LOCUS       NM_001012022            1824 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Rattus norvegicus claudin 4 (Cldn4), mRNA.
ACCESSION   NM_001012022 XM_222090
VERSION     NM_001012022.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Jie,H., Jie,W., Yingxue,G., Xin,Z., Runnan,X., Wenjie,H.,
            Jianxiong,M. and Bodong,L.
  TITLE     Cldn4 overexpression promotes penile cavernous smooth muscle cell
            fibrotic response via the JNK signaling pathway
  JOURNAL   J Sex Med 21 (6), 511-521 (2024)
   PUBMED   38477100
  REMARK    GeneRIF: Cldn4 overexpression promotes penile cavernous smooth
            muscle cell fibrotic response via the JNK signaling pathway.
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Ren,Q., Xu,Y., Xu,L., Lu,Y. and Zheng,Y.
  TITLE     Hypoxic bone marrow mesenchymal stem cell-derived exosomal lncRNA
            XIST attenuates lipopolysaccharide-induced acute lung injury via
            the miR-455-3p/Claudin-4 axis
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111066 (2023)
   PUBMED   37866316
  REMARK    GeneRIF: Hypoxic bone marrow mesenchymal stem cell-derived exosomal
            lncRNA XIST attenuates lipopolysaccharide-induced acute lung injury
            via the miR-455-3p/Claudin-4 axis.
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Xu,X., Zhang,X., Gao,L., Liu,C. and You,K.
  TITLE     Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1
            Expression in Rat Kidney Accompanied by Impaired Proximal Tubular
            Development
  JOURNAL   Oxid Med Cell Longev 2020, 2641461 (2020)
   PUBMED   33343804
  REMARK    GeneRIF: Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and
            ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal
            Tubular Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Berndt,P., Winkler,L., Cording,J., Breitkreuz-Korff,O., Rex,A.,
            Dithmer,S., Rausch,V., Blasig,R., Richter,M., Sporbert,A.,
            Wolburg,H., Blasig,I.E. and Haseloff,R.F.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Jo,C.H., Kim,S., Oh,I.H., Park,J.S. and Kim,G.H.
  TITLE     Alteration of Tight Junction Protein Expression in Dahl
            Salt-Sensitive Rat Kidney
  JOURNAL   Kidney Blood Press Res 42 (6), 951-960 (2017)
   PUBMED   29179201
  REMARK    GeneRIF: Both upregulation of claudin-4 and downregulation of
            occludin might increase paracellular NaCl transport in the kidney,
            resulting in impaired pressure natriuresis in SS rats.
REFERENCE   6  (bases 1 to 1824)
  AUTHORS   Kondoh,M., Masuyama,A., Takahashi,A., Asano,N., Mizuguchi,H.,
            Koizumi,N., Fujii,M., Hayakawa,T., Horiguchi,Y. and Watanbe,Y.
  TITLE     A novel strategy for the enhancement of drug absorption using a
            claudin modulator
  JOURNAL   Mol Pharmacol 67 (3), 749-756 (2005)
   PUBMED   15602007
  REMARK    GeneRIF: Clostridium enterotoxin enhances the absorption of dextran
            in rat jejunum, apparently through interactions with claudin-4.
REFERENCE   7  (bases 1 to 1824)
  AUTHORS   Tsukahara,M., Nagai,H., Kamiakito,T., Kawata,H., Takayashiki,N.,
            Saito,K. and Tanaka,A.
  TITLE     Distinct expression patterns of claudin-1 and claudin-4 in
            intraductal papillary-mucinous tumors of the pancreas
  JOURNAL   Pathol Int 55 (2), 63-69 (2005)
   PUBMED   15693851
REFERENCE   8  (bases 1 to 1824)
  AUTHORS   Peppi,M. and Ghabriel,M.N.
  TITLE     Tissue-specific expression of the tight junction proteins claudins
            and occludin in the rat salivary glands
  JOURNAL   J Anat 205 (4), 257-266 (2004)
   PUBMED   15447685
REFERENCE   9  (bases 1 to 1824)
  AUTHORS   Acharya,P., Beckel,J., Ruiz,W.G., Wang,E., Rojas,R., Birder,L. and
            Apodaca,G.
  TITLE     Distribution of the tight junction proteins ZO-1, occludin, and
            claudin-4, -8, and -12 in bladder epithelium
  JOURNAL   Am J Physiol Renal Physiol 287 (2), F305-F318 (2004)
   PUBMED   15068973
REFERENCE   10 (bases 1 to 1824)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083582.1.
