LOCUS       NM_001100813            3480 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus claudin 12 (Cldn12), mRNA.
ACCESSION   NM_001100813 XM_001067932 XM_575355
VERSION     NM_001100813.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Castro Dias M, Coisne C, Baden P, Enzmann G, Garrett L, Becker L,
            Holter SM, Hrabe de Angelis M, Deutsch U and Engelhardt B.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Claudin-12 is not required for blood-brain barrier tight junction
            function
  JOURNAL   Fluids Barriers CNS 16 (1), 30 (2019)
   PUBMED   31511021
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Berndt P, Winkler L, Cording J, Breitkreuz-Korff O, Rex A, Dithmer
            S, Rausch V, Blasig R, Richter M, Sporbert A, Wolburg H, Blasig IE
            and Haseloff RF.
  TITLE     Tight junction proteins at the blood-brain barrier: far more than
            claudin-5
  JOURNAL   Cell Mol Life Sci 76 (10), 1987-2002 (2019)
   PUBMED   30734065
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Wang J, Chen J, Tang Z, Li Y, Hu L and Pan J.
  TITLE     The Effects of Copper on Brain Microvascular Endothelial Cells and
            Claudin Via Apoptosis and Oxidative Stress
  JOURNAL   Biol Trace Elem Res 174 (1), 132-141 (2016)
   PUBMED   27038183
  REMARK    GeneRIF: identified four claudin isoforms (1, 3, 5, and 12) and
            showed that their expression levels were regulated as a group by
            copper
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Harris HJ, Davis C, Mullins JG, Hu K, Goodall M, Farquhar MJ, Mee
            CJ, McCaffrey K, Young S, Drummer H, Balfe P and McKeating JA.
  TITLE     Claudin association with CD81 defines hepatitis C virus entry
  JOURNAL   J Biol Chem 285 (27), 21092-21102 (2010)
   PUBMED   20375010
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Friedman LM, Dror AA, Mor E, Tenne T, Toren G, Satoh T, Biesemeier
            DJ, Shomron N, Fekete DM, Hornstein E and Avraham KB.
  TITLE     MicroRNAs are essential for development and function of inner ear
            hair cells in vertebrates
  JOURNAL   Proc Natl Acad Sci U S A 106 (19), 7915-7920 (2009)
   PUBMED   19416898
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig
            IE.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, Kojima
            T, Yamashita T and Sawada N.
  TITLE     Differential expression and subcellular localization of claudin-7,
            -8, -12, -13, and -15 along the mouse intestine
  JOURNAL   J Histochem Cytochem 54 (8), 933-944 (2006)
   PUBMED   16651389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111647.10 and BP465177.1.
            
            On or before Aug 9, 2007 this sequence version replaced
            XM_575355.2, XM_001067932.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.88334.1,
                                           SRR8487231.161489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC111647.10        103268-103320
            54-2965             AC111647.10        105998-108909
            2966-3480           BP465177.1         1-515               c
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..3480
                     /gene="Cldn12"
                     /gene_synonym="RGD1561053"
                     /note="claudin 12"
                     /db_xref="GeneID:500000"
                     /db_xref="RGD:1561053"
     exon            1..53
                     /gene="Cldn12"
                     /gene_synonym="RGD1561053"
                     /inference="alignment:Splign:2.1.0"
     exon            54..3479
                     /gene="Cldn12"
                     /gene_synonym="RGD1561053"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..817
                     /gene="Cldn12"
                     /gene_synonym="RGD1561053"
                     /codon_start=1
                     /product="claudin-12"
                     /protein_id="NP_001094283.1"
                     /db_xref="GeneID:500000"
                     /db_xref="RGD:1561053"
                     /translation="MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRN
                     EKNLTIYTGLWVKCARYDGSSDCLMYDRTWYLSVDQLDLRVLQFALPLSILIAMGALL
                     LCLIGMCNTAFKSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWAIFYNSH
                     LNKKFEPVFTFDYAVFVTIASSGGLFMTALLLFVWYCACKSLSSPFWQPLYSHPPGMH
                     TYSQPYSSRSRLSAIEIDIPVVSHST"
