LOCUS       NM_021997               4829 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus CAP-GLY domain containing linker protein 2
            (Clip2), mRNA.
ACCESSION   NM_021997
VERSION     NM_021997.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Neukirchen,D. and Bradke,F.
  TITLE     Cytoplasmic linker proteins regulate neuronal polarization through
            microtubule and growth cone dynamics
  JOURNAL   J Neurosci 31 (4), 1528-1538 (2011)
   PUBMED   21273437
  REMARK    GeneRIF: CLIPs enable neuronal polarization by controlling the
            stabilization of microtubules and growth cone dynamics.
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Peris,L., Thery,M., Faure,J., Saoudi,Y., Lafanechere,L.,
            Chilton,J.K., Gordon-Weeks,P., Galjart,N., Bornens,M., Wordeman,L.,
            Wehland,J., Andrieux,A. and Job,D.
  TITLE     Tubulin tyrosination is a major factor affecting the recruitment of
            CAP-Gly proteins at microtubule plus ends
  JOURNAL   J Cell Biol 174 (6), 839-849 (2006)
   PUBMED   16954346
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Komarova,Y., Lansbergen,G., Galjart,N., Grosveld,F., Borisy,G.G.
            and Akhmanova,A.
  TITLE     EB1 and EB3 control CLIP dissociation from the ends of growing
            microtubules
  JOURNAL   Mol Biol Cell 16 (11), 5334-5345 (2005)
   PUBMED   16148041
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Navarro-Lerida,I., Martinez Moreno,M., Roncal,F., Gavilanes,F.,
            Albar,J.P. and Rodriguez-Crespo,I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Hoogenraad,C.C., Koekkoek,B., Akhmanova,A., Krugers,H.,
            Dortland,B., Miedema,M., van Alphen,A., Kistler,W.M., Jaegle,M.,
            Koutsourakis,M., Van Camp,N., Verhoye,M., van der Linden,A.,
            Kaverina,I., Grosveld,F., De Zeeuw,C.I. and Galjart,N.
  TITLE     Targeted mutation of Cyln2 in the Williams syndrome critical region
            links CLIP-115 haploinsufficiency to neurodevelopmental
            abnormalities in mice
  JOURNAL   Nat Genet 32 (1), 116-127 (2002)
   PUBMED   12195424
  REMARK    Erratum:[Nat Genet 2002 Oct;32(2):331]
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   De Zeeuw,C.I., Hoogenraad,C.C., Goedknegt,E., Hertzberg,E.,
            Neubauer,A., Grosveld,F. and Galjart,N.
  TITLE     CLIP-115, a novel brain-specific cytoplasmic linker protein,
            mediates the localization of dendritic lamellar bodies
  JOURNAL   Neuron 19 (6), 1187-1199 (1997)
   PUBMED   9427243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On May 5, 2015 this sequence version replaced NM_021997.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000485.1, SRR26360176.453308.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               JAXUCZ010000012.1  27799685-27799902
            219-409             JAXUCZ010000012.1  27817566-27817756
            410-966             JAXUCZ010000012.1  27828921-27829477
            967-1091            JAXUCZ010000012.1  27833833-27833957
            1092-1305           JAXUCZ010000012.1  27834699-27834912
            1306-1503           JAXUCZ010000012.1  27835403-27835600
            1504-1607           JAXUCZ010000012.1  27837081-27837184
            1608-1668           JAXUCZ010000012.1  27842398-27842458
