LOCUS       NM_001014254            2136 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus CDC-like kinase 2 (Clk2), mRNA.
ACCESSION   NM_001014254 XM_345232
VERSION     NM_001014254.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Kulkarni P, Jolly MK, Jia D, Mooney SM, Bhargava A, Kagohara LT,
            Chen Y, Hao P, He Y, Veltri RW, Grishaev A, Weninger K, Levine H
            and Orban J.
  TITLE     Phosphorylation-induced conformational dynamics in an intrinsically
            disordered protein and potential role in phenotypic heterogeneity
  JOURNAL   Proc Natl Acad Sci U S A 114 (13), E2644-E2653 (2017)
   PUBMED   28289210
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Nam SY, Seo HH, Park HS, An S, Kim JY, Yang KH, Kim CS, Jeong M and
            Jin YW.
  TITLE     Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT
            controls cell survival after ionizing radiation
  JOURNAL   J Biol Chem 285 (41), 31157-31163 (2010)
   PUBMED   20682768
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Rodgers JT, Haas W, Gygi SP and Puigserver P.
  TITLE     Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic
            gluconeogenesis
  JOURNAL   Cell Metab 11 (1), 23-34 (2010)
   PUBMED   20074525
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Kunarso G, Wong KY, Stanton LW and Lipovich L.
  TITLE     Detailed characterization of the mouse embryonic stem cell
            transcriptome reveals novel genes and intergenic splicing
            associated with pluripotency
  JOURNAL   BMC Genomics 9, 155 (2008)
   PUBMED   18400104
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Moeslein FM, Myers MP and Landreth GE.
  TITLE     The CLK family kinases, CLK1 and CLK2, phosphorylate and activate
            the tyrosine phosphatase, PTP-1B
  JOURNAL   J Biol Chem 274 (38), 26697-26704 (1999)
   PUBMED   10480872
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Nayler O, Schnorrer F, Stamm S and Ullrich A.
  TITLE     The cellular localization of the murine serine/arginine-rich
            protein kinase CLK2 is regulated by serine 141 autophosphorylation
  JOURNAL   J Biol Chem 273 (51), 34341-34348 (1998)
   PUBMED   9852100
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Duncan PI, Stojdl DF, Marius RM, Scheit KH and Bell JC.
  TITLE     The Clk2 and Clk3 dual-specificity protein kinases regulate the
            intranuclear distribution of SR proteins and influence pre-mRNA
            splicing
  JOURNAL   Exp Cell Res 241 (2), 300-308 (1998)
   PUBMED   9637771
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Nayler O, Stamm S and Ullrich A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083788.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345232.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2136
                     /gene="Clk2"
                     /note="CDC-like kinase 2"
                     /db_xref="GeneID:365842"
                     /db_xref="RGD:1359711"
     exon            1..267
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1770
                     /gene="Clk2"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK2"
                     /protein_id="NP_001014276.1"
                     /db_xref="GeneID:365842"
                     /db_xref="RGD:1359711"
                     /translation="MPHPRRYHSSERGSRGSYHEHYRSRKHKRRRSRSWSSTSDRTRR
                     RRREDSYHVRSRSSYDDHSSDRRLYDRRYCGSYRRNDYSRDRGEAYYDTDFRHSYEYH
                     RENSSYRSQRSSRRKPRRRRRRSRTFSHSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQ
                     ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEK
                     DPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQ
                     AVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFD
