LOCUS       NM_001398551            6051 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus C-type lectin domain containing 16A (Clec16a),
            mRNA.
ACCESSION   NM_001398551 XM_008767508
VERSION     NM_001398551.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6051)
  AUTHORS   Tam,R.C., Li,M.W., Gao,Y.P., Pang,Y.T., Yan,S., Ge,W., Lau,C.S. and
            Chan,V.S.
  TITLE     Human CLEC16A regulates autophagy through modulating mTOR activity
  JOURNAL   Exp Cell Res 352 (2), 304-312 (2017)
   PUBMED   28223137
REFERENCE   2  (bases 1 to 6051)
  AUTHORS   Soleimanpour,S.A., Gupta,A., Bakay,M., Ferrari,A.M., Groff,D.N.,
            Fadista,J., Spruce,L.A., Kushner,J.A., Groop,L., Seeholzer,S.H.,
            Kaufman,B.A., Hakonarson,H. and Stoffers,D.A.
  TITLE     The diabetes susceptibility gene Clec16a regulates mitophagy
  JOURNAL   Cell 157 (7), 1577-1590 (2014)
   PUBMED   24949970
REFERENCE   3  (bases 1 to 6051)
  AUTHORS   Zuvich,R.L., Bush,W.S., McCauley,J.L., Beecham,A.H., De Jager,P.L.,
            Ivinson,A.J., Compston,A., Hafler,D.A., Hauser,S.L., Sawcer,S.J.,
            Pericak-Vance,M.A., Barcellos,L.F., Mortlock,D.P. and Haines,J.L.
  CONSRTM   International Multiple Sclerosis Genetics Consortium
  TITLE     Interrogating the complex role of chromosome 16p13.13 in multiple
            sclerosis susceptibility: independent genetic signals in the
            CIITA-CLEC16A-SOCS1 gene complex
  JOURNAL   Hum Mol Genet 20 (17), 3517-3524 (2011)
   PUBMED   21653641
REFERENCE   4  (bases 1 to 6051)
  AUTHORS   Martinez,A., Perdigones,N., Cenit,M.C., Espino,L., Varade,J.,
            Lamas,J.R., Santiago,J.L., Fernandez-Arquero,M., de la Calle,H.,
            Arroyo,R., de la Concha,E.G., Fernandez-Gutierrez,B. and Urcelay,E.
  TITLE     Chromosomal region 16p13: further evidence of increased
            predisposition to immune diseases
  JOURNAL   Ann Rheum Dis 69 (1), 309-311 (2010)
   PUBMED   19221398
  REMARK    Erratum:[Ann Rheum Dis. 2011 Jan;70(1):240]
REFERENCE   5  (bases 1 to 6051)
  AUTHORS   Zoledziewska,M., Costa,G., Pitzalis,M., Cocco,E., Melis,C., Moi,L.,
            Zavattari,P., Murru,R., Lampis,R., Morelli,L., Poddie,F.,
            Frongia,P., Pusceddu,P., Bajorek,M., Marras,A., Satta,A.M.,
            Chessa,A., Pugliatti,M., Sotgiu,S., Whalen,M.B., Rosati,G.,
            Cucca,F. and Marrosu,M.G.
  TITLE     Variation within the CLEC16A gene shows consistent disease
            association with both multiple sclerosis and type 1 diabetes in
            Sardinia
  JOURNAL   Genes Immun 10 (1), 15-17 (2009)
   PUBMED   18946483
REFERENCE   6  (bases 1 to 6051)
  AUTHORS   Skinningsrud,B., Husebye,E.S., Pearce,S.H., McDonald,D.O.,
            Brandal,K., Wolff,A.B., Lovas,K., Egeland,T. and Undlien,D.E.
