LOCUS       NM_001106846            3052 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus claudin 2 (Cldn2), mRNA.
ACCESSION   NM_001106846 XM_001054180 XM_236535
VERSION     NM_001106846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Rosas-Martinez,L., Rodriguez-Munoz,R., Namorado-Tonix,M.D.C.,
            Missirlis,F., Del Valle-Mondragon,L., Sanchez-Mendoza,A.,
            Reyes-Sanchez,J.L. and Cervantes-Perez,L.G.
  TITLE     Hyperglycemic levels in early stage of diabetic nephropathy affect
            differentially renal expression of claudins-2 and -5 by oxidative
            stress
  JOURNAL   Life Sci 268, 119003 (2021)
   PUBMED   33417957
  REMARK    GeneRIF: Hyperglycemic levels in early stage of diabetic
            nephropathy affect differentially renal expression of claudins-2
            and -5 by oxidative stress.
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   Montalbetti,N., Rued,A.C., Clayton,D.R., Ruiz,W.G., Bastacky,S.I.,
            Prakasam,H.S., Eaton,A.F., Kullmann,F.A., Apodaca,G. and
            Carattino,M.D.
  TITLE     Increased urothelial paracellular transport promotes cystitis
  JOURNAL   Am J Physiol Renal Physiol 309 (12), F1070-F1081 (2015)
   PUBMED   26423859
  REMARK    GeneRIF: While the integrity of the urothelial barrier was
            preserved in the rats transduced with CLDN-2, we found that the
            expression of this protein in the umbrella cells initiated an
            inflammatory process
REFERENCE   3  (bases 1 to 3052)
  AUTHORS   Molina-Jijon,E., Rodriguez-Munoz,R., Namorado Mdel,C.,
            Pedraza-Chaverri,J. and Reyes,J.L.
  TITLE     Oxidative stress induces claudin-2 nitration in experimental type 1
            diabetic nephropathy
  JOURNAL   Free Radic Biol Med 72, 162-175 (2014)
   PUBMED   24726862
  REMARK    GeneRIF: We suggest that loss of claudin-2 is associated with
            increased natriuresis in experimental type 1 diabetic nephropathy
REFERENCE   4  (bases 1 to 3052)
  AUTHORS   Yatabe,M.S., Yatabe,J., Takano,K., Murakami,Y., Sakuta,R., Abe,S.,
            Sanada,H., Kimura,J. and Watanabe,T.
  TITLE     Effects of a high-sodium diet on renal tubule Ca2+ transporter and
            claudin expression in Wistar-Kyoto rats
  JOURNAL   BMC Nephrol 13, 160 (2012)
   PUBMED   23199000
  REMARK    GeneRIF: Chronic high-salt diet for 8 weeks in Wistar-Kyoto rats
            decreases claudin-2 protein expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3052)
  AUTHORS   Westmoreland,J.J., Drosos,Y., Kelly,J., Ye,J., Means,A.L.,
            Washington,M.K. and Sosa-Pineda,B.
  TITLE     Dynamic distribution of claudin proteins in pancreatic epithelia
            undergoing morphogenesis or neoplastic transformation
  JOURNAL   Dev Dyn 241 (3), 583-594 (2012)
   PUBMED   22275141
REFERENCE   6  (bases 1 to 3052)
  AUTHORS   Imamura,M., Kojima,T., Lan,M., Son,S., Murata,M., Osanai,M.,
            Chiba,H., Hirata,K. and Sawada,N.
  TITLE     Oncostatin M induces upregulation of claudin-2 in rodent
            hepatocytes coinciding with changes in morphology and function of
            tight junctions
  JOURNAL   Exp Cell Res 313 (9), 1951-1962 (2007)
   PUBMED   17434483
  REMARK    GeneRIF: These results suggest that expression of claudin-2 in
            rodent hepatocytes may play a specific role as controlling the size
            of paracellular permeability in the barrier to keep bile in bile
            canaculi.
REFERENCE   7  (bases 1 to 3052)
  AUTHORS   Ohta,H., Adachi,H. and Inaba,M.
