LOCUS       NM_001107450            3963 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus chloride channel accessory 2 (Clca2), mRNA.
ACCESSION   NM_001107450 XM_001079234 XM_217690
VERSION     NM_001107450.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3963)
  AUTHORS   Hamalainen,L., Bart,G., Takabe,P., Rauhala,L., Deen,A.,
            Pasonen-Seppanen,S., Karkkainen,E., Karna,R., Kumlin,T., Tammi,M.I.
            and Tammi,R.H.
  TITLE     The calcium-activated chloride channel-associated protein rCLCA2 is
            expressed throughout rat epidermis, facilitates apoptosis and is
            downmodulated by UVB
  JOURNAL   Histochem Cell Biol 155 (5), 605-615 (2021)
   PUBMED   33486586
  REMARK    GeneRIF: The calcium-activated chloride channel-associated protein
            rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis
            and is downmodulated by UVB.
REFERENCE   2  (bases 1 to 3963)
  AUTHORS   Dietert,K., Mundhenk,L., Erickson,N.A., Reppe,K., Hocke,A.C.,
            Kummer,W., Witzenrath,M. and Gruber,A.D.
  TITLE     Murine CLCA5 is uniquely expressed in distinct niches of airway
            epithelial cells
  JOURNAL   Histochem Cell Biol 143 (3), 277-287 (2015)
   PUBMED   25212661
  REMARK    GeneRIF: The mCLCA5 protein is uniquely expressed in highly select
            bronchial epithelial cells and submucosal glands in naive mice,
            consistent with anatomical locations of progenitor cell niches.
REFERENCE   3  (bases 1 to 3963)
  AUTHORS   Evans,S.R., Thoreson,W.B. and Beck,C.L.
  TITLE     Molecular and functional analyses of two new calcium-activated
            chloride channel family members from mouse eye and intestine
  JOURNAL   J Biol Chem 279 (40), 41792-41800 (2004)
   PUBMED   15284223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 17, 2023 this sequence version replaced NM_001107450.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.11805.1,
                                           SRR26643299.12411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000002.1  236682167-236682458 c
            293-430             JAXUCZ010000002.1  236681218-236681355 c
            431-581             JAXUCZ010000002.1  236678386-236678536 c
            582-690             JAXUCZ010000002.1  236675076-236675184 c
            691-850             JAXUCZ010000002.1  236673659-236673818 c
            851-1078            JAXUCZ010000002.1  236671049-236671276 c
            1079-1309           JAXUCZ010000002.1  236669209-236669439 c
            1310-1487           JAXUCZ010000002.1  236667942-236668119 c
            1488-1594           JAXUCZ010000002.1  236667072-236667178 c
            1595-1819           JAXUCZ010000002.1  236663995-236664219 c
            1820-2090           JAXUCZ010000002.1  236661898-236662168 c
            2091-2261           JAXUCZ010000002.1  236659672-236659842 c
            2262-2492           JAXUCZ010000002.1  236657399-236657629 c
            2493-3963           JAXUCZ010000002.1  236655423-236656893 c
FEATURES             Location/Qualifiers
     source          1..3963
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..3963
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /note="chloride channel accessory 2"
                     /db_xref="GeneID:308016"
                     /db_xref="RGD:1304894"
     exon            1..292
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2935
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /note="chloride channel, calcium activated, family member
                     2; chloride channel calcium activated 5"
                     /codon_start=1
                     /product="calcium-activated chloride channel regulator 2"
