LOCUS       NM_001012738            1607 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus creatine kinase, mitochondrial 1 (Ckmt1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001012738 XM_342505 XM_347216
VERSION     NM_001012738.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1607)
  AUTHORS   Ren,M., Phoon,C.K. and Schlame,M.
  TITLE     Metabolism and function of mitochondrial cardiolipin
  JOURNAL   Prog Lipid Res 55, 1-16 (2014)
   PUBMED   24769127
  REMARK    Review article
REFERENCE   2  (bases 1 to 1607)
  AUTHORS   Gemelli,T., de Andrade,R.B., Rojas,D.B., Bonorino,N.F.,
            Mazzola,P.N., Tortorelli,L.S., Funchal,C., Filho,C.S. and
            Wannmacher,C.M.
  TITLE     Effects of beta-alanine administration on selected parameters of
            oxidative stress and phosphoryltransfer network in cerebral cortex
            and cerebellum of rats
  JOURNAL   Mol Cell Biochem 380 (1-2), 161-170 (2013)
   PUBMED   23620342
  REMARK    GeneRIF: Data indicate that the beta-alanine administration was
            able to inhibit the enzyme pyruvate kinase, cytosolic creatine
            kinase, and adenylate kinase activities in cerebral cortex, and
            increase in cerebellum.
REFERENCE   3  (bases 1 to 1607)
  AUTHORS   Cui,J., Yu,M., Niu,J., Yue,Z. and Xu,Z.
  TITLE     Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the
            processing of uMtCK to induce cell death in a cell culture model
            system
  JOURNAL   Biosci Rep 31 (5), 429-437 (2011)
   PUBMED   21370995
REFERENCE   4  (bases 1 to 1607)
  AUTHORS   Kim,D.W., Yeo,S.I., Ryu,H.J., Kim,J.E., Song,H.K., Kwon,O.S.,
            Choi,S.Y. and Kang,T.C.
  TITLE     Effects of creatine and beta-guanidinopropionic acid and
            alterations in creatine transporter and creatine kinases expression
            in acute seizure and chronic epilepsy models
  JOURNAL   BMC Neurosci 11, 141 (2010)
   PUBMED   20979657
  REMARK    GeneRIF: In chronic epilepsy rats, uMtCK immunoreactivity is
            markedly reduced in hippocampal CA1-3 pyramidal cells and hilar
            neurons due to massive neuronal loss.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1607)
  AUTHORS   Monge,C., Beraud,N., Kuznetsov,A.V., Rostovtseva,T., Sackett,D.,
            Schlattner,U., Vendelin,M. and Saks,V.A.
  TITLE     Regulation of respiration in brain mitochondria and synaptosomes:
            restrictions of ADP diffusion in situ, roles of tubulin, and
            mitochondrial creatine kinase
  JOURNAL   Mol Cell Biochem 318 (1-2), 147-165 (2008)
   PUBMED   18629616
  REMARK    GeneRIF: The role of ubiquitous mitochondrial creatine kinase
            (uMtCK) reaction in regulation of mitochondrial respiration was
            studied in purified preparations of rat brain synaptosomes and
            mitochondria.
REFERENCE   6  (bases 1 to 1607)
  AUTHORS   Chen,L., Roberts,R. and Friedman,D.L.
  TITLE     Expression of brain-type creatine kinase and ubiquitous
            mitochondrial creatine kinase in the fetal rat brain: evidence for
            a nuclear energy shuttle
  JOURNAL   J Comp Neurol 363 (3), 389-401 (1995)
   PUBMED   8847407
REFERENCE   7  (bases 1 to 1607)
  AUTHORS   Payne,R.M. and Strauss,A.W.
  TITLE     Developmental expression of sarcomeric and ubiquitous mitochondrial
            creatine kinase is tissue-specific
  JOURNAL   Biochim Biophys Acta 1219 (1), 33-38 (1994)
   PUBMED   8086475
REFERENCE   8  (bases 1 to 1607)
  AUTHORS   Friedman,D.L. and Perryman,M.B.
  TITLE     Compartmentation of multiple forms of creatine kinase in the distal
            nephron of the rat kidney
  JOURNAL   J Biol Chem 266 (33), 22404-22410 (1991)
   PUBMED   1939264
REFERENCE   9  (bases 1 to 1607)
  AUTHORS   Payne,R.M., Haas,R.C. and Strauss,A.W.
  TITLE     Structural characterization and tissue-specific expression of the
            mRNAs encoding isoenzymes from two rat mitochondrial creatine
            kinase genes
  JOURNAL   Biochim Biophys Acta 1089 (3), 352-361 (1991)
   PUBMED   1859839
REFERENCE   10 (bases 1 to 1607)
  AUTHORS   Kottke,M., Adams,V., Wallimann,T., Nalam,V.K. and Brdiczka,D.
