LOCUS       NM_001107449            3608 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus chloride channel accessory 1 (Clca1), mRNA.
ACCESSION   NM_001107449 XM_001079217 XM_217689
VERSION     NM_001107449.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Lee RM, Han KH and Han JS.
  TITLE     rbCLCA1 is a putative metalloprotease family member: localization
            and catalytic domain identification
  JOURNAL   Amino Acids 48 (3), 707-720 (2016)
   PUBMED   26510883
  REMARK    GeneRIF: amino acids H159 and E167 in the rbCLCA1 metalloprotease
            motif are important in rbCLCA1 processing for localization to the
            cell surface.
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Bell SM, Zhang L, Xu Y, Besnard V, Wert SE, Shroyer N and Whitsett
            JA.
  TITLE     Kruppel-like factor 5 controls villus formation and initiation of
            cytodifferentiation in the embryonic intestinal epithelium
  JOURNAL   Dev Biol 375 (2), 128-139 (2013)
   PUBMED   23266329
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Wu WL, Zhen HT and Gao M.
  TITLE     [Effects of glucocorticoid on calcium-activated chloride channel
            expression in nasal mucosa in allergic rhinitis rats]
  JOURNAL   Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44 (3), 242-245
            (2009)
   PUBMED   19558866
  REMARK    GeneRIF: Dexamethasone substantially downregulates the expression
            of CLCA3 mRNA and Muc5ac protein in nasal mucosa in allergic
            rhinitis.
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Wahl AS, Buchthal B, Rode F, Bomholt SF, Freitag HE, Hardingham GE,
            Ronn LC and Bading H.
  TITLE     Hypoxic/ischemic conditions induce expression of the putative
            pro-death gene Clca1 via activation of extrasynaptic
            N-methyl-D-aspartate receptors
  JOURNAL   Neuroscience 158 (1), 344-352 (2009)
   PUBMED   18616988
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Woodruff PG, Boushey HA, Dolganov GM, Barker CS, Yang YH, Donnelly
            S, Ellwanger A, Sidhu SS, Dao-Pick TP, Pantoja C, Erle DJ, Yamamoto
            KR and Fahy JV.
  TITLE     Genome-wide profiling identifies epithelial cell genes associated
            with asthma and with treatment response to corticosteroids
  JOURNAL   Proc Natl Acad Sci U S A 104 (40), 15858-15863 (2007)
   PUBMED   17898169
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Kamada F, Suzuki Y, Shao C, Tamari M, Hasegawa K, Hirota T, Shimizu
            M, Takahashi N, Mao XQ, Doi S, Fujiwara H, Miyatake A, Fujita K,
            Chiba Y, Aoki Y, Kure S, Tamura G, Shirakawa T and Matsubara Y.
  TITLE     Association of the hCLCA1 gene with childhood and adult asthma
  JOURNAL   Genes Immun 5 (7), 540-547 (2004)
   PUBMED   15318163
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Hauber HP, Tsicopoulos A, Wallaert B, Griffin S, McElvaney NG,
            Daigneault P, Mueller Z, Olivenstein R, Holroyd KJ, Levitt RC and
            Hamid Q.
  TITLE     Expression of HCLCA1 in cystic fibrosis lungs is associated with
            mucus overproduction
  JOURNAL   Eur Respir J 23 (6), 846-850 (2004)
   PUBMED   15218996
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Hegab,A.E., Sakamoto,T., Uchida,Y., Nomura,A., Ishii,Y.,
            Morishima,Y., Mochizuki,M., Kimura,T., Saitoh,W., Massoud,H.H.,
            Massoud,H.M., Hassanein,K.M. and Sekizawa,K.
  TITLE     CLCA1 gene polymorphisms in chronic obstructive pulmonary disease
  JOURNAL   J Med Genet 41 (3), e27 (2004)
   PUBMED   14985398
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Leverkoehne I and Gruber AD.
  TITLE     The murine mCLCA3 (alias gob-5) protein is located in the mucin
            granule membranes of intestinal, respiratory, and uterine goblet
            cells
  JOURNAL   J Histochem Cytochem 50 (6), 829-838 (2002)
   PUBMED   12019299
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Nakanishi A, Morita S, Iwashita H, Sagiya Y, Ashida Y, Shirafuji H,
            Fujisawa Y, Nishimura O and Fujino M.