  TITLE     Polymorphisms in CLEC16A and CIITA at 16p13 are associated with
            primary adrenal insufficiency
  JOURNAL   J Clin Endocrinol Metab 93 (9), 3310-3317 (2008)
   PUBMED   18593762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 20, 2021 this sequence version replaced XM_008767508.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.25267.1,
                                           SRR26643293.61350.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000010.1  5630372-5630619     c
            249-377             JAXUCZ010000010.1  5616748-5616876     c
            378-511             JAXUCZ010000010.1  5612954-5613087     c
            512-660             JAXUCZ010000010.1  5608046-5608194     c
            661-766             JAXUCZ010000010.1  5603416-5603521     c
            767-890             JAXUCZ010000010.1  5601554-5601677     c
            891-1065            JAXUCZ010000010.1  5597996-5598170     c
            1066-1119           JAXUCZ010000010.1  5596769-5596822     c
            1120-1233           JAXUCZ010000010.1  5593702-5593815     c
            1234-1417           JAXUCZ010000010.1  5578453-5578636     c
            1418-1550           JAXUCZ010000010.1  5564215-5564347     c
            1551-1651           JAXUCZ010000010.1  5561255-5561355     c
            1652-1774           JAXUCZ010000010.1  5549130-5549252     c
            1775-1884           JAXUCZ010000010.1  5545322-5545431     c
            1885-1929           JAXUCZ010000010.1  5544781-5544825     c
            1930-1980           JAXUCZ010000010.1  5542781-5542831     c
            1981-2109           JAXUCZ010000010.1  5539585-5539713     c
            2110-2230           JAXUCZ010000010.1  5533954-5534074     c
            2231-2382           JAXUCZ010000010.1  5488197-5488348     c
            2383-2587           JAXUCZ010000010.1  5485203-5485407     c
            2588-2752           JAXUCZ010000010.1  5482849-5483013     c
            2753-2911           JAXUCZ010000010.1  5448361-5448519     c
            2912-6051           JAXUCZ010000010.1  5434725-5437864     c
FEATURES             Location/Qualifiers
     source          1..6051
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..6051
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /note="C-type lectin domain containing 16A"
                     /db_xref="GeneID:287044"
                     /db_xref="RGD:1305773"
     exon            1..248
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..3267
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /note="C-type lectin domain family 16, member A"
                     /codon_start=1
                     /product="protein CLEC16A"
                     /protein_id="NP_001385480.1"
                     /db_xref="GeneID:287044"
                     /db_xref="RGD:1305773"
                     /translation="MFGRSRSWVGGGHGKSSRNIHSLDHLKYLYHVLTKNTTVTEQNR
                     NLLVETIRSITEILIWGDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLN
                     ILFENISHETSLYYLLSNNYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHF
                     FYNEHTNDFALYTEAIKFFNHPESMVRIAVRTITLNVYKVDNQAMLHYIRDKTAVPYF
                     SNLVWFIGSHVIELDNCVQTDEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDV
                     LTDHLLNRLFLPLYVHSLENPDKGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEV
