LOCUS       NM_001005897             724 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus C-type lectin domain family 4, member E (Clec4e),
            mRNA.
ACCESSION   NM_001005897 XM_579153
VERSION     NM_001005897.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 724)
  AUTHORS   N'diaye,M., Brauner,S., Flytzani,S., Kular,L., Warnecke,A.,
            Adzemovic,M.Z., Piket,E., Min,J.H., Edwards,W., Mela,F., Choi,H.Y.,
            Magg,V., James,T., Linden,M., Reichardt,H.M., Daws,M.R., van
            Horssen,J., Kockum,I., Harris,R.A., Olsson,T.,
            Guerreiro-Cacais,A.O. and Jagodic,M.
  TITLE     C-type lectin receptors Mcl and Mincle control development of
            multiple sclerosis-like neuroinflammation
  JOURNAL   J Clin Invest 130 (2), 838-852 (2020)
   PUBMED   31725411
  REMARK    GeneRIF: C-type lectin receptors Mcl and Mincle control development
            of multiple sclerosis-like neuroinflammation.
REFERENCE   2  (bases 1 to 724)
  AUTHORS   Wang,Y., Yin,J., Wang,C., Hu,H., Li,X., Xue,M., Liu,J., Cheng,W.,
            Wang,Y., Li,Y., Shi,Y., Tan,J., Li,X., Liu,F., Liu,Q. and Yan,S.
  TITLE     Microglial Mincle receptor in the PVN contributes to sympathetic
            hyperactivity in acute myocardial infarction rat
  JOURNAL   J Cell Mol Med 23 (1), 112-125 (2019)
   PUBMED   30353660
  REMARK    GeneRIF: Data suggest that therapeutic interventions targeting
            macrophage-inducible C-type lectin protein (Mincle protein)
            signalling pathway could constitute a novel approach for preventing
            infarction injury.
REFERENCE   3  (bases 1 to 724)
  AUTHORS   Honjoh,C., Chihara,K., Yoshiki,H., Yamauchi,S., Takeuchi,K.,
            Kato,Y., Hida,Y., Ishizuka,T. and Sada,K.
  TITLE     Association of C-Type Lectin Mincle with FcepsilonRIbetagamma
            Subunits Leads to Functional Activation of RBL-2H3 Cells through
            Syk
  JOURNAL   Sci Rep 7, 46064 (2017)
   PUBMED   28393919
  REMARK    GeneRIF: mast cells contribute to Mincle-mediated immunity through
            Syk activation triggered by association with the
            FcepsilonRIbetagamma complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 724)
  AUTHORS   He,Y., Xu,L., Li,B., Guo,Z.N., Hu,Q., Guo,Z., Tang,J., Chen,Y.,
            Zhang,Y., Tang,J. and Zhang,J.H.
  TITLE     Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling
            Pathway Contributes to Neuroinflammation After Subarachnoid
            Hemorrhage in Rats
  JOURNAL   Stroke 46 (8), 2277-2286 (2015)
   PUBMED   26138128
  REMARK    GeneRIF: The Mincle signaling pathway is involved in early brain
            injury after subarachnoid hemorrhage.
REFERENCE   5  (bases 1 to 724)
  AUTHORS   Lobato-Pascual,A., Saether,P.C., Fossum,S., Dissen,E. and Daws,M.R.
  TITLE     Mincle, the receptor for mycobacterial cord factor, forms a
            functional receptor complex with MCL and FcepsilonRI-gamma
  JOURNAL   Eur J Immunol 43 (12), 3167-3174 (2013)
   PUBMED   23921530
  REMARK    GeneRIF: The results presented in this paper suggest that the
            Mincle/MCL/FcepsilonRI-gamma complex is the functionally optimal
            form for these C-type lectin receptors on the surface of myeloid
            cells.
REFERENCE   6  (bases 1 to 724)
  AUTHORS   Furukawa,A., Kamishikiryo,J., Mori,D., Toyonaga,K., Okabe,Y.,
            Toji,A., Kanda,R., Miyake,Y., Ose,T., Yamasaki,S. and Maenaka,K.
  TITLE     Structural analysis for glycolipid recognition by the C-type
            lectins Mincle and MCL
  JOURNAL   Proc Natl Acad Sci U S A 110 (43), 17438-17443 (2013)
   PUBMED   24101491
REFERENCE   7  (bases 1 to 724)
  AUTHORS   Miyake,Y., Toyonaga,K., Mori,D., Kakuta,S., Hoshino,Y., Oyamada,A.,
            Yamada,H., Ono,K., Suyama,M., Iwakura,Y., Yoshikai,Y. and
            Yamasaki,S.
