LOCUS       NM_022198               4415 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus chloride voltage-gated channel 4 (Clcn4), mRNA.
ACCESSION   NM_022198
VERSION     NM_022198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4415)
  AUTHORS   Palmer,E.E., Stuhlmann,T., Weinert,S., Haan,E., Van Esch,H.,
            Holvoet,M., Boyle,J., Leffler,M., Raynaud,M., Moraine,C., van
            Bokhoven,H., Kleefstra,T., Kahrizi,K., Najmabadi,H., Ropers,H.H.,
            Delgado,M.R., Sirsi,D., Golla,S., Sommer,A., Pietryga,M.P.,
            Chung,W.K., Wynn,J., Rohena,L., Bernardo,E., Hamlin,D., Faux,B.M.,
            Grange,D.K., Manwaring,L., Tolmie,J., Joss,S., Cobben,J.M.,
            Duijkers,F.A.M., Goehringer,J.M., Challman,T.D., Hennig,F.,
            Fischer,U., Grimme,A., Suckow,V., Musante,L., Nicholl,J., Shaw,M.,
            Lodh,S.P., Niu,Z., Rosenfeld,J.A., Stankiewicz,P., Jentsch,T.J.,
            Gecz,J., Field,M. and Kalscheuer,V.M.
  CONSRTM   DDD Study
  TITLE     De novo and inherited mutations in the X-linked gene CLCN4 are
            associated with syndromic intellectual disability and behavior and
            seizure disorders in males and females
  JOURNAL   Mol Psychiatry 23 (2), 222-230 (2018)
   PUBMED   27550844
REFERENCE   2  (bases 1 to 4415)
  AUTHORS   Guzman,R.E., Bungert-Plumke,S., Franzen,A. and Fahlke,C.
  TITLE     Preferential association with ClC-3 permits sorting of ClC-4 into
            endosomal compartments
  JOURNAL   J Biol Chem 292 (46), 19055-19065 (2017)
   PUBMED   28972156
REFERENCE   3  (bases 1 to 4415)
  AUTHORS   Hu,H., Haas,S.A., Chelly,J., Van Esch,H., Raynaud,M., de
            Brouwer,A.P., Weinert,S., Froyen,G., Frints,S.G., Laumonnier,F.,
            Zemojtel,T., Love,M.I., Richard,H., Emde,A.K., Bienek,M.,
            Jensen,C., Hambrock,M., Fischer,U., Langnick,C., Feldkamp,M.,
            Wissink-Lindhout,W., Lebrun,N., Castelnau,L., Rucci,J.,
            Montjean,R., Dorseuil,O., Billuart,P., Stuhlmann,T., Shaw,M.,
            Corbett,M.A., Gardner,A., Willis-Owen,S., Tan,C., Friend,K.L.,
            Belet,S., van Roozendaal,K.E., Jimenez-Pocquet,M., Moizard,M.P.,
            Ronce,N., Sun,R., O'Keeffe,S., Chenna,R., van Bommel,A., Goke,J.,
            Hackett,A., Field,M., Christie,L., Boyle,J., Haan,E., Nelson,J.,
            Turner,G., Baynam,G., Gillessen-Kaesbach,G., Muller,U.,
            Steinberger,D., Budny,B., Badura-Stronka,M., Latos-Bielenska,A.,
            Ousager,L.B., Wieacker,P., Rodriguez Criado,G., Bondeson,M.L.,
            Anneren,G., Dufke,A., Cohen,M., Van Maldergem,L.,
            Vincent-Delorme,C., Echenne,B., Simon-Bouy,B., Kleefstra,T.,
            Willemsen,M., Fryns,J.P., Devriendt,K., Ullmann,R., Vingron,M.,
            Wrogemann,K., Wienker,T.F., Tzschach,A., van Bokhoven,H., Gecz,J.,
            Jentsch,T.J., Chen,W., Ropers,H.H. and Kalscheuer,V.M.
