LOCUS       NM_001170397            1225 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus C-type lectin domain family 4 member M (Clec4m),
            mRNA.
ACCESSION   NM_001170397 XM_001064144 XM_213687
VERSION     NM_001170397.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Zhang Y, Zhang S, He Y, Sun Z, Cai W, Lv Y, Jiang L, Li Q, Zhu S,
            Li W, Ye C, Wu B, Xue Y, Chen H, Cai H and Chen T.
  TITLE     Murine SIGNR1 (CD209b) Contributes to the Clearance of
            Uropathogenic Escherichia coli During Urinary Tract Infections
  JOURNAL   Front Cell Infect Microbiol 9, 457 (2020)
   PUBMED   31998663
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Fayssel N, Bensghir R, Ouladlahsen A, Abdelghaffar H, Sodqi M,
            Lahlou K, Benjelloun S, Marhoum El Filali K, Ezzikouri S and Wakrim
            L.
  TITLE     Association of CD209L tandem repeats polymorphism with
            susceptibility to human immunodeficiency virus-1 infection, disease
            progression, and treatment outcomes: a Moroccan cohort study
  JOURNAL   Clin Microbiol Infect 21 (5), 513 (2015)
   PUBMED   25656622
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   da Silva RC, Segat L, da Cruz HL, Schindler HC, Montenegro LM,
            Crovella S and Guimaraes RL.
  TITLE     Association of CD209 and CD209L polymorphisms with tuberculosis
            infection in a Northeastern Brazilian population
  JOURNAL   Mol Biol Rep 41 (8), 5449-5457 (2014)
   PUBMED   24874302
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Ezzikouri S, Rebbani K, Fakhir FZ, Alaoui R, Nadir S, Diepolder H,
            Thursz M, Khakoo SI and Benjelloun S.
  TITLE     The allele 4 of neck region liver-lymph node-specific
            ICAM-3-grabbing integrin variant is associated with spontaneous
            clearance of hepatitis C virus and decrease of viral loads
  JOURNAL   Clin Microbiol Infect 20 (5), O325-O332 (2014)
   PUBMED   24283933
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Liu SR, Weng HB, Wu J, Zhang ZD, Zeng YM and Tian HF.
  TITLE     [Relationship between intrauterine infection and the gene
            polymorphism of DC-SIGN/DC-SIGNR in the pregnant women of HBV
            positive]
  JOURNAL   Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 25 (5), 331-333
            (2011)
   PUBMED   22338216
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Koppel EA, Wieland CW, van den Berg VC, Litjens M, Florquin S, van
            Kooyk Y, van der Poll T and Geijtenbeek TB.
  TITLE     Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed
            by marginal zone macrophages is essential for defense against
            pulmonary Streptococcus pneumoniae infection
  JOURNAL   Eur J Immunol 35 (10), 2962-2969 (2005)
   PUBMED   16134084
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Lanoue A, Clatworthy MR, Smith P, Green S, Townsend MJ, Jolin HE,
            Smith KG, Fallon PG and McKenzie AN.
  TITLE     SIGN-R1 contributes to protection against lethal pneumococcal
            infection in mice
  JOURNAL   J Exp Med 200 (11), 1383-1393 (2004)
   PUBMED   15583012
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Jeffers SA, Tusell SM, Gillim-Ross L, Hemmila EM, Achenbach JE,
            Babcock GJ, Thomas WD Jr, Thackray LB, Young MD, Mason RJ,
            Ambrosino DM, Wentworth DE, Demartini JC and Holmes KV.
  TITLE     CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome
            coronavirus
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15748-15753 (2004)
   PUBMED   15496474
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Taylor PR, Brown GD, Herre J, Williams DL, Willment JA and Gordon
            S.
  TITLE     The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the
            nonopsonic recognition of yeast by specific macrophages
  JOURNAL   J Immunol 172 (2), 1157-1162 (2004)
   PUBMED   14707091
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Lozach PY, Lortat-Jacob H, de Lacroix de Lavalette A, Staropoli I,
            Foung S, Amara A, Houles C, Fieschi F, Schwartz O, Virelizier JL,
            Arenzana-Seisdedos F and Altmeyer R.