                     HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAM
                     MERILGPVPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHH
                     QLFDLIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSSRDISR"
     exon            268..437
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            438..666
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..754
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            755..821
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..938
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1105
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1200
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1330
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1413
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1493
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1584
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..2111
                     /gene="Clk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagaggcc agagccggag accgagctgg gatcgggccc cgggcggggg cggtgcgaga
       61 ggcgccgagc ggatcctggg ggcggggacg gagcccgggc gggcgggact ggagcagagc
      121 ccgggaacgg ggcgggaggt cccagggccc cgggttgggg ggtggaaccg cacttcgtcg
      181 ccgcgggggt gccgggactc cggccgcagt gccgccgcca tcacggactt cctgtgggac
      241 aagcgcacgg gcctcgccgc cagaacgatg cctcatcccc gaaggtacca ttcctcagag
      301 agaggtagcc ggggaagtta ccacgagcac tatcggagcc gaaaacataa gcgaagaaga
      361 agtcgctcct ggtcaagtac cagtgaccgg acaaggcggc ggcggaggga ggatagctac
      421 catgttcggt ctcgaagcag ctatgacgat cattcatctg accggcggct atacgatcga
      481 cgatactgtg gcagctacag gcgcaatgac tacagccggg atagaggaga ggcctactat
      541 gacacagact ttcggcattc ctatgaatac catcgagaga acagcagtta ccgaagccag
      601 cgcagcagcc gccggaaacc cagacggcgg agaagacgta gcagaacatt cagccactca
      661 tcttcacagc acagcagccg gagagccaag agtgtagagg acgacgctga gggccacctc
      721 atctaccacg tcggggactg gctacaagag cgatatgaaa ttgtaagcac cttaggagaa
      781 gggacctttg gccgagttgt acagtgtgtg gaccatcgca ggggcggagc acgagttgcc
      841 ctgaagatca ttaagaatgt ggagaagtac aaggaggccg ctcgactaga aatcaacgtg
      901 ctggagaaaa tcaatgagaa agatcctgac aacaagaacc tctgtgtcca gatgtttgac
      961 tggtttgact accatggcca catgtgtatc tcctttgagc ttctgggcct tagcaccttc
     1021 gatttcctca aagacaacaa ctacctgccc taccccatcc accaagtgcg ccacatggcc
     1081 ttccagctct gccaggccgt caagttcctc catgataaca agttgacaca tacggacctc
     1141 aaacctgaaa atattctgtt tgtgaattca gactacgaac tcacctacaa tctagagaag
     1201 aaacgagatg aacgcagtgt gaagagcaca gctgtgcggg tggtggactt cggcagtgcc
     1261 acctttgacc atgagcacca tagcaccatt gtctccactc gccattaccg agccccagaa
     1321 gtcatcctgg agttgggctg gtcacagccg tgcgacgtgt ggagcatagg ctgtatcatc
     1381 ttcgagtact acgtcggctt caccctcttc cagacccatg acaacagaga gcatctagcc
     1441 atgatggaaa ggatcctggg tcctgtcccc tctcggatga tcagaaagac aagaaaacag
     1501 aaatattttt atcggggtcg cctggattgg gatgagaaca cctcagctgg gcgctacgtc
     1561 cgtgagaact gcaaaccact acggcggtat ctgacctcag aggcagagga ccaccaccag
     1621 ctcttcgatc tgattgaaaa catgcttgag tatgaacctg ctaagcggct gaccttaggt
     1681 gaagcccttc agcacccttt cttcgcctgc cttcggactg agccacccaa caccaagttg
     1741 tgggactcca gtcgggatat cagtcggtga caatcaggct ttgggccccc tgctccctgt
     1801 gtagcagtgg gtgtccagtc caggacactg gtgctttttt atataagaga acagagccag
     1861 aactcgcccc ctctccagcc cctggctcct ttatacctgt gaatatgtga aatagtgtaa
     1921 atatgacaga acttgtacct atcgattcaa cccctgccat gtatatacta ctacttacac
     1981 tcttcaacct catctgcccc tcatgtggag tcggatgggg ggcagaatga cgtaaccagg
     2041 tggtgtctac cccatgtttt ataagggatt ttgtacagtc tttgtgaaat aaaatgacat
     2101 gcttcatctg aaaaaaaaaa aaaaaaaaaa aaaaaa
//
