LOCUS       NM_031568               2749 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus chloride voltage-gated channel 7 (Clcn7), mRNA.
ACCESSION   NM_031568
VERSION     NM_031568.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2749)
  AUTHORS   Li,X., Du,Y., Zhang,L., Chen,X. and He,D.
  TITLE     Chloride channel 7 protects from redox status impairment-induced
            renal tubular epithelial cell apoptosis by activating autophagy
  JOURNAL   Life Sci 261, 118484 (2020)
   PUBMED   32976885
  REMARK    GeneRIF: Chloride channel 7 protects from redox status
            impairment-induced renal tubular epithelial cell apoptosis by
            activating autophagy.
REFERENCE   2  (bases 1 to 2749)
  AUTHORS   Leisle,L., Ludwig,C.F., Wagner,F.A., Jentsch,T.J. and Stauber,T.
  TITLE     ClC-7 is a slowly voltage-gated 2Cl(-)/1H(+)-exchanger and requires
            Ostm1 for transport activity
  JOURNAL   EMBO J 30 (11), 2140-2152 (2011)
   PUBMED   21527911
REFERENCE   3  (bases 1 to 2749)
  AUTHORS   Schulz,P., Werner,J., Stauber,T., Henriksen,K. and Fendler,K.
  TITLE     The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II
            osteopetrosis does not abolish function but causes a severe
            trafficking defect
  JOURNAL   PLoS One 5 (9), e12585 (2010)
   PUBMED   20830208
  REMARK    GeneRIF: G213R mutation prevents ClC-7 from being correctly
            targeted to the lysosomal membrane.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2749)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2749)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   6  (bases 1 to 2749)
  AUTHORS   Auzanneau,C., Thoreau,V., Kitzis,A. and Becq,F.
  TITLE     A Novel voltage-dependent chloride current activated by
            extracellular acidic pH in cultured rat Sertoli cells
  JOURNAL   J Biol Chem 278 (21), 19230-19236 (2003)
   PUBMED   12637509
REFERENCE   7  (bases 1 to 2749)
  AUTHORS   Diewald,L., Rupp,J., Dreger,M., Hucho,F., Gillen,C. and Nawrath,H.
  TITLE     Activation by acidic pH of CLC-7 expressed in oocytes from Xenopus
            laevis
  JOURNAL   Biochem Biophys Res Commun 291 (2), 421-424 (2002)
   PUBMED   11846422
REFERENCE   8  (bases 1 to 2749)
  AUTHORS   Kornak,U., Kasper,D., Bosl,M.R., Kaiser,E., Schweizer,M.,
            Schulz,A., Friedrich,W., Delling,G. and Jentsch,T.J.
  TITLE     Loss of the ClC-7 chloride channel leads to osteopetrosis in mice
            and man
  JOURNAL   Cell 104 (2), 205-215 (2001)
   PUBMED   11207362
REFERENCE   9  (bases 1 to 2749)
  AUTHORS   Brandt,S. and Jentsch,T.J.
  TITLE     ClC-6 and ClC-7 are two novel broadly expressed members of the CLC
            chloride channel family
  JOURNAL   FEBS Lett 377 (1), 15-20 (1995)
   PUBMED   8543009
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Z67744.1.
            
            On Aug 31, 2012 this sequence version replaced NM_031568.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z67744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2749              Z67744.1           2-2750
FEATURES             Location/Qualifiers
     source          1..2749
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..2749
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /note="chloride voltage-gated channel 7"
                     /db_xref="GeneID:29233"
                     /db_xref="RGD:61836"
     exon            1..205
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2479
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /note="chloride channel protein 7; chloride channel 7
                     alpha subunit; chloride channel, voltage-sensitive 7"
                     /codon_start=1
                     /product="H(+)/Cl(-) exchange transporter 7"
                     /protein_id="NP_113756.1"
                     /db_xref="GeneID:29233"
                     /db_xref="RGD:61836"
                     /translation="MANVSKKVSWSGRDRDDEEGAPLLRRTGQPDEETPLLNGAGPGA
                     RQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSEN
                     QLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDN
                     IDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPH
                     VVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEY
                     FRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTF
                     TLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNA
                     LNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQL
                     FCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVS
                     AGVFIPSLLIGAAWGRLFGISMSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTV
                     IMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLT
                     AREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQL
                     IVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMN
                     PSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEEL
                     SLAQT"
     exon            206..274
