem,T., Persaud-Sawin,D.A., Miller,S. and
            Boustany,R.M.
  TITLE     CLN3p impacts galactosylceramide transport, raft morphology, and
            lipid content
  JOURNAL   Pediatr Res 63 (6), 625-631 (2008)
   PUBMED   18317235
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Hermansson,M., Kakela,R., Berghall,M., Lehesjoki,A.E.,
            Somerharju,P. and Lahtinen,U.
  TITLE     Mass spectrometric analysis reveals changes in phospholipid,
            neutral sphingolipid and sulfatide molecular species in progressive
            epilepsy with mental retardation, EPMR, brain: a case study
  JOURNAL   J Neurochem 95 (3), 609-617 (2005)
   PUBMED   16086686
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Wendt,K.D., Lei,B., Schachtman,T.R., Tullis,G.E., Ibe,M.E. and
            Katz,M.L.
  TITLE     Behavioral assessment in mouse models of neuronal ceroid
            lipofuscinosis using a light-cued T-maze
  JOURNAL   Behav Brain Res 161 (2), 175-182 (2005)
   PUBMED   15885820
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Messer,A., Plummer,J., MacMillen,M.C. and Frankel,W.N.
  TITLE     Genetics of primary and timing effects in the mnd mouse
  JOURNAL   Am J Med Genet 57 (2), 361-364 (1995)
   PUBMED   7668363
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Tanner,A. and Dice,J.F.
  TITLE     Batten disease fibroblasts in culture accumulate mitochondrial ATP
            synthase subunit 9
  JOURNAL   Cell Biol Int 19 (1), 71-75 (1995)
   PUBMED   7613514
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Mazurkiewicz,J.E.
  TITLE     Ubiquitin deposits are present in spinal motor neurons in all
            stages of the disease in the motor neuron degeneration (Mnd) mutant
            of the mouse
  JOURNAL   Neurosci Lett 128 (2), 182-186 (1991)
   PUBMED   1658691
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Callahan,L.M., Wylen,E.L., Messer,A. and Mazurkiewicz,J.E.
  TITLE     Neurofilament distribution is altered in the Mnd (motor neuron
            degeneration) mouse
  JOURNAL   J Neuropathol Exp Neurol 50 (4), 491-504 (1991)
   PUBMED   2061715
REFERENCE   10 (bases 1 to 2248)
  AUTHORS   Messer,A. and Flaherty,L.
  TITLE     Autosomal dominance in a late-onset motor neuron disease in the
            mouse
  JOURNAL   J Neurogenet 3 (6), 345-355 (1986)
   PUBMED   3783318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078982.1.
            
            On Nov 29, 2004 this sequence version replaced XM_225033.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078982.1, CK469209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2248
                     /gene="Cln8"
                     /note="CLN8, transmembrane ER and ERGIC protein"
                     /db_xref="GeneID:306619"
                     /db_xref="RGD:1359518"
     exon            1..45
                     /gene="Cln8"
                     /inference="alignment:Splign:2.1.0"
     exon            46..704
                     /gene="Cln8"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1028
                     /gene="Cln8"
                     /note="ceroid-lipofuscinosis, neuronal 8"
                     /codon_start=1
                     /product="protein CLN8"
                     /protein_id="NP_001007687.1"
                     /db_xref="GeneID:306619"
                     /db_xref="RGD:1359518"
