LOCUS       NM_001408966            8197 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CAP-GLY domain containing linker protein 1
            (Clip1), transcript variant 2, mRNA.
ACCESSION   NM_001408966
VERSION     NM_001408966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8197)
  AUTHORS   Nirschl,J.J., Magiera,M.M., Lazarus,J.E., Janke,C. and
            Holzbaur,E.L.
  TITLE     alpha-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate
            the Initiation of Dynein-Driven Transport in Neurons
  JOURNAL   Cell Rep 14 (11), 2637-2652 (2016)
   PUBMED   26972003
REFERENCE   2  (bases 1 to 8197)
  AUTHORS   D'Alessandro,M., Hnia,K., Gache,V., Koch,C., Gavriilidis,C.,
            Rodriguez,D., Nicot,A.S., Romero,N.B., Schwab,Y., Gomes,E.,
            Labouesse,M. and Laporte,J.
  TITLE     Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking
            the Nuclear Envelope to the Actin and Microtubule Cytoskeleton
  JOURNAL   Dev Cell 35 (2), 186-198 (2015)
   PUBMED   26506308
REFERENCE   3  (bases 1 to 8197)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 8197)
  AUTHORS   Swiech,L., Blazejczyk,M., Urbanska,M., Pietruszka,P.,
            Dortland,B.R., Malik,A.R., Wulf,P.S., Hoogenraad,C.C. and
            Jaworski,J.
  TITLE     CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology
  JOURNAL   J Neurosci 31 (12), 4555-4568 (2011)
   PUBMED   21430156
  REMARK    GeneRIF: We postulate that mTOR controls dendritic arbor morphology
            by enhancing cross talk between dynamic microtubules and actin
            through CLIP-170 and IQGAP1
REFERENCE   5  (bases 1 to 8197)
  AUTHORS   Neukirchen,D. and Bradke,F.
  TITLE     Cytoplasmic linker proteins regulate neuronal polarization through
            microtubule and growth cone dynamics
  JOURNAL   J Neurosci 31 (4), 1528-1538 (2011)
   PUBMED   21273437
  REMARK    GeneRIF: CLIPs enable neuronal polarization by controlling the
            stabilization of microtubules and growth cone dynamics.
REFERENCE   6  (bases 1 to 8197)
  AUTHORS   Komarova,Y., Lansbergen,G., Galjart,N., Grosveld,F., Borisy,G.G.
            and Akhmanova,A.
  TITLE     EB1 and EB3 control CLIP dissociation from the ends of growing
            microtubules
  JOURNAL   Mol Biol Cell 16 (11), 5334-5345 (2005)
   PUBMED   16148041
  REMARK    GeneRIF: indicating that CLIPs possess an intrinsic affinity for
            growing microtubule ends, which is enhanced by an interaction with
            the EBs.
REFERENCE   7  (bases 1 to 8197)
  AUTHORS   Wu,X.S., Tsan,G.L. and Hammer,J.A. 3rd.
  TITLE     Melanophilin and myosin Va track the microtubule plus end on EB1
  JOURNAL   J Cell Biol 171 (2), 201-207 (2005)
   PUBMED   16247022
  REMARK    Erratum:[J Cell Biol. 2006 Feb 13;172(4):633]
REFERENCE   8  (bases 1 to 8197)
  AUTHORS   Lallemand-Breitenbach,V., Quesnoit,M., Braun,V., El Marjou,A.,
            Pous,C., Goud,B. and Perez,F.
  TITLE     CLIPR-59 is a lipid raft-associated protein containing a
            cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that
            perturbs microtubule dynamics
  JOURNAL   J Biol Chem 279 (39), 41168-41178 (2004)
   PUBMED   15262990
REFERENCE   9  (bases 1 to 8197)
  AUTHORS   Sahin,U., Neumann,F., Tureci,O., Schmits,R., Perez,F. and
            Pfreundschuh,M.
