LOCUS       NM_001399428            1875 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus CDC-like kinase 4 (Clk4), transcript variant 1,
            mRNA.
ACCESSION   NM_001399428 XM_006246234
VERSION     NM_001399428.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1875)
  AUTHORS   Eisenreich,A., Bogdanov,V.Y., Zakrzewicz,A., Pries,A., Antoniak,S.,
            Poller,W., Schultheiss,H.P. and Rauch,U.
  TITLE     Cdc2-like kinases and DNA topoisomerase I regulate alternative
            splicing of tissue factor in human endothelial cells
  JOURNAL   Circ Res 104 (5), 589-599 (2009)
   PUBMED   19168442
REFERENCE   2  (bases 1 to 1875)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 9, 2022 this sequence version replaced XM_006246234.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.873257.1,
                                           SRR26360190.2063085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000010.1  36025740-36025823
            85-245              JAXUCZ010000010.1  36029593-36029753
            246-468             JAXUCZ010000010.1  36034276-36034498
            469-559             JAXUCZ010000010.1  36035538-36035628
            560-626             JAXUCZ010000010.1  36036023-36036089
            627-743             JAXUCZ010000010.1  36037630-36037746
            744-910             JAXUCZ010000010.1  36037831-36037997
            911-1005            JAXUCZ010000010.1  36038178-36038272
            1006-1135           JAXUCZ010000010.1  36038519-36038648
            1136-1218           JAXUCZ010000010.1  36039706-36039788
            1219-1298           JAXUCZ010000010.1  36041059-36041138
            1299-1389           JAXUCZ010000010.1  36041712-36041802
            1390-1875           JAXUCZ010000010.1  36041881-36042366
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1875
                     /gene="Clk4"
                     /note="CDC-like kinase 4"
                     /db_xref="GeneID:287269"
                     /db_xref="RGD:1310274"
     exon            1..84
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1530
                     /gene="Clk4"
                     /EC_number="2.7.12.1"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein kinase CLK4"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK4 isoform 1"
                     /protein_id="NP_001386357.1"
                     /db_xref="GeneID:287269"
                     /db_xref="RGD:1310274"
                     /translation="MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCK
                     PHHQFKDTDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDIESTYRIHCS
                     KSSVRSRRSSPKRKRNRHCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYE
                     IVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS
                     VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINF
                     LHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH
                     STLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERI
                     LGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFD
                     LVRRMLEYDPTKRITLDEALQHPFFDLLKGK"
     exon            85..245
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            246..468
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            469..559
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            560..626
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            627..743
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..910
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1005
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1135
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1218
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1298
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1389
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1875
                     /gene="Clk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggtgttt gtcgcagcgg ctggagagaa acgacggcgg tttggcgaca tttctcggcc
       61 aaaaggcctt ttgcttttgc ggagatgcgg cattccaaac gaactcactg tcctgattgg
      121 gatagcagag aaagctgggg ccatgaaagc tacagtggaa gtcacaaacg gaagaggaga
      181 tctcatagca gtacgcagga gaataggcat tgtaaaccac atcatcagtt taaagacact
      241 gattgtcact atttagaagc aagatgcttg aatgagagag attatcggga tcggagatac
      301 attgatgaat acagaaatga ctactgtgaa ggatatgttc caagacatta ccatagagac
      361 attgaaagca cttaccggat ccattgcagt aaatcctcag tcagaagcag gagaagcagc
      421 cctaaaagaa aacgtaacag acactgtgcg agtcatcagt cacattcgaa gagccaccga
      481 aggaaaagat ccaggagtat agaggatgat gaggagggtc acctgatctg tcaaagtgga
      541 gacgttctaa gagcaagata tgaaatcgtg gacactttag gtgaaggggc ctttggcaaa
      601 gttgtagagt gcattgatca tggcatggat ggcttacatg tggcagtgaa aattgtaaaa
      661 aatgtaggcc gttaccggga ggcagctcgc tctgaaatcc aagtgctgga gcacttgaac
      721 agcactgacc ccaatagtgt cttccgatgt gtccagatgc tagaatggtt tgatcatcat
      781 ggtcatgttt gtattgtgtt tgagctgctg ggccttagta cctatgattt tattaaagaa
      841 aacagctttc tgccatttca aattgatcac atcaggcaaa tggcttatca gatctgccaa
      901 tctataaatt ttttacatca taataaatta acacacacgg atctaaaacc tgaaaatatt
      961 ttatttgtaa agtctgacta tgtggtcaaa tacaattcta aaatgaaacg agatgagcgc
     1021 acgttgaaaa acacagatat caaagttgtt gactttggaa gtgcgacata tgacgatgaa
     1081 catcatagta ctttggtgtc cacaagacac tacagggctc cagaggtcat tttggcttta
     1141 ggttggtctc agccttgtga tgtttggagc ataggctgca ttcttattga gtattacctt
     1201 ggattcacag tctttcagac tcatgatagt aaagaacacc tggcaatgat ggagcggata
     1261 ctcgggccca tcccagcaca catgatccaa aagacaagga aacgcaagta tttccaccat
     1321 aaccagctag attgggatga gcatagttca gctgggagat acgttaggag acgctgcaag
     1381 ccgttaaagg aatttatgct gtgtcacgat gaagagcatg agaagctgtt tgacctggtt
     1441 cgaagaatgt tggagtatga cccaacaaaa aggattacct tggatgaagc tttgcagcac
     1501 cctttctttg acttattaaa agggaaatga atgggaatca gtggtcttcc tatatacttc
     1561 tctaggagca attactttaa gactgtgtca gtcaactaaa cattctaata tttttgtaaa
     1621 cattaaatta ttttgtacag ttaaatgtaa atactgtatg ttttgtatca atagcataac
     1681 taccttgtta agtatggtgt tgataatgaa tgcaatatga gttaaaatgg attttccttt
     1741 gatgttaatt gccattttta aaggccttta cagtgccctt tgtgtccagt ggtaaacgtg
     1801 attggtctca tcttttgtac attaaggtta actctgaagt gttttttttt tccctcaagt
     1861 aaaaggaaat cttga
//
