LOCUS       NM_001002807            1200 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Rattus norvegicus chloride intracellular channel 1 (Clic1), mRNA.
ACCESSION   NM_001002807 XM_345083
VERSION     NM_001002807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Ponnalagu,D., Gururaja Rao,S., Farber,J., Xin,W., Hussain,A.T.,
            Shah,K., Tanda,S., Berryman,M., Edwards,J.C. and Singh,H.
  TITLE     Molecular identity of cardiac mitochondrial chloride intracellular
            channel proteins
  JOURNAL   Mitochondrion 27, 6-14 (2016)
   PUBMED   26777142
  REMARK    GeneRIF: The authors report the presence of unique dimorphic
            chloride intracellular channel (CLIC) proteins namely CLIC1, CLIC4
            and CLIC5 as abundant CLICs in the rodent heart. Further, CLIC4,
            CLIC5, and an ortholog present in Drosophila (DmCLIC) localize to
            adult cardiac mitochondria.
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Skaper,S.D., Facci,L. and Giusti,P.
  TITLE     Intracellular ion channel CLIC1: involvement in microglia-mediated
            beta-amyloid peptide(1-42) neurotoxicity
  JOURNAL   Neurochem Res 38 (9), 1801-1808 (2013)
   PUBMED   23743620
  REMARK    GeneRIF: examined the effect of pharmacological blockade of CLIC1
            in protecting cortical neurons from toxicity caused by Abeta1-42-
            and lipopolysaccaride-stimulated microglia
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Frobel,J., Cadeddu,R.P., Hartwig,S., Bruns,I., Wilk,C.M.,
            Kundgen,A., Fischer,J.C., Schroeder,T., Steidl,U.G., Germing,U.,
            Lehr,S., Haas,R. and Czibere,A.
  TITLE     Platelet proteome analysis reveals integrin-dependent aggregation
            defects in patients with myelodysplastic syndromes
  JOURNAL   Mol Cell Proteomics 12 (5), 1272-1280 (2013)
   PUBMED   23382103
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   6  (bases 1 to 1200)
  AUTHORS   Pisitkun,T., Shen,R.F. and Knepper,M.A.
  TITLE     Identification and proteomic profiling of exosomes in human urine
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13368-13373 (2004)
   PUBMED   15326289
REFERENCE   7  (bases 1 to 1200)
  AUTHORS   Novarino,G., Fabrizi,C., Tonini,R., Denti,M.A.,
            Malchiodi-Albedi,F., Lauro,G.M., Sacchetti,B., Paradisi,S.,
            Ferroni,A., Curmi,P.M., Breit,S.N. and Mazzanti,M.
  TITLE     Involvement of the intracellular ion channel CLIC1 in
            microglia-mediated beta-amyloid-induced neurotoxicity
  JOURNAL   J Neurosci 24 (23), 5322-5330 (2004)
   PUBMED   15190104
  REMARK    GeneRIF: These results provide a direct link between Abeta-induced
            microglial activation and CLIC1 functional expression.
REFERENCE   8  (bases 1 to 1200)
  AUTHORS   Fan,L., Yu,W. and Zhu,X.
  TITLE     Interaction of Sedlin with chloride intracellular channel proteins
  JOURNAL   FEBS Lett 540 (1-3), 77-80 (2003)
   PUBMED   12681486
REFERENCE   9  (bases 1 to 1200)
  AUTHORS   Berryman,M. and Bretscher,A.
  TITLE     Identification of a novel member of the chloride intracellular
            channel gene family (CLIC5) that associates with the actin
            cytoskeleton of placental microvilli
  JOURNAL   Mol Biol Cell 11 (5), 1509-1521 (2000)
   PUBMED   10793131
REFERENCE   10 (bases 1 to 1200)
  AUTHORS   Valenzuela,S.M., Martin,D.K., Por,S.B., Robbins,J.M., Warton,K.,
            Bootcov,M.R., Schofield,P.R., Campbell,T.J. and Breit,S.N.