            1669-1773           JAXUCZ010000012.1  27847905-27848009
            1774-2709           JAXUCZ010000012.1  27849260-27850195
            2710-2767           JAXUCZ010000012.1  27852877-27852934
            2768-2851           JAXUCZ010000012.1  27853923-27854006
            2852-3008           JAXUCZ010000012.1  27856103-27856259
            3009-3168           JAXUCZ010000012.1  27858305-27858464
            3169-3354           JAXUCZ010000012.1  27860182-27860367
            3355-3417           JAXUCZ010000012.1  27860673-27860735
            3418-4829           JAXUCZ010000012.1  27862075-27863486
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..4829
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /note="CAP-GLY domain containing linker protein 2"
                     /db_xref="GeneID:29264"
                     /db_xref="RGD:62019"
     exon            1..218
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..409
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..3429
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /note="cytoplasmic linker 2; cytoplasmic linker protein 2;
                     cytoplasmic linker protein 115"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 2"
                     /protein_id="NP_068837.2"
                     /db_xref="GeneID:29264"
                     /db_xref="RGD:62019"
                     /translation="MQKPSGLKPPGRGGKHSSPVGRPSIGSASSSVVASASGSKEGSP
                     LHKQASGPSSAGATTTVSEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGET
                     QFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPAAEGSGSDAH
                     SVESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDK
                     DLHLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPK
                     FGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGR
                     PSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICE
                     VEKEIALLKAQHEQYVAEAEEKLQRARLLVENVRKEKVDLSNQLEEERRKVEDLQFRV
                     EEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQ
                     LEEELSLRRGEIEELQHCLLQSGPPPADHPEAAETLRLRERLLSASKEHQRDSTLLQD
                     KYEHMLKTYQTEVDKLRAANEKYAQEVADLKAKVQQATTENMGLMDNWKSKLDSLASD
                     HQKSLEDLKATLNSGPGAQQKEIGELKALVEGIKMEHQLELGNLQAKHDLETAMHGKE
                     KEGLRQKLQEAQEELAGLQQHWRAQLEEQASQHRLELQEAQDQCRDAQLRVQELEGLD
                     VEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRAEAQSRQEAERLREKLLVAENRLQAV
                     ESLCSAQHSHVIESNDLSEEKIRMKETVEGLQDKLNKRDKEVAALTSQMDMLRAQVSA
                     LENKCKSGEKKIDSLLKEKRRLEAELEAVSRKTHDASGQLVHISQELLRKERSLNELR
                     VLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSEQKR
                     YSLIDPASAPELLRLQHQLVSTEDALRDALDQAQQVERLVEALRGCSDRTQTISNSGS
                     ANGIHQPDKAHKQEDKH"
     exon            410..966
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1091
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1305
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1503
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1607
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1668
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1773
