LOCUS       NM_013147               3197 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus chloride voltage-gated channel 1 (Clcn1), mRNA.
ACCESSION   NM_013147
VERSION     NM_013147.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Ronstedt,K., Sternberg,D., Detro-Dassen,S., Gramkow,T.,
            Begemann,B., Becher,T., Kilian,P., Grieschat,M., Machtens,J.P.,
            Schmalzing,G., Fischer,M. and Fahlke,C.
  TITLE     Impaired surface membrane insertion of homo- and heterodimeric
            human muscle chloride channels carrying amino-terminal
            myotonia-causing mutations
  JOURNAL   Sci Rep 5, 15382 (2015)
   PUBMED   26502825
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Portaro,S., Altamura,C., Licata,N., Camerino,G.M., Imbrici,P.,
            Musumeci,O., Rodolico,C., Conte Camerino,D., Toscano,A. and
            Desaphy,J.F.
  TITLE     Clinical, Molecular, and Functional Characterization of CLCN1
            Mutations in Three Families with Recessive Myotonia Congenita
  JOURNAL   Neuromolecular Med 17 (3), 285-296 (2015)
   PUBMED   26007199
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Ulzi,G., Lecchi,M., Sansone,V., Redaelli,E., Corti,E.,
            Saccomanno,D., Pagliarani,S., Corti,S., Magri,F., Raimondi,M.,
            D'Angelo,G., Modoni,A., Bresolin,N., Meola,G., Wanke,E., Comi,G.P.
            and Lucchiari,S.
  TITLE     Myotonia congenita: novel mutations in CLCN1 gene and functional
            characterizations in Italian patients
  JOURNAL   J Neurol Sci 318 (1-2), 65-71 (2012)
   PUBMED   22521272
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Pedersen,T.H., de Paoli,F.V., Flatman,J.A. and Nielsen,O.B.
  TITLE     Regulation of ClC-1 and KATP channels in action potential-firing
            fast-twitch muscle fibers
  JOURNAL   J Gen Physiol 134 (4), 309-322 (2009)
   PUBMED   19786584
  REMARK    GeneRIF: Regulation of ClC-1 in action potential-firing fast-twitch
            muscle fibers
            Erratum:[J Gen Physiol. 2009 Dec;134(6):523. de Paoli, Frank
            Vinzenco [corrected to de Paoli, Frank Vincenzo]]
REFERENCE   5  (bases 1 to 3197)
  AUTHORS   Pierno,S., Camerino,G.M., Cippone,V., Rolland,J.F., Desaphy,J.F.,
            De Luca,A., Liantonio,A., Bianco,G., Kunic,J.D., George,A.L. Jr.
            and Conte Camerino,D.
  TITLE     Statins and fenofibrate affect skeletal muscle chloride conductance
            in rats by differently impairing ClC-1 channel regulation and
            expression
  JOURNAL   Br J Pharmacol 156 (8), 1206-1215 (2009)
   PUBMED   19220292
  REMARK    GeneRIF: Statins and fenofibrate affect skeletal muscle chloride
            conductance in rats by differently impairing ClC-1 channel
            regulation and expression.
REFERENCE   6  (bases 1 to 3197)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 3197)
  AUTHORS   Gurnett,C.A., Kahl,S.D., Anderson,R.D. and Campbell,K.P.
  TITLE     Absence of the skeletal muscle sarcolemma chloride channel ClC-1 in
            myotonic mice
  JOURNAL   J Biol Chem 270 (16), 9035-9038 (1995)
   PUBMED   7721815
REFERENCE   8  (bases 1 to 3197)
  AUTHORS   Lorenz,C., Meyer-Kleine,C., Steinmeyer,K., Koch,M.C. and
            Jentsch,T.J.
  TITLE     Genomic organization of the human muscle chloride channel CIC-1 and
            analysis of novel mutations leading to Becker-type myotonia
  JOURNAL   Hum Mol Genet 3 (6), 941-946 (1994)
   PUBMED   7951242
REFERENCE   9  (bases 1 to 3197)
  AUTHORS   Steinmeyer,K., Ortland,C. and Jentsch,T.J.
  TITLE     Primary structure and functional expression of a developmentally
            regulated skeletal muscle chloride channel
  JOURNAL   Nature 354 (6351), 301-304 (1991)
   PUBMED   1659664
REFERENCE   10 (bases 1 to 3197)
  AUTHORS   Mehrke,G., Brinkmeier,H. and Jockusch,H.