  TITLE     X-exome sequencing of 405 unresolved families identifies seven
            novel intellectual disability genes
  JOURNAL   Mol Psychiatry 21 (1), 133-148 (2016)
   PUBMED   25644381
REFERENCE   4  (bases 1 to 4415)
  AUTHORS   Veeramah,K.R., Johnstone,L., Karafet,T.M., Wolf,D., Sprissler,R.,
            Salogiannis,J., Barth-Maron,A., Greenberg,M.E., Stuhlmann,T.,
            Weinert,S., Jentsch,T.J., Pazzi,M., Restifo,L.L., Talwar,D.,
            Erickson,R.P. and Hammer,M.F.
  TITLE     Exome sequencing reveals new causal mutations in children with
            epileptic encephalopathies
  JOURNAL   Epilepsia 54 (7), 1270-1281 (2013)
   PUBMED   23647072
REFERENCE   5  (bases 1 to 4415)
  AUTHORS   Okkenhaug,H., Weylandt,K.H., Carmena,D., Wells,D.J., Higgins,C.F.
            and Sardini,A.
  TITLE     The human ClC-4 protein, a member of the CLC chloride
            channel/transporter family, is localized to the endoplasmic
            reticulum by its N-terminus
  JOURNAL   FASEB J 20 (13), 2390-2392 (2006)
   PUBMED   17023393
REFERENCE   6  (bases 1 to 4415)
  AUTHORS   Kawasaki,M., Fukuma,T., Yamauchi,K., Sakamoto,H., Marumo,F. and
            Sasaki,S.
  TITLE     Identification of an acid-activated Cl(-) channel from human
            skeletal muscles
  JOURNAL   Am J Physiol 277 (5), C948-C954 (1999)
   PUBMED   10564087
REFERENCE   7  (bases 1 to 4415)
  AUTHORS   Jentsch,T.J., Gunther,W., Pusch,M. and Schwappach,B.
  TITLE     Properties of voltage-gated chloride channels of the ClC gene
            family
  JOURNAL   J Physiol 482 (P), 19S-25S (1995)
   PUBMED   7730971
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC092209.1.
            
            On Sep 29, 2005 this sequence version replaced NM_022198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4415              BC092209.1         1-4415
FEATURES             Location/Qualifiers
     source          1..4415
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..4415
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /note="chloride voltage-gated channel 4"
                     /db_xref="GeneID:60586"
                     /db_xref="RGD:708381"
     exon            1..99
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            100..242
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..397
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2536
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /note="clC-4; chloride channel protein 4; chloride channel
                     4-2; chloride transporter ClC-4; putative chloride channel
                     4-2; putative chloride channel (similar to Mm Clcn4-2);
                     chloride channel, voltage-sensitive 4"
                     /codon_start=1
                     /product="H(+)/Cl(-) exchange transporter 4"
                     /protein_id="NP_071534.2"
                     /db_xref="GeneID:60586"
                     /db_xref="RGD:708381"
                     /translation="MSASGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKIT
                     SKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFW
                     YSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWALLFAFL
                     AVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKE
                     GPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEV
                     SYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGV
