LOCUS       NM_031702               1215 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus claudin 7 (Cldn7), mRNA.
ACCESSION   NM_031702 XM_006246805
VERSION     NM_031702.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Thuma,F., Heiler,S., Schnolzer,M. and Zoller,M.
  TITLE     Palmitoylated claudin7 captured in glycolipid-enriched membrane
            microdomains promotes metastasis via associated transmembrane and
            cytosolic molecules
  JOURNAL   Oncotarget 7 (21), 30659-30677 (2016)
   PUBMED   27120791
  REMARK    GeneRIF: Pancreatic adenocarcinoma cell line ASMLL-claudin7 (cld7)
            knockdown (kd) and ASML-cld7 mutated palmitoylation cells show
            reduced motility and invasiveness.
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Thuma,F. and Zoller,M.
  TITLE     EpCAM-associated claudin-7 supports lymphatic spread and drug
            resistance in rat pancreatic cancer
  JOURNAL   Int J Cancer 133 (4), 855-866 (2013)
   PUBMED   23390083
  REMARK    GeneRIF: cld7 supports tumorigenic features of EpC by provoking EpC
            cleavage and thereby its cotranscription factor activity
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Poon,C.E., Madawala,R.J., Day,M.L. and Murphy,C.R.
  TITLE     Claudin 7 is reduced in uterine epithelial cells during early
            pregnancy in the rat
  JOURNAL   Histochem Cell Biol 139 (4), 583-593 (2013)
   PUBMED   23180307
  REMARK    GeneRIF: claudin 7 demonstrates a distinct basal and lateral
            localisation in the uterine luminal and glandular epithelium
            throughout early pregnancy
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Lu,J., Zhang,S., Nakano,H., Simmons,D.G., Wang,S., Kong,S.,
            Wang,Q., Shen,L., Tu,Z., Wang,W., Wang,B., Wang,H., Wang,Y., van
            Es,J.H., Clevers,H., Leone,G., Cross,J.C. and Wang,H.
  TITLE     A positive feedback loop involving Gcm1 and Fzd5 directs chorionic
            branching morphogenesis in the placenta
  JOURNAL   PLoS Biol 11 (4), e1001536 (2013)
   PUBMED   23610556
REFERENCE   5  (bases 1 to 1215)
  AUTHORS   Guillemot,L., Schneider,Y., Brun,P., Castagliuolo,I., Pizzuti,D.,
            Martines,D., Jond,L., Bongiovanni,M. and Citi,S.
  TITLE     Cingulin is dispensable for epithelial barrier function and tight
            junction structure, and plays a role in the control of claudin-2
            expression and response to duodenal mucosa injury
  JOURNAL   J Cell Sci 125 (Pt 21), 5005-5014 (2012)
   PUBMED   22946046
REFERENCE   6  (bases 1 to 1215)
  AUTHORS   Tatum,R., Zhang,Y., Lu,Q., Kim,K., Jeansonne,B.G. and Chen,Y.H.
  TITLE     WNK4 phosphorylates ser(206) of claudin-7 and promotes paracellular
            Cl(-) permeability
  JOURNAL   FEBS Lett 581 (20), 3887-3891 (2007)
   PUBMED   17651736
  REMARK    GeneRIF: Wnk4 phosphorylates ser(206) of Cldn7 and promotes
            paracellular Cl-ion permeability.
REFERENCE   7  (bases 1 to 1215)
  AUTHORS   Yovchev,M.I., Grozdanov,P.N., Joseph,B., Gupta,S. and Dabeva,M.D.
  TITLE     Novel hepatic progenitor cell surface markers in the adult rat
            liver
  JOURNAL   Hepatology 45 (1), 139-149 (2007)
   PUBMED   17187413
  REMARK    GeneRIF: We identified novel cell surface markers specific for
            hepatic progenitor/oval cells. Six are unique for the adult
            progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
REFERENCE   8  (bases 1 to 1215)
  AUTHORS   Fujita,H., Chiba,H., Yokozaki,H., Sakai,N., Sugimoto,K., Wada,T.,
            Kojima,T., Yamashita,T. and Sawada,N.
  TITLE     Differential expression and subcellular localization of claudin-7,
            -8, -12, -13, and -15 along the mouse intestine
  JOURNAL   J Histochem Cytochem 54 (8), 933-944 (2006)
   PUBMED   16651389
REFERENCE   9  (bases 1 to 1215)
  AUTHORS   Ladwein,M., Pape,U.F., Schmidt,D.S., Schnolzer,M., Fiedler,S.,
            Langbein,L., Franke,W.W., Moldenhauer,G. and Zoller,M.