  TITLE     DC-SIGN and L-SIGN are high affinity binding receptors for
            hepatitis C virus glycoprotein E2
  JOURNAL   J Biol Chem 278 (22), 20358-20366 (2003)
   PUBMED   12609975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC091252.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_001064144.1, XM_213687.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091252.1, FQ227772.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1225              BC091252.1         1-1225
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..1225
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /note="C-type lectin domain family 4 member M"
                     /db_xref="GeneID:288378"
                     /db_xref="RGD:1561466"
     exon            1..65
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1003
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /codon_start=1
                     /product="CD209b antigen"
                     /protein_id="NP_001163868.1"
                     /db_xref="GeneID:288378"
                     /db_xref="RGD:1561466"
                     /translation="MQPLDSMEDGEMEVSGSRYSIKSSRLRPNSGIKSLAGCLGHNQA
                     PLVLQLLSFLFLAGLLLIILFQVFKTTNTQWQEEPKQEKILEELNQLTDELMSRIPIS
                     QGQNESMQEKISEQLTQLKVELLSRIPVFQVQNESMQEKISEQLTQLKAELLSKIPSL
                     QVQDESKQEKIYQQLVQMKTELLRLCRLCPWDWTFLLGNCYFLSKSQRNWNDAVRACK
                     EEKAQLVIINSDEEQTFLQLTSKAKGPTWMGLSDLKNEATWLWVDGSTLSSRFQKYWN
                     RGEPNNIGEEDCVEFAGDGWNDSKCELKKFWIFKKSATACTEG"
     exon            66..152
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            153..242
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            243..329
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            330..416
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            417..503
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..590
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            591..742
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            743..852
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1210
                     /gene="Clec4m"
                     /gene_synonym="Cd209b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaggggaca gcagtgactg tgggtgactc cgcagaagcc aggatgcagc ctcttgattc
       61 catggaggac ggcgagatgg aggtcagtgg cagcaggtat tctattaaaa gctccagact
      121 acgaccaaat tctggaatca agagtttggc aggatgcctg ggacacaacc aagccccctt
      181 ggtcctgcag ctgctctctt tcctgttctt ggctgggctc ctgctgatca ttcttttcca
      241 agtcttcaag accacaaata cccagtggca ggaggaaccc aagcaagaga agatccttga
      301 ggaactgaac cagctgacag acgaacttat gtccaggatc cccatctccc aggggcagaa
      361 tgagtccatg caggagaaga tctctgagca actgactcag ctgaaggttg aactcctatc
      421 caggatcccc gtcttccaag tgcagaatga atccatgcaa gagaagatct ctgagcaact
      481 gacacagctg aaggctgaac tcctttccaa gatccccagc ctccaggtac aggatgagtc
      541 taagcaggag aagatctacc aacagctggt acagatgaag actgaactcc tccgcctgtg
      601 tcgactctgc ccctgggact ggacattcct cctaggaaac tgttacttct tatccaagtc
      661 ccaacggaac tggaatgatg ccgtcagagc ttgcaaagaa gagaaggctc aattagtcat
      721 catcaatagt gatgaagagc agaccttcct acagctgact tctaaggcta aaggaccaac
      781 ctggatgggg ctgtcagacc tgaagaatga agccacatgg ctctgggtag atggttctac
      841 tctgtcatcc agattccaga aatattggaa tagaggggag cccaacaaca tcggtgaaga
      901 agactgtgta gaatttgctg gggatggctg gaatgactcc aaatgtgaac tcaaaaagtt
      961 ctggattttc aagaagtctg cgaccgcatg cactgaaggc tagctccccc agcttctacc
     1021 gccatgcttc tttgccagac aaatggatgt gcctcacttt cagctccttc ttcctggctg
     1081 ttggcctcag tattttggaa aaaaaaaaaa aaccctggta ttatattttt atcagattct
     1141 tcatcctcca agtttatcct agtttcgttt ctgttgatgt gataaaatgc tctaacaaaa
     1201 aaaaaaaaaa aaaaaaaaaa aaaaa
//
