LOCUS       NM_031699               3223 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus claudin 1 (Cldn1), mRNA.
ACCESSION   NM_031699
VERSION     NM_031699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Chang,R., Su,Y., Kong,H., Wang,F., Xing,Y., Jiang,L. and Xin,H.
  TITLE     Upregulation of SEMP1 Contributes to Improving the Biological
            Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia
  JOURNAL   Mol Biotechnol 66 (3), 531-543 (2024)
   PUBMED   37277581
  REMARK    GeneRIF: Upregulation of SEMP1 Contributes to Improving the
            Biological Functions of Trophoblast via the PI3K/AKT Pathway in
            Preeclampsia.
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Ma,T., Gu,J., Zhao,Y., Li,S., Zou,D. and Ge,D.
  TITLE     EZH2-mediated suppression of CLDN1 leads to barrier dysfunction in
            PPI-refractory gastroesophageal reflux disease
  JOURNAL   Dig Liver Dis 54 (6), 776-783 (2022)
   PUBMED   34789399
  REMARK    GeneRIF: EZH2-mediated suppression of CLDN1 leads to barrier
            dysfunction in PPI-refractory gastroesophageal reflux disease.
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Xie,Y., Tan,J., Qin,Y., Cao,Y., Wang,Y., Li,A., Wang,Z., Qiao,Z.
            and Yan,Z.
  TITLE     MiR-3571 modulates the proliferation and migration of vascular
            smooth muscle cells by targeting claudin 1
  JOURNAL   Int J Med Sci 19 (3), 511-524 (2022)
   PUBMED   35370461
  REMARK    GeneRIF: MiR-3571 modulates the proliferation and migration of
            vascular smooth muscle cells by targeting claudin 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Ben-Kraiem,A., Sauer,R.S., Norwig,C., Popp,M., Bettenhausen,A.L.,
            Atalla,M.S., Brack,A., Blum,R., Doppler,K. and Rittner,H.L.
  TITLE     Selective blood-nerve barrier leakiness with claudin-1 and
            vessel-associated macrophage loss in diabetic polyneuropathy
  JOURNAL   J Mol Med (Berl) 99 (9), 1237-1250 (2021)
   PUBMED   34018017
  REMARK    GeneRIF: Selective blood-nerve barrier leakiness with claudin-1 and
            vessel-associated macrophage loss in diabetic polyneuropathy.
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Chen,M., Hou,P., Zhou,M., Ren,Q., Wang,X., Huang,L., Hui,S., Yi,L.
            and Mi,M.
  TITLE     Resveratrol attenuates high-fat diet-induced non-alcoholic
            steatohepatitis by maintaining gut barrier integrity and inhibiting
            gut inflammation through regulation of the endocannabinoid system
  JOURNAL   Clin Nutr 39 (4), 1264-1275 (2020)
   PUBMED   31189495
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Duffy,H.S., John,G.R., Lee,S.C., Brosnan,C.F. and Spray,D.C.
  TITLE     Reciprocal regulation of the junctional proteins claudin-1 and
            connexin43 by interleukin-1beta in primary human fetal astrocytes
  JOURNAL   J Neurosci 20 (23), RC114 (2000)
   PUBMED   11090614
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   Lippoldt,A., Liebner,S., Andbjer,B., Kalbacher,H., Wolburg,H.,
            Haller,H. and Fuxe,K.
  TITLE     Organization of choroid plexus epithelial and endothelial cell
            tight junctions and regulation of claudin-1, -2 and -5 expression
            by protein kinase C
  JOURNAL   Neuroreport 11 (7), 1427-1431 (2000)
   PUBMED   10841351
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Furuse,M., Sasaki,H. and Tsukita,S.
  TITLE     Manner of interaction of heterogeneous claudin species within and
            between tight junction strands
  JOURNAL   J Cell Biol 147 (4), 891-903 (1999)
   PUBMED   10562289
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031699.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061992.1, SRR26360190.1055662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               JAXUCZ010000011.1  87926376-87926777
            403-567             JAXUCZ010000011.1  87935114-87935278
            568-652             JAXUCZ010000011.1  87937274-87937358
            653-3223            JAXUCZ010000011.1  87938963-87941533
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..3223
                     /gene="Cldn1"
                     /note="claudin 1"
                     /db_xref="GeneID:65129"
                     /db_xref="RGD:68422"
     exon            1..402
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..815
                     /gene="Cldn1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_113887.3"
                     /db_xref="GeneID:65129"
                     /db_xref="RGD:68422"
