LOCUS       NM_001014096            1574 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus claudin 18 (Cldn18), mRNA.
ACCESSION   NM_001014096 XM_236603
VERSION     NM_001014096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Linares,G.R., Brommage,R., Powell,D.R., Xing,W., Chen,S.T.,
            Alshbool,F.Z., Lau,K.H., Wergedal,J.E. and Mohan,S.
  TITLE     Claudin 18 is a novel negative regulator of bone resorption and
            osteoclast differentiation
  JOURNAL   J Bone Miner Res 27 (7), 1553-1565 (2012)
   PUBMED   22437732
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Fernandez,A.L., Koval,M., Fan,X. and Guidot,D.M.
  TITLE     Chronic alcohol ingestion alters claudin expression in the alveolar
            epithelium of rats
  JOURNAL   Alcohol 41 (5), 371-379 (2007)
   PUBMED   17889313
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088427.1.
            
            On Apr 20, 2005 this sequence version replaced XM_236603.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088427.1, CF110345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1574
                     /gene="Cldn18"
                     /note="claudin 18"
                     /db_xref="GeneID:315953"
                     /db_xref="RGD:1359696"
     exon            1..252
                     /gene="Cldn18"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..818
                     /gene="Cldn18"
                     /codon_start=1
                     /product="claudin-18 precursor"
                     /protein_id="NP_001014118.1"
                     /db_xref="GeneID:315953"
                     /db_xref="RGD:1359696"
                     /translation="MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTSVF
                     QYEGLWRSCVQQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGVIGILVSIFALK
                     CIRIGSMDDSAKAKMTLTSGIMFIISGVCAIIGVSVFANMLVTNFWMSTANMYSGMGG
                     MVQTVQTRYTFGAALFVGWIAGGLTLIGGVMMCIACRGLTPDDRNFKAVSYHASGQNV
                     AYKPGGFKASTGFGSNARNKKIYDGGARTEDDEQSHPTKYDYV"
     exon            253..417
                     /gene="Cldn18"
                     /inference="alignment:Splign:2.1.0"
     exon            418..535
                     /gene="Cldn18"
                     /inference="alignment:Splign:2.1.0"
     exon            536..646
                     /gene="Cldn18"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1538
                     /gene="Cldn18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctggaag tctgtgccca gcagctgaag ccatggccac caccacgtgc caggtggtag
       61 ggctcctcct gtccctcctg ggtctggccg gctgcatagc cgccactgga atggacatgt
      121 ggagcactca ggacctgtat gataacccag tcacctccgt gttccagtat gaagggctct
      181 ggaggagttg cgtgcaacag agctcggggt tcactgagtg ccggccatac ttcaccatcc
      241 tgggccttcc agccatgctg caagcagtgc gagccctgat gatcgtgggc attgttctgg
      301 gggtcatcgg catcctggtg tccatcttcg ccctgaagtg cattcgcatt ggcagcatgg
      361 atgactctgc caaggccaag atgactctga cttctgggat tatgttcatc atctcaggag
      421 tctgtgcaat cattggtgtg tctgtgtttg ccaacatgct ggtaaccaac ttctggatgt
      481 ccacggccaa catgtacagc ggcatgggtg ggatggtgca gaccgttcag accaggtaca
      541 cttttggtgc agctctgttt gtgggctgga tcgctggagg cctcacacta attggaggtg
      601 tgatgatgtg cattgcttgc cgtggcctga ctcctgatga ccgcaacttc aaagccgtgt
      661 cctaccacgc ttctggccaa aatgttgcct ataagcctgg aggctttaag gccagcactg
      721 gctttgggtc caacgccaga aacaagaaga tatatgatgg gggtgcccgc acagaagacg
      781 atgaacaatc tcatcctacc aagtacgact atgtgtagtg ctctaagacc gcccccccaa
      841 catgtgtgca gaagaaaccc ttccccaagg aaagctcacc ccaaagcaag gagattctac
      901 cttgttccct tgttgctttt gactgacggt tgaaagttgg taaagtctta atttcatctg
      961 tggggaggct agacagtctt ggccacacgt ctctaaatac tccatcacaa aacaaccgag
     1021 ttaccattta caggttaaga gaccaccaca cccacccttc ccaatcctct gtttttttac
     1081 catagtaaat ctggtgatgg aatgtaattc gactcatgga ctaatacttt gataatttct
     1141 agaaatttaa gcctgatgat gatctatttc ccagcttgac cccacccacc cccccaggga
     1201 aattttaaaa gaaaaaaata gattaaaagg cattatttac tactcaattt tgccttacca
     1261 acctcactga taataatgaa caccgattag agaaagaatg ctagaggaaa gatggttgtg
     1321 gcctccccag tctgtcatct gaacccttca tacatggtga tctagaacat tattagccac
     1381 ggtgatcttc aaggaggcaa acaagtcctg tctgcttctc ttggcatctg ctgactctaa
     1441 caagaccgtt tcagaacttt ccactggaag tcctcttcct ctcagaagtc agaaattctc
     1501 cctagaagaa taagaaataa attcttttgg taacctgaaa aaaaaaaaaa aaaaaaaaaa
     1561 aaaaaaaaaa aaaa
//