                     ILNGDLSETYTKPAQDAPRSSAKPSIRCFIKPTETLERSLEMNKHKGKKRMQKRPNYK
                     NVGEEEDEERGSAEDAQEDAEKTKEIEMVIMKLGKLSEVATAGASVQEQNTTDEEKSA
                     ATSSENAQWSRPFLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLKRIQLPV
                     PSEAEKTTYNHLLAERLIRIMNNAAQPDGRIRLATLELSCLLLKQQVLTSSGCVIKDV
                     HLACLEGAREESVHLVRHFYKGEEIFLDMFEDEYRSMTIKPMNVEYLMMDASILLPPT
                     GTPLTGIDFVKRLPCGDVEKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTD
                     DVLDLNNSDLIACTVITKDGGMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDM
                     QVTGVEDDSRALNITIHKPASSPHSKPFPILQATFVFSDHIRCIIAKQRLAKGRIQAR
                     RMKMQRIAALLDLPIQPTTEVLGFGLCSTSSQHLPFRFYEQCRRGSSDPTVQRSVFAS
                     VDKVPGFAVAQCINQHSSPSLSSPSPPFASGSPGGSGSTSHCDSGGSSSAPSATQSPA
                     DAPTTPEQPQPHLDQSVIGNEVDVNSKPSKNSSARSSEGETMHLSPSLLPAQQPTISL
                     LYEDTADTLSVESLTLVPPVDPHSLRALSGISQLPAMAAADSETPAEGAVSPEPAGPT
                     EH"
     exon            249..377
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            378..511
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            512..660
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            661..766
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            767..890
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1065
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1119
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1233
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1417
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1550
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1651
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1774
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1884
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1929
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..1980
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2109
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2230
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2382
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2587
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2752
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2911
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..6051
                     /gene="Clec16a"
                     /gene_synonym="RGD1305773"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccggctgaa tgtcagtgcg gggctgtggg ctggggatca aggtgcttgg cggtctctcc
       61 accgcccccg ccgctgccgg ctgggcttga gatgtcgcca cgagcaccgg gccgctgagc
      121 ggatcggaca tgaaaccgtg aggcaggcga cggggctggt ctgcggacat gtttggccgc
      181 tcacggagct gggtgggcgg gggccacggc aagtcctccc gcaacatcca ctccttggac
      241 cacctgaagt acctgtacca tgttttaacc aaaaacacca ctgtcacaga acagaaccgg
      301 aacctgcttg tggagaccat ccgttccatc actgagatcc tgatttgggg cgatcaaaat
      361 gacagctctg tgtttgactt cttcttggag aagaacatgt ttgttttctt cttgaacatt
      421 ctgcggcaga aatcaggccg ttatgtgtgt gtccagctgc tacagaccct gaacattctc
      481 tttgagaaca tcagccacga gacatcactc tattatttgc tgtctaataa ctatgtaaat
      541 tcgatcattg tccataaatt tgacttttcc gacgaggaga tcatggcgta ttatatatca
      601 ttcctgaaaa cactttcatt aaagctcaac aaccacactg tccatttctt ttacaatgag
      661 cacaccaatg actttgccct gtacacagaa gccatcaagt tcttcaatca tcctgaaagt