  TITLE     Hodgkin and Reed-Sternberg cell-associated autoantigen
            CLIP-170/restin is a marker for dendritic cells and is involved in
            the trafficking of macropinosomes to the cytoskeleton, supporting a
            function-based concept of Hodgkin and Reed-Sternberg cells
  JOURNAL   Blood 100 (12), 4139-4145 (2002)
   PUBMED   12433698
REFERENCE   10 (bases 1 to 8197)
  AUTHORS   Akhmanova,A., Hoogenraad,C.C., Drabek,K., Stepanova,T.,
            Dortland,B., Verkerk,T., Vermeulen,W., Burgering,B.M., De
            Zeeuw,C.I., Grosveld,F. and Galjart,N.
  TITLE     Clasps are CLIP-115 and -170 associating proteins involved in the
            regional regulation of microtubule dynamics in motile fibroblasts
  JOURNAL   Cell 104 (6), 923-935 (2001)
   PUBMED   11290329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               JAXUCZ010000012.1  38571834-38571949
            117-309             JAXUCZ010000012.1  38601437-38601629
            310-878             JAXUCZ010000012.1  38604985-38605553
            879-1003            JAXUCZ010000012.1  38609671-38609795
            1004-1226           JAXUCZ010000012.1  38611229-38611451
            1227-1424           JAXUCZ010000012.1  38614820-38615017
            1425-1528           JAXUCZ010000012.1  38615580-38615683
            1529-1589           JAXUCZ010000012.1  38616639-38616699
            1590-1694           JAXUCZ010000012.1  38621656-38621760
            1695-2639           JAXUCZ010000012.1  38625831-38626775
            2640-2756           JAXUCZ010000012.1  38629677-38629793
            2757-2814           JAXUCZ010000012.1  38633274-38633331
            2815-2898           JAXUCZ010000012.1  38633699-38633782
            2899-3055           JAXUCZ010000012.1  38634517-38634673
            3056-3221           JAXUCZ010000012.1  38637727-38637892
            3222-3437           JAXUCZ010000012.1  38638032-38638247
            3438-5705           JAXUCZ010000012.1  38640274-38642541
            5706-5822           JAXUCZ010000012.1  38643677-38643793
            5823-5929           JAXUCZ010000012.1  38645786-38645892
            5930-6050           JAXUCZ010000012.1  38651498-38651618
            6051-6103           JAXUCZ010000012.1  38665657-38665709
            6104-6221           JAXUCZ010000012.1  38672705-38672822
            6222-6372           JAXUCZ010000012.1  38672902-38673052
            6373-6422           JAXUCZ010000012.1  38673709-38673758
            6423-6547           JAXUCZ010000012.1  38676419-38676543
            6548-8197           JAXUCZ010000012.1  38677130-38678779
FEATURES             Location/Qualifiers
     source          1..8197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..8197
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /note="CAP-GLY domain containing linker protein 1"
                     /db_xref="GeneID:65201"
                     /db_xref="RGD:67404"
     exon            1..116
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            117..309
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..6773
