LOCUS       NM_001399751            1677 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cardiotrophin-like cytokine factor 1 (Clcf1),
            transcript variant 1, mRNA.
ACCESSION   NM_001399751 XM_039085464
VERSION     NM_001399751.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1677)
  AUTHORS   Kong,S.L., Chui,P., Lim,B. and Salto-Tellez,M.
  TITLE     Elucidating the molecular physiopathology of acute respiratory
            distress syndrome in severe acute respiratory syndrome patients
  JOURNAL   Virus Res 145 (2), 260-269 (2009)
   PUBMED   19635508
REFERENCE   2  (bases 1 to 1677)
  AUTHORS   Perret,D., Guillet,C., Elson,G., Froger,J., Plun-Favreau,H.,
            Rousseau,F., Chabbert,M., Gauchat,J.F. and Gascan,H.
  TITLE     Two different contact sites are recruited by cardiotrophin-like
            cytokine (CLC) to generate the CLC/CLF and CLC/sCNTFRalpha
            composite cytokines
  JOURNAL   J Biol Chem 279 (42), 43961-43970 (2004)
   PUBMED   15272019
REFERENCE   3  (bases 1 to 1677)
  AUTHORS   Heese,K., Yamada,T., Akatsu,H., Yamamoto,T., Kosaka,K., Nagai,Y.
            and Sawada,T.
  TITLE     Characterizing the new transcription regulator protein p60TRP
  JOURNAL   J Cell Biochem 91 (5), 1030-1042 (2004)
   PUBMED   15034937
REFERENCE   4  (bases 1 to 1677)
  AUTHORS   Senaldi,G., Stolina,M., Guo,J., Faggioni,R., McCabe,S.,
            Kaufman,S.A., Van,G., Xu,W., Fletcher,F.A., Boone,T., Chang,M.S.,
            Sarmiento,U. and Cattley,R.C.
  TITLE     Regulatory effects of novel neurotrophin-1/b cell-stimulating
            factor-3 (cardiotrophin-like cytokine) on B cell function
  JOURNAL   J Immunol 168 (11), 5690-5698 (2002)
   PUBMED   12023368
REFERENCE   5  (bases 1 to 1677)
  AUTHORS   Uemura,A., Takizawa,T., Ochiai,W., Yanagisawa,M., Nakashima,K. and
            Taga,T.
  TITLE     Cardiotrophin-like cytokine induces astrocyte differentiation of
            fetal neuroepithelial cells via activation of STAT3
  JOURNAL   Cytokine 18 (1), 1-7 (2002)
   PUBMED   12090754
REFERENCE   6  (bases 1 to 1677)
  AUTHORS   Plun-Favreau,H., Elson,G., Chabbert,M., Froger,J., deLapeyriere,O.,
            Lelievre,E., Guillet,C., Hermann,J., Gauchat,J.F., Gascan,H. and
            Chevalier,S.
  TITLE     The ciliary neurotrophic factor receptor alpha component induces
            the secretion of and is required for functional responses to
            cardiotrophin-like cytokine
  JOURNAL   EMBO J 20 (7), 1692-1703 (2001)
   PUBMED   11285233
REFERENCE   7  (bases 1 to 1677)
  AUTHORS   Elson,G.C., Lelievre,E., Guillet,C., Chevalier,S., Plun-Favreau,H.,
            Froger,J., Suard,I., de Coignac,A.B., Delneste,Y., Bonnefoy,J.Y.,
            Gauchat,J.F. and Gascan,H.
  TITLE     CLF associates with CLC to form a functional heteromeric ligand for
            the CNTF receptor complex
  JOURNAL   Nat Neurosci 3 (9), 867-872 (2000)
   PUBMED   10966616
REFERENCE   8  (bases 1 to 1677)
  AUTHORS   Senaldi,G., Varnum,B.C., Sarmiento,U., Starnes,C., Lile,J.,
            Scully,S., Guo,J., Elliott,G., McNinch,J., Shaklee,C.L.,
            Freeman,D., Manu,F., Simonet,W.S., Boone,T. and Chang,M.S.