      721 atggttcgaa ttgctgtgag aaccatcacc ttgaatgtct acaaagtgga taatcaggcc
      781 atgctgcact acatcagaga caaaaccgct gtcccatact tctccaattt ggtctggttc
      841 attgggagcc acgtgattga acttgacaac tgtgtacaga cagatgagga gcaccggaat
      901 cgggggaagc tgagtgacct agtggctgag cacctggacc acctgcacta cctcaatgac
      961 atcctgatca tcaactgtga gttcctcaac gacgtgctca cagaccacct gctcaacagg
     1021 ctcttcctgc ctctctacgt ccactccctg gagaatcccg acaagggagg agaacggccg
     1081 aaaatcagcc tgcctgtgtc cctctatctt ctctcccagg tcttcctcat tatacatcat
     1141 gccccgctgg tgaactctct ggctgaagtc attctgaatg gcgatctgtc tgagacatat
     1201 acgaagcctg cacaggatgc tcccagaagt tctgccaagc ccagcatccg ttgcttcatt
     1261 aagcccactg agacactgga gcggtccctt gagatgaaca agcacaaggg caagaagcgg
     1321 atgcaaaaga gacccaacta caaaaacgtt ggggaggagg aagacgagga gagagggtct
     1381 gcagaagatg cccaggaaga cgctgagaag actaaagaga ttgagatggt gatcatgaag
     1441 cttggcaagc tctcagaggt ggccactgcc ggggcctcgg tgcaggagca gaacaccaca
     1501 gacgaggaga agagcgctgc cacgagctca gagaacgcac agtggagcag acccttcctg
     1561 gatatggtgt accatgccct ggacagccct gacgatgatt atcatgccct cttcgtgctc
     1621 tgcctcctct atgccatgtc tcataacaaa ggcatggatc ctgaaaaact aaaacgaatc
     1681 cagctcccag tgccaagtga agctgagaaa accacctaca accatctgct ggcagagaga
     1741 ctcatcagga tcatgaacaa tgctgcccaa ccagatggca ggatccggct ggctacactg
     1801 gagctgagct gcctgctcct gaagcagcaa gtactgacca gctctggctg tgtcatcaag
     1861 gatgtgcatc tggcctgcct ggagggtgca agagaagaga gtgtccacct tgtacgtcat
     1921 ttctataagg gagaagagat ttttttggac atgtttgaag atgaatacag gagcatgaca
     1981 ataaagccca tgaatgtaga gtatctcatg atggatgctt ccatcctcct gcccccaacg
     2041 ggcactccac tgactggcat cgactttgtg aagcggctgc catgtggtga tgtggagaag
     2101 acacggcggg ccatccgggt attcttcatg ctgcgatccc tgtcactgca gctgcgaggg
     2161 gaacctgaga cccagttgcc actgactcga gaggaggacc tgatcaaaac agacgatgtc
     2221 ttggatctga ataacagtga cttgattgca tgcacagtca tcaccaagga tggcggtatg
     2281 gtccagaggt tcctggctgt ggacatttac cagatgagcc tggtggagcc tgacgtgtcc
     2341 agactcggct ggggagtggt taagtttgct ggccttctgc aggacatgca ggtgacagga
     2401 gtggaggatg acagccgcgc cctgaacatc accatccaca agcctgcctc cagcccgcac
     2461 tctaagccct tccctatcct gcaggccacc tttgtgttct ctgaccacat ccgctgcatt
     2521 attgccaagc agcgcctagc caagggccgc atccaggcca ggcgcatgaa gatgcagagg
     2581 atagccgccc ttctggacct cccaatccag ccgacaacgg aagtcctggg atttggactc
     2641 tgctccacct cctcccagca cctgcccttc cgtttctatg agcagtgccg ccgaggcagc
     2701 agtgacccca cagtgcaacg ctctgtgttt gcgtcggtag acaaggtgcc aggctttgct
     2761 gtggcccagt gcataaacca gcatagctct ccgtccctgt catcgccctc accaccattt
     2821 gccagcggga gccccggtgg cagcgggagc accagccact gtgactcagg aggctcctcc
     2881 tctgcaccct cagcaactca gagcccggca gatgccccca caactccaga acagcctcag
     2941 cctcacctag accagtcagt gattgggaat gaagtagatg tcaactccaa gcccagcaag
     3001 aactcgtcag ccaggagctc tgaaggggag accatgcacc tgtcccccag cctcctcccc
     3061 gcccagcagc ccaccatctc cttgctctac gaggacactg ctgacacact gagtgttgag
     3121 tcgctgaccc ttgtcccccc cgtcgatccc cacagccttc gagccctctc tggcatctcc
     3181 cagctccccg caatggctgc agcagattcg gagaccccag ctgagggtgc tgtaagccca
     3241 gagcctgcgg gccccacaga gcactgagtg ggcaccagaa atctcctttt gtgtgtgtgg
     3301 cccgctggca gggacccctg tgcagtttgt gacagcaaga cacactggga acacccacaa