                     FGGLWGTVFTRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELI
                     SELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVIT
                     IFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPG
                     LYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIY
                     EAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETD
                     YNGFPVVVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSP
                     HPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHM
                     AQMANQDPESIMFN"
     exon            398..497
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            498..685
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..808
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1015
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1096
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1642
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1829
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..2228
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2445
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..4333
                     /gene="Clcn4"
                     /gene_synonym="Clcn4-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaaaatgaa cttgtcagtt tctgtgtgct tcagactctc gacccaaagg agccaggaat
       61 tgcagtagca atttgccttt gtatcccaga gctataaagc cgcaggactt caaagatatc
      121 acgtggcagc gtggagcacg cctcctgatg acgtcacaga actcgcagca gacgcgctga
      181 agaaaggatg ctctaggatg ctgtccaggt ggacggccac gctgcaagat gcggcactgc
      241 aggagtaact agcacggtca gtgcaggagc catgagtgcc tctgggaacc taatggactt
      301 ccttgatgag cccttccctg atgtggggac ctatgaagac ttccacacca tagactggct
      361 gagggaaaag tcccgggaca ctgacagaca tagaaagata accagcaaaa gtaaagagtc
      421 tatttgggag ttcatcaaga gtctgctgga cgcatggtca ggatgggtgg tgatgctact
      481 tattggtctg ctagcaggta ccctggctgg agttatcgat ctcgctgttg actggatgac
      541 agacctcaag gagggcgtct gtctgtctgc attctggtac agccatgagc aatgctgctg
      601 gacctccaat gagaccactt ttgaggacag ggacaagtgt cccctgtggc agaagtggtc
      661 agagcttctt ctgagccagt cagagggtgc tagcgcttac attctgaatt acttaatgta
      721 cattctatgg gcattgctgt ttgcatttct ggctgtctcc ctggtacgtg tgtttgcacc
      781 atatgcctgt ggctctggca tacctgagat aaagactatt ttgagtggct ttatcatcag
      841 gggctacttg gggaaatgga ctcttctaat caagactgtc actctcgtgc tggttgtatc
      901 ctctggcctg agtcttggga aagaggggcc actggtgcat gtggcatgtt gctgtggcaa
      961 cttctttagc agccttttct ccaagtatag caagaatgaa ggcaagaggc gtgaggtgct
     1021 ttccgctgca gctgctgctg gtgtctctgt ggcctttggt gctcccatag gaggtgtact
     1081 cttcagtcta gaggaggtca gttactactt tcccttgaaa accttgtgga ggtcattttt
     1141 tgcagccctg gtggctgcct tcacactgcg ctccatcaac ccctttggaa atagccgcct
     1201 ggttctcttt tatgtggagt atcatacacc ttggtacatg gctgaactct tccctttcat
     1261 cctgcttgga gtctttgggg gtttgtgggg aaccgtcttc acacgctgca acattgcctg
     1321 gtgcaggagg cgtaaaacca ccaggctggg gaagtatcca gtgttggagg tcattgtggt
     1381 gacagccatc actgccatca ttgcttatcc caatccctac actcgccaga gcaccagtga
     1441 gctcatatct gagctattca atgattgtgg ggctcttgag tcttctcagc tctgtgacta
     1501 catcaatgac cccaacatga ctcggcctgt ggatgacatt ccggaccggc cagctggggt
     1561 tggagtttac acagccatgt ggcagctggc cttggcactg atcttcaaaa tagtcattac
     1621 tatatttacc tttggcatga agattccctc aggtctcttc atccccagta tggctgtagg