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            275..346
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            347..412
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            413..545
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            546..655
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            656..736
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            737..799
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            800..883
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            884..977
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1042
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1159
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1214
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1275
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1414
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1508
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1678
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1730
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1858
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1944
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2074
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2134
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2311
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2392
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2749
                     /gene="Clcn7"
                     /gene_synonym="ClC-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgcgggt cacgggaacg ctgccgggct gccggctgtt cttgtggagt ttggtcctca
       61 gtgggccatg gccaacgttt ctaagaaagt gtcttggtcc ggccgagatc gcgatgacga
      121 ggagggggcg ccgctgcttc gaaggacggg gcaacctgac gaggagacgc cgctgctgaa
      181 cggagccggg ccgggcgcgc gccagtctca ttctgcactt ttccgaattg gacagatgaa
      241 caacgtggag ctggatgatg aactcctgga cccggaagtg gaccctcctc acaccttccc
      301 caaggagatt ccacacaacg agaagctcct ctccctcaag tatgagagcc tggactatga
      361 caatagtgag aatcagctct tcctggagga ggaaagacga atcaaccaca cggctttccg
      421 gacagtggag atcaagcgct gggttatctg tgccctcatt ggaatcctca caggcctagt
      481 agcctgcttc attgacattg tagtggagaa cctggcaggc ctcaagtacc gagtcatcaa
      541 ggacaacatc gacaagttca cagagaaggg cggcctgtcc ttctccctcc tgctgtgggc
      601 cacactgaac tctgccttcg tgctcgtggg gtctgtgatt gtggccttca tagagccagt
      661 tgctgctggc agcggaatcc ctcagatcaa gtgcttcctc aatggggtga agatccccca
      721 cgtggtgcgg ctcaagacgc tggtgatcaa ggtgtctggc gtgattctgt ctgtggtagg
      781 gggactggct gtgggaaagg aagggccaat gatccactca ggatccgtga ttgctgcagg
      841 gatttcacag ggaaggtcga cgtcactcaa gcgagatttt aagatctttg aatatttccg
      901 cagagataca gagaagcggg attttgtctc agctggagct gcagctggag tgtctgctgc
      961 gtttggagca cctgtgggtg gggtcctgtt cagcctggaa gagggcgcct ccttctggaa
     1021 tcagttcctg acatggagaa ttttctttgc ttccatgatt tcgaccttta cactgaattt
     1081 tgttctgagc atctaccatg gaaacatgtg ggacctgtcc agccctggcc tcataaattt
     1141 tggaagattc gactcagaga aaatggccta cacaatccat gagattcctg tcttcatcgc
     1201 catgggtgtg gtgggtggca ttcttggagc cgtgttcaat gccttgaatt actggctaac
     1261 tatgtttcga atcaggtaca tccaccggcc ctgcctccaa gtgattgagg ccatgctggt
     1321 ggcagctgtc acagccacag ttgcatttgt cttgatttac tcgtctcgag attgccagcc
     1381 cctgcagggg agctccatgt cctacccact ccagctcttc tgtgcagatg gcgaatacaa
     1441 ctcaatggcc gcagccttct ttaacacccc tgagaagagc gtcgtcagcc tgttccacga
     1501 cccaccaggc tcctataatc ccatgactct cggcctgttc accctggtct acttcttcct
     1561 ggcctgctgg acctatggcc tcacagtatc tgctggtgtc ttcatcccat ccctgctcat
     1621 tggggctgcc tggggccgac tctttggcat ctccatgtcc tacctcacag gagcagcgat
     1681 ctgggcagat ccgggtaaat acgccctgat gggagctgct gctcagcttg gtgggatcgt
     1741 gaggatgacc cttagcctga cagtcatcat gatggaggcc accagcaacg tgacctacgg
     1801 ttttcccatc atgttggtgc tgatgactgc caagattgtg ggtgatgtct tcattgaggg
     1861 cctctatgac atgcacatcc agctgcaaag tgtgcccttc ctacactggg aagccccggt
     1921 cacctcacat tcgctcactg ccagggaagt aatgagcacg cctgtgacct gcctgaggag
     1981 gagagagaag gttggcatca tcgtggatgt cctaagtgac acagcgtcta atcacaatgg
     2041 gttccctgtg gtggaggatg taggagacac ccagccagcc agactccaag gcctaatcct
     2101 gcgttcccag ctcatcgtgc tcctgaagca caaggtgttt gtggagaggt ccaacatggg
     2161 tttggtgcag cggagactga ggctgaaaga ctttcgcgat gcctacccac gcttcccccc
     2221 aatccagtcc atccacgtat cccaggatga gcgggagtgc accatggacc tttctgagtt
     2281 catgaaccct tctccctaca ctgtgccaca ggaggcatct cttcctcgag tgttcaagct
     2341 gttccgggct ctgggcctga ggcacctggt cgtagtagac aaccacaatc aggtggtcgg
     2401 gctggtgacc aggaaggacc tagcaagata ccgcctagga aaaggaggcc tagaagagct
     2461 ttcactggcc cagacgtgag ggctggcccc cacccttggg cagcggcacc ccggcccctc
     2521 tgcacctcct cccagggtcc ctggtctcag ccaaagcctt gccctgggca gtgcagcaac
     2581 aggagcaaat gccctccccg ggcttggctg gtgtggggcc cagacccttt gtcctgggca
     2641 gttggtttac atcatcagca tttccctatt ccctgaacct gcagtcctca gacttgtccc
     2701 actcctgggt cccttctccc aggatgtaaa gtgtgttttc acacccctt
//