  TITLE     Location and regulation of octameric mitochondrial creatine kinase
            in the contact sites
  JOURNAL   Biochim Biophys Acta 1061 (2), 215-225 (1991)
   PUBMED   1998693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091335.1.
            
            On or before Mar 26, 2005 this sequence version replaced
            XM_342505.1, XM_347216.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091335.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1607
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1607
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /note="creatine kinase, mitochondrial 1"
                     /db_xref="GeneID:29593"
                     /db_xref="RGD:61976"
     exon            1..351
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1456
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /EC_number="2.7.3.2"
                     /note="creatine kinase, mitochondrial 1, ubiquitous;
                     creatine kinase U-type, mitochondrial; U-MtCK; mia-CK;
                     ubiquitous mitochondrial creatine kinase; acidic-type
                     mitochondrial creatine kinase; creatine kinase,
                     mitochondrial 1B"
                     /codon_start=1
                     /product="creatine kinase U-type, mitochondrial precursor"
                     /protein_id="NP_001012756.1"
                     /db_xref="GeneID:29593"
                     /db_xref="RGD:61976"
                     /translation="MAGPFSRLLSARPGLKLLALAGAGSLAAGILLRPESVRAATGER
                     RRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPF
                     IKTVGMVAGDEETYEVFAELFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYV
                     LSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQ
                     QQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEK
                     GGNMKRVFERFCRGLKEVEKLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHVKLP
                     LLSKDSRFPKILENLRLQKRGTGGVDTAATGSVFDISNLDRLGKSEVELVQLVIDGVN
                     YLIDCERRLEKGQDIRIPPPLVHGKH"
     exon            352..550
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     exon            551..646
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     exon            647..954
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1078
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1213
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1339
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1580
                     /gene="Ckmt1"
                     /gene_synonym="Ckmt1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggccgctt gcttgctgcg cttctcctgc agcctggtag gcactggctg ctacttcagc
       61 ttcagccttc gtcgcgaccc ctattttggc tccagtctcc gaccctgctc cgtcctctct
      121 ctacttggtt gcatcctccc tcctagttcc agatttgcgc cagatcctgc tccaaatccg
      181 gtagccgcat ccccaagcca tggctggtcc cttctcccgt ctgctgtctg cccgccccgg
      241 actcaagctc ctggctttgg ctggagctgg gtctctcgcc gccgggattc tgctccgtcc
      301 ggaatctgta cgagcggcca ccggtgaacg gaggagactg tatcccccga gcgctgagta
      361 cccagacctc cgaaagcaca acaactgcat ggccagtcac ctgaccccag cagtctatgc
      421 acggctctgc gacaagacca cacccactgg ctggacacta gatcagtgca tccagactgg
      481 agtggacaac cctggccacc ccttcatcaa gactgtgggc atggtggctg gagatgagga
      541 gacctatgag gtatttgccg aactgtttga ccctgtgatc caagagcggc ataatggata
      601 tgaccctaga acaatgaagc acaccactga ccttgatgcc agcaaaatcc gttctggcta
      661 ctttgatgag aggtacgtat tgtcctcaag agtcagaact ggccgaagta tcaggggact
      721 cagtctccct ccagcctgca ctcgggcaga gcgacgagag gtggagcgtg ttgtggtgga
      781 cgcgctgagt ggcctgaagg gcgacctggc tggacggtac tacaggctca gtgagatgac
      841 agaggctgag cagcagcagc ttattgacga ccatttcctg tttgataaac ctgtgtcccc
      901 attgctgaca gcagcaggca tggctcgaga ctggccagat gcccgaggaa tctggcacaa
      961 caatgagaag agtttcttga tctgggtgaa tgaggaggac cacacacggg tcatctctat
     1021 ggagaaaggc ggcaacatga agagagtgtt tgaaagattc tgccggggcc tcaaagaggt
     1081 ggagaagctg atccaggaac gaggctggga gttcatgtgg aatgagcgtt taggatacat
     1141 cttgacctgt ccatctaacc tgggcactgg acttcgggca ggagtacacg tcaaactgcc
     1201 actgctaagc aaagatagcc gcttcccaaa gatcctggag aacctaaggc tgcaaaagcg
     1261 tgggactgga ggagtggaca cggctgccac aggcagtgtc tttgacatct ctaatctgga
     1321 tcgacttggc aagtcagagg tggagctggt gcagctggtc atcgatgggg tgaactattt
     1381 gattgactgt gaacggcgtc tggagaaagg acaggatatt cgaatccctc cacctcttgt
     1441 ccacggcaaa cattaactcc ccgttcccag cagatgaatc aagattcccc aggacttctg
     1501 catatttaac agtggcccat tctacttgcc aaggacctgc ctctcaatcc ctgtcctagt
     1561 aaagactcca cgttctgttg aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