     1681 agccatggca ggccggatgg tgggaattgg tgtggagcag ctggcctacc atcatcatga
     1741 ctggatcatc ttcaggaact ggtgcaggcc tggagcggac tgtgtcacac cagggcttta
     1801 tgcgatggtg ggagctgcag cctgtctagg tggagtgact aggatgacag tgtctctggt
     1861 agtcatcatg tttgaactga ctggaggtct ggaatatatt gtacccctga tggcagctgc
     1921 tgttaccagc aagtgggtgg ctgatgcctt tgggaaagaa gggatttatg aagcccacat
     1981 ccatctgaat gggtacccat ttcttgatgt gaaggatgag ttcactcacc gtaccctagc
     2041 cactgatgtg atgcggcccc gcaggggaga accacctttg tcagtactaa cccaggacag
     2101 catgactgtg gaggatgtgg agactctcat aaaagagaca gactacaatg gctttcctgt
     2161 ggtggtctcg agagattcgg agcgcctcat aggctttgcc cagaggcggg agctaatctt
     2221 ggctataaaa aatgccagac agaggcaaga gggcatcgtg agcaattcca tcatgtactt
     2281 cacagaggag ccccctgagc tgcctgccaa cagcccacat ccactgaagc tgaggcgcat
     2341 tctgaacctg agccctttta ctgtcacaga ccacaccccc atggagacag tggtggacat
     2401 tttccggaaa ctggggctcc gacaatgcct ggtgacacgg agtgggaggc ttcttgggat
     2461 catcacaaaa aaagacgttc tgagacacat ggcgcagatg gcaaaccagg accctgaatc
     2521 catcatgttt aattagcaat aagatggaaa ttattttgag aagaccgata attatgtcat
     2581 ttttgaagaa ataaccaaat gatacattat gatcctaatg aaaaaacagg caactgagag
     2641 tagcagaaag ccttgtttga aaggaagggg agaaggatga aacatttttt aaagacaaac
     2701 cataaattaa taggcatttt ctagttttaa cctcttatga gttagaagct gcgtttctta
     2761 ataaatttac taactgcttt gggggcatgt gggagggtgt gaatgccatg aattatacga
     2821 agacacggaa cacaagaacc tttggcacct cactcaaggt ggatattcat aatttggaag
     2881 tatacatgat gctttgagtc caaaagacaa aggggtatta gcatgctgct gttatatatt
     2941 ggttcctaaa catttgctat tatgttatgg aatcatactg aaaatattgc acttactttg
     3001 ttgaaagaga aaagaaaatt caagttggat acagtgaaag ctacaagcag gccctgatgg
     3061 atggtctact agtgactatc tcatttcttg cctctgttct cagacccatt gttttgtttc
     3121 tttatcagtc tgaaccagta tcagtggtgc ccaccataat gaatatgaag tgaaagactt
     3181 ctctacagaa aacctcaaga ctggactaaa ctactggact gtgaaccatg tagtgctatg
     3241 cagacatttc ttctataaaa ggggacacag ttttactttg aggggacacc tgcctcatca
     3301 ctgatttgca accccaaagc atcaacttta cttattatat ggttacttgt gcatttgatg
     3361 tattgatcag tccagcactt ccatggatta ttgcctgtgt gctcctagat tgctatagtg
     3421 tgttttggtt ttcaggtagc atgtgcaata ctcaaaacca gctactcagt gtttctactt
     3481 aactttcttc tcatgtcttc cagatagagc catgataaga gtgaggtgta tgaattctca
     3541 gtgggaacat ctccaagtgg actgcaagag aaatagtaga ttgattctaa atctgttcca
     3601 ctctcttttc tgtaggctat aaaatgtcca gttttaatgc ctaagcatgt actttcaaac
     3661 tagcaatcat ggcacaggac agagttccat tttatacagc caattgaggc actaggtctc
     3721 tttatttgaa cttaatgtca cttttattct ctacattcta cacatctgtc ttttctgaag
     3781 gaagggatta gtgtttcagg gccattgcat gttttgtgta agatttgcgt catttcctat
     3841 ttcacttcat ctttgcccct cacttttcac tgagtcatca tccttctttt caatcttatt
     3901 gtaggtattg ttgcatcagg gacatgtgca ctaagtaaga aacctgggac atagccattc
     3961 caggattgtc tctacacatt gccagggttc caaattcttc tggtatttca ttttcacttt
     4021 tcttattctt tgtcctttgg cttactgcct catagttgta aaaatgttac ccagatgcta
     4081 ggtgtgatat ctactttctg tgtgggaaga aggaagaaga ggcaagtata aagatgaaat
     4141 gatgcatata cctttcccag agatgctcag cataaaacca ttggctggaa ttctattatc
     4201 tgtcccatcc tcctatctgt acagggagga taaattttag ctaaacatat tactttctgg
     4261 atgaaattta aattctgtta atagggaagg gggattgata tctatcatat taaattccaa
     4321 catcatgtcc ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