     3361 ttctccacac ccctgaaaac tgtcctttat acctctccct acaagacacc aagcaagcac
     3421 tcgtttgctc tgacctcttg ctgagcggac tgggatccta gcgacagcct cctgtgacag
     3481 acatggcatt ggccacctca gaggggtctg gggccctgac ccaaggggca ggacccactg
     3541 gctccctcct tcaggcagct cctctgtttt ctctcccagt ctgcacagaa gcggacaagg
     3601 ttactttgga tagaaatctg tggagatgca aacctaggta aacatctctt tgggctattt
     3661 atttctgttt tgggaaacag atgaagagat ttattttaaa agaatctatt ttgggggagg
     3721 ggcaaaaaaa aaaaagtcct caaccataag gctcggagtc acattagtgt cagctgtgaa
     3781 gattcccatc cttagaactt ctccatgttt ttattctgaa gttgtgggtg tcgcatcctc
     3841 cgtcttcctg agtgattctt ctttctctct ccccaactct gcaagcctct gagatgatga
     3901 agcctctccc tgaaacacgg aggcactttc aaaccaagtg agagacctgg atatgctcag
     3961 gttgcatggg gtgaggaggc cagaagcctc tgctcccacg tgacctgatg attctgctcc
     4021 ctgctcagga tgccaccttc tcttccttct ctcttcctcc aagaaagatc cattgacagg
     4081 aatcaaagga tttaaggcac agaaagtcat gctcagatgt aatcagcttc ccaagatgca
     4141 agtggatgcc cagctagggg cccagctgca aaacaggtga ccaaaagcag aatcccaccc
     4201 tttcccacac aatcctttcc cttgctgcca ccacacagct tatttatgaa aactccatat
     4261 ttctaggcat gtgccagcaa ggaccagatc tgtcccatgt ggccccagcc ttcctctgtg
     4321 ttcaccagcc aggtcaccac cccaggctcc atggcaatgc cctctatggc tctcctgtag
     4381 atttggcctc acagtttcag tatccatcaa aggagagata cacgggtacc cctcagacat
     4441 gtgtcactgt ctactcctcg ttagaccttg acactctgtt agctgatgtc actgcaagcc
     4501 ccaatgctca gtcttccaag gggccctggg aaggtagtga tgcccatgtg tactggcttc
     4561 tctggtcttt aaaagcactc ctgaaacaga aggctgggtc aggaagtgaa ccacccttgc
     4621 caccccaaag gccctggcaa agaagggctg taggacactt agcccctggg aagagaggag
     4681 agtgatggcc acggagaact agagctctct ggaccccaca gccaaccttg gttgtttctt
     4741 gctcatttgc agggaggggt agacaaagga gcaggctatc cctgtctcta ggacaactgt
     4801 acactacggg ttttgaaatg acagttgcta gggcagcgta aacgttatac aattcaagtg
     4861 actctccccc ctacagtgtg gtcttcagag aaaagcccat actgtacagg tcgccccatc
     4921 cttctgtgac tagcttcttt cttgccatcc agaggtttca aggaagggaa aagattgcat
     4981 ccaaggtggt cagcaaaccc tgagagggta gctgctatgt aaaattcacc aataacaagc
     5041 ctgtccccac agctggctcc caaagggttc ttgcagccag gagcctaaga catacctcca
     5101 ggtgagcaaa gatggacttc ctatgaccag agttatgacc cattgctgat gaagggtggg
     5161 gtcctggaag aagcaacagg acctcgggac ccagaaggag gacactttct cacctaaatc
     5221 ttggtggcaa tggatacaac ccagtcttca ggagcactct gctaacttgg cagctgtgct
     5281 ctccagacag acctagccag tgagaaccca ctgagtctca gtaggactaa gggataccag
     5341 gtccagtagt cccacagctc ctgacctgga ggtcccagag tcagcctcca aaatcattgt
     5401 cccatctccc aggccatgca ttctatgtct gccctggtca ccctccagtc tgcaactgcc
     5461 ccagggcaga ctagcagagc tggcctctaa atccctcacc ctagctttga tggtcaccat
     5521 ggagacgtac agtactgcct cctccttttt ggagtcttag gcatgtggga cacttcccac
     5581 aggtcagact cagtgtagca gtgagctcct tatttggtgg aagtggtgga agaggcttcc
     5641 agagctgacc cctctctgct gctctaccca cccagacagt tgcattgcca gaagctggct
     5701 ggctgcatcc taaggatggt actggctttc tctgtggcct ctgaaatgct gttgtacata
     5761 aggcgtgggt aaaccaagtc tgatcttttg tagatgcaat aaatatattt cacacagtca
     5821 caatgggcag aaggttaaat gtttcttccc tccctcagag ctgaagctgt gaggaaaaag
     5881 gggggagagg ggggcaagga ggctgagctg ggagggtccg gccagggaag tgcctgcgcc
     5941 tgccagcagg actcatactc tgtggggact gaacctgagg ggaggaatga aagctagaac
     6001 tttcttgtaa tttgaaactt ggcaataaaa agcaaaacca atggcccagg a
//
