LOCUS       NM_001127652            1481 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus creatine kinase, mitochondrial 2 (Ckmt2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001127652
VERSION     NM_001127652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Payne,R.M. and Strauss,A.W.
  TITLE     Developmental expression of sarcomeric and ubiquitous mitochondrial
            creatine kinase is tissue-specific
  JOURNAL   Biochim Biophys Acta 1219 (1), 33-38 (1994)
   PUBMED   8086475
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Payne,R.M., Haas,R.C. and Strauss,A.W.
  TITLE     Structural characterization and tissue-specific expression of the
            mRNAs encoding isoenzymes from two rat mitochondrial creatine
            kinase genes
  JOURNAL   Biochim Biophys Acta 1089 (3), 352-361 (1991)
   PUBMED   1859839
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Cheneval,D. and Carafoli,E.
  TITLE     Identification and primary structure of the cardiolipin-binding
            domain of mitochondrial creatine kinase
  JOURNAL   Eur J Biochem 171 (1-2), 1-9 (1988)
   PUBMED   3338460
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Muller,M., Moser,R., Cheneval,D. and Carafoli,E.
  TITLE     Cardiolipin is the membrane receptor for mitochondrial creatine
            phosphokinase
  JOURNAL   J Biol Chem 260 (6), 3839-3843 (1985)
   PUBMED   3972849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 28, 2022 this sequence version replaced NM_001127652.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ216119.1, FQ215000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000002.1  24845451-24845511   c
            62-233              JAXUCZ010000002.1  24829716-24829887   c
            234-432             JAXUCZ010000002.1  24827819-24828017   c
            433-528             JAXUCZ010000002.1  24826439-24826534   c
            529-750             JAXUCZ010000002.1  24825809-24826030   c
            751-836             JAXUCZ010000002.1  24824408-24824493   c
            837-960             JAXUCZ010000002.1  24822998-24823121   c
            961-1095            JAXUCZ010000002.1  24822019-24822153   c
            1096-1221           JAXUCZ010000002.1  24820149-24820274   c
            1222-1481           JAXUCZ010000002.1  24815008-24815267   c
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1481
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /note="creatine kinase, mitochondrial 2"
                     /db_xref="GeneID:688698"
                     /db_xref="RGD:61977"
     exon            1..61
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            62..233
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1341
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /EC_number="2.7.3.2"
                     /note="creatine kinase S-type, mitochondrial; basic-type
                     mitochondrial creatine kinase; sarcomeric mitochondrial
                     creatine kinase; creatine kinase, mitochondrial 2,
                     sarcomeric"
                     /codon_start=1
                     /product="creatine kinase S-type, mitochondrial precursor"
                     /protein_id="NP_001121124.1"
                     /db_xref="GeneID:688698"
                     /db_xref="RGD:61977"
                     /translation="MASAFSKLLTGRNASLLFTTLGTSALTTGYLLNRQKVSADAREQ
                     HKLFPPSADYPDLRKHNNCMAECLTPTIYAKLRNKMTPSGYTLDQCIQTGVDNPGHPF
                     IKTVGMVAGDEESYEVFADLFDPVIKLRHNGYDPRVMKHPTDLDASKITHGQFDERYV
                     LSSRVRTGRSIRGLSLPPACSRAERREVENVAITALEGLKGDLAGRYYKLSEMTEQDQ
                     QRLIDDHFLFDKPVSPLLTCAGMARDWPDARGIWHNYDKTFLIWINEEDHTRVISMEK
                     GGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVRIP
                     KLSKDPRFSKILENLRLQKRGTGGVDTAAVADVYDISNIDRIGRSEVELVQIVIDGVN
                     YLVDCEKKLERGQDIKVPPPLPQFGRK"
     exon            234..432
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            433..528
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            529..750
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            751..836
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            837..960
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1095
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1221
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1481
                     /gene="Ckmt2"
                     /gene_synonym="mib-CK; S-MtCK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacttcttg gctgtgtgca cgcagcagga tctggacacg acagactcct ccagcttcaa
       61 gacactcaac caagaagaag gatggccagt gccttctcta agttgctaac tggccgaaat
      121 gcatctctgc tgtttacgac actgggaacc agtgccctga ccacgggcta cctgttgaat
      181 aggcagaagg tatctgctga tgcccgggaa cagcacaagc tctttccccc aagtgcagac
      241 tatcctgacc ttcgaaaaca taacaactgc atggccgagt gcctcacccc aaccatctat
      301 gccaaactcc gaaacaagat gacacccagt ggctataccc tggaccagtg catccaaacc
      361 ggagtggaca accccggcca ccccttcatt aagactgtgg gcatggtggc tggtgacgag
      421 gagtcgtatg aggtgtttgc tgaccttttt gatcctgtca tcaagttaag gcacaatggc
      481 tatgacccta gggtgatgaa gcatcctact gacctggatg catccaagat cactcacggg
      541 cagtttgatg aacgctatgt gttgtcctct cgggtacgca ctggccgcag catccgcggg
      601 ctgagcctgc ctcctgcctg ctctcgggca gaaagaaggg aggtggagaa tgtggccatt
      661 actgccctgg agggcctcaa aggggatctg gctggtcgct actacaagct gtctgagatg
      721 acagagcagg atcaacaacg gctcatcgat gaccactttc tgtttgataa gccagtgtcc
      781 cctttactaa catgcgctgg gatggcccgt gactggcctg atgccagagg aatctggcat
      841 aattatgaca agacatttct catctggata aatgaagaag accacaccag ggtgatttca
      901 atggagaagg gaggcaatat gaaacgcgta tttgagcgat tctgtcgtgg actaaaggaa
      961 gtggaacgac taatccaaga acgaggctgg gagttcatgt ggaatgaacg tctaggatac
     1021 attttgactt gcccctcgaa cctcggaact ggattgcgag ctggtgtcca cgttaggatc
     1081 ccaaagctca gcaaggatcc acgcttttct aagatcttgg agaacctgcg gctccagaag
     1141 cgtggcacag gaggcgtgga cactgcagca gtggccgacg tgtacgacat ttccaacata
     1201 gatcggatcg gtagatctga ggttgagctt gttcagattg ttattgacgg agtcaactac
     1261 ctggtggatt gtgaaaagaa gctggagaga ggccaggaca tcaaggtgcc gcctcccctg
     1321 cctcagtttg gcaggaagtg aatttagcct gccaaggttc tgggtgatgt gtctgctggt
     1381 atgacagaca caggaagtct ctgctctgag agtttttgta gacttgaaaa catgtaaaat
     1441 tgtaggtact gctattttac aataaaactc tccttaatat c
//
