LOCUS       NM_001006955            2145 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus claudin domain containing 1 (Cldnd1), mRNA.
ACCESSION   NM_001006955 XM_213635
VERSION     NM_001006955.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Matsuoka,H., Tamura,A., Kinehara,M., Shima,A., Uda,A., Tahara,H.
            and Michihara,A.
  TITLE     Levels of tight junction protein CLDND1 are regulated by
            microRNA-124 in the cerebellum of stroke-prone spontaneously
            hypertensive rats
  JOURNAL   Biochem Biophys Res Commun 498 (4), 817-823 (2018)
   PUBMED   29530526
  REMARK    GeneRIF: When miR-124 is increased, CLDND1 mRNA translation is
            downregulated in the brain.
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Mineta,K., Yamamoto,Y., Yamazaki,Y., Tanaka,H., Tada,Y., Saito,K.,
            Tamura,A., Igarashi,M., Endo,T., Takeuchi,K. and Tsukita,S.
  TITLE     Predicted expansion of the claudin multigene family
  JOURNAL   FEBS Lett 585 (4), 606-612 (2011)
   PUBMED   21276448
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 11, 2015 this sequence version replaced NM_001006955.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083649.1, SRR26360181.1451780.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000011.1  55358481-55358672   c
            193-502             JAXUCZ010000011.1  55356814-55357123   c
            503-613             JAXUCZ010000011.1  55355134-55355244   c
            614-751             JAXUCZ010000011.1  55353826-55353963   c
            752-2145            JAXUCZ010000011.1  55352321-55353714   c
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2145
                     /gene="Cldnd1"
                     /note="claudin domain containing 1"
                     /db_xref="GeneID:288182"
                     /db_xref="RGD:1359273"
     exon            1..192
                     /gene="Cldnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..502
                     /gene="Cldnd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..972
                     /gene="Cldnd1"
                     /codon_start=1
                     /product="claudin domain-containing protein 1"
                     /protein_id="NP_001006956.2"
                     /db_xref="GeneID:288182"
                     /db_xref="RGD:1359273"
                     /translation="MDNRFATAFVIACVLSLISTIYMAASIGTDFWYEYQSPAQENSS
                     DANRIAWEDFMGDEADEKTYNDALFRYNGNLGLWRRCITIPKNTHWYAPPERTESFEV
                     VTKCMSFTLNEQFMEKYVDPGNHNSGIDLLRTYLWRCQFLLPFVSLGLMCFGALIGLC
                     ACVCRSLYPTIATGILHLLAGLCTLGSVSCYVAGIELLHQKLGLPKNVSGEFGWSFCL
                     ACVSAPLQFMASALFIWAAHTNRKEYTLMKAYRVA"
     exon            503..613
                     /gene="Cldnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..751
                     /gene="Cldnd1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..2145
                     /gene="Cldnd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcctacaa gtcccacaag gcccctcggc tcagggccgc tttggcccgg cctagggtgg
       61 aggcggaggc ggaggcgcgg gagttatgga gggggcgggc tctgcaggga agtgcgtcag
      121 aggaggcgcg gggagagtag gttgctgtgg tcggagctgg agggcgaagc cggtggagtg
      181 agaggatggg cgagcagtct gaatgccaga atggataacc gtttcgctac agcctttgtg
      241 attgcctgtg tgcttagtct tatctccacc atctacatgg ccgcctccat aggcacagac
      301 ttctggtatg agtatcaaag tcctgctcaa gagaattcta gtgatgcgaa tagaattgcc
      361 tgggaagatt tcatgggcga tgaggcggat gagaagacct acaacgatgc tctgttccgg
      421 tacaacggca acttgggatt gtggagacgc tgtatcacca ttcccaaaaa cactcactgg
      481 tatgctccgc cggaaaggac agagtcattt gaagtggtta caaaatgcat gagtttcaca
      541 ctaaacgaac agttcatgga gaagtatgtt gatcctggaa accacaacag tggcattgac
      601 ctgcttcgga cctacctctg gcgctgccag ttcctcttac cgtttgttag cttgggtctg
      661 atgtgcttcg gggctttgat tggactttgt gcctgtgtgt gccgcagcct gtaccccacc
      721 attgccacag gcattctcca tctccttgca ggtctgtgta cgctgggctc cgtgagttgt
      781 tatgttgctg gcattgagct gctccatcag aaactagggc tgcccaagaa cgtatctggg
      841 gaatttggat ggtccttctg cctggcctgc gtctcagctc ccttacagtt catggcttct
      901 gctctcttca tctgggctgc ccacaccaac cggaaggagt acaccttaat gaaggcttat
      961 cgtgtggcgt gaagggaggc tgccgccgat gattactatt tctactattt cttttttact
     1021 gttgaggttt tcccttgtct tcctctcagt tgtctttaat ttttattttt gtggatacgc
     1081 cattttattc taaaagtcct ttttatttat atacagtgcc actaaatacc atttaaaatg
     1141 tatgtggttt tctttgagtg gctcagtcat tttaccaaac tgatctaggt tcagtcagag
     1201 ttcagacaga aagaacttta gagatgtgac ccagatttgt aaaagaatat tagcagtgga
     1261 aaattgaccc caaacagggt ctgctaatgt ctgctaaatc cagtagtgta gtaactgtgt
     1321 gtgaaactag aaacgaattt ctgtatgata tcggttatca ctgtcagaac ttcataatca
     1381 ctttcctgta tttagtcagc tagcagaacc agcgttccta aagatgtgtg catacaaaat
     1441 tgggaaatta tctaacatct gtgtccctaa actttggtac attacttcat tcgaggtgaa
     1501 atatggcagc tgcttatact gtgattgtct acaagaaaaa aaagtgaaaa atgtttactt
     1561 gaaattgtag cttttaactg caaaatttca attcaatgag aaaagctggt tatacttttt
     1621 ttttttttaa aactgaaact cattaggatt ttcagtgcca ccaaaccatt gtggattttt
     1681 gctgctcccc cctcccccca tctggacaca ccaggcttat taaagagtac tttcttttta
     1741 acggagaaga atcacagcca attccccaac tgttttgtcc cagctgagta ctatatggga
     1801 ggtcctatca atatcgaccc cccagagctg ggggtcctac caccacaaga tctaaagctg
     1861 tggccaccta ctgacctcca gttgtgggtc tttatttctt gtggtgaaat gatgtgcctt
     1921 tccttgccca gatcccttcc tggtgtgtat caacattact cactgtcttc taattcagtc
     1981 atttttttat aatatgtctg taaacattga acttacaaat cttatttatt tactccatta
     2041 ttgtagcact tcacagatta aaaaaagtgt gactcagtac tttcttacca aatcctaaat
     2101 ctgtcttttt taaaaaataa aaaataaaaa agaaagagaa ccatg
//
