LOCUS       NM_001106479            3305 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus chloride voltage-gated channel 6 (Clcn6), mRNA.
ACCESSION   NM_001106479 XM_001074014 XM_227870
VERSION     NM_001106479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   Klemens CA, Dissanayake LV, Levchenko V, Zietara A, Palygin O and
            Staruschenko A.
  TITLE     Modulation of blood pressure regulatory genes in the Agtrap-Plod1
            locus associated with a deletion in Clcn6
  JOURNAL   Physiol Rep 10 (15), e15417 (2022)
   PUBMED   35927940
  REMARK    GeneRIF: Modulation of blood pressure regulatory genes in the
            Agtrap-Plod1 locus associated with a deletion in Clcn6.
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Klemens CA, Chulkov EG, Wu J, Hye Khan MA, Levchenko V, Flister MJ,
            Imig JD, Kriegel AJ, Palygin O and Staruschenko A.
  TITLE     Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle
            Contractility and Arterial Stiffness via Alterations to Golgi
            Calcium Stores
  JOURNAL   Hypertension 77 (2), 582-593 (2021)
   PUBMED   33390052
  REMARK    GeneRIF: Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth
            Muscle Contractility and Arterial Stiffness via Alterations to
            Golgi Calcium Stores.
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Zhang L, Zhang T, Xiang Z and Lu S.
  TITLE     The rs3737964 single-nucleotide polymorphism of the chloride
            channel-6 gene as a risk factor for coronary heart disease
  JOURNAL   Mol Genet Genomic Med 3 (6), 537-542 (2015)
   PUBMED   26740945
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Flister MJ, Tsaih SW, O'Meara CC, Endres B, Hoffman MJ, Geurts AM,
            Dwinell MR, Lazar J, Jacob HJ and Moreno C.
  TITLE     Identifying multiple causative genes at a single GWAS locus
  JOURNAL   Genome Res 23 (12), 1996-2002 (2013)
   PUBMED   24006081
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Schroder B, Wrocklage C, Pan C, Jager R, Kosters B, Schafer H,
            Elsasser HP, Mann M and Hasilik A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Tobasnick G and Curtis AS.
  TITLE     Chloride channels and the reactions of cells to topography
  JOURNAL   Eur Cell Mater 2, 49-61 (2001)
   PUBMED   14562255
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074014.1, XM_227870.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3305
                     /gene="Clcn6"
                     /note="chloride voltage-gated channel 6"
                     /db_xref="GeneID:295586"
                     /db_xref="RGD:1305379"
     exon            1..117
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2643
                     /gene="Clcn6"
                     /note="chloride transport protein 6; chloride channel 6;
                     chloride channel, voltage-sensitive 6"
                     /codon_start=1
                     /product="H(+)/Cl(-) exchange transporter 6"
                     /protein_id="NP_001099949.1"
                     /db_xref="GeneID:295586"
                     /db_xref="RGD:1305379"
                     /translation="MAGCRGSVCCCCRWCCCCGERESRTPEELTILGETQEEEDEILP
                     RKDYESLDYDRCINDPYLEVLETMDNKKGRRHEAVKWMVVFAIGVCTGLVGLFVDFSV
                     RLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIP
                     EIKCYLNGVKVPGIVRLRTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQ
                     SISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGL
                     TWKVLFCSMSATFTLNFFRSGIQFGSWGAFQLPGLLNFGEFKCSDSDKKCHLWTAMDL
                     GFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVA
                     SMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFCPNDTYNDMATLFFNSQESA
                     ILQLFHQDGTFSPVTLALFFALYFLMACWTFGTSVPSGLFVPSLLCGAAFGRLVANVL
                     KSYIGLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAK
                     WTGDFFNKGIYDIHIGLRGVPLLEWETEVEMDRLRASDIMEPNLTYVYPHTRIQSLVS
                     ILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSY
                     PSSELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPL
                     TFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRFPDIHDLDLTLLNP
                     RMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTT
                     EFLQARLRQHYQTL"
     exon            118..177
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            178..243
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            244..309
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            310..376
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            377..483
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            484..610
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            611..678
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            679..737
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            738..870