  TITLE     Role of gob-5 in mucus overproduction and airway
            hyperresponsiveness in asthma
  JOURNAL   Proc Natl Acad Sci U S A 98 (9), 5175-5180 (2001)
   PUBMED   11296262
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217689.4, XM_001079217.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676784
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..3608
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /note="chloride channel accessory 1"
                     /db_xref="GeneID:308015"
                     /db_xref="RGD:1306258"
     exon            1..176
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2747
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /note="calcium-activated chloride channel regulator 1;
                     chloride channel calcium activated 3"
                     /codon_start=1
                     /product="calcium-activated chloride channel regulator 1
                     precursor"
                     /protein_id="NP_001100919.1"
                     /db_xref="GeneID:308015"
                     /db_xref="RGD:1306258"
                     /translation="MGSLKSPVFLLVLYLLEGVLSNSLIQLNNNGYEGIVIAIDHDVP
                     EDEALIQRIKDMVTQASPYLFEATGKRFYFKNVAILIPENWNTKPEYKRPKLETLKNA
                     DVLVSTMSPIGNDEPYTEHIGACGERGIRIHLTPDFLAGKKQTEYGPQDRTFVHEWAH
                     FRWGVFDEYNNNEKFYLSNGKPQAVRCSATITGKHVVRRCQGGSCVTNGKCVIDRVTG
                     LYKDNCVFIPDKNQREKASIMFNQNINSVVEFCTEKNHNKEAPNAQNQRCNLRSTWEV
                     IQESEDFKQTTPMTAQPPAPTFSLLQTRQRIVCLVLDKSGSMQSDNRLNRMNQASRLF
                     LLQTVEQGSWVGMVTFDSTAYVQSELTQLNSGADRDLLIKRLPTVASGGTSICSGLQA
                     AFTSIKKKYPTDGAEIVLLTDGEDNTISSCFDLVKNSGAIIHTVALGPSAAKELEQLS
                     KMTGGLQTYSSDQIQNNGLVDAFAALSSGNAAISQHSIQLESRGVNLQNKQWMNGSVI
                     VDSTVGKDTLFLVTWTTNSPSIFIWDPSGVQQSGFVLDTNTKVAYLQVPGIAKVGFWK
                     YSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILR
                     ASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSIKIWALGGV
                     TADRQRMAPQRNGVMYIDGWIEDDGEIKMNPPHPETGNVQDSQVCFSRTSSGGSFVAT
                     NVPAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASSYIIRISTSIVD
                     LRNNFSTSLEVNTTDLIPKEASSEEMFEFELDNSFGNGTDVFIAIQAVDKSNLKSEIS
                     NIARVSLFIPAQEPPEDSTPSYPEVSINSTIPGIHVLNIVWKWLGEMHVTLGLH"
     exon            177..317
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            318..465
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..571
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..752
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..971
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1199
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1374
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1481
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1697
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1959
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2133
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2367
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..3608
                     /gene="Clca1"
                     /gene_synonym="Clca3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggaaagct gaagatggga tctttgaaga gtcctgtctt cctcttggtc ctctaccttc
       61 tggaaggggt tctgagcaat tccctcatcc agttgaacaa caatggctat gaaggcatcg
      121 tcattgccat agaccacgat gtgccagaag atgaagccct catccaacgg ataaaggaca
      181 tggtgactca ggcctctcca tacctgtttg aagctacagg gaaaagattt tacttcaaaa
      241 atgttgccat tttgattcct gagaattgga acacaaaacc tgaatataag aggccaaaac
      301 ttgaaacctt aaaaaatgct gatgtccttg tgtcaacaat gagccccata ggtaatgatg
      361 agccctacac cgagcacata ggagcatgtg gagaaagggg gatcaggatt cacctgactc
      421 ctgacttctt agcaggaaag aagcagactg agtatggccc acaagacagg acgtttgttc
      481 atgagtgggc tcacttccga tggggggtgt ttgacgagta caacaacaac gagaagttct
