LOCUS       NM_001106913            1791 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus CDC-like kinase 1 (Clk1), mRNA.
ACCESSION   NM_001106913 XM_001063325 XM_217405
VERSION     NM_001106913.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Wen K, Wang H, Chen Y, Yang H, Zheng Z, Yan Y, Realivazquez Pena A
            and Zeng M.
  TITLE     A new self-attenuated therapeutic influenza vaccine that uses host
            cell-restricted attenuation by artificial microRNAs
  JOURNAL   Int J Pharm 612, 121325 (2022)
   PUBMED   34883209
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Eisenreich A, Bogdanov VY, Zakrzewicz A, Pries A, Antoniak S,
            Poller W, Schultheiss HP and Rauch U.
  TITLE     Cdc2-like kinases and DNA topoisomerase I regulate alternative
            splicing of tissue factor in human endothelial cells
  JOURNAL   Circ Res 104 (5), 589-599 (2009)
   PUBMED   19168442
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Menegay HJ, Myers MP, Moeslein FM and Landreth GE.
  TITLE     Biochemical characterization and localization of the dual
            specificity kinase CLK1
  JOURNAL   J Cell Sci 113 (Pt 18), 3241-3253 (2000)
   PUBMED   10954422
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Moeslein FM, Myers MP and Landreth GE.
  TITLE     The CLK family kinases, CLK1 and CLK2, phosphorylate and activate
            the tyrosine phosphatase, PTP-1B
  JOURNAL   J Biol Chem 274 (38), 26697-26704 (1999)
   PUBMED   10480872
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Nayler O, Stamm S and Ullrich A.
  TITLE     Characterization and comparison of four serine- and arginine-rich
            (SR) protein kinases
  JOURNAL   Biochem J 326 (Pt 3) (Pt 3), 693-700 (1997)
   PUBMED   9307018
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Ben-David Y, Letwin K, Tannock L, Bernstein A and Pawson T.
  TITLE     A mammalian protein kinase with potential for serine/threonine and
            tyrosine phosphorylation is related to cell cycle regulators
  JOURNAL   EMBO J 10 (2), 317-325 (1991)
   PUBMED   1825055
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Howell BW, Afar DE, Lew J, Douville EM, Icely PL, Gray DA and Bell
            JC.
  TITLE     STY, a tyrosine-phosphorylating enzyme with sequence homology to
            serine/threonine kinases
  JOURNAL   Mol Cell Biol 11 (1), 568-572 (1991)
   PUBMED   1986248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC081942.1, CV127206.1 and AA923848.1.
            
            On Jun 23, 2009 this sequence version replaced NM_001106913.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ232068.1, SRR8487231.21288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BC081942.1         1-31
            32-715              CV127206.1         1-684
            716-1602            BC081942.1         1975-2861
            1603-1791           AA923848.1         1-189               c
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..1791
                     /gene="Clk1"
                     /note="CDC-like kinase 1"
                     /db_xref="GeneID:301434"
                     /db_xref="RGD:1311469"
     exon            1..133
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1585
                     /gene="Clk1"
                     /EC_number="2.7.12.1"
                     /codon_start=1
                     /product="dual specificity protein kinase CLK1"
                     /protein_id="NP_001100383.2"
                     /db_xref="GeneID:301434"
                     /db_xref="RGD:1311469"
                     /translation="MRHSKRTYCPDWDERDWDYGTWRSSSSHKRRKRSHSSARDYKRC
                     KYNHSKTTDSYYLESRSIHEKAYHSRRYVDEYRNDYMTYEPGYPYGEPGSRYQNHSSK
                     SSGRSGRSSYKSKHRSHHHTSHRRSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARY
                     EIVDTLGEGAFGKVVECIDHKVGGRHVAVKIVKNVDRYCEAAQSEIQVLEHLNATDPH
                     STFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVN
                     FLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEH
                     HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMER
                     ILGPLPKHMIEKTRKRTYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLF
                     DLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT"
     exon            134..294
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..520
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..611
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..678
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..795
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..962
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1057
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1187
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1270
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1350
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1441
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1775
                     /gene="Clk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagttttcg gacaagaatc tcttgctggt gttgttcgca ccattttgtg ctgagaggta
       61 gttgctgccg cttgcacact tccctccgtc gccttgagag ctttgtcttc agggttggag
      121 tctctgcgga aagatgagac attcaaagag aacttactgt cctgactggg atgaaagaga
      181 ttgggattat ggaacatgga gaagcagcag cagtcataaa agaaggaaga gatcacatag
      241 cagtgcccgt gattataagc gatgcaaata caatcactcc aaaacaacgg acagctatta
      301 tctggaaagt agatccatac atgagaaagc ctatcacagc cgacgctatg ttgatgaata
      361 caggaatgac tacatgacct acgagccagg gtatccctat ggagaacctg gaagcagata
      421 ccagaatcat agtagcaagt cctctggtag gagtggaaga agcagttaca aaagcaaaca
      481 taggagtcac caccacacgt cacatcgtcg ttcacatggg aagagtcacc gaaggaaaag
      541 atcgaggagt gtagaggatg atgaggaggg tcacctgatc tgtcagagtg gagacgtact
      601 aagtgcaaga tatgaaattg ttgatacttt aggtgaaggt gcttttggaa aagtggtgga
      661 gtgtatcgat cataaagtgg gaggtagaca tgtagcggta aaaatagtta aaaatgtgga
      721 tagatactgt gaagctgctc aatcggaaat acaagttttg gaacacttaa atgcaacaga
      781 cccccatagt actttccgtt gtgtccagat gttggaatgg tttgagcacc gaggtcacat
      841 ttgcattgtg tttgaacttc tggggcttag tacttacgat ttcattaagg aaaacagctt
      901 tctgccgttt cgaatggatc atatcaggaa gatggcatat caaatatgca aatctgtaaa
      961 ctttttgcat agtaataaat tgactcacac agacttgaag cctgaaaaca tcttatttgt
     1021 gaagtctgac tacacagagg cttataatcc caaaatgaaa cgtgatgaac gcactatagt
     1081 aaatcccgat attaaagtgg tggactttgg gagtgcaaca tatgatgacg aacatcacag
     1141 cacattggta tctacaagac attacagagc accagaagtc attctagccc tagggtggtc
     1201 acaaccatgt gatgtctgga gtataggatg tattcttatc gagtattatc ttggatttac
     1261 agtttttccg actcatgata gcagggaaca tttagcaatg atggaaagga ttcttggacc
     1321 actgccaaag cacatgattg agaaaaccag gaaacgcaca tacttccatc acgatcgatt
     1381 ggattgggat gagcacagtt ctgctggcag atatgtttct cggcgctgta agcctctgaa
     1441 ggagtttatg ctgtctcagg atgccgagca tgagcttctc tttgacctca ttgggaaaat
     1501 gttggagtat gatccagcca aaagaatcac tctcaaagaa gccctaaagc atcctttctt
     1561 ttacccgctt aaaaagcata catgatttat aaatatggtg ctctgaaaga aattttacag
     1621 actgtatcag tctagatttt aatttatttg tatagctttg tacactgatg ttttagaggc
     1681 tttatgagat acatggccaa gccatacaac atctttcagt aattatagaa cgatttattt
     1741 ggaataaact ttgtgcttat gaatgtataa aggtaaaaaa aaaaaaaaaa a
//