ORIGIN      
        1 gaatcagtgg cataggacag gctgtttgga gaaacactga ttattttgaa attacgaaac
       61 acactgccca agccctcctg ccatgggctg ccgagatgtc catgcagcca cggtcctctc
      121 cttcctgtgc ggcattgcct ctgtagcagg cctcttcgcg gggactctgc ttcccaactg
      181 gaggaagctg cgactcatca cattcaacag aaatgagaag aacctgacga tctacacggg
      241 cctgtgggtg aagtgcgccc ggtatgacgg aagcagtgac tgcctgatgt acgaccgcac
      301 ttggtacctg tcggtcgacc agctggacct gcgcgtcctc cagttcgccc tgcccctcag
      361 catcctgatc gcaatgggtg ccttgctgct ctgcctgatt gggatgtgca acacggcctt
      421 caagtcttcg gtgcctaaca tcaaactggc caagtgtctg gtcaatagtg caggctgcca
      481 cctggtggct ggactcctgt ttttcctggc aggtaccgtg agcctctctc catccatctg
      541 ggccatcttc tataacagcc atctcaacaa gaagttcgag ccggtcttta cctttgacta
      601 tgcagtgttt gtcacgatcg ctagctcagg gggtctgttc atgactgctc ttctgctgtt
      661 tgtttggtac tgtgcatgca agtctttgtc ctctcctttc tggcagccac tgtactccca
      721 tcctcctggg atgcacactt actcacagcc ctattcatca cggtcccgcc tctctgccat
      781 tgaaattgac attccggtag tttcacatag cacttaacag ttataattaa ctgctcaaag
      841 tgtgtctggt agcctcacag ccccctgcat aacgagcctt tttggacctg tgtacatttt
      901 tcctttgttc cttacccatc agtggagccg catttgtata tcttggtaga aaggaaggct
      961 gctagacttt atgaggtaca tggttcattc ttctaaatgt gaaacattcc ttttatcttg
     1021 cttctaagac caagggtctt tggcctcctt gttgatgtct gtgatcagtc acttaggtga
     1081 gagggcctgt gataacgact gaggcaatga agacggcata ctgagcaatg ctgtttgatc
     1141 cttaccgata tttcagattg tgcatcgtct ccgatgactt aaaagtgaaa ggggcagttt
     1201 cagatttcag gagtctcggt cagatacggc tagtgcttgt cttcacactc taccagcctg
     1261 aaggtataat ttcgttctct cttgggacta atcgagtagg gcatctgtat actgaagatt
     1321 agtatcttct acctcatttc agtgaaaagc agaacgtggc ttaaatgatg acagagtaag
     1381 gctaacattt aaacacagtt aacgtttgac ttctttgttg gtttcacgta gggtcttgct
     1441 gtgtagccct ggctggccta gaactcactc tgtagaccag tctggactca cacgtgaccg
     1501 ttctccagct tgcctcctga gcactaacta ccggcatgcc ccactcttgt gtaacacccc
     1561 gtaagtttta gttactgatt atatcgccgg agttaaaagg ctgtcaggag acagcatgtc
     1621 gcttcattca aagcaagaat ccctttccag atacccttcc ttcaggtagt gctcatgccc
     1681 tgggcaagct cttagtgcct aagacaaatg aataaaaggt tgttgaagcc aaatggttgt
     1741 cttttagaca caaatgctag ggcacaggag gctgtcggtc agtgtcagcg ccaaagattc
     1801 atttggtggc tcctatttga gttgtggctt tgctctgttc agtttctgct tctaacactg
     1861 cttcacactt gagcaagtgc tttagaggat acacaaacag gagaagtagc catgtaggag
     1921 ttttgctcta acacacctga taaccagtgg gaagtctgac tttacggtag ctggtaaact
     1981 tcaggcattg actgaggaat gtgtttcacc tgaaacatgt ctttctgaca cagccaacct
     2041 acgtacacca ccagcggtag cctggactct gggaattcac tttagtatgt ctcctcccgt
     2101 agctcacaag ctgtaataac ggcctcagat catgagaatg ggcgagatag gagagagatt
     2161 aaattatacc tgttctacct ctgaaactaa gatgagatat taaagaggga taagttttaa
     2221 aaatatctct tccgatgtga cgtcaaatgg ataaaaccat ttagtactaa cctcccactt
     2281 tgacattgag agatgttggg tcttaactat taggaatttg agctggtcac taattggtat
     2341 gatgtccact tactagcgtt gtgttttgta aggattgtgg aatattacag tcaagagttt
     2401 tttacaagca gctgatttta cggtaacagt ctatgatgcc acctttccaa atctgagtat
     2461 ttctgtagaa tatgtagtac ttttccctaa gtccaacact actactttat gtaggcaagt
     2521 aaatccaatt gtataatttt taaaaaccgt cagtacaaag catgcatttc tatgtgtttt
     2581 ttgtttaaat tatggcttct agtcttttcc acctccgcct tttctcattc ataagtaaag
     2641 ctgagtgttg gtcctgttga agttttgaga ttaatactag ttttcttccc ttttattaac
     2701 taatcttagt tcttctctca ctaaactgtt ttcagaaaga ttaaaaatcc cgccatgcct
     2761 tggcgttagt ataaagagat aaaagcaggg ccaggtgtag tggcttttga ctttaccacc
     2821 agcactgagg aggccgagac aggtgcatct ctggaaattc cggtctccat ggcaagttcc
     2881 aagccagtca gagccacaca gaaagaccct gtcttaaaaa caaaattagg gaaagaaaaa
     2941 aaaaagtgga ctcagccatg aggacactag acagttttca gctcacagga ttgtaactac
     3001 aggcattaag ctttcttatg agaatttttt ggcattacca tccatagcct ccaattactg
     3061 cttattacaa attcgctcag gaagagaaac agctgtttca gtattatctt tttagtgttc
     3121 cagattgggc ataaatagtg ctttttagag ccatcaaagg aaagcatgta tttacaatcc
     3181 ttctgagtca ctgccggggc tgttcttcag atggggtggg taacgtcttt tgttgctaaa
     3241 aagctgttgg ttttgaaggc cttccatgga gccagtgtgt cagacaacct tgaatgtgag
     3301 atggcgcagc aagtctgtgt cacccacctt tgggagaaga gtaagcctaa gatcccaagt
     3361 tcactctgcg tgtacatacg ccctgtgatg gatagcgtgt gctgtaaacc acaaggtaga
     3421 gacctcagtg ggtgtgctgt gctgctgcct cacgtttatt aaaagatgta tttttacaaa
//