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /note="isoform 2 is encoded by transcript variant 2;
                     restin (Reed-Steinberg cell-expressed intermediate
                     filament-associated protein); restin (Reed-Steinberg
                     cell-espressed intermediate filament-associated protein);
                     CAP-Gly domain-containing linker protein 1; cytoplasmic
                     linker protein 170"
                     /codon_start=1
                     /product="CAP-Gly domain-containing linker protein 1
                     isoform 2"
                     /protein_id="NP_001395895.1"
                     /db_xref="GeneID:65201"
                     /db_xref="RGD:67404"
                     /translation="MSMLKPSGLKAPTKILKPGSTALKTPAAAAAPLEKTVPSEKASG
                     PPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS
                     VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTAHARAASPLSTAAATMVSSSP
                     ATPSNIPQKPSQPVAKETSATPQISNLTKTASESISNLSEAGSVKKGERELKIGDRVL
                     VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHK
                     VTKIGFPSTTPAKAKAAAVRRVMATTPASLKRSPSASSLSSMSSVASSVSSKPSRTGL
                     LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA
                     LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT
                     KGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLA
                     LRVQEVAELRRRLESSKPPGDVDMSLSLLQEISALQEKLEVTHTDHQNEVTSLKDHFG
                     TREEMFQKEIKALHAATEKLSKENESLRSKLDHANKENSDVIALWKSKLETAIASHQQ
                     AMEELKVSFSKGIGTDSAEFAELKTQIERLRLDYQHEIESLQSKQDSERSAHAKEMES
                     MKAKLMKIIKEKEDSLEAVKARLDTAEDQHLVEMEEMLSKLQEAEIKVKELEVLQAKY
                     SEQTQVVGHLTSQLSVVEEQLLDLDALRKANSEGKLEIETLRQQLEGAEKQIKNLEME
                     RNAESSKANSITKDLQGKELMLTSLQSNLNEVNQVKETLEKELQTLKEKFASASEEAV
                     STQTSMQDTVNKLHQKEEQFNMLSSELEKLRENLTDMEAKFKEKDEREDQLVKAKEKL
                     ENDIAEIMKMSGDNSSQLTKMNDELRLKERSVEELQLKLTKANENASLLQKSIGEVTL
                     KAEQSQQEAAKKHEEEKKELENKLLELEKKMETSHYQCQDLKAKYEKASSETKIKHEE
                     ILQNFQKMLVDTEDKLKAAQEANRDLMQDMEELKSQADKAKSLTYLLTSAKKEIEVMS
                     EELRGLKSEKQLFAQEASALKLEKGSLLSKLIEVETKITLLQEDQQKLWSVNENLHLE
                     KERISEEKQVAEKRYQQEHRDKESLVVEREKLLKEINVTQEELLKMHMEKDSLEASKV
                     SMQVLIEELRFCKDKLMAMSEKARAEKEQLEGQVKKLTAENMVLVKDKDDVIQKLQSA
                     YEELVKDQKALVQEIEDLTTEKKSAAEKQMNLDNTCLTLKAERENLLQSNRDLQFEKD
                     TLRQGQEKLSASLEATLQVKQLLSTEAETLRTQLDCATKALRKAELDMRQLQTSNTSL
                     TKLLEEIKTCRAITDSECIQLLHEKESLAASERALLAEKEELLNENRVITEKLNKHSE
                     EVTRLEVSLNEKITYLTSEKEMACQKVARLKKQQDSLLKEKSALEVQNGDLLADRESS
                     IKAIGDLKRKYEQEATNRRLAVQEKVKLLGNIDALKKELQQRKKENQELASSKCDLSL
                     MLKEAQTAKKNLEKEHTSMMQAKEDLNAELKTCCCEKNILLRDGLNLQEECQKLNEEI
                     REIQQTLMLEKEARAKESESSLYESNKLHGRIVLLEEEIQGLRTCSEQLQTENFTLTQ
                     EKTNSEQKVVEIIKEKELLSAETAQLAANIETLKSDFAALSKSKLELQELHSCLTKIL
                     DDLRLNHEVAVTERAEVLQDNKNLLAEKREMMLRNEEVLKEKEKLEESYFVLQKEISQ