  TITLE     Molecular cloning and expression of a chloride ion channel of cell
            nuclei
  JOURNAL   J Biol Chem 272 (19), 12575-12582 (1997)
   PUBMED   9139710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM067949.1, BC099823.1 and FM115459.1.
            
            On Sep 30, 2009 this sequence version replaced NM_001002807.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219968.1, CF111110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132273, SAMD00132300
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               FM067949.1         1-516
            517-645             BC099823.1         469-597
            646-1078            FM115459.1         268-700
            1079-1200           BC099823.1         1031-1152
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1200
                     /gene="Clic1"
                     /note="chloride intracellular channel 1"
                     /db_xref="GeneID:406864"
                     /db_xref="RGD:1303043"
     exon            1..271
                     /gene="Clic1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..958
                     /gene="Clic1"
                     /EC_number="1.8.5.1"
                     /note="glutaredoxin-like oxidoreductase CLIC1;
                     glutathione-dependent dehydroascorbate reductase CLIC1"
                     /codon_start=1
                     /product="chloride intracellular channel protein 1"
                     /protein_id="NP_001002807.1"
                     /db_xref="GeneID:406864"
                     /db_xref="RGD:1303043"
                     /translation="MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVT
                     TVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPE
                     SNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDE
                     GISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREE
                     FASTCPDDEEIELAYEQVARALK"
     exon            272..381
                     /gene="Clic1"
                     /inference="alignment:Splign:2.1.0"
     exon            382..507
                     /gene="Clic1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..614
                     /gene="Clic1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..796
                     /gene="Clic1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1190
                     /gene="Clic1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctgagc taaacgggag ggaacgaggt ggagcagctg ggtgtggggt gcactgagcc
       61 ggtgggtaag ccgcgttgga gagaactaaa gggtctgatc ggacttaggt tgcgccgaag
      121 ggacagctct gagtctggag gagagaatcc cgggccgtga gacccgcctt cccttgcccg
      181 ggcccctccc agttccccca gcgacggctg cttcctggtc cccgacgcaa ccatggctga
      241 agaacaacct caggtcgaat tgttcgtgaa ggctgggagt gatggcgcca agattgggaa
      301 ctgccccttc tcccagagac tgttcatggt gctgtggctc aagggagtca ccttcaacgt
      361 taccaccgtg gacaccaaga gacggacaga gacggtacag aagctttgcc ccggtgggca
      421 gctcccgttc ctgctctacg gcaccgaagt gcacacagat accaacaaaa tcgaggagtt
      481 cctggaggcc gtgctgtgcc ctcccaggta cccaaagttg gctgctctga accccgaatc
      541 caacacctcg gggctggaca tatttgccaa gttttctgcc tacatcaaga actcaaaccc
      601 ggccctcaat gacaacctag agaagggact cctgaaagcc ctgaaggttc tagacaatta
      661 cttgacatcc cccctcccgg aagaagtgga tgaaaccagc gccgaggatg agggcatctc
      721 tcagaggaag tttctggatg gcaatgagct caccctggct gactgcaacc tgctgccaaa
      781 gcttcacata gtccaggtgg tgtgcaaaaa gtacagagga ttcaccatcc cggaggcgtt
      841 ccgtggagtg catcggtact tgagcaacgc ttacgctcgg gaagaattcg cctccacctg
      901 tcctgacgat gaagagatag agctggccta tgagcaagtg gccagggctc tcaaatgagc
      961 acctttttaa gggtccttca cccactctgt gctctccaca gaggcttcca cgttgctaca
     1021 taatggacac actccgatat agccaatggg caggaaatcc ggggcacttg tgcagggccg
     1081 gggatgggac tggggataag ggaaagatta gaggacaagg gtaagatttt tatttttggg
     1141 tgggttgggt aagacaacgt atttcagtaa taaaatacag aatggaaaaa aaaaaaaaaa
//
