LOCUS       NM_001173386            2464 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus C-type lectin domain containing 7A (Clec7a),
            mRNA.
ACCESSION   NM_001173386 XM_001067977 XM_578404
VERSION     NM_001173386.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2464)
  AUTHORS   Wang J, Tian J, He YH, Yang ZW, Wang L, Lai YX and Xu P.
  TITLE     Role of CARD9 in inflammatory signal pathway of peritoneal
            macrophages in severe acute pancreatitis
  JOURNAL   J Cell Mol Med 24 (17), 9774-9785 (2020)
   PUBMED   32790017
  REMARK    GeneRIF: Role of CARD9 in inflammatory signal pathway of peritoneal
            macrophages in severe acute pancreatitis.
REFERENCE   2  (bases 1 to 2464)
  AUTHORS   Zhong J, Huang W, Deng Q, Wu M, Jiang H, Lin X, Sun Y, Huang X and
            Yuan J.
  TITLE     Inhibition of TREM-1 and Dectin-1 Alleviates the Severity of Fungal
            Keratitis by Modulating Innate Immune Responses
  JOURNAL   PLoS One 11 (3), e0150114 (2016)
   PUBMED   26963514
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2464)
  AUTHORS   Cohen-Kedar S, Baram L, Elad H, Brazowski E, Guzner-Gur H and Dotan
            I.
  TITLE     Human intestinal epithelial cells respond to beta-glucans via
            Dectin-1 and Syk
  JOURNAL   Eur J Immunol 44 (12), 3729-3740 (2014)
   PUBMED   25251945
REFERENCE   4  (bases 1 to 2464)
  AUTHORS   Kimura Y, Chihara K, Honjoh C, Takeuchi K, Yamauchi S, Yoshiki H,
            Fujieda S and Sada K.
  TITLE     Dectin-1-mediated signaling leads to characteristic gene
            expressions and cytokine secretion via spleen tyrosine kinase (Syk)
            in rat mast cells
  JOURNAL   J Biol Chem 289 (45), 31565-31575 (2014)
   PUBMED   25246527
  REMARK    GeneRIF: Syk is critical for Dectin-1-mediated activation of mast
            cells, although the signaling differs from that triggered by FcRI
            activation
REFERENCE   5  (bases 1 to 2464)
  AUTHORS   van den Berg LM, Zijlstra-Willems EM, Richters CD, Ulrich MM and
            Geijtenbeek TB.
  TITLE     Dectin-1 activation induces proliferation and migration of human
            keratinocytes enhancing wound re-epithelialization
  JOURNAL   Cell Immunol 289 (1-2), 49-54 (2014)
   PUBMED   24721111
REFERENCE   6  (bases 1 to 2464)
  AUTHORS   Zhu W, Gu B, Miao J, Lu J and Zou S.
  TITLE     Dectin1 activation of beta-(1-3)/(1-6)-D-glucan produces an
            anti-mastitis effect in rats
  JOURNAL   Inflamm Res 60 (10), 937-945 (2011)
   PUBMED   21691936
  REMARK    GeneRIF: Dectin1 activation of beta-(1-3)/(1-6)-D-glucan produces
            an anti-mastitis effect in rats
REFERENCE   7  (bases 1 to 2464)
  AUTHORS   Flornes LM, Nylenna O, Saether PC, Daws MR, Dissen E and Fossum S.
  TITLE     The complete inventory of receptors encoded by the rat natural
            killer cell gene complex
  JOURNAL   Immunogenetics 62 (8), 521-530 (2010)
   PUBMED   20544345
REFERENCE   8  (bases 1 to 2464)
  AUTHORS   Skrzypek F, Cenci E, Pietrella D, Rachini A, Bistoni F and
            Vecchiarelli A.
  TITLE     Dectin-1 is required for human dendritic cells to initiate immune
            response to Candida albicans through Syk activation
  JOURNAL   Microbes Infect 11 (6-7), 661-670 (2009)
   PUBMED   19358895
REFERENCE   9  (bases 1 to 2464)
  AUTHORS   Kato Y, Adachi Y and Ohno N.
  TITLE     Characterization of rat beta-glucan receptor dectin-1
  JOURNAL   Microbiol Immunol 52 (8), 418-428 (2008)
   PUBMED   18667041
  REMARK    GeneRIF: Dectin-1 binds fungal beta-glucan and activates innate
            immune signaling and also plays essential roles in immune responses
            against fungi.
REFERENCE   10 (bases 1 to 2464)
  AUTHORS   Willment JA, Gordon S and Brown GD.
