LOCUS       NP_068837               1047 aa            linear   ROD 09-APR-2024
DEFINITION  CAP-Gly domain-containing linker protein 2 [Rattus norvegicus].
ACCESSION   NP_068837
VERSION     NP_068837.2
DBSOURCE    REFSEQ: accession NM_021997.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1047)
  AUTHORS   Neukirchen,D. and Bradke,F.
  TITLE     Cytoplasmic linker proteins regulate neuronal polarization through
            microtubule and growth cone dynamics
  JOURNAL   J Neurosci 31 (4), 1528-1538 (2011)
   PUBMED   21273437
  REMARK    GeneRIF: CLIPs enable neuronal polarization by controlling the
            stabilization of microtubules and growth cone dynamics.
REFERENCE   2  (residues 1 to 1047)
  AUTHORS   Peris,L., Thery,M., Faure,J., Saoudi,Y., Lafanechere,L.,
            Chilton,J.K., Gordon-Weeks,P., Galjart,N., Bornens,M., Wordeman,L.,
            Wehland,J., Andrieux,A. and Job,D.
  TITLE     Tubulin tyrosination is a major factor affecting the recruitment of
            CAP-Gly proteins at microtubule plus ends
  JOURNAL   J Cell Biol 174 (6), 839-849 (2006)
   PUBMED   16954346
REFERENCE   3  (residues 1 to 1047)
  AUTHORS   Komarova,Y., Lansbergen,G., Galjart,N., Grosveld,F., Borisy,G.G.
            and Akhmanova,A.
  TITLE     EB1 and EB3 control CLIP dissociation from the ends of growing
            microtubules
  JOURNAL   Mol Biol Cell 16 (11), 5334-5345 (2005)
   PUBMED   16148041
REFERENCE   4  (residues 1 to 1047)
  AUTHORS   Navarro-Lerida,I., Martinez Moreno,M., Roncal,F., Gavilanes,F.,
            Albar,J.P. and Rodriguez-Crespo,I.
  TITLE     Proteomic identification of brain proteins that interact with
            dynein light chain LC8
  JOURNAL   Proteomics 4 (2), 339-346 (2004)
   PUBMED   14760703
REFERENCE   5  (residues 1 to 1047)
  AUTHORS   Hoogenraad,C.C., Koekkoek,B., Akhmanova,A., Krugers,H.,
            Dortland,B., Miedema,M., van Alphen,A., Kistler,W.M., Jaegle,M.,
            Koutsourakis,M., Van Camp,N., Verhoye,M., van der Linden,A.,
            Kaverina,I., Grosveld,F., De Zeeuw,C.I. and Galjart,N.
  TITLE     Targeted mutation of Cyln2 in the Williams syndrome critical region
            links CLIP-115 haploinsufficiency to neurodevelopmental
            abnormalities in mice
  JOURNAL   Nat Genet 32 (1), 116-127 (2002)
   PUBMED   12195424
  REMARK    Erratum:[Nat Genet 2002 Oct;32(2):331]
REFERENCE   6  (residues 1 to 1047)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
REFERENCE   7  (residues 1 to 1047)
  AUTHORS   De Zeeuw,C.I., Hoogenraad,C.C., Goedknegt,E., Hertzberg,E.,
            Neubauer,A., Grosveld,F. and Galjart,N.
  TITLE     CLIP-115, a novel brain-specific cytoplasmic linker protein,
            mediates the localization of dendritic lamellar bodies
  JOURNAL   Neuron 19 (6), 1187-1199 (1997)
   PUBMED   9427243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On May 5, 2015 this sequence version replaced NP_068837.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000485.1, SRR26360176.453308.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     Protein         1..1047
                     /product="CAP-Gly domain-containing linker protein 2"
                     /note="cytoplasmic linker 2; cytoplasmic linker protein 2;
                     cytoplasmic linker protein 115"
                     /calculated_mol_wt=115687
     Region          1..72
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55156.1)"
     Site            50
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0H8; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Region          82..146
                     /region_name="CAP_GLY"
                     /note="CAP-Gly domain; pfam01302"
                     /db_xref="CDD:460154"
     Region          196..216
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55156.1)"
     Site            203
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Site            208
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0H8; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Region          222..286
                     /region_name="CAP_GLY"
                     /note="CAP-Gly domain; pfam01302"
                     /db_xref="CDD:460154"
     Region          314..340
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55156.1)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0H8; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Region          <357..>954
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Site            924
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Site            974
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0H8; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Site            980
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9Z0H8; propagated from
                     UniProtKB/Swiss-Prot (O55156.1)"
     Region          1022..1047
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O55156.1)"
     CDS             1..1047
                     /gene="Clip2"
                     /gene_synonym="CLIP-115; Cyln2"
                     /coded_by="NM_021997.2:286..3429"
                     /db_xref="GeneID:29264"
                     /db_xref="RGD:62019"
ORIGIN      
        1 mqkpsglkpp grggkhsspv grpsigsass svvasasgsk egsplhkqas gpssagattt
       61 vsekpgpkaa evgddflgdf vvgervwvng vkpgvvqylg etqfapgqwa gvvlddpvgk
      121 ndgavggvry fecpalqgif trpskltrqp aaegsgsdah svesltaqnl slhsgtatpp
      181 ltgrviplre svlnssvktg nesgsnlsds gsvkrgdkdl hlgdrvlvgg tktgvvryvg
      241 etdfakgewc gveldeplgk ndgavagtry fqcppkfglf apihkvirig fpstspakak
      301 ktkrmamgvs althspssss issvssvass vggrpsrsgl ltetssryar kisgttalqe
      361 alkekqqhie qllaerdler aevakatshi cevekeiall kaqheqyvae aeeklqrarl
      421 lvenvrkekv dlsnqleeer rkvedlqfrv eeesitkgdl etqtqlehar igeleqslll
      481 ekaqaerllr eladnrlttv aeksrvlqle eelslrrgei eelqhcllqs gpppadhpea
      541 aetlrlrerl lsaskehqrd stllqdkyeh mlktyqtevd klraanekya qevadlkakv
      601 qqattenmgl mdnwksklds lasdhqksle dlkatlnsgp gaqqkeigel kalvegikme
      661 hqlelgnlqa khdletamhg kekeglrqkl qeaqeelagl qqhwraqlee qasqhrlelq
      721 eaqdqcrdaq lrvqelegld veyrgqaqai eflkeqisla ekkmldyeml qraeaqsrqe
      781 aerlrekllv aenrlqaves lcsaqhshvi esndlseeki rmketveglq dklnkrdkev
      841 aaltsqmdml raqvsalenk cksgekkids llkekrrlea eleavsrkth dasgqlvhis
      901 qellrkersl nelrvlllea nrhspgperd lsrevhkaew rikeqklkdd irglrekltg
      961 ldkekslseq kryslidpas apellrlqhq lvstedalrd aldqaqqver lvealrgcsd
     1021 rtqtisnsgs angihqpdka hkqedkh
//