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2709
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2767
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2851
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3008
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3168
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3354
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3417
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..4829
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcggggcg cgcaagcagc ggccgagctt acagaatcgg cccctccctc tatcccttct
       61 ggccgtagag cctgtccgag gcccggactc agaacgcgga gaacgggtta gggtagcggc
      121 cgggcgtgag gggaccggca cagcatcctt gttcccagga cgcgcggacc aagaggaagc
      181 gaggggtgtc gggtcctgtt cgctgctgga gctccaaggt gaccaaggat ggcagagagg
      241 atatgaccgg cggctgccgt cgtctgccct cctagtggca tcaccatgca gaagcccagt
      301 ggcctgaagc cccctggccg aggggggaag cactccagtc ccgtgggtag gccctccatc
      361 gggtctgcct catcttctgt ggtggcatcg gcgagcggct ccaaagaagg gtctcccctg
      421 cacaagcagg cgtcgggccc ctcctcggct ggagccacca ctactgtctc cgagaagcca
      481 ggtccaaagg cagccgaagt gggtgatgac ttcttgggag acttcgtggt gggcgagagg
      541 gtgtgggtga atggcgtgaa gcccggcgtg gtgcagtacc tgggtgagac acagtttgcg
      601 ccaggccagt gggccggcgt ggtcttggat gatcctgtgg gcaagaacga tggagctgtg
      661 ggtggcgtgc gctacttcga gtgcccagct ctacagggca tcttcacacg gccctccaag
      721 ctgacccgcc agcccgcagc tgagggctcc ggcagtgacg cccactcagt ggaatccctc
      781 accgcccaga acctgtccct gcattctggc acggccacgc ccccactcac cggccgagtc
      841 atccccctgc gggagagtgt tctcaacagc tccgtgaaga cgggcaatga gtctggctcc
      901 aacctctcgg acagtggttc tgtgaagcgt ggtgacaagg acctccacct gggagaccgt
      961 gtgctggttg gtgggacgaa gaccggtgtg gtacgatatg ttggggagac ggactttgcc
     1021 aaaggcgagt ggtgtggtgt ggagctggac gagccccttg ggaagaacga tggggcagtg
     1081 gcaggcacca ggtacttcca gtgcccaccc aagttcggtc tctttgcacc aatccacaag
     1141 gtcatccgaa ttggcttccc atctaccagt ccagccaagg ccaagaagac caagcgcatg
     1201 gctatgggtg tctcagcctt gacccacagc cccagcagtt cttccatcag ctctgtcagc
     1261 tctgtggcct cctctgttgg tggccggccg agccgtagtg gcctgctcac agagacctct
     1321 tcacgctatg cccggaagat ctcaggcacc acagccctgc aggaggcact gaaggagaaa
     1381 cagcagcaca tcgaacagct gctggctgag cgtgacttgg agagggcaga agtagccaag
     1441 gctaccagtc atatctgtga ggtggagaag gaaattgccc tgctgaaggc acagcatgag
     1501 cagtatgttg cagaagctga ggagaagctg cagcgggcac ggttgctggt ggaaaacgtg
     1561 aggaaggaga aggtggatct gtccaatcag ctggaggagg agaggaggaa ggtggaggac
     1621 ctgcagttcc gggtggaaga agagtccatc accaaaggag acttggagac ccagacccag
     1681 ctggagcacg cgcgcattgg ggagctggag cagagtctgc tattggagaa ggcgcaggcc
     1741 gagcggctgc tcagagaatt agcggataac aggctgacca cagtggctga gaagtctcgg
     1801 gtgctgcagt tagaagaaga gctgagcctg cggcgtggtg agatcgaaga gctacaacac
     1861 tgcctcctcc agtcaggtcc accacctgcg gaccacccag aggccgctga gaccctgcgg
     1921 ctgcgagagc ggctgctgtc ggctagcaag gagcaccagc gggacagcac cctgctccag
     1981 gacaagtatg agcacatgct aaagacgtac cagacagaag tggacaagct tcgggcagcc
     2041 aacgagaagt acgctcagga agtggcagac ctcaaggcca aggtccagca ggccaccacc
     2101 gagaacatgg ggctcatgga caactggaaa tccaagctgg actctctggc ctccgatcac
     2161 cagaaatctt tagaagacct gaaggccacg ctgaactctg gcccaggcgc ccagcagaag