                     /translation="MTPVSNHGVAESIFDLDYASWKIRSTLAVAGFVFYLGVFVVCHQ
                     LSSSLNATYRSLLAKEKVFWNLAATRAVFGIQSTAAGLWALLGDPVLYSNKALGQQNW
                     CWFHITTATGFFFFENAAVHLSNLFFRTFDLFLVVHHLFAFLGFLGSAVNLRAGHYLA
                     MTTLLLEMSTPFTCVSWMLLKAGWSHSLFWKVNQWLMIHMFHCRMILTYHMWWVCFQH
                     WDALASSLYLPHLALFLFGLALLTVIINPYWTHKKTQQLLNPVDWNFAQPEAKGDRQE
                     RTNGQVPRKKRL"
     exon            705..2225
                     /gene="Cln8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggggcca agaggcagcg cccccttctg ctcacctgaa tgcaggttga ggatgggtac
       61 ccgatgaccc tcgagacagc ttcgctgaaa gtgaggagtg gtgtcaagcc cagctgcccc
      121 gtgttggccc cagggacact cctggcatcc agattaagat catgactcct gtgagcaacc
      181 atggcgttgc ggagagcatt tttgacctgg actatgcttc ctggaagatt cgatcaactc
      241 tagcagtagc tggctttgtc ttctacctgg gcgtctttgt ggtctgccac cagctttcgt
      301 cctccctgaa tgccacctac cgctctctgt tggccaaaga gaaggtcttc tggaacctgg
      361 ctgcgacgcg cgctgtcttc ggcatccaga gcacagccgc aggcctgtgg gcgctgctgg
      421 gagaccccgt gctctactct aacaaggctc tcgggcagca gaactggtgc tggttccaca
      481 tcaccactgc cacgggattc ttcttcttcg agaatgcggc cgttcacctg tccaacctgt
      541 tcttccgtac ttttgacctg tttctggtcg tccaccacct ctttgccttt cttgggttcc
      601 ttgggtcagc ggtcaatctc agagctggcc actacctagc catgaccact ttgctcctag
      661 agatgagcac gcccttcacc tgcgtttcct ggatgctcct gaaggctggc tggtcacact
      721 ccctgttctg gaaggtgaac cagtggctga tgatccacat gtttcactgc agaatgatcc
      781 ttacctacca catgtggtgg gtgtgcttcc agcactggga cgccctcgcc agcagcctgt
      841 acctgcccca cttggcgctg ttcctcttcg ggctggccct gctcacagtc atcattaacc
      901 cttactggac acacaagaag acccagcagc ttctcaatcc cgtggattgg aactttgcac
      961 agccggaagc caagggcgac cggcaagaaa ggaccaatgg ccaggtgcct cggaaaaaga
     1021 ggctgtagcg cccacccagg gaccccggtg gctggcgacg ccagtcggcg agccgcggtc
     1081 acacggacag tgacttttca cgtacggatg tggacgagag tgagtttgga tctaggtgac
     1141 tactaacttg ttctttagta ctaattctaa agtacccatg aagtattgtt ggggccttga
     1201 cgtgcctgca agaggtcttt gccatcatga ccttcctccg agtcctccgg cccgggccca
     1261 accacagcct atctgccaag gtggtgttag ggaaggagct gtggcggcca cgtgtgcagg
     1321 cagccgagga ggccagtctg gatccccgag aggattcatt aggaaggacc cccgcgtggg
     1381 tgtggacgtg ccttatttgg aagtcacgta ctttttcgtt gcaacgaatc gaccctaaga
     1441 aaatgtttac tagcatgtgg gatttttttt taagcccgcg gccatgcact gccctctggt
     1501 ggccagaggc ggaaggacac agttatggta aggggctctt ggtggtggct tactagagtc
     1561 tgtccaccct tcctggcgcc gtggcggtgt gaaatcttgt acttcaaaaa caacaacaat
     1621 aaccacaaaa cccaaggaac ctaataacct cttttttaaa tgagaatttt tagtgatgta
     1681 tttcttaatt gacagaataa ggtgtctgga tctttgagct atttctaatt gaccgaagtg
     1741 gctaccctgc tctgtctttc ccctctaggc tgtgaggggg tcctacactc agagatgctc
     1801 gtcctgagtt gctagggccc agatgatgag cactgtttgc gggttagacc tccagaccct
     1861 ggccagcaat gctctcggtg gacacaaaaa cttttcccag agaacaattg tacagggttt
     1921 tttgttttgt tttgttttgt ttttgtcaaa actacctgtg aaatggtggt tgctcttgaa
     1981 aatcatgtgt gacttccgcc tgccatggat tgccggcctt ggcatatttt gcgtgttagc
     2041 cctttaactt ttatcaggat gtatgacgcc tatttatttc ggtctaagaa agcccttacc
     2101 ttgcgttcct aagattatca actgaaaacc ccatagcccc caggtctgct ttgtcgaggc
     2161 tccagcctgg cggtttttaa ctgggcagaa gtttaataaa acgacagctc tttccaaaac
     2221 ccaaaaaaaa aaaaaaaaaa aaaaaaaa
//