  TITLE     The cell-cell adhesion molecule EpCAM interacts directly with the
            tight junction protein claudin-7
  JOURNAL   Exp Cell Res 309 (2), 345-357 (2005)
   PUBMED   16054130
  REMARK    GeneRIF: An association between claudin-7 and EpCAM/Tacstd1 is
            noted in rat and human tumors and in non-transformed tissues of the
            gastrointestinal tract.
REFERENCE   10 (bases 1 to 1215)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_006246805.3, NM_031702.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159404.1, BQ195179.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               JAXUCZ010000010.1  55188670-55189291
            623-787             JAXUCZ010000010.1  55190079-55190243
            788-872             JAXUCZ010000010.1  55190355-55190439
            873-1215            JAXUCZ010000010.1  55190529-55190871
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1215
                     /gene="Cldn7"
                     /gene_synonym="cld-7"
                     /note="claudin 7"
                     /db_xref="GeneID:65132"
                     /db_xref="RGD:68432"
     exon            1..622
                     /gene="Cldn7"
                     /gene_synonym="cld-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1035
                     /gene="Cldn7"
                     /gene_synonym="cld-7"
                     /codon_start=1
                     /product="claudin-7"
                     /protein_id="NP_113890.1"
                     /db_xref="GeneID:65132"
                     /db_xref="RGD:68432"
                     /translation="MANSGLQLLGFSMAMLGWVGLIASTAIPQWQMSSYAGDNIITAQ
                     AMYKGLWMECVTQSTGMMSCKMYDSVLALPAATQATRALMIVSLVLGFLAMFVATMGM
                     KCTRCGGDDKVKKARIAMTGGIIFIVAGLAALVACSWIGHQIVTDFYNPLTPMNIKYE
                     FGPAIFIGWAGSALVLLGGALLSCSCPGSESKAAYRAPRSYPKSNSSKEYV"
     exon            623..787
                     /gene="Cldn7"
                     /gene_synonym="cld-7"
                     /inference="alignment:Splign:2.1.0"
     exon            788..872
                     /gene="Cldn7"
                     /gene_synonym="cld-7"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1215
                     /gene="Cldn7"
                     /gene_synonym="cld-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgccgactt caccgcctgc tccttcgctg cgcaccgcag cccgggaccc aagggcccgc
       61 agactttctg gggccacgcc ctaacagccc ctccacttct tggggaagtc tcagagcacg
      121 cctgagggaa ccgcctggcc ttcggggacc gcttttgtct ggaaccagtc cttcgagcga
      181 agccggttcc ctcagttgtg agagtgtcgc ttcaccggag gggacgattt gtgtttggct
      241 cggttaacaa gatttttagt tacccggtca aaaaaatttt ttttctcctc tgggtgactt
      301 aaatctctat acaaaatttc ttgtgtggct gctccccaga tttttgtttt actatagggt
      361 cgccctcccg gcgcgtccca tcttttctga gacaaggaaa tggctaactc gggcctgcaa
      421 ctactgggct tttcaatggc catgcttggc tgggtgggtc tgatagcgag cactgctatc
      481 ccacagtggc agatgagctc ctatgcaggc gacaacatca tcacagccca ggccatgtac
      541 aaggggctct ggatggagtg tgtcacgcag agtaccggca tgatgagctg caaaatgtac
      601 gactcggtgc ttgccctgcc agcggccacg caggccactc gagccttaat gattgtgtcc
      661 ttggtgttgg gcttcttggc catgtttgtc gccacgatgg gcatgaaatg cacacgctgt
      721 gggggagatg acaaagtgaa gaaggcccgc atagctatga ctggaggcat tattttcatc
      781 gtggcaggtc ttgctgcttt ggtagcatgc tcctggattg gtcatcagat tgtcacagac
      841 ttttataacc ccttgacgcc catgaatatt aagtacgagt ttggtcctgc catctttatc
      901 ggctgggcag ggtctgctct ggtccttctg ggaggggccc tgctctcttg ctcctgcccc
      961 ggcagtgaaa gcaaagctgc ataccgtgca ccccgctcct accctaagtc caactcctct
     1021 aaggaatacg tgtgagctgg ggaccccagc ctgtgggcaa ggtgtgaggc aaaggcctcc
     1081 tggtcactcc accgccaaac accatgtata gttccctgtg ggaggggggg gagggccgag
     1141 gggggtgggt gggagaggaa gacaaaacat ggggagggtg tgcttttgta cagtaataaa
     1201 attaagtttt ggaaa
//