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            871..984
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1151
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1278
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1405
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1559
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1719
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1826
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2013
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2171
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2328
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2436
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2562
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..3305
                     /gene="Clcn6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggtccgg agtggcagga aaggaggaag atggcggggt gcagggggtc tgtgtgctgc
       61 tgctgcaggt ggtgctgctg ctgcggcgaa cgcgagagcc gcactcccga ggagctgacc
      121 atccttgggg agacacagga agaggaagat gagatccttc caaggaaaga ctatgagagt
      181 ctggactatg accgctgtat caacgaccct tacctggagg tattggagac catggataat
      241 aagaaagggc gaagacatga ggcggtgaag tggatggtgg tgtttgccat tggcgtctgt
      301 actgggctgg tgggcctctt cgtggacttt tctgtgcgac tcttcaccca actcaagttc
      361 ggagtggttc aaacgtcggt ggaggaatgc agtcagaaag gctgccttgc cctgtctctc
      421 ctggaactcc ttggctttaa cttgaccttt gtcttcctgg caagccttct tgtcttgata
      481 gagccggtgg cagcaggctc tggaatccca gagatcaagt gctatctgaa tggtgtgaaa
      541 gtgccaggaa ttgtccggct ccgaaccctg ctctgcaaag tctttggggt gctgttcagt
      601 gtggctggag ggctctttgt ggggaaagaa ggccccatga tccacagtgg tgccgtggta
      661 ggagctggcc tccctcagtt tcagagcatc tccttaagga agatccagtt taacttcccc
      721 tacttccgca gcgacagaga caagcgtgac ttcgtatcag caggggcggc tgctggagtt
      781 gctgcagctt ttggggcccc tatagggggc accttgttca gcctggagga gggctcgtcc
      841 ttctggaacc agggactcac gtggaaagtg ctcttctgtt ccatgtctgc caccttcacc
      901 ctcaacttct tccgctctgg gatccagttt ggaagttggg gtgccttcca gctgcctgga
      961 ctgctgaact ttggtgaatt taagtgctct gactctgata aaaaatgtca tctctggaca
     1021 gctatggatt tgggtttctt cgtcgtgatg ggggtcattg ggggcctcct gggagccaca
     1081 ttcaactgtc tgaacaagag gcttgcaaag taccgtatgc gcaacgtgca cccgaaacct
     1141 aagctcgtca gggtcttaga gagcctcttg gtgtccctgg tgacgactgt ggtggtgttt
     1201 gtggcctcca tggtgttggg agaatgccga cagatgtctt ccacgagtca aacgggtaat
     1261 ggctcattcc agctccaggt cacatcggaa gatgtgaatt caactatcaa gacatttttc
     1321 tgtcccaatg acacctacaa cgacatggcc acactcttct tcaactccca ggagtctgcc
     1381 atcctgcagc tcttccatca ggatgggact ttcagccccg tcaccctggc cttattcttc
     1441 gccctctatt tcctgatggc atgctggact ttcggcacct ctgtccccag tggcctcttc
     1501 gtgccttccc tgctgtgtgg agcagctttt ggacgtttag ttgccaatgt cctgaaaagc
     1561 tacattggac tgggccacct ctattctggg accttcgccc tgattggtgc ggcagctttc
     1621 ttgggtgggg ttgtaagaat gaccatcagc ctcacagtca tcctgattga gtccacaaat
     1681 gagatcacct atgggcttcc tattatggtc actttgatgg tggccaagtg gactggagac
     1741 tttttcaata agggcattta cgacatccac attgggctga gaggtgtgcc tcttctggag
     1801 tgggagacag aggtggagat ggacaggctg agagccagcg acatcatgga gcccaacttg
     1861 acgtatgtct acccacatac tcgtatccag tctctggtga gcatcctgcg tactacagtc
     1921 caccatgcct tcccagtggt cacagagaat cgcggcaacg agaaggagtt catgaaaggc
     1981 aaccagctca taagcaacaa cattaagttc aagaagtcca gcatcctcac ccgtgctggt
     2041 gagcagcgca agcggggcca gtccatgaag tcttaccctt ccagcgagct gcgcaacgtg
     2101 tgtgatgagc atgtggcttc tgaggagcca gcagagaagg aggacctgct acagcagatg
     2161 ctggagagga gatacactcc ctaccccaac ctataccctg accagtcccc gagtgaagac
     2221 tggaccatgg aggagcgatt ccgtccgctg accttccatg gcctcgtcct gcgctcccag
     2281 ctcgtcaccc tgctcgtccg aggcgtgtgt tactcggaaa gtcagtccag tgccagccaa
     2341 ccacgccttt cttatgctga gatggctgag gactacccga ggtttccgga catacatgac
     2401 ctggacctca cactgctgaa tccccgcatg attgtggacg tcacaccata tatgaatcct
     2461 tcaccattta ctgtctcccc caacacccac gtttctcaag ttttcaacct gttcagaacc
     2521 atgggcctgc gccacttgcc ggtggtgaat gcggtgggcg agatcgtggg gatcattaca
     2581 cgacacaacc tgacgactga gttcctgcag gcccggctac ggcagcatta ccagaccctc
     2641 tgacagttga gcccggctgc agccagccca ctgtcccaga gatgcctctg cagtggccag
     2701 ctcacttgct ggcctccaca gccagcacga aggctcccag tcaaccattt gctcagatgc
     2761 ctggagtcct ggaagatggg ggtcagaggt ttttggggat gtgctgagca ggaagttggg
     2821 gttttactaa attcctctgt aagaatcttc cattccccag ctcccctaga gagagatcag
     2881 ggtactcttg ggctggatcc taggtggaac ttggtgcctc tttgttgctg tttctcggag
     2941 agccccgctg ttgcccagac ctttccggga aggagttgga ctgaggccga cactgaggat
     3001 cttgtttgta tatcaagaat taggcactaa gaacccttcc ccgtgtctgg ggaggcctgg
     3061 gatcagaacc aggacctcat atacactctg cctcttcagt gttctgtttc ctaggagtga
     3121 gctcatgctc ttgaccctgg ggcttgaatg tccttagaat cattcctgac cagacccctg
     3181 atgctaacat tccagctaac agcctctaag cattaaatcc caccacagga accacagcgt
     3241 ctcccctctg tgaacattca gtagtcccca ctcactgctt acacctgctc tcccagtgac
     3301 ctgcg
//