  TITLE     Developmental changes in the expression of tight junction protein
            claudins in murine metanephroi and embryonic kidneys
  JOURNAL   J Vet Med Sci 68 (2), 149-155 (2006)
   PUBMED   16520537
REFERENCE   8  (bases 1 to 3052)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   9  (bases 1 to 3052)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   10 (bases 1 to 3052)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1, CB696787.1, CB790981.1, CV120097.1, CO392895.1,
            CB808365.1, CB806944.1 and BM392116.1.
            
            On Mar 4, 2008 this sequence version replaced NM_001106846.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no quality transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1686209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000021.1  108248513-108248563
            52-156              CB696787.1         53-157
            157-166             JAXUCZ010000021.1  108248669-108248678
            167-174             JAXUCZ010000021.1  108255979-108255986
            175-281             CB696787.1         176-282
            282-659             CB790981.1         59-436
            660-1256            CV120097.1         113-709
            1257-1713           CO392895.1         103-559
            1714-1715           JAXUCZ010000021.1  108257526-108257527
            1716-1885           CO392895.1         562-731
            1886-2025           CB808365.1         82-221
            2026-2243           JAXUCZ010000021.1  108257838-108258055
            2244-2511           CB806944.1         20-287
            2512-3052           BM392116.1         1-541               c
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq32"
     gene            1..3052
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /note="claudin 2"
                     /db_xref="GeneID:300920"
                     /db_xref="RGD:1560247"
     exon            1..166
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /inference="alignment:Splign:2.1.0"
     exon            167..3035
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1041
                     /gene="Cldn2"
                     /gene_synonym="RGD1560247"
                     /codon_start=1
                     /product="claudin-2"
                     /protein_id="NP_001100316.1"
                     /db_xref="GeneID:300920"
                     /db_xref="RGD:1560247"
                     /translation="MASLGVQLVGYILGLLGLLGTSIAMLLPNWRTSSYVGASIVTAV
                     GFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAMSSLACIISVVGM
                     RCTVFCQESRAKDRVAVVGGVFFILGGILGFIPVAWNLHGILRDFYSPLVPDSMKFEI
                     GEALYLGIISALFSLVAGVILCFSCSPQGNRTNYYDGYQAQPLATRSSPRSAQQPKAK
                     SEFNSYSLTGYV"
ORIGIN      
        1 agaaggctca gatttacagg tggattttac aaagctgtgg ctaataatta gaaatccctt
       61 atcaccacag cccgtggccc cttggaccca gttcaccttt ccctggacct agtcctcttt
      121 tccgctggag catctctccc agagcccttc gagaaagaac agctccgttt tctagatgcc
      181 ttcttgagcc tgcttgtggc cacccacaga tacttgtaag gaggaaagaa gtcagcttgc
      241 cagagacact gtgaaatgag ggattagagg ccgggatcca agaaacaaga gccgcagcca
      301 aaagacaagc gaacaggttc cgaagatact tctactgaga ggtctgccat ggcctccctt
      361 ggcgtccaac tggtgggcta catcctaggc cttttggggc tattaggcac atcgattgcc
