LOCUS       NM_053603               6161 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Rattus norvegicus chloride intracellular channel 5 (Clic5), mRNA.
ACCESSION   NM_053603
VERSION     NM_053603.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6161)
  AUTHORS   Ponnalagu,D., Gururaja Rao,S., Farber,J., Xin,W., Hussain,A.T.,
            Shah,K., Tanda,S., Berryman,M., Edwards,J.C. and Singh,H.
  TITLE     Molecular identity of cardiac mitochondrial chloride intracellular
            channel proteins
  JOURNAL   Mitochondrion 27, 6-14 (2016)
   PUBMED   26777142
  REMARK    GeneRIF: The authors report the presence of unique dimorphic
            chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4
            and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4,
            CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to
            adult cardiac mitochondria.
REFERENCE   2  (bases 1 to 6161)
  AUTHORS   Seco,C.Z., Oonk,A.M., Dominguez-Ruiz,M., Draaisma,J.M., Gandia,M.,
            Oostrik,J., Neveling,K., Kunst,H.P., Hoefsloot,L.H., del
            Castillo,I., Pennings,R.J., Kremer,H., Admiraal,R.J. and
            Schraders,M.
  TITLE     Progressive hearing loss and vestibular dysfunction caused by a
            homozygous nonsense mutation in CLIC5
  JOURNAL   Eur J Hum Genet 23 (2), 189-194 (2015)
   PUBMED   24781754
REFERENCE   3  (bases 1 to 6161)
  AUTHORS   Salles,F.T., Andrade,L.R., Tanda,S., Grati,M., Plona,K.L.,
            Gagnon,L.H., Johnson,K.R., Kachar,B. and Berryman,M.A.
  TITLE     CLIC5 stabilizes membrane-actin filament linkages at the base of
            hair cell stereocilia in a molecular complex with radixin, taperin,
            and myosin VI
  JOURNAL   Cytoskeleton (Hoboken) 71 (1), 61-78 (2014)
   PUBMED   24285636
REFERENCE   4  (bases 1 to 6161)
  AUTHORS   Pierchala,B.A., Munoz,M.R. and Tsui,C.C.
  TITLE     Proteomic analysis of the slit diaphragm complex: CLIC5 is a
            protein critical for podocyte morphology and function
  JOURNAL   Kidney Int 78 (9), 868-882 (2010)
   PUBMED   20664558
  REMARK    GeneRIF: Study identifies CLIC5 as a new component that is enriched
            in and necessary for foot process integrity and podocyte function
            in vivo.
REFERENCE   5  (bases 1 to 6161)
  AUTHORS   Bradford,E.M., Miller,M.L., Prasad,V., Nieman,M.L., Gawenis,L.R.,
            Berryman,M., Lorenz,J.N., Tso,P. and Shull,G.E.
  TITLE     CLIC5 mutant mice are resistant to diet-induced obesity and exhibit
            gastric hemorrhaging and increased susceptibility to torpor
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 298 (6), R1531-R1542 (2010)
   PUBMED   20357015
REFERENCE   6  (bases 1 to 6161)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 6161)
  AUTHORS   Gagnon,L.H., Longo-Guess,C.M., Berryman,M., Shin,J.B., Saylor,K.W.,
            Yu,H., Gillespie,P.G. and Johnson,K.R.
  TITLE     The chloride intracellular channel protein CLIC5 is expressed at
            high levels in hair cell stereocilia and is essential for normal
            inner ear function
  JOURNAL   J Neurosci 26 (40), 10188-10198 (2006)
   PUBMED   17021174
REFERENCE   8  (bases 1 to 6161)
  AUTHORS   Shanks,R.A., Larocca,M.C., Berryman,M., Edwards,J.C.,
            Urushidani,T., Navarre,J. and Goldenring,J.R.
  TITLE     AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a
            novel chloride intracellular channel (CLIC) family member
  JOURNAL   J Biol Chem 277 (43), 40973-40980 (2002)
   PUBMED   12163479
REFERENCE   9  (bases 1 to 6161)
  AUTHORS   Berryman,M. and Bretscher,A.
  TITLE     Identification of a novel member of the chloride intracellular
            channel gene family (CLIC5) that associates with the actin
            cytoskeleton of placental microvilli
  JOURNAL   Mol Biol Cell 11 (5), 1509-1521 (2000)
   PUBMED   10793131
REFERENCE   10 (bases 1 to 6161)
  AUTHORS   Steinmeyer,K., Schwappach,B., Bens,M., Vandewalle,A. and
            Jentsch,T.J.