  TITLE     The myotonic mouse mutant ADR: electrophysiology of the muscle
            fiber
  JOURNAL   Muscle Nerve 11 (5), 440-446 (1988)
   PUBMED   2453798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X62894.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X62894.1, AY112740.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3197
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /note="chloride voltage-gated channel 1"
                     /db_xref="GeneID:25688"
                     /db_xref="RGD:2360"
     exon            1..263
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3068
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /note="chloride channel protein, skeletal muscle; clC-1;
                     chloride channel, voltage-sensitive 1; chloride channel 1,
                     skeletal muscle"
                     /codon_start=1
                     /product="chloride channel protein 1"
                     /protein_id="NP_037279.1"
                     /db_xref="GeneID:25688"
                     /db_xref="RGD:2360"
                     /translation="MERSQSQQHGGEQSWWGTAPQYQYMPFEHCTSYGLPSENGGLQH
                     RPRKDLGPRHNAHPTQIYGHHKEQYSYQAQDRGIPKKTDSSSTVDSLDEDHYSKCQDC
                     VHRLGRVLRRKLGEDWIFLVLLGLLMALVSWCMDYVSAKSLQAYKWTYAQMQPSLPLQ
                     YLAWVTFPLILILFSALFCQLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVA
                     LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFSGVYEQPYYYTDILTVGCAVGVG
                     CCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFR
                     TNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLL
                     YPGIVTFVIASLTFPPGMGQFMAGELMPREAISTLFDNNTWVKHIGDPKSLGQSAVWI
                     HPQVNVVIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPE
                     GILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILA
                     NMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGE
                     LRNLLQTTTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLCAERRLKAAQDMARKLS
                     ELPYNGQAQLAGEWHPGGRPESFAFVDEDEDEDVSRKTELPQTPTPPPPPPPPLPPQF
                     PIAPSYPEEPNGPLPSHKQPPEASDSADQRSSIFQRLLHCLLGKAHSTKKKITQDSTD
                     LVDNMSPEEIEAWEREQLSQPVCFDFCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAY
                     VTSMGKLRGVLALEELQKAIKGHTKSGVQLRPPLASFRNTTSIRKTPGGPPPPAESWN
                     VPEGEDGAPEREVMVPTMPETPVPPPSPEVPSCLAPARVEGELEELEMVGNLGPEEDL
                     ADILHGPSLRSTDEEDEDELIL"
     exon            264..384
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            385..516
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            517..645
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            646..779
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            780..857
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            858..936
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1062
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1147
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1249
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1334
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1484
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1554
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1665
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1879
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2013
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2246
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2385
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2465
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2504
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2609
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2696
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..3197
                     /gene="Clcn1"
                     /gene_synonym="SMCC"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaaagcaga ggcttaagga ggtactaggg ggagactagg agcaagcagg ccaaggcctg