                     /protein_id="NP_001100920.1"
                     /db_xref="GeneID:308016"
                     /db_xref="RGD:1304894"
                     /translation="MILGGNTGPVGRLKLVTLLFALSPELVFLGAGLKLKENGYDGLL
                     VAINPRVPEDLKLIRNIQEMITEASFYLFNATKRRVFFRSVQILIPATWTAHNYSRVK
                     QESFDKANVLVTEQNGVPGEDPYTLQHRGCGQEGKYIHFTPNFLLNDELAAGYGSRGR
                     VFVHEWAHLRWGVFDEYNSDKPFYVNGRNEIQVTRCSSDITGVFVCEKGLCPHEDCII
                     SKLFREGCTFLYNSTQSATGSIMFMQSLPSVVEFCNEGTHNREAPNLQNRVCSLRSTW
                     DVITGSSDLNHSLPVLGVELPAPPSFSLLQAGDRVVCLVIDVSRKMAEGDRLLRLQQA
                     AELFLMQVVEAHTFVGIVTFDSKGEIRAPLQQINSDDDRKLLVSYLPTTVSTEAETNI
                     CAGVKKGFEVVEKQNGRADGSVMILVTSGADEHITNCLLTAMSSGSTIHSMALGSSAA
                     RRLGELSHVTGGLEFFIPDPFTSSRMTEAFSGISSGAGDIFQQSLQLESTCETVQPQH
                     QLANTVTVDRAVGNDTFFLVMWQTGGPSEIVLLDPSGRKYNTGDFIINLPFRTASLKI
                     PGTAKHGHWTYTLNNTHHSPQALKVTVASRASSLAVSPATVDAFVERDSTYFPQPVII
                     YANVRKGLYPILNATVMATVEPEAGDPVVLQLLDEGAGADVIKNDGIYSRYFFSFAVS
                     GRYSLTVHVRHSPSTSTLAHSVPGNHAMYVPGYVTNDNIQMNAPKRTGRRPVKERWDF
                     SRVSSGGSFSVLGVPDGPHPDVFPPCRITDLAAMNVEEDVTLSWTAPGEDFDQGQTTS
                     YEIRMSKSLQRIRDDFDNAILVNSSGLIPQHAGTRETFTFSPKLVTHELEHEPDEEAQ
                     ETYIVYVALRAMDRSSLRSAVSNIVLVSMSLPPNSAPVVSRDDRILKGVLTIVGLITI
                     LCLLLVVSHCTLNRKKRASRKENETKFL"
     exon            293..430
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            431..581
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            582..690
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            691..850
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1078
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1309
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1487
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1594
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1819
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2090
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2261
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2492
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..3963
                     /gene="Clca2"
                     /gene_synonym="Clca5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaagacctt ctgagttccg aaagaagcca tttgcttcca cattgatcag ctgactcgag
       61 gtgcccagca ggctccccgt gagtaaccca gaggcttcac tacaagatga tcctcggggg
      121 taacacagga cctgttggca ggctgaaact cgtgactctt ctgtttgccc taagtccaga
      181 acttgtgttc ctgggagctg gattgaagct gaaagagaat ggttatgatg gattgcttgt
      241 tgcgatcaat cctcgggtac cggaggactt gaagctgatc agaaacattc aggagatgat
      301 caccgaagct tccttttacc tgttcaatgc gaccaagaga agggtgtttt tcagaagtgt
      361 acagattcta atacctgcca cttggacagc gcataattac agcagggtta aacaggaatc
      421 ctttgacaag gcaaatgtct tagtgactga gcagaatggg gtacccgggg aagaccctta
      481 taccctacaa cacagagggt gtggacaaga ggggaaatac atccatttca cccccaactt
      541 cctactcaac gatgagttag cagcaggata tggctctcga ggccgagtgt ttgtccacga
      601 gtgggcccat ctccgctggg gtgtgtttga tgaatataac agtgacaagc cgttctacgt
      661 gaatggacgg aatgagattc aagtcaccag gtgttcatct gacatcacgg gtgtttttgt
      721 ttgtgaaaag ggcctttgcc cccacgaaga ctgcatcatt agcaagcttt ttagggaagg
      781 atgcacattc ctctacaaca gcacccagag tgcaactgga tcaataatgt tcatgcagag
      841 tttaccttct gtggttgaat tctgtaacga aggcacccac aatcgagaag ccccaaatct
      901 ccagaaccga gtgtgcagcc tcagaagcac ttgggatgtg atcactggct cctcagacct
      961 gaaccacagc ctcccggtgc tgggggttga gcttccagcc cctccctcgt tctccctctt