     2221 gagattggcg agctgaaggc cctggtggag ggcatcaaaa tggagcacca actggagtta
     2281 gggaacctgc aggccaagca tgacttagag acggccatgc atgggaagga gaaagagggc
     2341 ctgcggcaga agctgcaaga ggcccaggag gagctggccg ggctgcagca gcactggagg
     2401 gcacagctgg aggagcaggc cagccagcac cggctggagc tacaagaagc ccaggaccaa
     2461 tgtcgtgacg cccagctacg tgtgcaggag ctggagggac tggatgtgga ataccgcggc
     2521 caggctcagg ccatcgagtt cctcaaagaa cagatctcgc tggctgaaaa gaagatgctg
     2581 gattacgaga tgttgcagag ggcggaagcc cagagcaggc aggaggccga gcggctgcgg
     2641 gaaaagcttc tggtggctga gaatagactg caggctgtcg agtccctgtg ctcagcccag
     2701 cacagccatg tgatcgagtc caatgacctt tctgaggaga agattcggat gaaggagact
     2761 gtggagggcc tgcaggacaa gctgaacaag agggacaaag aggtggcagc cttgacatcc
     2821 cagatggaca tgctcagggc ccaagtaagt gctctcgaga acaagtgcaa atcaggagag
     2881 aagaagatag actctctcct gaaggagaag aggcggctgg aggcagagct ggaggccgtg
     2941 tctcggaaga cccatgatgc ctctggccag ctggtccaca tcagccaaga gttgctacgg
     3001 aaggagagga gtctgaatga gctgagggtg ttgctgttag aagccaatcg gcactcccca
     3061 gggcccgaga gagacctgag ccgtgaggta cacaaagctg aatggcgaat aaaggaacaa
     3121 aaactgaaag atgacatccg gggcctgcgt gaaaagctga ccgggctgga caaggagaag
     3181 tccctgtcgg agcagaaacg ctactccctc attgacccag cttcagcgcc cgagttgctg
     3241 agactgcaac atcagttagt gagcacggag gatgccctgc gggacgcact ggaccaggcc
     3301 cagcaggtgg agaggctggt ggaggccctg aggggctgct cagataggac tcagaccatc
     3361 agcaattccg gttctgccaa tggtatccac cagccagaca aggcccacaa acaggaggac
     3421 aaacactgac ccccaaggga caccatggac cggccctact cacaccagaa gccctgccag
     3481 gcttcccagc agcgccacct tcaggcagga gccagaactt tccctttgga gatgagactg
     3541 tgtttgtaac gataattgtc ctcactgccg tggacacatc ccacctgaac cccctgccgg
     3601 accaggaggc tcccacagac acggccttcc acagagcgcg gtacagctgg gcccagccct
     3661 ggaggacctc tcttgtccca aggagcttct tgaatttgcg gaggctgaag cgatccagtt
     3721 gggcctctct tggctatagc aggctgcccc gaggcttgtc tgggcacccg ggtacttccc
     3781 catctccctt tccttctggt gtcccccagg tcccctgcag gcccctgaga ggtggagcag
     3841 ggctcctgct tggacgcgta acacaccaag aagggcttca gtcttcagaa actagggagg
     3901 ggatgcttga cttcatatgc tgatcctcta acacaatggt acaaggtcgc ttgggcctct
     3961 agccagggaa gatttggggg tgacaggttc cttattcctc gacaccacgc tagtatgcgt
     4021 tacccacttc ccctctgctg cccagaaagc attgagcaga cagcttcagt attaggtgag
     4081 ctcgcaaacc cactcttctt accttgacct tgagctggga ctggctcagg ggcttacagc
     4141 caagagcggg aagaaaactc tttaaacaaa gcattcacgc ggtgttttgc tgggtgagag
     4201 gaatcacgct ggttcccttt atttccggga acccctgcca tgttactcca aagaccccag
     4261 caacccacag agggtcctgc ttctatcttc ccagggcggg aaccacagtg ggtgacaggt
     4321 atggtaagtc cttaggattg gcccaggtgg cctctgtgag caccattaga caccagcagg
     4381 tggcgctcac gctcttgtcc ttagggagaa gctgaattag cagccccaca gcccaacccc
     4441 ctgcttcctg ttggcttttg ggtagcactt gccgttaaca acagcagcct agagcctaga
     4501 attgacgctt tagtggccca actgcagagc cagtatatcg ctctttccag cacaatcggg
     4561 cagctcacag attaggaatt aacagccaaa ggctcccaca gtagggacca gacggggctg
     4621 agccccaccc tggagtgggc ttgcacctgg taggtgtgca agaagccatt tccccataag
     4681 cactggcctt tgacggcccc ctcagcctac ccggtgtggc cacccagtgg tggctcagcc
     4741 attccctccc ctccccctcc cctcagtgga attgtggaag tgtggcaagt ccatgttcgg
     4801 acaataaagc ttgtgattaa ggtacagga
//