            
            On Feb 11, 2005 this sequence version replaced XM_222090.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC083582.1, DN932106.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1824
                     /gene="Cldn4"
                     /note="claudin 4"
                     /db_xref="GeneID:304407"
                     /db_xref="RGD:1307932"
     exon            1..1799
                     /gene="Cldn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..824
                     /gene="Cldn4"
                     /codon_start=1
                     /product="claudin-4"
                     /protein_id="NP_001012022.1"
                     /db_xref="GeneID:304407"
                     /db_xref="RGD:1307932"
                     /translation="MASMGLQVLGISLAVLGWLGVILSCSLPMWRVTAFIGSNIVTAQ
                     TSWEGLWMNCVVQSTGQMQCKMYDSMLALPQDLQAARALMVISIIVGALGMLLSVVGG
                     KCTNCMEDETVKAKVMITAGAVFIVASMLIMVPVSWTAHNVIRDFYNPLVASGQKREM
                     GASLYIGWAASGLLLLGGGLLCCNCPPRRNEKPYSAKYSAARSVPASNYV"
ORIGIN      
        1 ccgctcccaa ttgcaggtgc gggctggaaa gagctgcagt gttcgcgctt ggtagctggt
       61 ggaccgggct cagcaccttc ggctggcttt gtgtcccaga ggctcaccgg aaaaagactt
      121 tctcagccct cggactccag agagagatac ttttcgtgct ccccaacctt gactcctgca
      181 gaagctgagc gatggcgtcc atggggctgc aggtgctggg aatctccttg gccgtcctgg
      241 gctggttagg agtcatcctg agttgttcgc tccccatgtg gcgggtgacc gccttcatcg
      301 gcagcaacat cgtcacggcg cagacgagct gggaaggcct gtggatgaac tgcgtggtgc
      361 agagcaccgg ccagatgcag tgcaagatgt acgactcgat gctggccctg ccgcaggacc
      421 tgcaggccgc ccgagccctg atggtcatca gcatcatcgt gggtgctctg gggatgcttc
      481 tctcagtcgt agggggcaag tgcaccaact gcatggagga cgagaccgtc aaggccaagg
      541 tcatgatcac agccggagcc gtgttcatcg tggcaagcat gctgattatg gtgcctgtgt
      601 cctggacggc acacaacgtc atccgcgact tctacaaccc tctggtggct tccgggcaga
      661 aaagggagat gggggcctcg ctttacatcg gctgggcggc ttctgggctg ctgctcctgg
      721 gaggaggcct cctctgctgc aattgcccac ctcgccgcaa cgaaaagccc tactccgcca
      781 agtactccgc cgcccgctct gttcccgcca gcaactatgt gtaaggtggg ccactctctg
      841 tccacattgc ctttattttc ttggattgaa ctcataacgg cctgtggccc ctcacattct
      901 ccaggacctg accagctgtg ggctactgac tgcttgcaaa cccggactgt gctaagttac
      961 tagcgtgtag cccttgggga cccacctggc ccatctggac acatctcaag gctccagcga
     1021 ggatagatgt aaaaatattt ccttgcttgc atccagattg ctcatggata cggggctgaa
     1081 ggcagaagca gctgtctggg tacgacagtg gagggggagc tgggtcctgc tggccgggat
     1141 agctcagctg tgactttggt ctctggagtg gatgtcctgg tcatgttagc aaacattcac
     1201 tgccctttct cagtgccctc gctctctcgc ctccacgtta ctcccgcgct actcttgccg
     1261 tttctcgccc gcgtttctga gcacaccagg tcctgcctgg agtcttggtg tcgaggatga
     1321 ctgactgaag gggcctttga gagctgatgg gttctgccat ggactcctcc cggtgattag
     1381 caatgactgg ggccttaccc acccacctac cctcgtaatg aagttctgtg gagtggctgg
     1441 acaggtttga gggaagggtg gaggtggttt aaactggttt ggggagtgct agggctgggg
     1501 acccagaagc agcccagggt gtccccaccc ctttcccata cggtcttgct aaatgttctg
     1561 atctctgtat accccctccc tcttcagaag gaccctgggt gggcccctct gaattcccta
     1621 cccttgtcca tttcaaggac gctggccagt ctgtggaagg tacgggggtc tgatggcatt
     1681 gcaccaggga gcctcctgga ctcccttgcc ttctctgtgg tttcttgttt tgtaatttaa
     1741 ggtctgttca cagctgtaat tattattttc tacaataaat ggcacctgca tacaggaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaa
//