  TITLE     Cloning and functional expression of rat CLC-5, a chloride channel
            related to kidney disease
  JOURNAL   J Biol Chem 270 (52), 31172-31177 (1995)
   PUBMED   8537381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 18, 2021 this sequence version replaced NM_053603.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.25132.1,
                                           SRR26643290.31866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               JAXUCZ010000009.1  24310568-24310964   c
            398-507             JAXUCZ010000009.1  24262070-24262179   c
            508-633             JAXUCZ010000009.1  24253740-24253865   c
            634-740             JAXUCZ010000009.1  24246510-24246616   c
            741-922             JAXUCZ010000009.1  24221177-24221358   c
            923-6161            JAXUCZ010000009.1  24208455-24213693   c
FEATURES             Location/Qualifiers
     source          1..6161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..6161
                     /gene="Clic5"
                     /note="chloride intracellular channel 5"
                     /db_xref="GeneID:94272"
                     /db_xref="RGD:620659"
     exon            1..397
                     /gene="Clic5"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1090
                     /gene="Clic5"
                     /note="glutaredoxin-like oxidoreductase CLIC5"
                     /codon_start=1
                     /product="chloride intracellular channel protein 5"
                     /protein_id="NP_446055.1"
                     /db_xref="GeneID:94272"
                     /db_xref="RGD:620659"
                     /translation="MTDSATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWL
                     KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYP
                     KLAARHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNTPLPEEI
                     DTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYL
                     KNAYARDEFTNTCAADSEIELAYADVARRLSRS"
     exon            398..507
                     /gene="Clic5"
                     /inference="alignment:Splign:2.1.0"
     exon            508..633
                     /gene="Clic5"
                     /inference="alignment:Splign:2.1.0"
     exon            634..740
                     /gene="Clic5"
                     /inference="alignment:Splign:2.1.0"
     exon            741..922
                     /gene="Clic5"
                     /inference="alignment:Splign:2.1.0"
     exon            923..6161
                     /gene="Clic5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatcgctg acagtcgcgg atcctgtgac acctcccagc agccaggcac ttgttgctct
       61 cgggacctgt tgtcaatccc ttagctcgct cttcctttta gccccctgct ggatcttgga
      121 gtctgctctt tccgtttgac acctgggact ccgagctctt ctctcagaca tagctgtcct
      181 tgcttggaga aattgatgag aaactgttag tcttaaaaga aaaaaaaaat taaacgccgt
      241 gcagaagaga ggcccctcgc tgtgagcagg agcctgaagc gctgcagagg tggcgcctct
      301 ccggcccggg accgtggtcc ggggcgccga cggcatgacg gactcagcga cagctaatgg
      361 ggacgacagg gaccccgaga tcgagctctt cgtgaaggct ggcatcgatg gagagagcat
      421 tggcaactgt cctttctctc agcgtctctt catgatcctc tggctgaaag gagtcgtgtt
      481 caacgtcacc accgtggatc tgaaaagaaa gccagccgat ctacacaacc tggctcctgg
      541 cacacacccg cccttcctga ccttcaatgg ggacgtgaag actgatgtca acaagattga
      601 ggagttcctg gaggagacct taacccctga gaagtacccc aaactggctg caaggcacag