                     LAQTNSHISADLLEAQSENRTLRKDKSKLTLKIRELETLHSFTAAQTAEDAMQIMEQM
                     TKEKTETLASLEDTKQTNAKLQSELDTLKENNLKTVEELNKSKELLNEENQKMEEFKK
                     EIETLKQAAAQKSQQLSALQEENVKLAEELGRTRDEVTSHQKLEEERSVLNNQLLEMK
                     KRESEYRKDADEEKASLQKSISLTSALLTEKDAELEKLRNEVTVLRGENASAKSLHSV
                     VQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDVQTEEDERAQESQIDFLNSVI
                     VDLQRKNQDLKMKVEMMSEAALNGNGEDPNSYDSDDQEKQSKKKPRLFCDICDCFDLH
                     DTEDCPTQAQMSEDPPHSTHHGSRSEERPYCEICEMFGHWATNCNDDETF"
     exon            310..878
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1003
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1226
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1424
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1528
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1589
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1694
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..2639
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2756
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2814
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2898
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3055
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3221
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3437
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..5705
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            5706..5822
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            5823..5929
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            5930..6050
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            6051..6103
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            6104..6221
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            6222..6372
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            6373..6422
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            6423..6547
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
     exon            6548..8197
                     /gene="Clip1"
                     /gene_synonym="CLIP-170; Rsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttccccg ccccgagccg aagagccggg gaggcgggag gcggcggccg cggcggctgc
       61 tgctgctgct gctgctactg ggaggcaggt gacggcgacc gacggcgtct caggcgactt
      121 aaccaagaga ctaagttctc tatagaaaca cccacatttg tatggatgat tggggaaaga
      181 tagtggcagc agacaaggga aaagcatcct gaccttccga gaaaatgagt atgctgaaac
      241 ccagcgggct gaaggccccg accaagatcc taaagcctgg gagcacagcc ttgaagaccc
      301 ctgctgctgc tgcagctcca ttggagaaga cagtacccag tgaaaaagcc tcaggccctc
      361 catcctctga gacccaagag gagtttgtgg acgacttccg agttggagaa cgtgtttggg
      421 tgaacgggaa taaacctgga tttatccagt ttcttgggga aactcagttt gcaccaggcc
      481 agtgggctgg tattgttttg gatgaaccca taggaaagaa cgacggctca gtggcaggag
      541 tgcggtattt ccagtgtgag cctttaaagg gcatcttcac ccgaccgtca aagctaacga
      601 ggaaggtaca agcagaggat gaagccaacg gcctgcagac agctcacgcg agagctgctt
      661 cacctctgtc cactgctgca gccaccatgg tgtcctcttc tccagccact ccctcaaata