  TITLE     Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the
            IL-6 family
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11458-11463 (1999)
   PUBMED   10500198
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 13, 2022 this sequence version replaced XM_039085464.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.121619.1,
                                           SRR26360186.2331972.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000001.1  210937763-210937838
            77-243              JAXUCZ010000001.1  210943741-210943907
            244-1677            JAXUCZ010000001.1  210945631-210947064
FEATURES             Location/Qualifiers
     source          1..1677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1677
                     /gene="Clcf1"
                     /gene_synonym="Bsf3; Clc; NNT-1"
                     /note="cardiotrophin-like cytokine factor 1"
                     /db_xref="GeneID:365395"
                     /db_xref="RGD:1303171"
     exon            1..76
                     /gene="Clcf1"
                     /gene_synonym="Bsf3; Clc; NNT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..738
                     /gene="Clcf1"
                     /gene_synonym="Bsf3; Clc; NNT-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; novel neurotrophin-1; B-cell stimulating factor
                     3"
                     /codon_start=1
                     /product="cardiotrophin-like cytokine factor 1 isoform 1
                     precursor"
                     /protein_id="NP_001386680.1"
                     /db_xref="GeneID:365395"
                     /db_xref="RGD:1303171"
                     /translation="MDLRAGDSWGMLACLCTVLWHLPAVPALNRTGDPGPGPSIQKTY
                     DLTRYLEHQLRSLAGTYLNYLGPPFNEPDFNPPRLGAETLPRATVNLEVWRSLNDRLR
                     LTQNYEAYSHLLCYLRGLNRQAATAELRRSLAHFCTSLQGLLGSIAGVMATLGYPLPQ
                     PLPGTEPAWAPGPAHSDFLQKMDDFWLLKELQTWLWRSAKDFNRLKKKMQPPAASVTL
                     HLEAHGF"
     exon            77..243
                     /gene="Clcf1"
                     /gene_synonym="Bsf3; Clc; NNT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1677
                     /gene="Clcf1"
                     /gene_synonym="Bsf3; Clc; NNT-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccactcc gccagcctct gggagaggag ccgcgcccgg ccggcccggc ccccagcccc
       61 atggacctcc gagcagggga ctcgtggggg atgttagctt gcctctgcac ggtgctgtgg
      121 cacctccctg cagtgccagc tcttaatcga acaggagatc caggccctgg cccctccatc
      181 cagaaaacct atgacctcac ccgctacctg gagcatcaac tccgcagctt agctgggacc
      241 tacctgaact acctggggcc ccctttcaac gagcctgact tcaatcctcc tcggctgggg
      301 gcagaaactc tgcccagggc cacggtcaac ttggaagtgt ggcgaagcct caatgacagg
      361 ctacggctga cccagaacta tgaggcctac agtcacctcc tgtgttactt gcgtggcctc
      421 aaccgtcaag ctgccacagc tgaactacga cgtagtctgg cccatttctg taccagtctc
      481 cagggcctgc tgggaagcat tgcaggtgtc atggcaactc ttggctaccc attaccccag
      541 cctctgccag ggactgagcc agcctgggcc cctggccctg cccacagcga cttcctccag
      601 aagatggatg acttctggct gctgaaggag ctgcagacct ggctatggcg ttcagccaaa
      661 gacttcaacc ggcttaagaa gaagatgcaa cctccagcag cttcagtcac cctgcacttg
      721 gaggcccatg gtttctgatc tctgaccctt cacccccaca ccttcagccc cagtcaactg
      781 tgcttccatt gtggggtgaa aaatcctcta taccaatatt tgttgagcca ggagccagac
      841 catagtagct ctaccctcct cgccttggat gggggtgtaa ctcaataagc cctctagctc
      901 cttgagtcct agggtctggg gaaaaggtac agtgggcacc aagaggtaat gcctgaggga
      961 gtcgaatggc tcagtggata gaaaggccct ctctgcctcc tgctttctgc ttgccacttg
     1021 ccagtaacca ctcagttcct catgtggcac ttgcagaaac atacctggag ggcatgggtg
     1081 ggggccactg tagcatgtgc ctttctggga taaggcccct tggcttccct ccctctcctt
     1141 ggatgggtgt tgcttcccta ccccaataac tacatatcca gttcaggaaa caaagtgacc
     1201 agtctaaaga agagtgtgat agaagtggag gggtagggtc tgtgctggag gtggcctaga
     1261 aaccagaaga tgtaattcta aaagagaagg gcagggacag aacagaccca gcagtcacca
     1321 agacagtggt ggcacagggc ggaaaacaaa agccatgttg agcattaaga ccttgccttg
     1381 aattttcttg ccagcatctt ggtacctcct ctctgccccc tttcccaagg tatctgtggt
     1441 tgcctgggct ggggagggca gccatagcca tagccacagg gtttcctgaa agtttacatt
     1501 gcagtagcat tgtggggtaa gggggatggc tccccaggct ctatccccag ccccacccac
     1561 tcatgactct taagtttgtt gtattaatat ttatttattt ggagatgtta tttattagat
     1621 gatatttatt gcagaatttc tattcttgta ttaacaaata aaatgcttgc cccagaa
//