      541 acttgtccaa cggaaagccc caggcagtaa gatgttcggc aaccattacc ggtaaacatg
      601 tagttcgtcg gtgccaggga ggcagttgcg tcactaacgg aaagtgcgta atcgacagag
      661 taacgggact gtataaagat aactgtgtat tcataccaga taaaaaccag agagagaagg
      721 cgtccatcat gtttaaccaa aatatcaact ctgtggttga attctgtaca gaaaaaaatc
      781 acaataaaga agcccccaat gcccaaaacc aacgatgcaa cctccgaagc acttgggaag
      841 tcatccagga atctgaggac ttcaagcaaa ccactcccat gacagcccag ccacccgcac
      901 ccaccttctc actgctgcaa accagacaaa gaatcgtgtg cctcgttctt gataagtccg
      961 ggagcatgca gagcgataac cgtcttaacc gaatgaatca ggcaagccgg cttttcctgc
     1021 tgcagactgt ggagcaggga tcctgggtcg ggatggtgac cttcgacagt accgcctatg
     1081 tacaaagcga actcacacag ttaaacagtg gtgctgacag agacctgctg atcaagcgct
     1141 tacccacagt agcttcagga gggacgtcta tatgctctgg gcttcaggca gcatttacat
     1201 cgataaagaa gaagtacccg acggatggag ctgaaatcgt gctgctgacc gacggggaag
     1261 ataacaccat tagcagctgc tttgacctgg tgaagaacag tggggccatc attcacacag
     1321 tggccctggg accgtctgcc gctaaagagc ttgaacagct gtccaaaatg acaggaggct
     1381 tgcaaacgta ttcttccgat cagattcaga acaacggtct tgttgatgct ttcgcagctc
     1441 tctcctcagg aaatgcagct atctctcagc actccatcca gctggagagc agaggagtta
     1501 atctccagaa taagcagtgg atgaatggct cagtgatcgt ggacagcaca gtggggaagg
     1561 acaccttgtt tcttgtcacc tggactacga attctccttc aatatttatc tgggatccca
     1621 gtggagtgca acaaagtggt tttgtactag acaccaacac caaggtggcc tacctccaag
     1681 tcccaggcat agccaaggtt ggcttttgga aatacagcat tcaagcgagc tcacagactc
     1741 tcactttgac tgtcacctcc cgggcagcaa gcgctacact gcctccaatt acagtgaccc
     1801 cagtagtgaa taagaacaca gggaaattcc ccagccctgt aaccgtgtat gcaagcattc
     1861 gccaaggagc ctcgcctatt ctcagggcca gtgtcacagc cctgattgaa tctgtgaatg
     1921 gaaaaacagt aaccctggaa ttactggata acggagcagg tgccgatgct accaagaatg
     1981 atggtgtcta ctcaaggttt tttacagctt ttgatgcaaa tggtagatac agcatcaaaa
     2041 tatgggctct gggaggagtt actgcagaca gacagagaat ggcccctcag aggaatggag
     2101 tcatgtacat agatggctgg attgaagacg acggtgaaat aaaaatgaat ccaccacacc
     2161 ctgaaactgg taatgttcaa gacagccaag tgtgcttcag caggacatcc tcagggggat
     2221 cgtttgtggc caccaacgtc cccgcagctc ccattcctga cctctttcca ccttgccaaa
     2281 tcactgacct gaaggctagc attcaagggc agaaccttgt gaatctgacg tggacggctc
     2341 ctggggatga ttacgaccac gggagagctt ccagttacat catccgaata agcacgagta
     2401 tcgtcgatct cagaaacaac ttcagcacct cactcgaagt gaacactacc gatctcatcc
     2461 ccaaggaggc cagctccgag gaaatgtttg agtttgaact ggacaacagc tttggaaatg
     2521 gcacagatgt cttcattgct atccaggctg tggataagtc caacctgaaa tcagaaatct
     2581 ccaacattgc ccgggtgtct ctgttcatcc ccgctcagga gccgccagaa gactcaactc
     2641 cttcttatcc cgaagtcagc atcaacagca cgattcctgg catccacgtg ctgaatatag
     2701 tgtggaagtg gctaggggaa atgcatgtga cactaggttt gcactgaatc ttcaggcaag
     2761 aagtaaatcg ctcctgtcat tgtattttag acttcctgaa gggggcgatg tagtaacacg
     2821 tgaagctgta aaattgggcc caggtgcatt aaaaattatc tgttcgaatc caaaagttta
     2881 accatcgctc agtctttgaa gggtaatttg aatgcttgct cgtgttgctt gtaccaatag
     2941 atgggagtag atttaagttt gtcctagggc acttggctaa aaataagatc caattacagt
     3001 tagttaatct actaactact atactaaact atcagaaatg cctactgaac tatttaaata
     3061 caaaaggcct ggtttcttat tcaggacctt ggattaacat cagcaagaat gtgtcttctt
     3121 ttctttaggt aggaatgagg attgcacaat tttgaaatgg ggtacacttt ggagagaact
     3181 cacaccttgg aggtcccatg ggtttagaaa tgcatactac gtgcctatga tgcttagagc
     3241 cacagtagaa ggaaatgggg aggggtaggt agatttaggg caagtgataa agaaataata
     3301 tgtttcacag tttttacaaa tattctatta gccagggact gggcctgttg tggacttttg
     3361 aaacctcata tcccaccccc agtgaaatac caattccaaa aggcaatggc taatgcttct
     3421 caaaacaatt ctaccaacaa gggaccaagc attcacatat gcgagcctac gggagccacc
     3481 acaaccactt acaagtatgt gctcaattag gggtgctctg ttaaatccag ggttgatgtt
     3541 caactgctaa tgaagtaggc cattgtttct acataccaaa cgctaataaa ataatccact
     3601 gtttccac
//