      721 ttccccagaa accgtcccag ccagtggcaa aagaaacttc agcgacacct caaattagca
      781 accttacgaa aaccgccagc gagtcaatct ccaacctttc agaggctggc tctgtcaaga
      841 agggagagcg agagctcaag atcggagaca gggtgctggt cggtggcacg aaggctggcg
      901 tggtccggtt tcttggagag actgacttcg ccaaggggga gtggtgtggt gtggaattgg
      961 acgaaccttt ggggaagaac gacggtgctg ttgctggaac aaggtatttt caatgtcaac
     1021 ccaagtacgg attgttcgct cccgtccaca aagtgacaaa gattggcttc ccttctacca
     1081 ccccagccaa agccaaagcc gctgctgtga ggcgagtgat ggccaccacg cccgccagcc
     1141 tgaagcgaag cccttctgcc tcctccctca gctccatgag ctctgtggcc tcctctgtga
     1201 gcagcaagcc cagccggaca ggactattga ctgaaacctc ttcccgctac gcccgcaaga
     1261 tctcgggcac cactgccctc caggaggcgc tgaaggagaa gcagcagcac attgagcagc
     1321 tgctggctga gcgggacctg gagcgggccg aggtggccaa ggctaccagc cacgtggggg
     1381 aaatagagca ggagctagcc ctggcccgag atgggcatga ccagcatgtc ctggaactgg
     1441 aggccaagat ggaccagctg cgtaccatgg tagaagctgc tgacagggag aaagtggagc
     1501 tcctcaacca gctggaagag gagaaaagga aggttgagga ccttcagttc cgagttgaag
     1561 aagaatcaat taccaaaggt gatcttgaga cgcagaccaa actggagcat gcccgcatta
     1621 aggagcttga acagagcctg ctctttgaaa agaccaaagc tgacaaactc cagagggagt
     1681 tagaagacac tagggtggct acagtatcag aaaagtcccg aataatggaa ctagaaaagg
     1741 acctagcgtt gagagtacag gaagtagctg agctccgaag aaggctagag tccagtaaac
     1801 ctcccggaga tgtggatatg tctctttctc ttttgcaaga aatcagtgct ttgcaagaaa
     1861 agctagaagt cacacatact gaccaccaga acgaggtgac gtctctgaag gaccactttg
     1921 gaactcggga agagatgttt cagaaggaga tcaaggctct gcacgctgcc actgaaaagc
     1981 tctccaaaga gaacgagtcc ttgaggagca agcttgacca tgccaacaag gagaactcag
     2041 acgtcatcgc tctgtggaag tccaaactgg agaccgccat cgcgtcccac cagcaggcaa
     2101 tggaggagct gaaggtgtcc tttagcaaag ggattggaac tgactcggct gagtttgctg
     2161 agttaaagac acagatagag agactcagac tagattacca gcacgaaata gaaagtttac
     2221 agagtaagca ggactccgaa cggtctgccc atgctaaaga gatggagtcc atgaaggcca
     2281 agctgatgaa gatcatcaaa gagaaggagg acagcctgga ggccgtcaaa gcacggctgg
     2341 acacggcgga agaccagcac ctggtggaga tggaggagat gctcagcaag ctgcaggagg
     2401 cagagattaa ggtaaaggaa ctagaggttc tgcaggccaa gtacagtgaa caaacccagg
     2461 tcgttggtca tctcacatca caactcagtg ttgtcgaaga acagctcttg gatctggatg
     2521 cccttcggaa ggccaactcc gaaggtaaac tggagatcga gacacttagg cagcagcttg
     2581 agggagccga aaagcagatt aaaaacttag agatggagag gaacgctgaa agtagcaagg
     2641 ctaatagcat taccaaagac ctccagggaa aagaactaat gctcactagt ctgcagagca
     2701 atttgaatga agtcaatcaa gtgaaggaga ctttggaaaa agaacttcag actttgaaag
     2761 aaaagtttgc cagcgcttca gaggaggccg tctctactca gacaagtatg caagatactg
     2821 ttaataaact gcaccaaaag gaggaacagt ttaatatgtt gtcttctgaa ctggagaagc
     2881 tgagagaaaa tttaacagac atggaggcaa aatttaaaga gaaggatgaa cgggaagatc
     2941 agctggtaaa ggcaaaggaa aagttagaaa atgacattgc agaaataatg aagatgtcag
     3001 gggacaactc ttctcagctg acaaagatga atgacgaatt acgtctgaag gaaaggtctg
     3061 tggaagaact acaactcaaa cttacaaagg ctaatgaaaa tgcaagtctt ctgcagaaaa
     3121 gtatcgggga agtaactctt aaagctgaac agagtcaaca ggaagcagcc aaaaaacatg
     3181 aagaggaaaa gaaagaactg gagaacaaat tgttggaact ggaaaagaag atggaaacta