                     /translation="MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQ
                     AIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGM
                     KCMRCLEDDEVQKMWMAVIGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPVNARYE
                     FGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV"
     exon            403..567
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..652
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..3223
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacttccaga ctccaccacc gacccggacc agaagccagg agcctcgccc gcagccgcac
       61 agggagcagg ggtatcagcg ctaacctcct ggctgagact ccatcacctt cggggagccc
      121 aagcgcgcac tttgcaaact ccgctttctg cacctgccac tgagcctcag aaaagagcca
      181 tggccaacgc ggggttgcag cttctgggtt tcatcctggc ttcgctggga tggatcggct
      241 ctatcgtcag cactgccctg ccccaatgga agatttactc ctatgctggg gacaacatcg
      301 tgactgctca ggccatctac gagggactgt ggatgtcctg cgtttcgcaa agcaccgggc
      361 agatacagtg caaagtcttc gactccttgc tgaatctgaa tagtactttg caggcaacca
      421 gagccttgat ggtaattggc atcctgctgg ggctgatcgc aatctttgtg tccaccattg
      481 gcatgaagtg catgaggtgc ttagaagatg atgaagtgca aaagatgtgg atggctgtca
      541 tcgggggcat aatatttgta atttcaggtc tggcgacatt agtggccaca gcatggtatg
      601 gaaatagaat tgttcaagaa ttctatgacc ccatgacccc tgtcaatgcc aggtatgaat
      661 ttggccaggc tctctttact ggctgggctg ctgcctccct ctgcctcctg ggaggtgccc
      721 tactttcctg ctcctgtccc cggaaaacaa cctcttaccc aacaccacgg ccttatccca
      781 agccaacacc ttctagtggg aaagactacg tgtgacagcg gcgaaggaag agatcctcct
      841 ggagcgaata caaaatggac attgagacta gcattgacat taaggcctca aactgttgac
      901 tatggttatc taaactgtgg tagaacaaaa gcaagcatat ttttatacgt ccccatggct
      961 atgagggtct tggctgtgcc ttaccatctt tcctgagtac aggagggaag ccttttgcct
     1021 ttgaactgct gcttgccact gagtgatgac actcaaatgg gcgaagggtg ctccttaagt
     1081 gtgtatagat atgtacatat acatattttc tattaaaaat agacagctag caatctctta
     1141 ttctccccat attgtaccag catactttaa atgactataa aatatataca attccacatt
     1201 gattaaataa gctttctggt gtatttttct tttctctatg aacataagtg atcagtcaaa
     1261 tattacccct tcgatcagca tttagtatct ttgccataag accagacttc cttacgaact
     1321 cagactatgt tctttttttt ttttccatta tgtcttcttt acatcaaaat atttgttctc
     1381 catgttttct tttactctaa cagctgcttt ttcagattgt tattctgagg cttgattcta
     1441 actcctgaat ctaataatga actttgagcc catatgttaa aacttaaaac cagtaagaat
     1501 ctcatactgt gtttctgagc tgtgggggcc aatgttccag agagatgatg tttctccact
     1561 gacctttccc acacggtccc tgcactttgg tctgcagctg gcttgtttgc tttaaaaata
     1621 tttgtttccc tgagtggcta agctgctaac cctgtggttg aaacagtttt attgactgca
     1681 tttttcaggt actaattttc cattccagat cctgcaaact gcagctctcc tcttccctcc
     1741 tcagctatct tgttttccca cgtataatta tcctacagtt tagttctttg cagataggtg
     1801 tggtccattt atctacacaa actgctagac ttgccagagt gataatctag tgacaaatat
     1861 tctctctgta gccgtggaca atttacaatc cttatacctc gttttcccat ctgtcaaatt
     1921 gggataatta cacttaaaca gctggtagag gtaatgcgag tattaattag ttgatatgac
     1981 tctcattctt tgaacatgaa atatgcctaa gtagtgtttt tccttgctca attagcagtt
     2041 ctgaagtcac tgaataaaat ctacacacat gcctccaatg ccgttctgta tctctctttg
     2101 tcatgagttc atttcctccc atctagctgt gcatggcctg tcattggtgc tgtttcattt
     2161 tgatcattct catctgtagc aaaggccctt cagcagagca aggtgttgta atacaaaggg
     2221 tgttgccatt gccatgggta gacctggatt tgcatcttgg tgctatcact taattactga
     2281 ggttgggcag aggccctcga ttgccctaaa tgtattgctc catctagaca acgggttcat
     2341 taacttctgc catgcctatg tcgcatgagt caagagggac gcaggcaaac atggttttat
     2401 gttggaaaac aacatgtcac tctataaatt aaggaattta agttaatggg ttttgtcttt
     2461 atttttcaaa caataggaaa gagaaacatg ttaaatagtt tctttcctta agaactctca
     2521 aatgaggagt tccaaagctt actaagttaa actgatctta agtctttaag gctttcggtt
     2581 gtgagtcagt gtttcagcct atggtccacg ctggccaaga actcctgtgc cacacaaaca
     2641 tccttctgcc tcagcctcac aactgttatg atgacaggaa tgagccccat cccactgtta
     2701 caccctagtt tcagaagttt ggcctggtac ttctattgct aagcaaatgc aatggcggaa
     2761 agtgacagtg tatggatact ctaaaagcat aaagcgtgct ctttgtgaag tgatactttc
     2821 aaagtctaat ggaagctggc agttctagga gaggttaaga attataactt atggtaaaac
     2881 cacatggatg aagttataga aagaatgaag tcttatgtga atttgtacta tgtaagtttg
     2941 actgtattta gatgtgtaaa gtaatcatgc aaagatcttt tgccacaatt actgtgccta
     3001 atgtgtaatg taaacacata gaaataacac ttgctaaact acacaaaatt ctatattcca
     3061 aaataatccc atagaagtct tatgtcagaa cttacctaga tttgatattt ttatacccta
     3121 ataccaaacc tggaaacaga tcaattgata tttgggggct gaggtgggaa tttgtataag
     3181 tactactctt tttcaataaa ttgttggttt tttttaatta aaa
//