      661 ggaatctaac actgcgggca tcgatatctt ctccaagttt tcagcctaca tcaaaaacac
      721 caaacagcag aacaatgctg cccttgagag aggcctgaca aaggcgctga ggaagctgga
      781 tgactacctg aacacccctc tgccagagga gattgacacc aacacccatg gggacgagaa
      841 gggctcccag cgcaagttcc tggatgggga tgagctaacc ctggccgact gcaatctact
      901 gcccaaactc catgtggtca agattgtggc taagaagtac agaaactatg acatcccagc
      961 tgagatgaca ggcttgtggc ggtacctcaa gaatgcctat gcacgggacg agttcaccaa
     1021 cacctgtgca gctgacagcg agatcgagtt ggcctacgca gatgtcgcca ggcgcctcag
     1081 ccgatcctga gcttggccgt ctgacccgat ttctgctgca gaagaatttc atttctccca
     1141 aaggctttca gctctacaga ctcttcttca ccattgcctt ggggaggcat caaaaaagtt
     1201 aggccacatc ctactggcac ccctgaactc agctccagcc ttctaccttc taagatcagt
     1261 gccatccttc tgccttgacc tgcagaagcc cagtaagcag cgaggacgca gtagcagatg
     1321 tttccacctg ctggtctgac ctagggtcag tgtgtcaggg gtcagtttgc ggagctccca
     1381 tgggattgtc actgttcctt tctgccaatg tcataatgct ttctcagatg ctctaacaac
     1441 tcgaaatgcc agcttccccc ttcccctcct tcctcagcaa ctgcaaggtg atggacaaat
     1501 gccatgacat gatcgttagg gagagatcta tgctttgatt ggggagagag tggttggggg
     1561 tagtcagata ggtatgactc tggatatgta gcaaaacagt tccagctgct cactgtttct
     1621 gtcagtgggc cagattgaaa cacccacccc accccacata cacaatacac cccaatttcc
     1681 tgcagtttgg gggctggtgc aatatgattg tgtcctggcc agcactgacc caagttttcc
     1741 tcctgtctcc atttgttttg ccacaaaggc agttgaccta taaactctaa actggtgacc
     1801 cagaaaagga gggacttctg ggaagcaatg ttgatgccaa aaggcctacc agggtctgca
     1861 gccacagggg tcactgactg aagagtagtc atccactggg gatcacgtgt gtgtgtgtgt
     1921 gtgtgtgtgt gtgtgtgcgc gcgcgcgcgt gcacgtgtgt gtgttcttca gtggatggct
     1981 tcaggttgga gcaagaggtg gaagtggaga gtgatggaag gagataaagt tccatatgag
     2041 tttgacgtag cctagaaaac tttcagagca tcttctctct tgttatctaa atcttggact
     2101 ggtgttacct cacgcctacc aactgtagag cagactctaa catcagccaa aaatgtcttc
     2161 caggcccttc ctcgtcactt gccacctgac tatgatcaga ctcccagttt ctttagcccc
     2221 agcctctgag ggaggagaaa gtctattaag ggctacctta ggaagaaagt ccatgggtct
     2281 ttctgactgg gaagccacaa cttgaatttg gaaactatct actgccctgg gtccattttc
     2341 ccaccatcag actcagctat cagattttta agaaagagaa atcttttttt aaaaagtttt
     2401 gtaagctaac atgtctctcc ttagtccttc tccttgagtt tcacctacaa agctcacagg
     2461 gcctgattat ggcaacctag gctgattagg aactatgacc aattagtcaa tcattagctc
     2521 ttcctctacc agtgagctag tgagtaccta gaagaaatcc atccccaggg cctcaactcc
     2581 aacaatcctg cttctgtgtc actgacagtg gaggcgaggc tcctgagggc cggaaaggcc
     2641 ctggacttgg cttactgctc tggagggtgg agcagcaccg gtcctttcca tagaaatatc
     2701 aacatggtct aaccctagca gtcactgagc ccacctgcct ctagggatct ccaaagcaaa
     2761 gagtgtccat tgatccaagg agggaggaaa gaggaggtct ctctagtcca ctggggaaga
     2821 ggactctgcc tgctaggaca ttttacaaac ctaaaagggc tttgaagagg aaaaatgagt
     2881 tgattcattt ccatcgctac aggaaccttt ccacaggccc tccataagat gcccctgggg
     2941 atgtttaaaa gtgtagcact gctgagggaa cagccctctt ttctttaggg aagagctctc
     3001 aataggcctc ctggggaagt agaacttccg gaactatccg gaaggctgtt taatgaaaag
     3061 aaacccacgc tgttctcaga gatccttcct agaatttaca agcaggcagg gtgatcccag
     3121 gcagttcaca cccctatttt ccacaggtgg gctgatggta aagatatgaa gactagcgta
     3181 catacagagg ggctttagag ggagggaaag aattctcctc atgtgatgtt ctgagcccgg
     3241 cgattggcaa gtctttaaaa acaaactttc caagccgagt aaatattgtt tctagacggt
     3301 cctcctatgg ttgagttagt ttcacataaa tcacaatatt taggcaatgt tggacattat
     3361 aggatcaatc agaacccctt taaagagagg caagactgta gaagggaggc tttcctaagt