     3241 gccactacca gtgtcaggac ctgaaagcca agtatgaaaa agccagttct gagactaaaa
     3301 taaagcacga agaaatcctg caaaacttcc agaagatgct ggtggacacg gaggataaac
     3361 tgaaggctgc ccaggaggcc aacagagacc tgatgcagga catggaggag ctgaaatccc
     3421 aggccgacaa agccaaatcg ctaacttatt tgttaacgtc agccaaaaaa gagattgaag
     3481 taatgtcaga agagctgagg ggtctgaagt cagagaagca gctctttgcc caggaggcaa
     3541 gcgctttaaa gttagagaaa ggttctcttt tatcaaagct tatagaagtg gagaccaaga
     3601 taaccttgct tcaggaagac caacagaagc tatggtcagt aaacgaaaac ctccatttag
     3661 aaaaggagag gatctccgag gaaaagcagg ttgccgagaa gcgttatcag caggagcatc
     3721 gggataagga gtctctggtg gttgagagag agaagctgct gaaggagatc aatgtgaccc
     3781 aggaagagct cctgaagatg cacatggaga aagactccct ggaggcctcc aaggtgagca
     3841 tgcaggtgct gatcgaggag ctgcgcttct gcaaggacaa actgatggcc atgtcggaga
     3901 aggcccgggc agagaaggag cagctggagg ggcaggtcaa gaagctcact gcggagaaca
     3961 tggtcttggt caaagacaag gatgacgtca ttcagaaact tcagagcgct tacgaggagc
     4021 tcgtcaagga ccagaaggcc ttggtccaag agatcgagga cctcacgacc gagaagaagt
     4081 cagccgccga gaagcagatg aacctcgata acacctgcct caccctaaag gcagagcggg
     4141 agaaccttct ccagagtaac cgagacctgc agtttgagaa ggacacactg cgccagggcc
     4201 aggagaagct gagcgccagc ctggaggcca ccctgcaggt caagcagctg ctcagcacgg
     4261 aggcagagac gctgcgcacg cagctggact gcgccaccaa ggcgctgagg aaggcggagc
     4321 tggacatgag acagctgcag acctccaaca ccagtctcac gaagctcctg gaagagatta
     4381 agacctgccg ggccatcacg gactcggagt gtatccagct tctccatgag aaggagagct
     4441 tggcggcctc cgagagagcg ctcctggcgg agaaagagga actgctaaat gaaaataggg
     4501 tcatcactga gaaactcaac aaacactcgg aagaggtaac ccgtctcgag gtgagcctga
     4561 acgagaagat cacgtacctg acttctgaga aggagatggc ttgtcagaaa gtcgctaggc
     4621 tcaaaaagca gcaggacagc ctcttgaaag aaaaatcagc cctggaggtg caaaatggag
     4681 atctgcttgc tgacagggag agttccatca aggccatagg ggacctgaag aggaaatatg
     4741 agcaggaggc cacaaacagg cggctcgcgg tgcaggagaa ggtgaagctg ctgggcaaca
     4801 tcgacgcgct gaagaaagag cttcagcaga gaaagaagga gaaccaggag ctggcgagca
     4861 gcaagtgcga cctctccttg atgctcaaag aggctcagac ggccaagaag aaccttgaaa
     4921 aagagcacac gagcatgatg caggccaagg aggacctgaa cgccgagctg aagacgtgct
     4981 gctgcgagaa gaacatcctg ctgagggatg gcttgaacct gcaggaggag tgtcagaaac
     5041 taaatgagga gattcgggaa atccaacaga cgttaatgct ggagaaggag gccagggcca
     5101 aggagagcga gagctctttg tatgaaagca acaagctcca cgggagaata gtgctcttag
     5161 aggaagagat acaggggctg aggacatgta gtgagcagct ccagactgag aattttaccc
     5221 ttacccaaga gaagaccaac tcagagcaaa aagtggtgga gatcattaag gaaaaggaac
     5281 ttctgagcgc agagacggct cagctcgcgg ccaacatcga gaccctcaaa agtgacttcg
     5341 ctgccctttc caagtccaag ttggaattgc aagaactaca cagctgcctc accaagatcc
     5401 tggatgacct ccggctgaac catgaggtgg ccgtgaccga gagggccgag gtgcttcagg
     5461 acaacaagaa cctcctggct gagaaacgag agatgatgct gagaaatgag gaggtgctga
     5521 aggagaagga gaagctggaa gaaagctact tcgtcctcca gaaggagatt agccagctgg
     5581 cccaaaccaa cagccacatt tcagccgacc tcctagaagc ccaaagcgaa aaccggactt
     5641 tgaggaaaga caagagcaag ctaaccctta aaattagaga gcttgagacc ctccattcgt