     1021 gcaggctggt gaccgagtgg tctgcttagt gattgatgtg tccaggaaga tggcagaggg
     1081 agacagactc ctccggctac aacaagcagc cgaactgttc ttgatgcagg tcgttgaagc
     1141 tcatactttt gtgggcattg tcacttttga cagcaaagga gaaatccgag ccccgttgca
     1201 acaaattaac agcgacgatg accggaagtt gctggtttcg tacctgccga ccactgtgtc
     1261 cactgaagca gagaccaaca tctgtgcagg ggttaagaaa ggctttgagg tggttgagaa
     1321 gcagaatgga cgagcggatg gctctgtcat gatattagtg accagcggag cagatgaaca
     1381 catcaccaac tgcctgctca ccgcaatgag cagtgggtcc accattcatt ccatggccct
     1441 gggctcctct gcagccagaa gactggggga attatcacat gttacaggag gtttggagtt
     1501 cttcattcca gatccattta cctctagccg aatgactgaa gccttcagtg gaatctcttc
     1561 tggggcagga gacattttcc agcaaagctt acagcttgaa agcacgtgcg agactgtgca
     1621 accccagcac caactggcaa atactgtgac tgtggatagg gctgtgggca atgacacgtt
     1681 tttcctagtc atgtggcaga ccggtggtcc ctctgagatt gtattattgg accctagtgg
     1741 aagaaaatac aacactggtg actttatcat caatctgccc tttcggacag ccagccttaa
     1801 gattccagga actgctaagc atgggcactg gacttacacg ctgaacaata cccaccattc
     1861 tcctcaagct ctgaaagtga ctgtggcctc ccgtgcctcc agtctggccg tgtccccagc
     1921 caccgtggac gcctttgtgg aaagggacag cacctatttt cctcagccgg tgataattta
     1981 tgcaaacgtg aggaagggtc tgtaccccat actcaatgcc actgtgatgg caacggttga
     2041 gcctgaggct ggagaccctg ttgtgctgca acttttggat gaaggagcag gcgccgatgt
     2101 tataaaaaat gatggaattt actccaggta ttttttctcc tttgctgtaa gtggtagata
     2161 tagcttgaca gtgcatgtcc gtcactctcc cagcacaagc accctagccc actctgtccc
     2221 aggaaaccat gctatgtatg taccaggtta cgtaaccaac gataatattc aaatgaatgc
     2281 tcccaaaaga acaggccgca gacctgtgaa ggagcggtgg gacttcagtc gagtaagctc
     2341 tggaggctcc ttctcagtgc tgggagtccc agacggcccc caccctgacg tgttcccacc
     2401 atgcagaatt acggacctgg cagccatgaa cgtagaagag gatgtgaccc tctcttggac
     2461 ggcacctggg gaagacttcg atcaggggca aaccacaagc tatgaaataa gaatgagcaa
     2521 aagtctacag cgtattcggg atgactttga caatgccatc ttggtgaact cgtcggggct
     2581 aattcctcag catgctggca ccagggagac atttacattc tcacccaagc ttgtcaccca
     2641 tgaacttgaa catgaacctg atgaagaagc acaagaaacc tacatagtgt atgtggccct
     2701 gagagccatg gatagaagct ccctccggtc agctgtgtca aacattgtcc tggtatcaat
     2761 gtctctcccc ccaaactctg ctcctgtagt gagcagagat gacaggatac tgaaaggagt
     2821 tttaacaata gtaggtttga taacgattct ttgccttctt ctggttgtat cacactgtac
     2881 tttaaacagg aaaaagagag catcaaggaa agagaatgaa acaaaatttc tatgagtaga
     2941 cgtaatacct tccttcttag atatgatgac catagccttt acagccacaa aaatgccaac
     3001 aaaatcaaat tagccttaac attgggactt ttacatagca gatagttgcc ttctcccgcc
     3061 ttcctccccc ccaaaaagcc taacttttaa tactcgtttt agggaaaggg tttgaaaaca
     3121 gtgtaaggtt ccaatggaaa aataataaaa tatattgctc aaggtaatgg cttgaaaggc
     3181 aaggacaaaa tcaaatggga gtcaggaaaa gcttgtttta ttgaagttga ggtcagggga
     3241 agttctgtgt acggaaaagg atgttgggcc tgagtcagac agtgtaacta ccggtatgaa
     3301 gcgaaagtat tacagtgatg aatttctctc tctgcttatc tgtgcagagc agggtgagtg
     3361 tttataactg acaaccaagc ttctttatag acaaggcccc gctacagggt tctttatacc
     3421 ttctcctttg gttaaacaca ctgtgatgac ccacaagcca ccactaatgc tcaggcaggt
     3481 cttttctcac cgtgagagga gaccttagaa tgcagttgtt atccctgctc cttggattct
     3541 gatctacaac agaggtcacc ttagtttatt gtttgtcaga tttcagtgcc actgaagtag
     3601 cttcctaagt tattgccttg gaagtaactg agtaaaaatg gtcaccactc ccatgaggct
     3661 ttaagtaaag ggtaaaagac atcattgtga aataatttta atatatacac catgtagttt
     3721 tattctattg caaagaagaa gtcatggatg gaaaggtgtt tagaagcaac tagcaaattc
     3781 tgtcctggtt aaataacaat ctgcaatcct tgcttcatcg aggacagaga gaagacagca
     3841 gagataatgt ggaaataaaa accatctaat gttacgtcct cctcttaaaa attgttgttg
     3901 aatattaata tgtcatttct aaattcaaga acttaaaatt ttattgaata aatatgtcac
     3961 aga
//
