LOCUS       NM_134340               1754 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CDC-like kinase 3 (Clk3), mRNA.
ACCESSION   NM_134340
VERSION     NM_134340.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   Ma,X., Gao,L., Ge,R., Yuan,T., Lin,B. and Zhen,L.
  TITLE     CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 333-342 (2024)
   PUBMED   38438604
  REMARK    GeneRIF: CDC-like kinase 3 deficiency aggravates hypoxia-induced
            cardiomyocyte apoptosis through AKT signaling pathway.
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Duncan,P.I., Stojdl,D.F., Marius,R.M., Scheit,K.H. and Bell,J.C.
  TITLE     The Clk2 and Clk3 dual-specificity protein kinases regulate the
            intranuclear distribution of SR proteins and influence pre-mRNA
            splicing
  JOURNAL   Exp Cell Res 241 (2), 300-308 (1998)
   PUBMED   9637771
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Nayler,O., Stamm,S. and Ullrich,A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Becker,W., Kentrup,H., Heukelbach,J. and Joost,H.G.
  TITLE     cDNA cloning and characterization of rat Clk3, a LAMMER kinase
            predominately expressed in testis
  JOURNAL   Biochim Biophys Acta 1312 (1), 63-67 (1996)
   PUBMED   8679717
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Mar 12, 2025 this sequence was replaced by
            NM_134340.3.
            
            On Nov 26, 2020 this sequence version replaced NM_134340.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X94351.1, SRR26643293.45544.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                JAXUCZ010000008.1  67061602-67061649   c
            49-200              JAXUCZ010000008.1  67058757-67058908   c
            201-417             JAXUCZ010000008.1  67057799-67058015   c
            418-514             JAXUCZ010000008.1  67055507-67055603   c
            515-581             JAXUCZ010000008.1  67055164-67055230   c
            582-698             JAXUCZ010000008.1  67052689-67052805   c
            699-865             JAXUCZ010000008.1  67051925-67052091   c
            866-960             JAXUCZ010000008.1  67050871-67050965   c
            961-1090            JAXUCZ010000008.1  67050644-67050773   c
            1091-1173           JAXUCZ010000008.1  67050006-67050088   c
            1174-1253           JAXUCZ010000008.1  67049514-67049593   c
            1254-1344           JAXUCZ010000008.1  67049175-67049265   c
            1345-1754           JAXUCZ010000008.1  67048123-67048532   c
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1754
                     /gene="Clk3"
                     /note="CDC-like kinase 3"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
     exon            1..48
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1521
                     /gene="Clk3"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK3"
                     /protein_id="NP_599167.2"
                     /db_xref="GeneID:171305"
                     /db_xref="RGD:621259"
                     /translation="MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPP
                     RRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYR
                     TRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVG
                     NLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFL
                     CVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHE
                     NQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTI
                     VATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
                     IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMR
                     RMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR"
     exon            49..200
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            201..417
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..514
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            515..581
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..698
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..865
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..960
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1090
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1173
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1253
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1344
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1754
                     /gene="Clk3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggctgct cctcggtccg gtcgggagcc tctatgcttt agttccggat gcatcactgt
       61 aagcgatacc gttccccaga gccagaccca tacctgagct accgctggaa gaggaggcgg
      121 tcttacagtc gggagcatga aggtcgacta cgatacccat cccgaaggga gcctccccca
      181 cggagatcaa ggtccagaag ccatgatcgt ataccctacc agaggaggta ccgggaacac
      241 cgagacagcg atacatatcg gtgtgaagag cggagcccat cctttggaga ggactgctat
      301 gggtcttcac gttctcgaca tcggagacgg tcacgagaga gggggccgta ccgtacccgc
      361 aagcatgccc accactgtca caaacgtcgt accaggtctt gtagcagcgc ctcctcgaga
      421 agccaacaga gcagtaagcg cagcagccgg agtgtggaag atgacaagga gggccacctg
      481 gtgtgccgga tcggcgattg gctccaagag cgatatgaga tcgtggggaa cctgggtgaa
      541 ggcacctttg gcaaggtggt ggagtgcttg gaccatgcca gagggaagtc acaggttgcc
      601 ctgaagatca tccgtaatgt gggcaagtac cgggaagctg ctcgtctaga aattaatgtt
      661 ctcaagaaaa tcaaggagaa agacaaagaa aataagttcc tttgtgtcct gatgtctgac
      721 tggttcaact tccatggtca tatgtgtatc gcctttgagc tcctgggcaa gaacaccttt
      781 gagttcctga aggagaacaa cttccagcct tatcccctac cacatgtccg gcacatggcc
      841 taccagctct gtcatgccct tagatttcta catgagaacc agctgaccca cacagacttg
      901 aagccagaga acatcttgtt tgtgaattct gagtttgaaa ccctctacaa tgagcacaag
      961 agctgcgagg agaagtcagt gaagaacacc agcatccgag tggcagactt tggcagtgcc
     1021 acatttgacc atgaacatca caccaccatt gtcgccaccc ggcattaccg cccacctgag
     1081 gtgatccttg agctgggctg ggcacagccc tgtgatgtct ggagtatcgg ctgcattctc
     1141 tttgagtact accgtggctt tacactcttc cagacccatg aaaacagaga acacttggtt
     1201 atgatggaga agatcctagg acccatccca tcacacatga tccaccgtac caggaagcag
     1261 aagtatttct acaaaggggg cctggtttgg gatgagaaca gctctgacgg gcggtatgtg
     1321 aaggagaact gcaaacctct gaagagttac atgctccagg actccctgga gcatgtgcag
     1381 ctgtttgacc tgatgaggag gatgttagag ttcgaccctg ctcagcgcat cacactggca
     1441 gaagctttgc tgcacccctt ctttgctggc ctgacccctg aggagcggtc cttccacagc
     1501 agccgtaacc ccagcagatg acaggtgcag gccagcacac gaagagttgg agagctggac
     1561 tgggctgctg gccccttttc tccagcctct cctactggct tcagagccag agccaccgat
     1621 gaacagtgca atgtgaagga aggcaggaac ctgcaaggga ttgggggtgt ggtgcccagc
     1681 tgccagaaag cacagattgg acccaagcta tttatatgtt gtaaagttat aataaagtgt
     1741 ttcttactgt ttgt
//