     5701 tcacggctgc tcagactgca gaagacgcca tgcagatcat ggaacagatg accaaagaga
     5761 aaacagaaac actggcctcc ttggaggaca ccaagcaaac gaatgcaaaa ctacagagcg
     5821 aattggacac acttaaggaa aacaacttga aaactgtgga agagctgaac aagtcaaaag
     5881 aacttctgaa cgaagagaac caaaaaatgg aagaattcaa gaaggaaata gaaaccctaa
     5941 agcaggcagc agctcagaag tcccagcagc tttcagcact gcaggaagag aacgtcaaac
     6001 ttgccgagga gctggggagg acgcgggacg aagtcacaag tcatcaaaag ctggaagaag
     6061 aacgatctgt actcaataat cagttgttag aaatgaaaaa gagagaatcc gagtacagaa
     6121 aagacgccga tgaagagaaa gcctccttgc agaaatccat cagcctcacc agtgccttac
     6181 tcacggagaa ggacgcagag ctggagaagc tgaggaatga ggtcacagtg ctcagggggg
     6241 aaaacgcctc tgccaagtcc ctgcactcag tcgtgcagac cctggagtcg gataaggtga
     6301 agcttgagct caaggtcaaa aacctggaac ttcaactcaa ggaaaacaag aggcagctca
     6361 gcagctcctc aggtaacact gatgttcaga cagaagagga tgagagagcc caggagagtc
     6421 agattgattt cctcaactcg gtaatagtgg accttcaaag aaagaaccaa gacctcaaga
     6481 tgaaggtgga gatgatgtct gaagctgcgc tgaacggcaa cggggaggat ccgaacagtt
     6541 acgacagtga tgaccaggag aagcagtcca agaagaaacc ccgcctcttc tgtgacattt
     6601 gtgactgctt tgatctccac gacacagagg actgccccac ccaggcgcag atgtcagaag
     6661 accctccgca ctccactcac cacggcagcc ggagcgagga gcggccatac tgtgagatct
     6721 gtgagatgtt tggccactgg gccaccaact gcaacgacga tgagaccttc tgaggaggcc
     6781 gggcacacag gactgggctt cccggacgcc ggcccctcag cagctttcca ccagcgctgc
     6841 ccacgtgact tcggaagaac tccttatttt ttgacccccc tgtcaacaaa tctgagaaag
     6901 tattttgatc ttcaacagat ttccctttct tttcctctcg taagttaaaa taataaacat
     6961 ttggtaggtg ggcttgcact tccgtccttg ttttctggat ttttaaagtt taagacattg
     7021 tacgaggtgc tacagtaact ttttgttccc ggagaaacac cctgggacaa gctggaccct
     7081 ggcagtgtct tatttaagaa actttaaatt atgacgttaa gcctcatatt tgcactaaaa
     7141 tgtttcctgg cttcatctgt atatttcggt ggttgttttt gttacgcttt gacactggaa
     7201 tgagttgcaa aaagaaaaaa aagcgccact ttgtgaattc gtgccctcct ttaaatactt
     7261 tttttcctaa gtgtccaagc tgtcggcact acccactgtc agtagtgccc ttttccaggc
     7321 ttgacaagac ttgggcgaga ttataaatca tgaaacaggt aaaagggagg ggaaagcccc
     7381 aaactgctgt ggggacattt tctaatctat atgctacacc cctggtggtg ttttctttat
     7441 tggttttaca taatttcaac ctctatatat tatatgtata tatatttttt aaaaaacaaa
     7501 atctatattt tgggaaaaaa aagtctatac agtgtgtctt cttttcagat ttttttacct
     7561 ttacaaaaaa gaaaacacct aaaggctcac caggatgtga ccggctgggc cagagacagg
     7621 ctctgcggtg tcacggccat cgtctttgtt tccgtgttgt ttcttagcca gctcgtcggt
     7681 tgttcccctt ctttagcaga taaccccagc agcaaaccaa gccgctctta cggccgccaa
     7741 actaaccggt ccacagccct cccttatgca tctgtgcggt tcgtttgttg tttgttgttt
     7801 gttttttctt ttactgtatt tttaatgaat gtatgatgag aaattcaaca tggataattt
     7861 tgaattttct tatcacaaaa agataaaaca aaggacctca atcaactgaa gagtttatca
     7921 gccagtctga gtctgtctgt cttcacttga atgtctttga aaatatgtaa gaaggagtca
     7981 gacgcgtgtc catgccacgt gcaggataag agcttccacc tttgtatata aataagcctt
     8041 cgccatgtcc cccgtaagat tatccactgt gcttgacgag tgaacattca acaaacctgt
     8101 taccagttgg cattttgggt taataaaact ataggaatta tttcacaaac gaaatatgta
     8161 aagcagtatt aaaatctgag ttctgtacct acttcaa
//