       61 gctggggctt ggggggagga cacatggagc ggtcccagtc ccagcaacat ggaggtgaac
      121 aaagctggtg gggcactgcc ccccagtacc agtacatgcc cttcgaacat tgtaccagct
      181 atggactgcc ctcagagaat gggggccttc agcaccggcc ccgaaaggac ctgggtccca
      241 ggcacaatgc ccacccaaca cagatatatg gccatcacaa agaacaatat tcatatcagg
      301 cacaggacag gggaataccc aagaagacgg actccagttc tactgtggac agcttggatg
      361 aggaccacta ttctaaatgt caagactgtg tccatcgcct gggacgtgtg ctgagaagga
      421 agctggggga agactggatc tttcttgtgc tcctgggcct actgatggct cttgtcagct
      481 ggtgcatgga ctatgttagc gccaagagcc ttcaggccta caagtggacc tatgcccaga
      541 tgcagcccag ccttcctcta cagtacttgg cctgggtcac cttcccactt atcctcatcc
      601 tcttcagtgc cctcttttgc caactcatct ctccccaggc tgtgggctct ggaatccctg
      661 agatgaagac aattcttcgt ggtgttgtct tgaaggaata cctcacactc aaggcctttg
      721 tagccaaggt ggtggccttg acagccggtc tgggcagtgg tatccctgtg gggaaagagg
      781 gtccctttgt tcacattgcc agcatctgtg ctgctgtcct cagcaaattc atgtccatgt
      841 tctctggtgt ctatgagcag ccatactatt acactgacat cctgacagtg ggctgtgccg
      901 tgggggtcgg ttgctgtttt ggaacaccac ttggaggagt gctgttcagc atcgaggtca
      961 cctctaccta ctttgccgtt cggaattact ggcgaggatt ctttgcagcc accttcagtg
     1021 cctttgtgtt ccgcgtcctg gcagtgtgga acaaggatgc tgtcactatt actgctctgt
     1081 tcagaactaa tttccggatg gatttcccct ttgacctgaa ggaactccca gcttttgctg
     1141 tcattgggat ttgctgcggg ttcttgggag ctgtttttgt ttatctgcat cgccaagtca
     1201 tgctcggtgt ccgaaagcac aaggctctca gccagtttct tgctaagcac cgcctgctct
     1261 atcctggaat cgttactttt gtcatcgcct cactcacctt tccaccagga atgggtcaat
     1321 tcatggctgg agagctgatg ccccgtgaag ctatcagcac cctctttgac aacaacacat
     1381 gggtaaagca cataggtgat cccaaaagct tgggccagtc agctgtgtgg attcaccccc
     1441 aggtcaacgt ggtcatcatc atccttctct tcttcgtcat gaagttttgg atgtccattg
     1501 tggccacgac tatgcccata ccctgtggag gcttcatgcc tgtttttgtg ctaggagctg
     1561 cctttggaag gctggtagga gagatcatgg ccatgctgtt ccctgagggt atcttatttg
     1621 atgatatcat ctataagatc ttaccagggg gctatgcagt gattggagca gcagctttga
     1681 caggggctgt ctctcacaca gtctccacag ctgtgatttg cttcgaatta actggtcaga
     1741 ttgctcacat cctgcccatg atggtggctg ttatcttggc caacatggtg gcccaaagtc
     1801 tgcagccctc cctctatgac agcatcatcc aggtcaagaa gcttccctat ttgccagacc
     1861 ttggttggaa ccagctcagc aaatttacaa tttttgttga ggacatcatg gtacgtgacg
     1921 tgaagtttgt ttcagcttct tgtacatacg gggaactaag aaacctactc cagaccacca
     1981 cagtcaagac tttaccattg gttgactcca aagattcaat gatcctgcta ggctctgtgg
     2041 aacgctcaga actgcagtcc ctcctgcagc gccacctgtg tgcagagcga aggttgaagg
     2101 ctgcccagga catggctcga aagttatcag agctgcccta taatggccag gctcagctgg
     2161 ctggggagtg gcatcctggt ggtcgacctg agtcctttgc cttcgtagat gaagatgaag
     2221 atgaggacgt ctcccggaag acagagcttc cacagactcc aactcctcct cctcctcccc
     2281 ctcctcctct gcctccccag tttcctattg ctccatcata ccctgaagag cctaacgggc
     2341 cactgcccag ccacaaacag ccccctgaag cttcagactc tgcagatcaa aggtcctcca
     2401 tcttccagcg cctgctgcac tgcttactgg gcaaagctca ctccacaaag aagaaaataa
     2461 cccaggattc aacagattta gtggataaca tgtcacctga agagattgag gcctgggagc
     2521 gggagcagct gagccagcct gtgtgttttg atttctgctg cattgaccag tctcccttcc
     2581 agctggtgga gcagacaact ctgcacaaga ctcatacact cttctcactt cttggcctcc
     2641 atcttgccta tgtgaccagc atggggaagc tcagaggtgt cttggcacta gaagagctac
     2701 agaaagctat caagggccac accaaatctg gagtgcagct tcgccctcca cttgccagct
     2761 tccggaatac aacttcaatt cggaagaccc ctggggggcc accccctcct gcagagagct
     2821 ggaatgtgcc tgagggtgaa gatggagctc ctgaaagaga agtcatggtt cctaccatgc
     2881 cagagactcc tgtcccacca ccatctccag aggtcccttc ctgcctggcc ccagccagag
     2941 tggagggtga gctggaggaa ctggagatgg tggggaacct agggcctgag gaggacctgg
     3001 ctgacatctt gcatggcccc agtctgcggt ccactgatga ggaagatgag gacgagctga
     3061 tcctgtgaac aacaccctcc aagctttctt cataaaaacc acagggccca tgtcagagag
     3121 tgggcttgta tatgaaatgg gtgccctgaa gttggggaga cctccatttc atcgttgttc
     3181 ctaccccact atgaaag
//