      421 atgctgctcc ccaactggcg aacaagttct tatgttggtg ccagcattgt gacggcggtt
      481 ggcttttcca agggcctctg gatggagtgt gcgacccaca gcactggcat cacccagtgt
      541 gatatctaca gtactctttt aggacttcct gctgacatcc aggctgccca ggccatgatg
      601 gtgacatcca gtgcaatgtc ctcgctggcc tgcattatct ctgtggtggg catgagatgc
      661 acagtgttct gccaggaatc tcgagctaag gacagagtgg ctgtagtggg tggagtcttt
      721 ttcatccttg gtggtatcct gggttttatc ccagttgctt ggaatcttca cggcattctc
      781 cgggacttct actcaccact ggtccctgac agcatgaaat ttgagattgg agaagctctg
      841 tacttgggaa tcatttcagc gctgttttcc ttggtagctg gagtcatcct ctgcttttcc
      901 tgctcacctc agggaaatcg taccaactac tatgatggct accaggccca gcctcttgcc
      961 actaggagct ctccaagatc tgctcaacag cccaaagcca agagtgagtt caactcatac
     1021 agcctgactg ggtatgtgtg aagaaccagg ggccagagct gggggtgggg tggggtggtg
     1081 gctgggacta taaaaatagt agtggacaat gcccccaggg ttacaggcaa aggacattgc
     1141 cattgaatca tgtgtaaggt gctgctgagg gtagaatgac tttggccatt ggatgaagta
     1201 aaggcagaga tgagaacagg ggtgacagca tgtacatcga attgccaagg acacttatca
     1261 agcgagcttt tctatttctt ttctcactaa ggcaccttct gtgccctgaa tgctcaaccc
     1321 aaaagtctaa atcccattgc tgccactttt tgctatgccc agaggctctc ttctgccctt
     1381 tggtttactt ggagatctgt tccccaacca atcatattcc attgactaac catctgtgat
     1441 caaaagacct tctccctctg gctgaaattg gctcttgact caaatactag gggacagaga
     1501 gaagaaagag gggtggcttc tgcgagaatg tttctagctc ccttctcaca tctccagcca
     1561 aagaaatgga ttggtcagtt ataggccctg aagcctctct tccagttttg ctatgagtgc
     1621 aatatgtcca gactggtttg ggaaggaact gaaggaaagc tatctcatgg catcccacag
     1681 aaagcagctg agtataggat gggaggcaac ctgggctcca aagaaacaaa aacaaacaac
     1741 aaagcccacc agaatcactt ctcagatcat ctcctctaat tgccacccat ttgtgggtca
     1801 ggaatggaag cactgctaca ggaagacagt agaggcatac agaaagctga aggctgcagc
     1861 cccctcactc caccgaggac tggccaagaa gctgaagtga actaccgctc aaagtgctgt
     1921 ctcccactga ggtgtctgac ccagcttcct gataaaccac aagacttgga gccctagaca
     1981 agggtttcct tagggacaat aaagcagttt ttctagaact gccctttgac atgggagcag
     2041 cagagggcta aaaggactct ttagccctgg ccaaaaacga atggggactt tggtatggaa
     2101 gaactgctgg gcagagatgc atggtaggtg tgtgtgctcc tactgttttg gagaggcaac
     2161 cctaccagat actttagact tgttgggaaa aacaacctat ctgggtcttt actcagcact
     2221 acagagcctc tgaaaggcca cagcatcaga gaggtccttt gtcactttta atattcgagt
     2281 catcgcccat cagaagatat tcttacaggt atgcaaagtc ttcagtgtgg aacatctttt
     2341 gaccaaggtg ttgtgttcat gacctgagtg attggtgaac ttctgcctgg gattgtgatt
     2401 gaggtgggag gacagagact ggttctcagt gcaacactcc atggtcttaa aatgctccgt
     2461 tttcctctgt ggtagatggg ggtcagaatc tagagacatt aaccccaaca gcctaatagc
     2521 accaacttca gaagattccc agcacacctc atcaaaactt cagcagcggc aagagaggcc
     2581 catatgtgag gtttccttta acacgccttt cctatttcca ccatattact tgggttcaag
     2641 ctgttatgct gacctggaag ccatttcatc cccatgcttg gagaacttgc tcaccgtcat
     2701 ccccttcatt gagccttctc taatcactcc ttcctgccct tcccctcctc caattcccaa
     2761 tatataaatt gcttaatcct tatcattcat aattttgatt aacagtttat agttcttgta
     2821 tgcgcatttg tatgtgtgtg tgtgtgtgtg tgtttgtgtg tgtgtgtgtg tgtgtgtgtg
     2881 tgtctatccg tctacctgtc tatctgtgtg atctcaaaag ttcactgtaa gtacttggag
     2941 ggcaattgcc atatcttaga cctgtctata tgtatactca agactgtaac agtgctgagc
     3001 acacacaagg tgatcaataa atggatgttg attgaaaaaa aaaaaaaaaa aa
//