     3421 agtttaatgc agaagtaact ctaatgttac cggataatca aaatgagact gaccaatgtc
     3481 ttaggacata attatcatgg tatataaaaa atagcaataa aggtaatgat gattacccac
     3541 accaccctct ccaaggagat ttttctctgg aggctccagc ttctctggac cttggtctta
     3601 accttgacat gtgcctgttt tatcatctgc agccacactg tggtgagttc caagtcccgc
     3661 tttgcagtgt agactctacc tgcagaaatt ctggataaaa gcttttctga taaatgccag
     3721 ccccccagga agcatttgga tggcagagaa aagggagcta tctccacaga gctattttgc
     3781 attcccctct cgccttggat tgtcacatga tgatcttgta tgtgtaaaat ataagtgcaa
     3841 ggcaaaacag acagaaaggt tccaactcag aattcttgag ctgagtgtac ctacctattt
     3901 aaaaaatgcc cagttcttcg attgatccag agagaagaca ttcattaaga tgttagtaac
     3961 tattcaaaat aagatagaaa gttaatgctt tgcttgtttc agaatataat ttcatattct
     4021 cctaaaaata agaaaagttc gtgatacatt caggatcata gtcacgtgtc tatctcacct
     4081 tttaaacgag gggtctaggc agcctactgg aaccagaaga atcagttgca caataggacc
     4141 tggtcagtca gtttatttaa ccaatcaatc ccgaactagt tccaacttcc tggaaggtgg
     4201 caatgtcccc attgttcccc tctggcattg gtgggaaggg acaggatcat catcttcctc
     4261 ctcctcctcc tcctcctcct cctcttctcc tcctcctcct cttcctcctc ctcctcctcc
     4321 tcccctcctc ctcctcctcc tcctcctcct cctcttcttc ttcttcttct tctcttcctc
     4381 ttcttcctcc tcctcttcct cctcctcctc ctcccctcct cctcctcttc ttcttctctt
     4441 cctcttcttc ctcctcctcc tcctcctcct cttcctcctc ctcctcctcc tcctcttcct
     4501 cctcctcctc ctcctcctcc tcctcctcct cttcttcttc ttcttctccc cctccccctc
     4561 cccctccccc tcctctaaaa caagctattc caaaaatgaa gtctgaggaa gaacgttctg
     4621 gtaccttctg gttcttgtga ggtgaggcaa caatagtgac tacattgcct gtgtctagag
     4681 gggtggacat tctgcagaga gacagtcgca agcattttag gtccatcatg gaatgaaaca
     4741 tgcttgatac agacatatgt tgatggtttc agagtccctt ggggacctgc cagaccaggt
     4801 aaattgtatt atgagggaag ccaaagctga agctgtgttt ccatctaata aaagctcacc
     4861 atcactaaaa gagtttgcac ctacaatcaa acccttctag aagcagtagg tgtctggtca
     4921 ggaggtactt ctggggtttc tctccattcc tccatggttc aggagtctac tcagctataa
     4981 gaggaggcag aatactaacg cggccttgct tggaaacatg aaacactaac tcgtggctga
     5041 aactaagttc agtcattctc aaagattata gtttgagagc tacgtgttta tatcatccat
     5101 attcatatac attatatcta tatatagcat tacaaagaac ctttagaaag catgtaggaa
     5161 agaagtgtgc ctctgaggca ccagactact gttgggagaa cgtttgtgat cttgtcactg
     5221 gccttggggc ccttgtacag acaggccagt gactttgtat ccattgctct ttattattta
     5281 aactaatagc ttgtccctga gttataagtg tattctttct cctttaccaa tgttccaatc
     5341 ccagcctagt ttcaagatac tttcatctca ttattatgaa tgagtataaa tcaaactgca
     5401 caatcttatt taatgttgtt tctggaaata gatggatgta ttctccacta tcaccacatg
     5461 caccagcaaa aataaacaaa ccatagtcct aaaataaggt ttaacttaaa ccgaactttc
     5521 cacaaaattg atctggtgtt tggcaagaac agttttgaag acatggtgtt tttgtatata
     5581 gctagagata ttccaacaca gactatgaat atatttatag gagatataag gctaggatct
     5641 agcttggttg tagagtgttt gcttagcgtg aatgaaggcc taggtcagat ctccagcact
     5701 acgtaaacca ggcctggtag caaccactgg taatctgagc acaaggaaac tgacggcagg
     5761 aagatcaagg tcagccgcat agcagactgg agtccagtct gagctacgtg agacctttcc
     5821 ccaaaacaaa taaaaacaag taaaatattc agctgatatt tgaatcccct cccccacagt
     5881 cacctagttt ttccatgtta taagccaagg agttaactga ttagcagctc taattcactg
     5941 tatatagaga cactccaaat gatggtaact ctcatttctt gagaccttta actgtggtga
     6001 gaacagacct tgcttccaag ccttactaaa tgcaccatgc ctttgaatac acaccaagct
     6061 gaatgctttc ttcatatcct cgagccagct gtaaatgcgt ttcctggtct tgattggtat
     6121 tttgactgat tcaaataaag ttggtttatt ttcaaatatt a
//