  TITLE     C-type lectin MCL is an FcRgamma-coupled receptor that mediates the
            adjuvanticity of mycobacterial cord factor
  JOURNAL   Immunity 38 (5), 1050-1062 (2013)
   PUBMED   23602766
REFERENCE   8  (bases 1 to 724)
  AUTHORS   Yamasaki,S., Matsumoto,M., Takeuchi,O., Matsuzawa,T., Ishikawa,E.,
            Sakuma,M., Tateno,H., Uno,J., Hirabayashi,J., Mikami,Y., Takeda,K.,
            Akira,S. and Saito,T.
  TITLE     C-type lectin Mincle is an activating receptor for pathogenic
            fungus, Malassezia
  JOURNAL   Proc Natl Acad Sci U S A 106 (6), 1897-1902 (2009)
   PUBMED   19171887
REFERENCE   9  (bases 1 to 724)
  AUTHORS   Yamasaki,S., Ishikawa,E., Sakuma,M., Hara,H., Ogata,K. and Saito,T.
  TITLE     Mincle is an ITAM-coupled activating receptor that senses damaged
            cells
  JOURNAL   Nat Immunol 9 (10), 1179-1188 (2008)
   PUBMED   18776906
REFERENCE   10 (bases 1 to 724)
  AUTHORS   Flornes,L.M., Bryceson,Y.T., Spurkland,A., Lorentzen,J.C.,
            Dissen,E. and Fossum,S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001005897.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY363175.1, AY494064.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000004.1  158298387-158298467 c
            82-177              JAXUCZ010000004.1  158297616-158297711 c
            178-267             JAXUCZ010000004.1  158295283-158295372 c
            268-419             JAXUCZ010000004.1  158295059-158295210 c
            420-535             JAXUCZ010000004.1  158294355-158294470 c
            536-724             JAXUCZ010000004.1  158293311-158293499 c
FEATURES             Location/Qualifiers
     source          1..724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..724
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="C-type lectin domain family 4, member E"
                     /db_xref="GeneID:450223"
                     /db_xref="RGD:1359298"
     exon            1..81
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..692
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /note="immunoreceptor; C-type lectin superfamily member 9;
                     macrophage-inducible C-type lectin"
                     /codon_start=1
                     /product="C-type lectin domain family 4 member E"
                     /protein_id="NP_001005897.2"
                     /db_xref="GeneID:450223"
                     /db_xref="RGD:1359298"
                     /translation="MNSTKSPASHHTERECFKNSQVLLWTMAGASILFLSVCFITRCV
                     VTYHSFQIYGQKKLQPHKTIKELSCYLEASGSVKNCCPLNWKHFQSSCYFFSTTTLTW
                     PSSLNNCSDMGAHLVVINTWEEQEFLFRTKPRKKEFYIGLTDQVVEGQWRWVDDTPFT
                     ESLSFWDAGEPNNIVFVEDCATMRDSSNPRKNWNDVSCFFSMPWICEMPEISPLD"
     exon            82..177
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            178..267
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            268..419
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            420..535
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
     exon            536..724
                     /gene="Clec4e"
                     /gene_synonym="Clecsf9; Mincle"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcaggggc tctttctaaa ctgagacgag aaggaaaggg aagaatgaat tcaaccaaat
       61 cgcctgcatc acaccacaca gagagagaat gcttcaaaaa ctcccaagtg cttttatgga
      121 cgatggctgg ggcctccatc ctgtttctca gtgtctgttt catcaccaga tgtgttgtaa
      181 catatcacag ttttcaaatt tatgggcaga agaagttaca gccacataaa actattaagg
      241 agctttcctg ctaccttgaa gcatcaggtt cagtcaagaa ttgctgccct ttgaactgga
      301 aacattttca atctagttgc tactttttct ctacaaccac cttaacctgg ccatcaagtc
      361 taaataattg ctcagacatg ggggctcacc tggtggttat caacacatgg gaagagcagg
      421 aattcctttt tcgcacaaaa cccagaaaga aagagtttta cattggactg acagaccagg
      481 ttgtggaggg tcagtggcga tgggtggatg atacaccttt cacagagtcc ctgagcttct
      541 gggatgctgg agagcccaat aacatagttt ttgtggagga ctgtgccacc atgagggact
      601 cttcaaaccc caggaagaac tggaatgatg tatcctgttt cttcagtatg ccttggattt
      661 gtgagatgcc agaaataagt cctttggact aggtgcaagg gaacacagaa gacatggttt
      721 acat
//