  TITLE     Characterization of the human beta -glucan receptor and its
            alternatively spliced isoforms
  JOURNAL   J Biol Chem 276 (47), 43818-43823 (2001)
   PUBMED   11567029
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166774.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001067977.2, XM_578404.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166774.1, AB455106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2464
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2464
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /note="C-type lectin domain containing 7A"
                     /db_xref="GeneID:502902"
                     /db_xref="RGD:1565140"
     exon            1..144
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..776
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /note="dectin-1; C-type lectin domain family 7, member A"
                     /codon_start=1
                     /product="C-type lectin domain family 7 member A"
                     /protein_id="NP_001166857.1"
                     /db_xref="GeneID:502902"
                     /db_xref="RGD:1565140"
                     /translation="MDEDGYTQLDFGTRNIHKRPVKSEKGSPAPSSRWRSIAVALGIL
                     CLLTVVVAAVLGALAFRRFNSGRYPEEKDNFPSRNKENHKPTEPSLDEKVAPSKASQT
                     TGVFSGPCLPNWIMHAKSCYLFSFSENSWYGSRRHCSQLGAHLLKIDNAKEFEFIESQ
                     TSSHRVNSFWIGLSRNQSEGPWFWEDGSAFTPNSFQVRNTAPQESLPHNCVWIHGSEV
                     YNQMCIASSFTICEKEL"
     exon            145..243
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /inference="alignment:Splign:2.1.0"
     exon            244..378
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /inference="alignment:Splign:2.1.0"
     exon            379..530
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /inference="alignment:Splign:2.1.0"
     exon            531..649
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /inference="alignment:Splign:2.1.0"
     exon            650..2427
                     /gene="Clec7a"
                     /gene_synonym="Clec7b; RGD1565140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacattcaa gtgctctgcc tacgtagagt cctgtgaagc agtggaatat cattctcaaa
       61 tagagaacat ggacgaagat ggatatactc aattagactt cggcactcga aacatccaca
      121 aaagacctgt aaaatcagag aaaggaagcc cagctccatc ttctcgttgg cggtccattg
      181 cggtagcttt aggaatcctg tgcttgctca cagtagtggt cgcagcagtg ctgggtgccc
      241 tagcatttcg gagattcaat tcagggagat atccagagga gaaagacaac ttcccatcaa
      301 gaaataagga gaaccacaaa cccacagaac catctttaga tgagaaggtg gctccctcca
      361 aggcatccca aactacaggc gtcttttctg gaccttgcct tcccaattgg atcatgcatg
      421 ccaagagctg ttatctattt agcttctcag aaaattcctg gtatggaagt aggagacact
      481 gttcccagct aggagctcat ctattgaaga tagacaatgc aaaagaattt gagttcattg
      541 aaagccaaac atcttctcac cgtgttaact cattctggat aggtctatct cgcaatcaga
      601 gtgaagggcc gtggttctgg gaggatggat cagcatttac ccccaactcg tttcaagtca
      661 gaaatacagc tccccaagaa agcttacccc acaattgtgt ttggatccat gggtcagagg
      721 tctacaacca aatgtgcatt gcttcctcat tcactatctg tgagaaggaa ctgtaaaatg
      781 taatgtatgt gagagtgtaa aggtggaatg catgtgtgtg tgcatgcaca cacacaccca
      841 cacacatcac caccaccata accaccaaca caaccaataa caacaacaac aataaaacaa
      901 cacaacaaca acagcaacaa caaaacagaa cagaacagaa caggaaagat gaatattgaa
      961 aatcagagaa aacgctgaaa tgctaagaga ctttaacctc agctgagaac ttggatgcag
     1021 aagctaagac ttctgcactt gccagcttca taaagaaggc agcgctatct tccagttagt
     1081 aagccactag atgtgaaatg aaggcagctc agaaataggg aatatgtgaa catgaggtat
     1141 cctaacccaa atgccacaac cacaacaaaa cccctacacc atcaggaaat actgtagaag
     1201 ggggctgaag actctaagcg tcagaggacc agcatgccta ctgctagtgt cttctagaca
     1261 ggactcactt ccaagaagtg agtacccagg taataacaat acaatttagc aaacaagatg
     1321 tgcataataa caacctcagt tggtatgcca atacagatgt agaaatttca cagggtccta
     1381 ctccccacat gaaggactac aggccattaa tgattctcaa agagagggac aagcctcctg
     1441 atgggttact gaaccccgag cagtcagcac tgaacacacg tacagaacag tatcattgaa
     1501 ccagtaagac atatgcatat gtgttaatca aaaggtatta ctggagcaca cactgtgtta
     1561 gcgtgatttg ctcagtgtct agcagtacat cagacacagg gagaaggcat gatgcacttc
     1621 taaattgaga cgtgaaggga tgagggagga aaatcttcat tataaccaga gcttttattt
     1681 tcatccacat gatcactatt aagatgatca tcattcagac gtagtgaccc aagcttcttc
     1741 cccaactaga taacccagag agtctgcctg ccttttctga tagcaaaatc tgctacgaca
     1801 aggtgcttcc ctcacaggaa gcactctcct taaatgttag agttggaaag agaaatgata
     1861 tcggatagtg gatatttaaa aggcacccag tcaggattcg tgtttttgag cacagaatgt
     1921 atttcatctt tttaggacat actattttgc agttaacaat caattcttta gtcgtttcct
     1981 tacaaacgtg cgactggaat gtgcctctgt ttcctagtgt gacctgcctt gctgccttct
     2041 aagattgtcc attaatgcca cccatatttc ctgtgtgaat ttccatattg ctggggatct
     2101 atttgtagct tcctcagact gatcaatgtg tgggtagaaa ttgttctggg tccactgaat
     2161 tattcacttg aaagtgattg gttttatgtc actttcatct taactgaaaa aaaaaactgc
     2221 ttattaaagg atctttggcc tctggataac ttgcctatat gtagcaatca ctaacataat
     2281 tcttgccttc tccctaaaaa gttgatgaat ttgatactag gaaatgtgta tactagatag
     2341 tttttcactg aagcataaac ttgcgttctt aaagatttta taatgtctcc aagaaaaaaa
     2401 taaacatttt tgtgaggttt gctctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaa
//
