LOCUS       NM_001005891             779 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus C-type lectin domain family 4, member A3
            (Clec4a3), mRNA.
ACCESSION   NM_001005891 XM_342752
VERSION     NM_001005891.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Nagae M, Ikeda A, Hanashima S, Kojima T, Matsumoto N, Yamamoto K
            and Yamaguchi Y.
  TITLE     Crystal structure of human dendritic cell inhibitory receptor
            C-type lectin domain reveals the binding mode with N-glycan
  JOURNAL   FEBS Lett 590 (8), 1280-1288 (2016)
   PUBMED   27015765
  REMARK    Erratum:[FEBS Lett. 2016 May;590(10 ):1552. PMID: 27218798]
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Klechevsky E, Flamar AL, Cao Y, Blanck JP, Liu M, O'Bar A,
            Agouna-Deciat O, Klucar P, Thompson-Snipes L, Zurawski S, Reiter Y,
            Palucka AK, Zurawski G and Banchereau J.
  TITLE     Cross-priming CD8+ T cells by targeting antigens to human dendritic
            cells through DCIR
  JOURNAL   Blood 116 (10), 1685-1697 (2010)
   PUBMED   20530286
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Guo JP, Verdrengh M, Tarkowski A, Lange S, Jennische E, Lorentzen
            JC and Harris RA.
  TITLE     The rat antigen-presenting lectin-like receptor complex influences
            innate immunity and development of infectious diseases
  JOURNAL   Genes Immun 10 (3), 227-236 (2009)
   PUBMED   19279651
  REMARK    GeneRIF: APLEC influences innate immunity and responses to
            infectious agents.
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de
            Vries IJ and Adema GJ.
  TITLE     Targeting DCIR on human plasmacytoid dendritic cells results in
            antigen presentation and inhibits IFN-alpha production
  JOURNAL   Blood 111 (8), 4245-4253 (2008)
   PUBMED   18258799
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Lorentzen JC, Flornes L, Eklow C, Backdahl L, Ribbhammar U, Guo JP,
            Smolnikova M, Dissen E, Seddighzadeh M, Brookes AJ, Alfredsson L,
            Klareskog L, Padyukov L and Fossum S.
  TITLE     Association of arthritis with a gene complex encoding C-type
            lectin-like receptors
  JOURNAL   Arthritis Rheum 56 (8), 2620-2632 (2007)
   PUBMED   17665455
  REMARK    GeneRIF: Rat APLEC is associated with susceptibility to
            polyarthritis.
REFERENCE   6  (bases 1 to 779)
  AUTHORS   Flornes LM, Bryceson YT, Spurkland A, Lorentzen JC, Dissen E and
            Fossum S.
  TITLE     Identification of lectin-like receptors expressed by antigen
            presenting cells and neutrophils and their mapping to a novel gene
            complex
  JOURNAL   Immunogenetics 56 (7), 506-517 (2004)
   PUBMED   15368084
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY397671.1.
            
            On Oct 22, 2004 this sequence version replaced XM_342752.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY397671.1, FQ230051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PVG"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..779
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /note="C-type lectin domain family 4, member A3"
                     /db_xref="GeneID:362431"
                     /db_xref="RGD:1359528"
     exon            1..115
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..747
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /note="antigen-presenting cell lectin-like receptor
                     complex APLEC; dendritic cell inhibitory receptor 3"
                     /codon_start=1
                     /product="C-type lectin domain family 4, member A3"
                     /protein_id="NP_001005891.1"
                     /db_xref="GeneID:362431"
                     /db_xref="RGD:1359528"
                     /translation="MFSENIYINTNFKNKYDSSDIDTDFRPDPPKKSKSQKSCHKFSK
                     VLFTSLIIYFLLLTILFSSALIILFKKYSQLLEEKTIMKELNYTELECTKWDSLLEDK
                     VWSCCPKDWKPFDSNCYFPSTDSVESWMESEEKCSGIGAHLVVIHSQEEQDFLPRILD
                     THAAYFIGLSDPGHRQWQWVDQTPYNGNATFWHEGEPSSDNEQCVIINHHENTGWGWS
                     DSSCSDKQKLVCQVKKIYL"
     exon            116..232
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            233..334
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            335..489
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..602
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..779
                     /gene="Clec4a3"
                     /gene_synonym="Dcir3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcttctgagg gcaggggaaa atttcttctc aacatgtttt cagaaaacat ttatattaac
       61 acgaacttca aaaataaata tgactcctca gacatcgaca cagactttcg gccagatccc
      121 ccaaagaaga gcaagtctca gaaaagttgc cacaagttct ccaaggtcct ctttacctca
      181 ctcataatct atttcctgct gttgacaatc ttattctcca gtgctctgat cattctgttt
      241 aaaaaatatt ctcagcttct ggaagaaaaa acaattatga aggaactgaa ctatactgaa
      301 ttggagtgta caaaatggga ttcactcttg gaagacaaag tctggagctg ttgcccaaag
      361 gattggaagc catttgattc caactgctac ttcccttcca ctgactcagt agaatcttgg
      421 atggagagtg aggagaagtg ctccggcata ggtgctcatc tggtggtgat ccacagccag
      481 gaagagcagg atttcctgcc caggatcctg gatactcatg ctgcttattt tataggactt
      541 tcagatccag gtcatcgaca atggcaatgg gtcgatcaga caccatacaa tgggaatgcc
      601 acattctggc atgaaggtga gcccagcagt gacaatgaac aatgtgttat aataaatcat
      661 catgagaata ctggatgggg ctggagtgat agctcttgca gtgataaaca gaagttggtt
      721 tgtcaggtga aaaaaatata cttatgaacc acacattctc cttgactgtg ggattgcat
//
